Vaccinia virus infection of HeLa cells. I. Synthesis of vaccinia DNA in host cell nuclei.

abstract：:The Graffi murine leukemia virus (MuLV) is a retroviral mixture that induces predominantly myeloid leukemia in several inbred strains of mice. To analyze the viral component responsible for the myeloid leukemogenesis, we cloned several proviruses from a Graffi MuLV-infected cell line. Several infectious molecular clon...

journal_title：Journal of virology

authors： Ru M,Shustik C,Rassart E

更新日期：1993-08-01 00:00:00

abstract：:Intracellular mature vaccinia virions are wrapped by cisternae, derived from virus-modified trans-Golgi or endosomal membranes, and then transported via microtubules to the cell periphery. Two viral proteins, encoded by the F13L and B5R open reading frames, are essential for the membrane-wrapping step. Previous transf...

journal_title：Journal of virology

authors： Husain M,Moss B

更新日期：2002-08-01 00:00:00

abstract：UNLABELLED:Many murine leukemia viruses (MLVs) are partially resistant to restriction by mouse APOBEC3 (mA3) and essentially fully resistant to induction of G-to-A mutations by mA3. In contrast, Vif-deficient HIV-1 (ΔVif HIV-1) is profoundly restricted by mA3, and the restriction includes high levels of G-to-A mutation...

journal_title：Journal of virology

authors： Nair S,Sanchez-Martinez S,Ji X,Rein A

更新日期：2014-04-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) induces interferon (IFN) secretion and an antiviral state in murine peritoneal macrophages (PM). These cells secrete predominantly IFN-beta, as shown by neutralization assays with monoclonal antibodies. Secretion of IFN-beta is also induced in PM by IFN-gamma. LPS and IFN-gamma syner...

journal_title：Journal of virology

authors： Gessani S,Belardelli F,Pecorelli A,Puddu P,Baglioni C

更新日期：1989-06-01 00:00:00

abstract：:The Group B Staphylococcus phage P11-M15 is shown to be 51% protein and 49% deoxyribonucleic acid (DNA). The intact virion has a molecular weight of 66.7 x 10(6) daltons. The purified viral DNA has a molecular weight of 32.7 x 10(6) daltons. The intact virion is shown to be composed of a polyhedral head which is attac...

journal_title：Journal of virology

authors： Brown DT,Brown NC,Burlingham BT

更新日期：1972-04-01 00:00:00

abstract：:The time course and extent of mengovirus production were the same in metaphase-arrested and interphase L-cells, yet the expression of cytopathology was delayed several hours in metaphase cells. ...

journal_title：Journal of virology

authors： Lake RS,Winkler DC,Ludwig EH

更新日期：1970-02-01 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of biologically active lymphotoxin (LT; tumor necrosis factor-beta) protein and LT mRNA. To understand the regulation of LT transcription by HTLV-I, we analyzed the ability of a series of deletions of the LT promoter t...

journal_title：Journal of virology

authors： Paul NL,Lenardo MJ,Novak KD,Sarr T,Tang WL,Ruddle NH

更新日期：1990-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) uses nasal mucosa-associated lymphoid tissue (NALT) as a portal of entry to establish life-long persistence in memory B cells. We previously showed that naïve and memory B cells from NALT are equally susceptible to EBV infection. Here we show that memory B cells from NALT are significantly mor...

journal_title：Journal of virology

authors： Dorner M,Zucol F,Alessi D,Haerle SK,Bossart W,Weber M,Byland R,Bernasconi M,Berger C,Tugizov S,Speck RF,Nadal D

更新日期：2010-07-01 00:00:00

abstract：:Previous studies with simian virus 40-transformed mouse 3T3 cells which are temperature sensitive for the expression of the transformed phenotype (ts SV3T3 cells) have shown that T-antigen expression and viral DNA transcription are under cell cycle control. Using these ts SV3T3 cells, we studied the expression of the ...

journal_title：Journal of virology

authors： Zouzias D,Basilico C

更新日期：1979-06-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) Tat protein, which is essential for HIV gene expression and viral replication, is known to mediate pleiotropic effects on various cell functions. For instance, Tat protein is able to regulate the rate of transcription of host cellular genes and to interact with the signa...

journal_title：Journal of virology

authors： Calzado MA,Sancho R,Muñoz E

更新日期：2004-07-01 00:00:00

abstract：:Proteolytic processing of the Rous sarcoma virus (RSV) Gag precursor was altered in vivo through the introduction of amino acid substitutions into either the polyprotein cleavage junctions or the PR coding sequence. Single amino acid substitutions (V(P2)S and P(P4)G), which are predicted from in vitro peptide substrat...

