Abstract:
UNLABELLED:Since the 1960s, simian hemorrhagic fever virus (SHFV; Nidovirales, Arteriviridae) has caused highly fatal outbreaks of viral hemorrhagic fever in captive Asian macaque colonies. However, the source(s) of these outbreaks and the natural reservoir(s) of this virus remain obscure. Here we report the identification of two novel, highly divergent simian arteriviruses related to SHFV, Mikumi yellow baboon virus 1 (MYBV-1) and Southwest baboon virus 1 (SWBV-1), in wild and captive baboons, respectively, and demonstrate the recent transmission of SWBV-1 among captive baboons. These findings extend our knowledge of the genetic and geographic diversity of the simian arteriviruses, identify baboons as a natural host of these viruses, and provide further evidence that baboons may have played a role in previous outbreaks of simian hemorrhagic fever in macaques, as has long been suspected. This knowledge should aid in the prevention of disease outbreaks in captive macaques and supports the growing body of evidence that suggests that simian arterivirus infections are common in Old World monkeys of many different species throughout Africa. IMPORTANCE:Historically, the emergence of primate viruses both in humans and in other primate species has caused devastating outbreaks of disease. One strategy for preventing the emergence of novel primate pathogens is to identify microbes with the potential for cross-species transmission in their natural state within reservoir species from which they might emerge. Here, we detail the discovery and characterization of two related simian members of the Arteriviridae family that have a history of disease emergence and host switching. Our results expand the phylogenetic and geographic range of the simian arteriviruses and define baboons as a natural host for these viruses. Our findings also identify a potential threat to captive macaque colonies by showing that simian arteriviruses are actively circulating in captive baboons.
journal_name
J Viroljournal_title
Journal of virologyauthors
Bailey AL,Lauck M,Sibley SD,Pecotte J,Rice K,Weny G,Tumukunde A,Hyeroba D,Greene J,Correll M,Gleicher M,Friedrich TC,Jahrling PB,Kuhn JH,Goldberg TL,Rogers J,O'Connor DHdoi
10.1128/JVI.02203-14subject
Has Abstractpub_date
2014-11-01 00:00:00pages
13231-9issue
22eissn
0022-538Xissn
1098-5514pii
JVI.02203-14journal_volume
88pub_type
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pub_type: 杂志文章
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doi:10.1128/JVI.00389-08
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更新日期:1998-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.4.2643-2649.1996
更新日期:1996-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.2.643-650.1993
更新日期:1993-02-01 00:00:00
abstract::Most of the viral DNA extracted from simian virus 40 (SV40)-infected African green monkey kidney cells consists of circular molecules about 5.3 kilobases in contour length. However, about 1% of the viral DNA was found to occur as closed circular dimers that appeared to be formed, preferentially, late in infection. The...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.24.1.295-302.1977
更新日期:1977-10-01 00:00:00