Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. 3. Base composition, molecular weight, and conformation of the Ad2+ND genome.

abstract：:Two mutant strains (vi12 and vi13) of herpes simplex virus that contain insertion mutations in the sequences that encode the DNA-binding domain of viral regulatory protein ICP4 were generated. Both mutations disrupted specific DNA binding and resulted in transcriptionally inactive molecules; however, the ability of th...

journal_title：Journal of virology

authors： Shepard AA,DeLuca NA

更新日期：1991-01-01 00:00:00

abstract：:Homologous recombination is an important biological process that facilitates genome rearrangement and repair of DNA double-strand breaks (DSBs). The induction of Epstein-Barr virus (EBV) lytic replication induces ataxia telangiectasia-mutated (ATM)-dependent DNA damage checkpoint signaling, leading to the clustering o...

journal_title：Journal of virology

authors： Kudoh A,Iwahori S,Sato Y,Nakayama S,Isomura H,Murata T,Tsurumi T

更新日期：2009-07-01 00:00:00

abstract：:In humans, homologous to the E6-AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-like domain-containing protein 5 (HERC5) is an interferon-induced protein that inhibits replication of evolutionarily diverse viruses, including human immunodeficiency virus type 1 (HIV-1). To better understan...

journal_title：Journal of virology

authors： Paparisto E,Woods MW,Coleman MD,Moghadasi SA,Kochar DS,Tom SK,Kohio HP,Gibson RM,Rohringer TJ,Hunt NR,Di Gravio EJ,Zhang JY,Tian M,Gao Y,Arts EJ,Barr SD

更新日期：2018-06-13 00:00:00

abstract：:Retrovirus vectors were constructed with large (0.85- to 1.3-kilobase-pair) direct repeats in their genomes. Deletions involving the direct repeats occurred at a high frequency. Deletions occurred both when the direct repeats were in tandem and when they were separated by additional sequences. These deletions occurred...

journal_title：Journal of virology

authors： Rhode BW,Emerman M,Temin HM

更新日期：1987-03-01 00:00:00

abstract：:The affinity of human immunodeficiency virus (HIV) envelope for CD4 and CCR5 appears to be associated with aspects of R5 virus (virus using the CCR5 coreceptor) pathogenicity. However, entry efficiency results from complex interactions between the viral envelope glycoprotein and both CD4 and CCR5, which limits attempt...

journal_title：Journal of virology

authors： Johnston SH,Lobritz MA,Nguyen S,Lassen K,Delair S,Posta F,Bryson YJ,Arts EJ,Chou T,Lee B

更新日期：2009-11-01 00:00:00

abstract：:We have previously reported that infection of 9- to 13-day-old chicken embryos with RAV-1 results in rapid development of a novel B-cell lymphoma in which proviral insertion has activated expression of the c-myb gene (E. Pizer and E. H. Humphries, J. Virol. 63:1630-1640, 1989). The biological properties of these B-cel...

journal_title：Journal of virology

authors： Pizer ES,Baba TW,Humphries EH

更新日期：1992-01-01 00:00:00

abstract：:Maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) latent infection depends on the viral episomes in the nucleus being distributed to daughter cells following cell division. The latency-associated nuclear antigen (LANA) is constitutively expressed in all KSHV-infected cells. LANA binds sequences in the term...

journal_title：Journal of virology

authors： Krithivas A,Fujimuro M,Weidner M,Young DB,Hayward SD

更新日期：2002-11-01 00:00:00

abstract：:Retroviral genomes are dimeric, comprised of two sense-strand RNAs linked at their 5' ends by noncovalent base pairing and tertiary interactions. Viral maturation involves large-scale morphological changes in viral proteins and in genomic RNA dimer structures to yield infectious virions. Structural studies have largel...

journal_title：Journal of virology

authors： Gherghe C,Leonard CW,Gorelick RJ,Weeks KM

更新日期：2010-01-01 00:00:00

abstract：:H9N2 influenza viruses are panzootic in domestic poultry in Eurasia and since 1999 have caused transient infections in humans and pigs. To investigate the zoonotic potential of H9N2 viruses, we studied the evolution of the viruses in live-poultry markets in Hong Kong in 2003. H9N2 was the most prevalent influenza viru...

journal_title：Journal of virology

authors： Choi YK,Ozaki H,Webby RJ,Webster RG,Peiris JS,Poon L,Butt C,Leung YH,Guan Y

更新日期：2004-08-01 00:00:00

abstract：:In this study we report the complete sequence and genome organization of the serotype I feline coronavirus (FCoV) strain Black. Furthermore, a reverse genetic system was established for this FCoV strain by cloning a full-length cDNA copy into vaccinia virus. This clone served as basis for the generation of recombinant...