journal_title：Journal of virology

authors： Xiang Y,Ridky TW,Krishna NK,Leis J

更新日期：1997-03-01 00:00:00

abstract：:V3-glycan-targeting broadly neutralizing antibodies (bNAbs) are a focus of HIV-1 vaccine development. Understanding the viral dynamics that stimulate the development of these antibodies can provide insights for immunogen design. We used a deep-sequencing approach, together with neutralization phenotyping, to investiga...

journal_title：Journal of virology

authors： Anthony C,York T,Bekker V,Matten D,Selhorst P,Ferreria RC,Garrett NJ,Karim SSA,Morris L,Wood NT,Moore PL,Williamson C

更新日期：2017-08-24 00:00:00

abstract：:This study reports the identification and initial characterization of the precursors, modified forms, and oligomers of bovine herpesvirus 1 (BHV-1) gI and gE proteins with polyvalent rabbit serum specific for gI or gE. Our experiments used the Colorado strain of BHV-1 and mutant viruses with insertions of the Escheric...

journal_title：Journal of virology

authors： Whitbeck JC,Knapp AC,Enquist LW,Lawrence WC,Bello LJ

更新日期：1996-11-01 00:00:00

abstract：:Infectious cDNA clones of mild (CHV1-Euro7) and severe (CHV1-EP713) hypovirus strains responsible for virulence attenuation (hypovirulence) of the chestnut blight fungus Cryphonectria parasitica were used to construct viable chimeric viruses. Differences in virus-mediated alterations of fungal colony morphology, growt...

journal_title：Journal of virology

authors： Chen B,Geletka LM,Nuss DL

更新日期：2000-08-01 00:00:00

abstract：:Identification of cellular receptors used by coronavirus (CoV) entry into the host cells is critical to an understanding of pathogenesis and to development of intervention strategies. The fourth CoV genus, Deltacoronavirus, evolutionarily related to the Gammacoronavirus, has just been defined recently. In the current ...

journal_title：Journal of virology

authors： Wang B,Liu Y,Ji CM,Yang YL,Liang QZ,Zhao P,Xu LD,Lei XM,Luo WT,Qin P,Zhou J,Huang YW

更新日期：2018-05-29 00:00:00

abstract：:Both exponentially growing and serum-arrested subcloned CV-1 cell cultures were infected with simian virus 40 (SV40). By 24 h after infection 96% of the nuclei of these permissive cells contained SV40 T-antigen. Analysis of the average DNA content per cell at various times after infection indicated that by 24 h most o...

journal_title：Journal of virology

authors： Gershey EL

更新日期：1979-04-01 00:00:00

abstract：:Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and intracellular virus differed by buoyant density (1.237 versus 1.272 g/cm3), phospholipid content and composition, and polypep...

journal_title：Journal of virology

authors： Hiller G,Eibl H,Weber K

更新日期：1981-09-01 00:00:00

abstract：:The replication of positive-strand RNA viral genomes involves various cis-acting RNA sequences. Generally, regulatory RNA sequences are present at or near genomic termini; however, internal replication elements (IREs) also exist. Here we report the structural and functional characterization of an IRE present in the re...

journal_title：Journal of virology

authors： Monkewich S,Lin HX,Fabian MR,Xu W,Na H,Ray D,Chernysheva OA,Nagy PD,White KA

更新日期：2005-04-01 00:00:00

abstract：:The HTLV-1 oncoprotein Tax is a potent activator of classical and alternative NF-κB pathways and is thought to promote cell proliferation and transformation via NF-κB activation. We showed recently that hyperactivation of NF-κB by Tax triggers a cellular senescence response (H. Zhi et al., PLoS Pathog. 7:e1002025, 201...

journal_title：Journal of virology

authors： Ho YK,Zhi H,DeBiaso D,Philip S,Shih HM,Giam CZ

更新日期：2012-09-01 00:00:00

abstract：:Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections and are associated with a variety of malignancies, including lymphomas. Interferon regulatory factor 7 (IRF-7) is an innate immune transcription factor that restricts acute replication of diverse viruses, including murine gammaherpesvirus 6...

journal_title：Journal of virology

authors： Johnson KE,Aurubin CA,Jondle CN,Lange PT,Tarakanova VL

更新日期：2020-11-23 00:00:00

abstract：:Normal levels of the hypermodified pyrimidine, alpha-putrescinylthymine, which is formed from hydhydroxymethyluracil at the polynucleotide level (Maltman et al., J. Virol. 34:354-359, 1984), are not required in bacteriophage luminal diameterW-14 DNA for the DNA to serve as a replicative template in luminal diameterW-1...

