The p92 polymerase coding region contains an internal RNA element required at an early step in Tombusvirus genome replication.

abstract：:Herpesviruses encode a set of core proteins essential for lytic replication of their genomes. Three of these proteins form a tripartite helix-primase complex that, in the case of Epstein-Barr virus (EBV), consists of the helicase BBLF4, the primase BSLF1, and the linker protein BBLF2/3. BBLF2/3 and its homologs in the...

journal_title：Journal of virology

authors： Liao G,Huang J,Fixman ED,Hayward SD

更新日期：2005-01-01 00:00:00

abstract：:The molecular defect in the nonconditional B-tropic MuLV pol mutant, clone 23 (Gerwin et al., J. Virol. 31:741-751, 1979), has been characterized by recombinant DNA technology. The entire mutant genome was cloned from an EcoRI digest of integrated cellular DNA into bacteriophage lambda Charon 4A and then subcloned at ...

journal_title：Journal of virology

authors： Levin JG,Hu SC,Rein A,Messer LI,Gerwin BI

更新日期：1984-08-01 00:00:00

abstract：:Retrovirus assembly involves a complex series of events in which a large number of proteins must be targeted to a point on the plasma membrane where immature viruses bud from the cell. Gag polyproteins of most retroviruses assemble an immature capsid on the cytoplasmic side of the plasma membrane during the budding pr...

journal_title：Journal of virology

authors： Parker SD,Hunter E

更新日期：2000-01-01 00:00:00

abstract：:Intragastric inoculation with whole-virion vaccine of inactivated influenza virus resulted in production of hemagglutinin (HA)-specific immunoglobulin A (IgA) and IgG both in lung lavage fluids and in serum samples of mice. HA-specific IgA was the predominant isotypic antibody secreted in the lung lavage fluids (avera...

journal_title：Journal of virology

authors： Chen KS,Burlington DB,Quinnan GV Jr

更新日期：1987-07-01 00:00:00

abstract：:Prion diseases are progressive fatal neurodegenerative illnesses caused by the accumulation of transmissible abnormal prion protein (PrP). To find treatments for prion diseases, we searched for substances from natural resources that inhibit abnormal PrP formation in prion-infected cells. We found that high-molecular-w...

journal_title：Journal of virology

authors： Hamanaka T,Nishizawa K,Sakasegawa Y,Oguma A,Teruya K,Kurahashi H,Hara H,Sakaguchi S,Doh-Ura K

更新日期：2017-02-28 00:00:00

abstract：:The assembly of human cytomegalovirus (HCMV) is thought to be similar to that which has been proposed for alphaherpesviruses and involve envelopment of tegumented subviral particles at the nuclear membrane followed by export from the cell by a poorly defined pathway. However, several studies have shown that at least t...

journal_title：Journal of virology

authors： Sanchez V,Greis KD,Sztul E,Britt WJ

更新日期：2000-01-01 00:00:00

abstract：:Canine parvovirus type 2 (CPV-2) is a severe enteric pathogen of dogs, causing high mortality in unvaccinated dogs. After emerging, CPV-2 spread rapidly worldwide. However, there is now some evidence to suggest that international transmission appears to be more restricted. In order to investigate the transmission and ...

journal_title：Journal of virology

authors： Clegg SR,Coyne KP,Parker J,Dawson S,Godsall SA,Pinchbeck G,Cripps PJ,Gaskell RM,Radford AD

更新日期：2011-08-01 00:00:00

abstract：:Reverse transcription in avian sarcoma virus (ASV) initiates from the 3' end of a tRNA(Trp) primer, which anneals near the 5' end of the RNA genome. The region around the primer-binding site (PBS) forms an elaborate stem structure composed of the U5-inverted repeat (U5-IR) stem, the U5-leader stem, and the association...

journal_title：Journal of virology

authors： Morris S,Johnson M,Stavnezer E,Leis J

更新日期：2002-08-01 00:00:00

abstract：:Endogenous retroviruses (ERV) are found throughout vertebrate genomes, and failure to silence their activation can have deleterious consequences on the host. Mutation and subsequent disruption of ERV loci is therefore an indispensable component of the cell-intrinsic defenses that maintain the integrity of the host gen...

