The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer.

abstract：:Hepatitis C virus (HCV) often causes a persistent infection associated with hypergammaglobulinemia, high levels of antiviral antibody and circulating immune complexes, and immune complex disease. We previously reported that only a limited neutralizing activity to vesicular stomatitis virus or HCV pseudotype is generat...

journal_title：Journal of virology

authors： Meyer K,Ait-Goughoulte M,Keck ZY,Foung S,Ray R

更新日期：2008-03-01 00:00:00

abstract：:In previous reports it was demonstrated that the Nipah virus V and W proteins have interferon (IFN) antagonist activity due to their ability to block signaling from the IFN-alpha/beta receptor (J. J. Rodriguez, J. P. Parisien, and C. M. Horvath, J. Virol. 76:11476-11483, 2002; M. S. Park et al., J. Virol. 77:1501-1511...

journal_title：Journal of virology

authors： Shaw ML,García-Sastre A,Palese P,Basler CF

更新日期：2004-06-01 00:00:00

abstract：:Synthetic peptides of increasing length and corresponding in sequence to the C-terminal end of the HA1 molecule of influenza virus were constructed and examined for their immunogenic and antigenic properties. Peptides containing at least the four C-terminal amino acids, when coupled to keyhole limpet hemocyanin, were ...

journal_title：Journal of virology

authors： Tang XL,Tregear GW,White DO,Jackson DC

更新日期：1988-12-01 00:00:00

abstract：:The common virus integration site (VIS) Evi11 was recently identified within the gene encoding the hematopoietic G-protein-coupled peripheral cannabinoid receptor Cnr2 (also referred to as Cb2). Here we show that Cnr2 is a frequent target (12%) for insertion of Cas-Br-M murine leukemia virus (MuLV) in primary tumors i...

journal_title：Journal of virology

authors： Valk PJ,Vankan Y,Joosten M,Jenkins NA,Copeland NG,Löwenberg B,Delwel R

更新日期：1999-05-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) major immediate-early (MIE) enhancer contains five functional cyclic AMP (cAMP) response elements (CRE). Because the CRE in their native context do not contribute appreciably to MIE enhancer/promoter activity in lytically infected human fibroblasts and NTera2 (NT2)-derived neurons, we ...

journal_title：Journal of virology

authors： Keller MJ,Wu AW,Andrews JI,McGonagill PW,Tibesar EE,Meier JL

更新日期：2007-06-01 00:00:00

abstract：:The 5' untranslated region (UTR) of hepatitis C virus (HCV), which is composed of four domains (I, II, III, and IV) and a pseudoknot, is essential for translation and viral replication. Equine nonprimate hepacivirus (EHcV) harbors a 5' UTR consisting of a large 5'-terminal domain (I); three additional domains (I', II,...

journal_title：Journal of virology

authors： Tanaka T,Otoguro T,Yamashita A,Kasai H,Fukuhara T,Matsuura Y,Moriishi K

更新日期：2018-03-14 00:00:00

abstract：:Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues, such as the liver. ...

journal_title：Journal of virology

authors： Ylösmäki E,Martikainen M,Hinkkanen A,Saksela K

更新日期：2013-01-01 00:00:00

abstract：UNLABELLED:Human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are the two major causative agents for hand-foot-and-mouth disease (HFMD). Previously, we demonstrated that a virus-like particle (VLP) for EV71 produced from Saccharomyces cerevisiae is a potential vaccine candidate against EV71 infection, and an EV...

journal_title：Journal of virology

authors： Lyu K,He YL,Li HY,Chen R

更新日期：2015-06-01 00:00:00

abstract：:The chimpanzee monoclonal antibody (MAb) 5H2 is specific for dengue virus type 4 (DENV-4) and neutralizes the virus at a high titer in vitro. The epitope detected by the antibody was mapped by sequencing neutralization escape variants of the virus. One variant contained a Lys174-Glu substitution and another contained ...

journal_title：Journal of virology

authors： Lai CJ,Goncalvez AP,Men R,Wernly C,Donau O,Engle RE,Purcell RH

更新日期：2007-12-01 00:00:00

abstract：:We previously conducted a phase I/II study using arterial infusions of ONYX-015 (dl1520), a replication-selective adenoviral vector, with E1b deleted, for patients with metastatic colorectal cancer. No dose-limiting toxicities occurred, but >90% of the patients experienced fever. The effects of temperature on the repl...