journal_title：Journal of virology

authors： Tekes G,Hofmann-Lehmann R,Stallkamp I,Thiel V,Thiel HJ

更新日期：2008-02-01 00:00:00

abstract：:Due to increasing concerns about human infection by various H7 influenza viruses, including recent H7N9 viruses, we evaluated the genetic relationships and cross-protective efficacies of three different Eurasian H7 avian influenza viruses. Phylogenic and molecular analyses revealed that recent Eurasian H7 viruses can ...

journal_title：Journal of virology

authors： Kwon HI,Kim YI,Park SJ,Song MS,Kim EH,Kim SM,Si YJ,Lee IW,Song BM,Lee YJ,Yun SJ,Kim WJ,Choi YK

更新日期：2017-05-12 00:00:00

abstract：:Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors recently approved or currently in late-stage clinical trials shows great promise for the treatment of human immunodefic...

journal_title：Journal of virology

authors： Goethals O,Clayton R,Van Ginderen M,Vereycken I,Wagemans E,Geluykens P,Dockx K,Strijbos R,Smits V,Vos A,Meersseman G,Jochmans D,Vermeire K,Schols D,Hallenberger S,Hertogs K

更新日期：2008-11-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is frequently associated with extrahepatic manifestations, including nonmalignant and malignant B-cell lymphoproliferative disorders. It has been reported that specific changes or recurring motifs in the amino acid sequence of the HCV hypervariable region 1 (HVR1) may be assoc...

journal_title：Journal of virology

authors： Bianchettin G,Bonaccini C,Oliva R,Tramontano A,Cividini A,Casato M,Merlini G,Silini E,Mondelli MU

更新日期：2007-05-01 00:00:00

abstract：:The assembly of hepatitis C virus (HCV) is poorly understood, largely due to the lack of mammalian cell culture systems that are easily manipulated and produce high titers of virus. This problem is highlighted by the inability of the recently established HCV replicon systems to support HCV capsid assembly despite high...

journal_title：Journal of virology

authors： Klein KC,Polyak SJ,Lingappa JR

更新日期：2004-09-01 00:00:00

abstract：:An effective vaccine for AIDS may require development of novel vectors capable of eliciting long-lasting immune responses. Here we report the development and use of replication-competent and replication-defective strains of recombinant herpes simplex virus (HSV) that express envelope and Nef antigens of simian immunod...

journal_title：Journal of virology

authors： Murphy CG,Lucas WT,Means RE,Czajak S,Hale CL,Lifson JD,Kaur A,Johnson RP,Knipe DM,Desrosiers RC

更新日期：2000-09-01 00:00:00

abstract：:As nonacademic careers in science have become less and less "alternative," one field that has consistently attracted early-career virologists is public health research. The desire to make tangible contributions to public health needs and better protect the public from infectious disease often motivates the transition....

journal_title：Journal of virology

authors： Konopka-Anstadt JL,Burns CC

更新日期：2017-04-13 00:00:00

abstract：:Recombinant adenovirus serotype 5 (rAd5) vector-based vaccines are currently being developed for both human immunodeficiency virus type 1 and other pathogens. The potential limitations associated with rAd5 vectors, however, have led to the construction of novel rAd vectors derived from rare Ad serotypes. Several rare ...

journal_title：Journal of virology

authors： Abbink P,Lemckert AA,Ewald BA,Lynch DM,Denholtz M,Smits S,Holterman L,Damen I,Vogels R,Thorner AR,O'Brien KL,Carville A,Mansfield KG,Goudsmit J,Havenga MJ,Barouch DH

更新日期：2007-05-01 00:00:00

abstract：:Processing of the hepatitis C virus polyprotein is accomplished by a series of cotranslational and posttranslational cleavages mediated by host cell signalases and two virally encoded proteinases. Of these the NS3 proteinase is essential for processing at the NS3/4A, NS4A/4B, NS4B/5A, and NS5A/5B junctions. Processing...

journal_title：Journal of virology

authors： Bartenschlager R,Ahlborn-Laake L,Yasargil K,Mous J,Jacobsen H

更新日期：1995-01-01 00:00:00

abstract：:Poliovirus has been studied as a live recombinant vaccine vector because of its attractive characteristics. The genetic instability, however, has hampered recombinant polioviruses (PVs) from being developed as an appropriate vaccine. A variety of different foreign inserts were cloned directly into our poliovirus Sabin...

