Abstract:
:A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.
journal_name
J Viroljournal_title
Journal of virologyauthors
Sullivan BM,Welch MJ,Lemke G,Oldstone MBdoi
10.1128/JVI.03268-12subject
Has Abstractpub_date
2013-04-01 00:00:00pages
4071-4issue
7eissn
0022-538Xissn
1098-5514pii
JVI.03268-12journal_volume
87pub_type
杂志文章abstract::Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1 production was impaired in patients with chronic infections of hepatitis C virus (HCV), implying that IL-1 may play a role in viral clearance. Using an HCV subgenomic replicon cell line, we demonstrate th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.9.5493-5498.2003
更新日期:2003-05-01 00:00:00
abstract::The replication of vaccinia virus is thought to take place exclusively in the cytoplasm of host cells. However, using DNA-DNA hybridization techniques, it can be shown that a significant fraction of the synthesis of vaccinia DNA takes place in the nucleus as well as the cytoplasm. The (3H) thymiding pulse-labeled vacc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.15.2.305-315.1975
更新日期:1975-02-01 00:00:00
abstract::The Tf1 retrotransposon of Schizosaccharomyces pombe represents a group of eukaryotic long terminal repeat (LTR) retroelements that, based on their sequences, were predicted to use an RNA self-primer for initiating reverse transcription while synthesizing the negative-sense DNA strand. This feature is substantially di...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01370-08
更新日期:2008-11-01 00:00:00
abstract::Physiological microenvironments such as blood, seminal plasma, mucosal secretions, or lymphatic fluids may influence the biology of the virus-host cell and immune interactions for human immunodeficiency virus type 1 (HIV-1). Relative to media, physiological levels of human plasma were found to enhance the infectivity ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.10.6054-6062.1995
更新日期:1995-10-01 00:00:00
abstract::The mutational alterations in polyoma virus mutants ts-a and ts-25E which cause their large T-antigens to be thermolabile have been identified. In ts-a, a G leads to A transition at nucleotide 2193 causes the replacement of Ala (GCT) by Thr (ACT). In ts-25E, a G leads to T transversion at nucleotide 2883 causes the re...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.37.3.1094-1098.1981
更新日期:1981-03-01 00:00:00
abstract::The DNA molecules from T7 bacteriophage and a recently obtained mutant form of T4D were studied. The DNA of this T4 mutant contains cytosine in place of all of the glucosylated hydroxymethylcytosines normally present in T4. Molecular weights were measured with an electron microscope technique, and sedimentation coeffi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.33.1.438-448.1980
更新日期:1980-01-01 00:00:00
abstract::The possible addition of extra sequences to simian virus 40 (SV40) DNA was analyzed by electron microscopy in two different cell systems, productively infected monkey cells and activated heterokaryons on monkey and transformed mouse 3T3 cells. We found that the closed circular DNA fraction, extracted from monkey cells...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.23.2.323-337.1977
更新日期:1977-08-01 00:00:00
abstract::In this study, we investigated the interaction of reovirus particles with cell membranes by using a 51Cr release assay. We confirmed prior observations (J. Borsa, B. D. Morash, M. D. Sargent, T. P. Copps, P. A. Lievaart, and J. G. Szekely, J. Gen. Virol. 45:161-170, 1979) that intermediate subviral particles (ISVPs) o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.9.5339-5345.1993
更新日期:1993-09-01 00:00:00
abstract::To better understand the virological aspect of the expanding AIDS epidemic in southern Africa, a set of 23 near-full-length clones of human immunodeficiency virus type 1 (HIV-1) representing eight AIDS patients from Botswana were sequenced and analyzed phylogenetically. All study viruses from Botswana belonged to HIV-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.5.4427-4432.1999
更新日期:1999-05-01 00:00:00
abstract::Host-virus interactions control disease progression in human immunodeficiency virus-infected human beings and in nonhuman primates infected with simian or simian/human immunodeficiency viruses (SHIV). These interactions evolve rapidly during acute infection and are key to the mechanisms of viral persistence and AIDS. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.12.10236-10244.1999
更新日期:1999-12-01 00:00:00
abstract::Of the numerous endogenous retroviral elements that are present in the human genome, the abundant HERV-K family is distinct because several members are transcriptionally active and coding for biologically active proteins. A detailed phylogeny of the HERV-K family based on the partial sequence of the reverse transcript...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.3.2365-2375.1999
更新日期:1999-03-01 00:00:00
abstract::The influenza A virus (IAV) envelope protein hemagglutinin binds α2,6- or α2,3-linked sialic acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this rule and do not bind sialic acid but enter cells via major histocompatibility complex (MHC) class II. Here, we review current knowledge...