journal_title：Journal of virology

authors： Treger RS,Tokuyama M,Dong H,Salas-Briceno K,Ross SR,Kong Y,Iwasaki A

更新日期：2019-09-30 00:00:00

abstract：UNLABELLED:The genome of nonsegmented negative-strand RNA viruses is tightly embedded within a nucleocapsid made of a nucleoprotein (N) homopolymer. To ensure processive RNA synthesis, the viral polymerase L in complex with its cofactor phosphoprotein (P) binds the nucleocapsid that constitutes the functional template....

journal_title：Journal of virology

authors： Brunel J,Chopy D,Dosnon M,Bloyet LM,Devaux P,Urzua E,Cattaneo R,Longhi S,Gerlier D

更新日期：2014-09-01 00:00:00

abstract：:Nucleotide sequencing and phylogenetic analysis of 10 recognized prototype strains of the porcine enterovirus (PEV) cytopathic effect (CPE) group I reveals a close relationship of the viral genomes to the previously sequenced strain F65, supporting the concept of a reclassification of this virus group into a new picor...

journal_title：Journal of virology

authors： Zell R,Dauber M,Krumbholz A,Henke A,Birch-Hirschfeld E,Stelzner A,Prager D,Wurm R

更新日期：2001-02-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage t...

journal_title：Journal of virology

authors： Patterson S,Rae A,Hockey N,Gilmour J,Gotch F

更新日期：2001-07-01 00:00:00

abstract：:Prior studies have demonstrated that a small proportion of blood lymphocytes from patients with human cytomegalovirus (HCMV) infection express only the viral immediate-early (IE) genes (L. Einhorn and A. Ost, J. Infect. Dis. 149:207-214, 1984; G. P. A. Rice, R. D. Schrier, and M. B. A. Oldstone, Proc. Natl. Acad. Sci....

journal_title：Journal of virology

authors： Hunninghake GW,Monick MM,Liu B,Stinski MF

更新日期：1989-07-01 00:00:00

abstract：:Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable dif...

journal_title：Journal of virology

authors： Neumann G,Geisbert TW,Ebihara H,Geisbert JB,Daddario-DiCaprio KM,Feldmann H,Kawaoka Y

更新日期：2007-03-01 00:00:00

abstract：:During paramyxovirus entry into a host cell, receptor engagement by a specialized binding protein triggers conformational changes in the adjacent fusion protein (F), leading to fusion between the viral and cell membranes. According to the existing paradigm of paramyxovirus membrane fusion, the initial activation of F ...

journal_title：Journal of virology

authors： Porotto M,Devito I,Palmer SG,Jurgens EM,Yee JL,Yokoyama CC,Pessi A,Moscona A

更新日期：2011-12-01 00:00:00

abstract：:Homologous recombination is an important biological process that facilitates genome rearrangement and repair of DNA double-strand breaks (DSBs). The induction of Epstein-Barr virus (EBV) lytic replication induces ataxia telangiectasia-mutated (ATM)-dependent DNA damage checkpoint signaling, leading to the clustering o...

journal_title：Journal of virology

authors： Kudoh A,Iwahori S,Sato Y,Nakayama S,Isomura H,Murata T,Tsurumi T

更新日期：2009-07-01 00:00:00

abstract：:The principal neutralizing epitope of the human immunodeficiency virus type 1 (HIV-1) lies between two invariant cysteines in the third variable region (V3) of the viral envelope (gp120), and its amino acid sequence varies among different HIV-1 isolates. HIV-2 carries an analogous amino acid sequence between two cyste...

journal_title：Journal of virology

authors： Boeri E,Giri A,Lillo F,Ferrari G,Varnier OE,Ferro A,Sabbatani S,Saxinger WC,Franchini G

更新日期：1992-07-01 00:00:00

abstract：:The polyomavirus proteins VP1, VP2, and VP3 move from their cytoplasmic site of synthesis into the nucleus, where virus assembly occurs. To identify cellular or viral components which might control this process, we determined the distribution of VP1, VP2, and VP3 in a soluble fraction, a cytoplasmic cytoskeleton fract...

journal_title：Journal of virology

authors： Stamatos NM,Chakrabarti S,Moss B,Hare JD

更新日期：1987-02-01 00:00:00

abstract：:Rigorous investigation of many functions encoded by cytomegaloviruses (CMVs) requires analysis in the context of virus-host interactions. To facilitate the construction of rhesus CMV (RhCMV) mutants for in vivo studies, a bacterial artificial chromosome (BAC) containing an enhanced green fluorescent protein (EGFP) cas...

