Picornavirus-specific CD4+ T lymphocytes possessing cytolytic activity confer protection in the absence of prophylactic antibodies.

abstract：:In this study, we show that human cytomegalovirus DNA synthesis is inhibited in infected confluent human embryonic lung cells treated with the DNA-intercalative topoisomerase II inhibitor 4-9'-(acridinylamino)methanesulfon-m-anisidide (m-AMSA). Similar inhibitory effects were observed with VM-26, a nonintercalative to...

journal_title：Journal of virology

authors： Benson JD,Huang ES

更新日期：1988-12-01 00:00:00

abstract：:Moloney murine leukemia virus (M-MuLV) is capable of inducing promonocytic leukemia in 50% of adult BALB/c mice that have received peritoneal injections of pristane, but Friend MuLV strain 57 (F-MuLV) is nonleukemogenic under similar conditions. It was shown earlier that these differences could not be mapped to the U3...

journal_title：Journal of virology

authors： Mukhopadhyaya R,Richardson J,Nazarov V,Corbin A,Koller R,Sitbon M,Wolff L

更新日期：1994-08-01 00:00:00

abstract：:The HXLF (HindIII-X left reading frame) gene family is a group of five genes that share one or two regions of homology and are arranged in tandem within the short unique component of the human cytomegalovirus genome (K. Weston and B.G. Barrell, J. Mol. Biol. 192:177-208, 1986). These genes were cloned into an SP6 expr...

journal_title：Journal of virology

authors： Gretch DR,Kari B,Gehrz RC,Stinski MF

更新日期：1988-06-01 00:00:00

abstract：:The matrix (M1) protein of influenza virus is a major structural component, involved in regulation of viral ribonucleoprotein transport into and out of the nucleus. Early in infection, M1 is distributed in the nucleus, whereas later, it is localized predominantly in the cytoplasm. Using immunofluorescence microscopy a...

journal_title：Journal of virology

authors： Whittaker G,Kemler I,Helenius A

更新日期：1995-01-01 00:00:00

abstract：:Mouse-adapted dengue type 4 virus (DEN4) strain H241 is highly neurovirulent for mice, whereas its non-mouse-adapted parent is rarely neurovirulent. The genetic basis for the neurovirulence of the mouse-adapted mutant was studied by comparing intratypic chimeric viruses that contained the three structural protein gene...

journal_title：Journal of virology

authors： Kawano H,Rostapshov V,Rosen L,Lai CJ

更新日期：1993-11-01 00:00:00

abstract：:West Nile virus (WNV) is a human pathogen that can cause neurological disorders, including meningoencephalitis. Experiments with mice and mammalian cell cultures revealed that WNV exhibited resistance to the innate immune program induced by alpha interferon (IFN-alpha). We have investigated the nature of this inhibiti...

journal_title：Journal of virology

authors： Guo JT,Hayashi J,Seeger C

更新日期：2005-02-01 00:00:00

abstract：:The Ebola filoviruses are aggressive pathogens that cause severe and often lethal hemorrhagic fever syndromes in humans and nonhuman primates. To date, no effective therapies have been identified. To analyze the entry and fusion properties of Ebola virus, we adapted a human immunodeficiency virus type 1 (HIV-1) virion...

journal_title：Journal of virology

authors： Yonezawa A,Cavrois M,Greene WC

更新日期：2005-01-01 00:00:00

abstract：:The 86-kDa IE2 protein (IE86) of human cytomegalovirus (HCMV) can act as both an activator and a repressor of gene expression. The mechanisms for both of these functions are not well defined. It has recently been demonstrated that this protein has sequence-specific DNA binding properties: it interacts directly with a ...

journal_title：Journal of virology

authors： Arlt H,Lang D,Gebert S,Stamminger T

更新日期：1994-07-01 00:00:00

abstract：:Infection of normal rat fibroblasts (FR 3T3) with the early tsa mutant of polyoma virus may lead to either the A or the N phenotype, tsa-A transformants, originally derived by agar selection, are not temperature dependent for maintenance of the transformed phenotype, whereas tsa-N transormants revert at high temperatu...

journal_title：Journal of virology

authors： Rassoulzadegan M,Seif R,Cuzin F

更新日期：1978-11-01 00:00:00

abstract：:A detailed restriction endonuclease map for the genome of Bacillus subtilis phage SP01 is presented. Sites of cleavage for the restriction enzymes BglII, EcoRI, HaeIII, and SalI were determined. This physical map showed that SP01 DNA was 140 kilobases in length and contained a repeated sequence of 12.4 kilobases at it...