journal_title：Journal of virology

authors： Lee SG,Kim DY,Hyun BH,Bae YS

更新日期：2002-02-01 00:00:00

abstract：:Three monkeypox virus (MPV) antibody-secreting murine monoclones were characterized as being of the immunoglobulin G1 isotype, gave a 4+ reaction in the indirect fluorescent-antibody test, gave a positive reaction in the enzyme immunoassay, and did not neutralize MPV. These monoclonal antibodies were determined by the...

journal_title：Journal of virology

authors： Roumillat LF,Patton JL,Davis ML

更新日期：1984-10-01 00:00:00

abstract：:Picornaviruses are a family of positive-strand RNA viruses that are responsible for a variety of devastating human and animal diseases. An attenuated strain of mengovirus (vMC24) is serologically indistinguishable from the lethal murine wild-type mengovirus and encephalomyocarditis virus (EMCV). Immunogen-specific sti...

journal_title：Journal of virology

authors： Neal ZC,Splitter GA

更新日期：1995-08-01 00:00:00

abstract：:Interferon-induced transmembrane protein 3 (IFITM3) is a cellular factor that reduces HIV-1 infectivity by an incompletely understood mechanism. We show here that viruses differing only in the envelope glycoprotein (Env) expressed on their surface have different sensitivities to IFITM3. Measurements of the sensitivity...

journal_title：Journal of virology

authors： Drouin A,Migraine J,Durand MA,Moreau A,Burlaud-Gaillard J,Beretta M,Roingeard P,Bouvin-Pley M,Braibant M

更新日期：2020-12-09 00:00:00

abstract：:Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy...

journal_title：Journal of virology

authors： Chang J,Naif HM,Li S,Sullivan JS,Randle CM,Cunningham AL

更新日期：1996-11-01 00:00:00

abstract：:The herpes simplex virus 2 (HSV-2) viral microRNA (miRNA) designated miR-H6 is located upstream of the latency-associated transcript (LAT) promoter region on the strand opposite the LAT. Deletion of the LAT promoter and part of LAT exon 1 abolished HSV-2 miR-H6 expression in acutely and latently infected guinea pig do...

journal_title：Journal of virology

authors： Tang S,Bertke AS,Patel A,Margolis TP,Krause PR

更新日期：2011-05-01 00:00:00

abstract：:A murine retrovirus encoding the middle T protein of polyomavirus infected and transformed nonestablished chicken embryo cells. The infected cultures formed colonies in soft agar-containing medium and released infectious transforming virus. Middle T protein expressed in the transformed chicken cells associated with p6...

journal_title：Journal of virology

authors： Kaplan PL,Simon S,Eckhart W

更新日期：1985-12-01 00:00:00

abstract：:Hepatitis B virus particles contain three related viral envelope proteins, the small, middle, and large S (surface) proteins. All three proteins contain the small S amino acid sequence at their carboxyl terminus. It is not clear which of these S proteins functions as the viral attachment protein, binding to a target c...

journal_title：Journal of virology

authors： Pontisso P,Petit MA,Bankowski MJ,Peeples ME

更新日期：1989-05-01 00:00:00

abstract：:Region 1 DNA sequences (map positions 0 to 11% on the linear adenovirus 2 genome) are expressed both early and late in lytic infection and are required for transformation by the virus. During productive infection six distinct cytoplasmic RNAs are synthesized from this region. These RNAs comprise two families, each con...

journal_title：Journal of virology

authors： Halbert DN,Spector DJ,Raskas HJ

更新日期：1979-09-01 00:00:00

abstract：:A contiguously linked T-B synthetic viral epitope (110HA120-150HA159,T-B) was investigated for its potency in inducing humoral and cellular immune responses in vivo. The T-cell epitope 110HA120 corresponds to the site 1 hemagglutinin (HA) of the A/PR/8/34 (PR8) influenza virus and is recognized by CD4 T cells in assoc...

journal_title：Journal of virology

authors： Brumeanu TD,Casares S,Bot A,Bot S,Bona CA

更新日期：1997-07-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with ...

journal_title：Journal of virology

authors： Park J,Seo T,Hwang S,Lee D,Gwack Y,Choe J

更新日期：2000-12-01 00:00:00

abstract：:Resistance to erythroleukemia induced by infection with the Friend virus complex (FV) has been mapped to several genes residing both within and outside the murine major histocompatibility complex (MHC). MHC genes located in the A, D, and Qa/Tla regions of the murine H-2 complex have been shown to affect disease resist...

journal_title：Journal of virology

authors： Perry LL,Miyazawa M,Hasenkrug K,Wehrly K,David CS,Chesebro B

更新日期：1994-08-01 00:00:00