journal_title：Journal of virology

authors： Thorne SH,Brooks G,Lee YL,Au T,Eng LF,Reid T

更新日期：2005-01-01 00:00:00

abstract：:Proliferation responses of naïve CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV(+)) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healt...

journal_title：Journal of virology

authors： Bazdar DA,Sieg SF

更新日期：2007-11-01 00:00:00

abstract：:Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of cholesterol to form a solub...

journal_title：Journal of virology

authors： Doms A,Sanabria T,Hansen JN,Altan-Bonnet N,Holm GH

更新日期：2018-08-29 00:00:00

abstract：:The EFII cis element is a 38-bp sequence at the 5' end of the Rous sarcoma virus long terminal repeat, extending from nucleotides -229 to -192 (with respect to the viral transcription start site), which is recognized by sequence-specific DNA-binding proteins in avian fibroblast nuclear extracts (L. Sealy and R. Chalkl...

journal_title：Journal of virology

authors： Sears RC,Sealy L

更新日期：1992-11-01 00:00:00

abstract：:Several independent cell lines transformed by simian virus 40 carry a species of viral RNA of 900,000 to 1,000,000 daltons. A viral RNA species of similar size is found early in the lytic cycle. Late in the viral lytic cycle, two prominent viral RNA species of about 600,000 and 900,000 daltons are seen. The larger lat...

journal_title：Journal of virology

authors： Weinberg RA,Ben-Ishai Z,Newbold JE

更新日期：1974-06-01 00:00:00

abstract：:Inhibitors of hemagglutination by type A2 influenza virus and a recently isolated strain of type B influenza virus were separated by sucrose density gradient centrifugation and agarose gel filtration from horse serum. Using selected reagents, it was demonstrated that the active substituent on the horse serum inhibitor...

journal_title：Journal of virology

authors： Levinson B,Pepper D,Belyavin G

更新日期：1969-05-01 00:00:00

abstract：:The large-particle fraction from the cytoplasm of chick embryo fibroblasts infected with Semliki Forest virus was found to catalyze the incorporation of the 5'-triphosphates of guanosine, adenine, cytidine, and uridine into an acid-insoluble alkali-labile product. The conditions affecting the preparation and assay of ...

journal_title：Journal of virology

authors： Martin EM,Sonnabend JA

更新日期：1967-02-01 00:00:00

abstract：:In various positive-sense single-stranded RNA viruses, a low-fidelity viral RNA-dependent RNA polymerase (RdRp) confers attenuated phenotypes by increasing the mutation frequency. We report a negative-sense single-stranded RNA virus RdRp mutant strain with a mutator phenotype. Based on structural data of RdRp, rationa...

journal_title：Journal of virology

authors： Naito T,Shirai K,Mori K,Muratsu H,Ushirogawa H,Ohniwa RL,Hanada K,Saito M

更新日期：2019-10-29 00:00:00

abstract：:We investigated the protective role of antibodies in vaginal secretions of mice that were immune to vaginal challenge with herpes simplex virus type 2 (HSV-2). Unfractionated vaginal immunoglobulins from immune and nonimmune mice and affinity-purified immunoglobulin G (IgG) and secretory IgA (S-IgA) from immune secret...

journal_title：Journal of virology

authors： Parr EL,Parr MB

更新日期：1997-11-01 00:00:00

abstract：:Rotavirus infection is one of the most common causes of diarrheal illness in humans. In neonatal mice, rhesus rotavirus (RRV) can induce biliary atresia (BA), a disease resulting in inflammatory obstruction of the extrahepatic biliary tract and intrahepatic bile ducts. We previously showed that the amino acid arginine...

journal_title：Journal of virology

authors： Mohanty SK,Donnelly B,Dupree P,Lobeck I,Mowery S,Meller J,McNeal M,Tiao G

更新日期：2017-07-12 00:00:00

abstract：:Human cytomegalovirus (HCMV) lytic DNA replication is initiated at the complex cis-acting oriLyt region, which spans nearly 3 kb. DNA synthesis requires six core proteins together with UL84 and IE2. Previously, two essential regions were identified within oriLyt. Essential region I (nucleotides [nt] 92209 to 92573) ca...

journal_title：Journal of virology

authors： Colletti KS,Smallenburg KE,Xu Y,Pari GS

更新日期：2007-07-01 00:00:00

abstract：:Infection of cells with enveloped viruses is accomplished through membrane fusion. The binding and fusion processes are mediated by the spike proteins in the envelope of the virus particle and usually involve a series of conformational changes in these proteins. We have studied the low-pH-mediated fusion process of th...