journal_title：Journal of virology

authors： Miller PB,Warren RA

更新日期：1984-12-01 00:00:00

abstract：:Recombinant DNA clones of a viral clone of spleen necrosis virus, an avian retrovirus, were found to have long terminal repeats of different sizes. The variation was in the U3 region of the long terminal repeats, and any one clone had U3 of the same size in both long terminal repeats. The U3 regions in the 5' and 3' l...

journal_title：Journal of virology

authors： Shimotohno K,Temin HM

更新日期：1982-01-01 00:00:00

abstract：:Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication core origin sufficient for initiating eukaryotic DNA replication in the presence of wild-type MCV large T protein (LT). The origin includes a poly(T...

journal_title：Journal of virology

authors： Kwun HJ,Guastafierro A,Shuda M,Meinke G,Bohm A,Moore PS,Chang Y

更新日期：2009-12-01 00:00:00

abstract：:Lassa fever (LF) is a zoonotic viral hemorrhagic fever caused by Lassa virus (LASV), which is endemic to West African countries. Previous studies have suggested an important role for T-cell-mediated immunopathology in LF pathogenesis, but the mechanisms by which T cells influence disease severity and outcome are not w...

journal_title：Journal of virology

authors： Port JR,Wozniak DM,Oestereich L,Pallasch E,Becker-Ziaja B,Müller J,Rottstegge M,Olal C,Gómez-Medina S,Oyakhliome J,Ighodalo Y,Omomoh E,Olokor T,Adomeh DI,Asogun D,Ogbani-Emovon E,Hartmann K,Krasemann S,Nelson EV,Esc

更新日期：2020-10-14 00:00:00

abstract：:The nucleotide sequence of the region of human polyoma virus JC DNA between 0.5 and 0.7 map units from a unique EcoRI cleavage site was determined and compared with those of the corresponding regions of another human polyoma virus, BK, and simian virus 40 DNAs. Within this region consisting of 945 base pairs, we locat...

journal_title：Journal of virology

authors： Miyamura T,Jikuya H,Soeda E,Yoshiike K

更新日期：1983-01-01 00:00:00

abstract：:Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense vacuolation of the central nervous system gray matter and vacuolation and hypomyelination of some white matter tracts. Bas...

journal_title：Journal of virology

authors： Carlson GA,Banks S,Lund D,Reichert C,Groth D,Torchia M,Dearmond SJ,Prusiner SB

更新日期：1997-03-01 00:00:00

abstract：:Our previous studies with influenza A viruses indicated that the association of M1 with viral RNA and nucleoprotein (NP) is required for the efficient formation of helical ribonucleoprotein (RNP) and for the nuclear export of RNPs. RNA-binding domains of M1 map to the following two independent regions: a zinc finger m...

journal_title：Journal of virology

authors： Liu T,Ye Z

更新日期：2004-09-01 00:00:00

abstract：:The nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, Ad2(+)ND(1), differs from the defective Ad-SV40 hybrid populations previously described, in that this hybrid virus can replicate without the aid of nonhybrid adenovirus helper. Consequently, the deoxyribonucleic acid (DNA) from this virus, which ...

journal_title：Journal of virology

authors： Crumpacker CS,Henry PH,Kakefuda T,Rowe WP,Levin MJ,Lewis AM Jr

更新日期：1971-03-01 00:00:00

abstract：:Retroviral integrases associate during the early viral life cycle with preintegration complexes that catalyze the integration of reverse-transcribed viral cDNA into the host chromosomes. Several cellular and viral proteins have been reported to be incorporated in the preintegration complex. This study demonstrates tha...

journal_title：Journal of virology

authors： Inayoshi Y,Okino Y,Miyake K,Mizutani A,Yamamoto-Kishikawa J,Kinoshita Y,Morimoto Y,Imamura K,Morshed M,Kono K,Itoh T,Nishijima K,Iijima S

更新日期：2010-08-01 00:00:00

abstract：:Herpesviruses use a cascade of interactions with different cell surface molecules to gain entry into cells. In many cases, this involves binding to abundant glycosaminoglycans or integrins followed by interactions with more limited cell surface proteins, leading to fusion with cellular membranes. Human cytomegalovirus...

journal_title：Journal of virology

authors： Vanarsdall AL,Ryckman BJ,Chase MC,Johnson DC

更新日期：2008-12-01 00:00:00