journal_title:Journal of virology
pub_type: 杂志文章,评审
doi:10.1128/JVI.01357-19
更新日期:2020-01-31 00:00:00
abstract::The major human tRNA(Lys) isoacceptors, and, are selectively packaged into human immunodeficiency virus type 1 (HIV-1) during assembly, where acts as a primer for reverse transcription. Lysyl-tRNA synthetase (LysRS) is also incorporated into HIV-1, independently of tRNA(Lys), via its interaction with Gag, and is a str...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.18.9817-9822.2003
更新日期:2003-09-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine leads to a serious disease characterized by a delayed and defective adaptive immune response. It is hypothesized that a suboptimal innate immune response is responsible for the disease pathogenesis. In the study presented here we tested thi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01326-09
更新日期:2010-02-01 00:00:00
abstract::The Borna disease virus (BDV) is the prototype member of the Bornaviridae, and it replicates in the cell nucleus. The BDV p24P and p40N proteins carry nuclear localization signals (NLS) and are found in the nuclei of infected cells. The BDV p10 protein does not have an NLS, but it binds with P and/or N and is transloc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.7.3413-3417.2000
更新日期:2000-04-01 00:00:00
abstract::Ribosomes are observed intimately associated with nucleocapsids of vesicular, stomatitis virus, especially those that line structures that are either cytoplasmic vesicles or invaginations of the plasma membrane. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.16.2.447-452.1975
更新日期:1975-08-01 00:00:00
abstract::The human immunodeficiency virus (HIV) gag polyprotein is processed by the viral protease to yield the structural proteins of the virus. One of these structural proteins, p15, and its protease cleavage products, p7 and p6, are believed to be responsible for the viral RNA binding which is prerequisite for assembly of i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.10.6207-6214.1994
更新日期:1994-10-01 00:00:00
abstract::Mouse mammary tumor virus (MMTV) DNA fragments were cloned into M13 bacteriophage, and the single-stranded recombinant phage DNAs were used as strand-specific nucleic acid hybridization probes to measure synthesis of plus (genomic) and minus strands of MMTV RNA in cultured cell lines and in cell-free preparations of n...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.1.60-65.1984
更新日期:1984-04-01 00:00:00
abstract::It has been suggested that sequences located within the 5' noncoding region of human foamy virus (HFV) are critical for expression of the viral Gag and Pol structural proteins. Here, we identify a discrete approximately 151-nucleotide sequence, located within the R region of the HFV long terminal repeat, that activate...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.15.6817-6824.2001
更新日期:2001-08-01 00:00:00
abstract::CtBP has been shown to be a highly conserved corepressor of transcription. E1A and all the various transcription factors to which CtBP binds contain a conserved PLDLS CtBP-interacting domain, and EBNA3C includes a PLDLS motif (amino acids [aa] 728 to 732). Here we show that EBNA3C binds to CtBP both in vitro and in vi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.16.7749-7755.2001
更新日期:2001-08-01 00:00:00
abstract::The E6 oncoproteins encoded by the cancer-associated human papillomaviruses (HPVs) can associate with and promote the degradation of wild-type p53 in vitro. To gain further insight into this process, the ability of HPV-16 E6 to complex with and promote the degradation of mutant forms of p53 was studied. A correlation ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.8.5100-5105.1992
更新日期:1992-08-01 00:00:00
abstract::This paper describes Q beta noninfectious particles produced at 41 degrees C in a streptomycin-resistant Escherichia coli mutant which is temperature sensitive for suppression of a nonsense codon. The noninfectious particles resembled Q beta under the electron microscope and contained coat protein molecules in an amou...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.3.1107-1117.1979
更新日期:1979-03-01 00:00:00
abstract::For efficient and versatile use of adenovirus (Ad) as an in vivo gene therapy vector, modulation of the viral tropism is highly desirable. In this study, a novel method to genetically alter the Ad fiber tropism is described. The knob and the last 15 shaft repeats of the fiber gene were deleted and replaced with an ext...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.16.7280-7289.2001
更新日期:2001-08-01 00:00:00
abstract:UNLABELLED:Human noroviruses (NoVs) cause acute epidemic gastroenteritis. Susceptibility to the majority of NoV infections is determined by genetically controlled secretor-dependent expression of histo-blood group antigens (HBGAs), which are also critical for NoV attachment to host cells. Human NoVs are classified into...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00201-14
更新日期:2014-06-01 00:00:00
abstract::We have mapped the temperature-sensitive (ts) lesions of three mutants, ts51, ts53, and ts65, and two other mutants, ts7 and ts20, to regions on the vaccinia virus genome that encode the 147- and 22-kilodalton subunits of the viral DNA-dependent RNA polymerase, respectively. Plasmid and bacteriophage clones from the H...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.2.705-713.1989
更新日期:1989-02-01 00:00:00
abstract::The human immunodeficiency virus type 1 Vpu protein is a 16-kDa phosphoprotein which enhances the efficiency of virion production and induces rapid degradation of CD4, the cellular receptor for human immunodeficiency virus. The topology of membrane-inserted Vpu was investigated by using in vitro-synthesized Vpu cotran...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.8.5056-5061.1993
更新日期:1993-08-01 00:00:00
abstract::Transcription of herpesviral late genes is stimulated after the onset of viral DNA replication but otherwise restricted. Late gene expression in gammaherpesviruses requires the coordination of six early viral proteins, termed viral transactivation factors (vTFs). Here, we mapped the organization of this protein comple...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02157-15
更新日期:2015-10-14 00:00:00
abstract::Enteroviral persistence has been implicated in the pathogenesis of several chronic human diseases, including dilated cardiomyopathy, insulin-dependent diabetes mellitus, and chronic inflammatory myopathy. However, these viruses are considered highly cytolytic, and it is unclear what mechanisms might permit their long-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.9.4430-4440.2002
更新日期:2002-05-01 00:00:00
abstract::The cell culture lines HTG2 and HTG3 were established from a transplantable hamster tumor induced by a murine sarcoma virus (strain Gz-MSV) after 17 and 60 in vivo passages, respectively. The viruses released by these two cell lines markedly differ in morphology, antigenic composition, infectivity, transforming abilit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.12.4.931-936.1973
更新日期:1973-10-01 00:00:00
abstract::The retrovirus SL3 induces T-cell lymphomas in mice. The transcriptional enhancer in the long terminal repeat (LTR) of SL3 contains two 72-bp repeats. Each repeat contains a binding site for the transcription factor CBF (also called AML1). The CBF binding sites are called core elements. SAA is a mutant that is identic...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.9.7599-7606.1999
更新日期:1999-09-01 00:00:00