journal_title：Journal of virology

authors： Wahlberg JM,Bron R,Wilschut J,Garoff H

更新日期：1992-12-01 00:00:00

abstract：:Our previous studies with influenza A viruses indicated that the association of M1 with viral RNA and nucleoprotein (NP) is required for the efficient formation of helical ribonucleoprotein (RNP) and for the nuclear export of RNPs. RNA-binding domains of M1 map to the following two independent regions: a zinc finger m...

journal_title：Journal of virology

authors： Liu T,Ye Z

更新日期：2004-09-01 00:00:00

abstract：:The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the primary virus receptor, CD4, with gp120. Here, we extended the investigation of the VRC01-gp120 core interaction to the biologically relevant vira...

journal_title：Journal of virology

authors： Li Y,O'Dell S,Walker LM,Wu X,Guenaga J,Feng Y,Schmidt SD,McKee K,Louder MK,Ledgerwood JE,Graham BS,Haynes BF,Burton DR,Wyatt RT,Mascola JR

更新日期：2011-09-01 00:00:00

abstract：:The phenotypic defects of two mutants of vaccinia virus, the lesions of which map to gene G2R, were characterized in vivo, and the results suggest a role for the G2R protein in viral transcription elongation. Both a temperature-sensitive mutant, Cts56, and an isatin-beta-thiosemicarbazone-dependent deletion mutant, G2...

journal_title：Journal of virology

authors： Black EP,Condit RC

更新日期：1996-01-01 00:00:00

abstract：:Avian influenza virus (AIV) surveillance in Antarctica during 2013 revealed the prevalence of evolutionarily distinct influenza viruses of the H11N2 subtype in Adélie penguins. Here we present results from the continued surveillance of AIV on the Antarctic Peninsula during 2014 and 2015. In addition to the continued d...

journal_title：Journal of virology

authors： Hurt AC,Su YCF,Aban M,Peck H,Lau H,Baas C,Deng YM,Spirason N,Ellström P,Hernandez J,Olsen B,Barr IG,Vijaykrishna D,Gonzalez-Acuna D

更新日期：2016-10-14 00:00:00

abstract：:Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a transmissible lung cancer of sheep known as ovine pulmonary carcinoma. Recently, we have found that the expression of the JSRV envelope (Env) is sufficient to transform mouse NIH 3T3 cells in classical transformation assays. To further investigate the mech...

journal_title：Journal of virology

authors： Palmarini M,Maeda N,Murgia C,De-Fraja C,Hofacre A,Fan H

更新日期：2001-11-01 00:00:00

abstract：UNLABELLED:Children with acute respiratory syncytial virus (RSV) infection often develop sequelae of persistent airway inflammation and wheezing. Pulmonary C fibers (PCFs) are involved in the generation of airway inflammation and resistance; however, their role in persistent airway diseases after RSV is unexplored. Her...

journal_title：Journal of virology

authors： Zang N,Zhuang J,Deng Y,Yang Z,Ye Z,Xie X,Ren L,Fu Z,Luo Z,Xu F,Liu E

更新日期：2015-12-16 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an arbovirus that causes disease in livestock and humans in Africa and the Middle East. While human disease is typically mild and self-limiting, some individuals develop severe manifestations, such as hepatitis, hemorrhagic fever, or encephalitis. Encephalitis occurs 2 to 3 weeks afte...

journal_title：Journal of virology

authors： Harmon JR,Spengler JR,Coleman-McCray JD,Nichol ST,Spiropoulou CF,McElroy AK

更新日期：2018-11-27 00:00:00

abstract：:The complete genomic sequence of a new Muscovy duck-origin reovirus (N-MDRV), strain J18 from China, was determined. The virus has a tricistronic S1 genome segment that is distinct from the originally described MDRV, which possesses a bicistronic S4 genome segment. Pairwise comparisons and phylogenetic analyses sugges...

journal_title：Journal of virology

authors： Wang D,Xu F,Ma G,Zhang C,Huang Y,Li H,Zhang D

更新日期：2012-11-01 00:00:00

abstract：:To reliably infect a primate model for human immunodeficiency virus (HIV), approximately 10,000-fold more virus must be delivered vaginally than intravenously. However, the vaginal mechanisms that help protect against HIV are poorly understood. Here, we report that human cervicovaginal mucus (CVM), obtained from donor...

journal_title：Journal of virology

authors： Lai SK,Hida K,Shukair S,Wang YY,Figueiredo A,Cone R,Hope TJ,Hanes J

更新日期：2009-11-01 00:00:00