journal_title：Journal of virology

authors： Pero J,Hannett NM,Talkington C

更新日期：1979-07-01 00:00:00

abstract：:The replication of porcine endogenous retrovirus subgroup A (PERV-A) and PERV-B in certain human cell lines indicates that PERV may pose an infectious risk in clinical xenotransplantation. We have previously reported that human-tropic PERVs isolated from infected human cells following cocultivation with miniature swin...

journal_title：Journal of virology

authors： Wood JC,Quinn G,Suling KM,Oldmixon BA,Van Tine BA,Cina R,Arn S,Huang CA,Scobie L,Onions DE,Sachs DH,Schuurman HJ,Fishman JA,Patience C

更新日期：2004-03-01 00:00:00

abstract：:In wild aquatic birds and poultry around the world, influenza A viruses carrying 15 antigenic subtypes of hemagglutinin (HA) and 9 antigenic subtypes of neuraminidase (NA) have been described. Here we describe a previously unidentified antigenic subtype of HA (H16), detected in viruses circulating in black-headed gull...

journal_title：Journal of virology

authors： Fouchier RA,Munster V,Wallensten A,Bestebroer TM,Herfst S,Smith D,Rimmelzwaan GF,Olsen B,Osterhaus AD

更新日期：2005-03-01 00:00:00

abstract：:In the spherical capsid of hepatitis B virus (HBV), intermolecular disulfide bonds cross-link the approximately 180 p21.5 capsid protein subunits into a stable lattice. In this study, we used mutant capsid proteins to investigate the role that disulfide bonds and the four p21.5 Cys residues (positions 48, 61, 107, and...

journal_title：Journal of virology

authors： Zhou S,Standring DN

更新日期：1992-09-01 00:00:00

abstract：:We have used a replication-competent shuttle vector based on the genome of Rous sarcoma virus to characterize genomic rearrangements that occur during retrovirus replication. The strategy involved cloning circular DNA that was generated during an acute infection. While analyzing a class of retroviral DNA clones that a...

journal_title：Journal of virology

authors： Dunn MM,Olsen JC,Swanstrom R

更新日期：1992-10-01 00:00:00

abstract：:Trigeminal ganglia (TG) from rabbits latently infected with either wild-type herpes simplex virus type 1 (HSV-1) or the latency-associated transcript (LAT) promoter deletion mutant 17DeltaPst were assessed for their viral chromatin profile and transcript abundance. The wild-type 17syn+ genomes were more enriched in th...

journal_title：Journal of virology

authors： Giordani NV,Neumann DM,Kwiatkowski DL,Bhattacharjee PS,McAnany PK,Hill JM,Bloom DC

更新日期：2008-06-01 00:00:00

abstract：:The beginning of the second century of research in the field of virology (the first virus was discovered in 1898) was marked by its amalgamation with bioinformatics, resulting in the birth of a new domain--viroinformatics. The availability of more than 100 Web servers and databases embracing all or specific viruses (f...

journal_title：Journal of virology

authors： Sharma D,Priyadarshini P,Vrati S

更新日期：2015-02-01 00:00:00

abstract：:Nonglucosylated T6 phage (T6gtam 16am30, hereafter called T6alpha gt-) were found to have two structural anomalies when compared with wild-type T6. The DNA of T6alpha gt- phage contains single-strand interruptions. These can be seen both during infection, in the pool of replicating DNA, and in DNA extracted from purif...

journal_title：Journal of virology

authors： Hewlett MJ,Mathews CK

更新日期：1975-04-01 00:00:00

abstract：:RNA silencing is a conserved eukaryotic gene regulatory system in which sequence specificity is determined by small RNAs. Plant RNA silencing also acts as an antiviral mechanism; therefore, viral infection requires expression of a silencing suppressor. The mechanism and the evolution of silencing suppression are still...

journal_title：Journal of virology

authors： Mérai Z,Kerényi Z,Molnár A,Barta E,Válóczi A,Bisztray G,Havelda Z,Burgyán J,Silhavy D

更新日期：2005-06-01 00:00:00

abstract：:The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protec...

journal_title：Journal of virology

authors： Bukh J,Engle RE,Faulk K,Wang RY,Farci P,Alter HJ,Purcell RH

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:Flaviviruses pose a significant threat to both animals and humans. Recently, a novel flavivirus, duck Tembusu virus (DTMUV), was identified to be the causative agent of a serious duck viral disease in Asia. Its rapid spread, expanding host range, and uncertain transmission routes have raised substantial conc...

