Abstract:
:HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that HLA-B*58:01 binds and presents KF11 peptide, but HIV-infected HLA-B*58:01(+) cells fail to process KF11. This unexpected finding demonstrates that immunodominance patterns can be influenced by intracellular events independent of HLA binding motifs.
journal_name
J Viroljournal_title
Journal of virologyauthors
Kløverpris HN,Stryhn A,Harndahl M,Payne R,Towers GJ,Chen F,Riddell L,Walker BD,Ndung'u T,Leslie A,Buus S,Goulder Pdoi
10.1128/JVI.01122-13subject
Has Abstractpub_date
2013-10-01 00:00:00pages
10889-94issue
19eissn
0022-538Xissn
1098-5514pii
JVI.01122-13journal_volume
87pub_type
杂志文章abstract::The great majority of viral mRNAs in mouse C127 cells transformed by bovine papillomavirus type 1 (BPV) have a common 3' end at the early polyadenylation site which is 23 nucleotides (nt) downstream of a canonical poly(A) consensus signal. Twenty percent of BPV mRNA from productively infected cells bypasses the early ...
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更新日期:2001-07-01 00:00:00