Abstract:
:The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they matured. Older C57BL/6 mice were also resistant to raf/myc lymphomas, whereas BALB/c mice remained susceptible to the virus at all ages, indicating that different genes control susceptibility to raf and raf/myc tumors. From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait.
journal_name
J Viroljournal_title
Journal of virologyauthors
Klinken SP,Hartley JW,Fredrickson TN,Rapp UR,Morse HC 3rddoi
10.1128/JVI.63.5.2411-2414.1989subject
Has Abstractpub_date
1989-05-01 00:00:00pages
2411-4issue
5eissn
0022-538Xissn
1098-5514journal_volume
63pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.14.6.1611-1612.1974
更新日期:1974-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1978-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-10-27 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.8.5157-5160.1992
更新日期:1992-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1968-10-01 00:00:00