journal_title：Journal of virology

authors： Wang HJ,Li XF,Liu L,Xu YP,Ye Q,Deng YQ,Huang XY,Zhao H,Qin ED,Shi PY,Gao GF,Qin CF

更新日期：2016-06-24 00:00:00

abstract：:Envelope glycoprotein E1 (gp51 to gp54) is the most antigenic protein of hog cholera virus or classical swine fever virus (CSFV). Four antigenic domains, A to D, have been mapped on E1 with a panel of monoclonal antibodies (MAbs) raised against CSFV strain Brescia. The boundaries of these domains have been established...

journal_title：Journal of virology

authors： van Rijn PA,Miedema GK,Wensvoort G,van Gennip HG,Moormann RJ

更新日期：1994-06-01 00:00:00

abstract：:Targeted vectors will be necessary for many gene therapy applications. To target retroviruses to melanomas, we fused a single-chain variable fragment antibody (scFv) directed against the surface glycoprotein high-molecular-weight melanoma-associated antigen (HMW-MAA) to the amphotropic murine leukemia virus envelope. ...

journal_title：Journal of virology

authors： Martin F,Neil S,Kupsch J,Maurice M,Cosset F,Collins M

更新日期：1999-08-01 00:00:00

abstract：:Human CD4(+) T-helper 1 cell responses to Epstein-Barr virus (EBV) infection are likely to be important in the maintenance of virus-specific CD8(+) memory and/or as antiviral effectors in their own right. The present work has used overlapping peptides as stimulators of gamma interferon release (i) to identify CD4(+) e...

journal_title：Journal of virology

authors： Leen A,Meij P,Redchenko I,Middeldorp J,Bloemena E,Rickinson A,Blake N

更新日期：2001-09-01 00:00:00

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：:In eukaryotic cells, cell growth and division occur in a stepwise, orderly fashion described by a process known as the cell cycle. The relationship between positive-strand RNA viruses and the cell cycle and the concomitant effects on virus replication are not clearly understood. We have shown that infection of asynchr...

journal_title：Journal of virology

authors： Dove B,Brooks G,Bicknell K,Wurm T,Hiscox JA

更新日期：2006-04-01 00:00:00

abstract：:The DNA product of the endogenously instructed RNA-dependent DNA polymerase reaction of murine sarcoma virus continued to be synthesized for as long as 64 h in the presence of 0.008% Triton X-100. Higher detergent concentrations and actinomycin D inhibited DNA product synthesis. The DNA product from long-term polymera...

journal_title：Journal of virology

authors： East JL,Knesek JE,Allen PT,Dmochowski L

更新日期：1973-11-01 00:00:00

abstract：:Processing of the hepatitis C virus polyprotein is accomplished by a series of cotranslational and posttranslational cleavages mediated by host cell signalases and two virally encoded proteinases. Of these the NS3 proteinase is essential for processing at the NS3/4A, NS4A/4B, NS4B/5A, and NS5A/5B junctions. Processing...

journal_title：Journal of virology

authors： Bartenschlager R,Ahlborn-Laake L,Yasargil K,Mous J,Jacobsen H

更新日期：1995-01-01 00:00:00

abstract：:N-terminal modifications of the chemokine RANTES bind to C-C chemokine receptor 5 (CCR5) and block human immunodeficiency virus type 1 (HIV-1) infection with greater efficacy than native RANTES. Modified RANTES compounds induce rapid CCR5 internalization and much slower receptor reexpression than native RANTES, sugges...

journal_title：Journal of virology

authors： Sabbe R,Picchio GR,Pastore C,Chaloin O,Hartley O,Offord R,Mosier DE

更新日期：2001-01-01 00:00:00

abstract：:Varicella-zoster virus (VZV), an alphaherpesvirus restricted to humans, infects differentiated cells in vivo, including T lymphocytes, keratinocytes, and neurons, and spreads rapidly in confluent cultured dermal fibroblasts (HFFs). In VZV-infected HFFs, atypical expression of cyclins D3 and B1 occurs along with the in...

journal_title：Journal of virology

authors： Leisenfelder SA,Kinchington PR,Moffat JF

更新日期：2008-12-01 00:00:00

abstract：:Poxviruses express proteins that limit host immune responses to infection. For example, the molluscum contagiosum virus MC160 protein inhibits tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB activation. This event correlates with MC160-induced IKK1 protein degradation, suggesting a mechanism for the above-me...

journal_title：Journal of virology

authors： Nichols DB,Shisler JL

更新日期：2009-04-01 00:00:00