journal_title：Journal of virology

authors： Chang WL,Barry PA

更新日期：2003-05-01 00:00:00

abstract：:Nonhuman primates are widely used to study correlates of protective immunity in AIDS research. Successful cellular immune responses have been difficult to identify because heterogeneity within macaque major histocompatibility complex (MHC) genes results in quantitative and qualitative differences in immune responses. ...

journal_title：Journal of virology

authors： Wiseman RW,Wojcechowskyj JA,Greene JM,Blasky AJ,Gopon T,Soma T,Friedrich TC,O'Connor SL,O'Connor DH

更新日期：2007-01-01 00:00:00

abstract：:The murine polyomavirus (Py) enters mouse fibroblasts and kidney epithelial cells via an endocytic pathway that is caveola-independent (as well as clathrin-independent). In contrast, uptake of simian virus 40 into the same cells is dependent on caveola. Following the initial uptake of Py, both microtubules and microfi...

journal_title：Journal of virology

authors： Gilbert JM,Goldberg IG,Benjamin TL

更新日期：2003-02-01 00:00:00

abstract：:The human immunodeficiency virus rev gene product regulates the expression of viral structural genes. It was recently shown that Rev regulates the export of viral structural mRNAs from the nucleus to the cytoplasm. Analysis of Rev subcellular localization reveals marked accumulation in the nucleolus, suggesting a role...

journal_title：Journal of virology

authors： Cochrane AW,Perkins A,Rosen CA

更新日期：1990-02-01 00:00:00

abstract：:The TAATGARAT motif in the herpes simplex virus (HSV) immediate-early (IE) gene promoters plays a key role in their activation by the Oct-1-Vmw65 complex, but its role in mediating inhibitory effects of cellular octamer-binding proteins is less clear. We have used indicator viruses containing reporter constructs with ...

journal_title：Journal of virology

authors： Thomas S,Coffin RS,Watts P,Gough G,Latchman DS

更新日期：1998-04-01 00:00:00

abstract：:Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS), in combination with proteolytic protection assays, has been used to identify the functional epitope on human immunodeficiency virus envelope glycoprotein gp41 for the broadly neutralizing anti-gp41 human monoclonal antibody 2F5. In this protecti...

journal_title：Journal of virology

authors： Parker CE,Deterding LJ,Hager-Braun C,Binley JM,Schülke N,Katinger H,Moore JP,Tomer KB

更新日期：2001-11-01 00:00:00

abstract：:The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The re...

journal_title：Journal of virology

authors： Aubagnac S,Brahic M,Bureau JF

更新日期：2002-06-01 00:00:00

abstract：UNLABELLED:Despite encoding multiple viral proteins that modulate the retinoblastoma (Rb) protein in a manner classically defined as inactivation, human cytomegalovirus (HCMV) requires the presence of the Rb protein to replicate efficiently. In uninfected cells, Rb controls numerous pathways that the virus also command...

journal_title：Journal of virology

authors： VanDeusen HR,Kalejta RF

更新日期：2015-12-01 00:00:00

abstract：:Tick-borne encephalitis virus (TBEV), a major tick-borne viral pathogen of humans, is known to cause neurological diseases such as meningitis, encephalitis, and meningoencephalitis. However, the life cycle and pathogenesis of TBEV are not well understood. Here, we show that the knockdown or knockout of ADAM15 (a disin...

journal_title：Journal of virology

authors： Yang Q,Pei R,Wang Y,Zhou Y,Yang M,Chen X,Chen J

更新日期：2021-01-28 00:00:00

abstract：:A sequence of polyadenylic acid, homogeneous in composition but heterogeneous in length, was isolated from complete pancreatic RNase digests of both middle and bottom RNAs of cowpea mosaic virus. The polyadenylic acid was 3'-terminal and occurred once per molecule. A fragment consisting of the polyadenylic acid and ap...

journal_title：Journal of virology

authors： Steele KP,Frist RH

更新日期：1978-05-01 00:00:00

abstract：:Arenaviruses can cause lethal hemorrhagic fevers in humans with few preventative and therapeutic measures. The arenaviral glycoprotein stable signal peptide (SSP) is unique among signal peptides in that it is an integral component of the mature glycoprotein complex (GPC) and plays important roles not only in GPC expre...

journal_title：Journal of virology

authors： Shao J,Liu X,Ly H,Liang Y

更新日期：2016-10-28 00:00:00

abstract：:Viral infection induces production of type I interferons (IFNs), which stimulate the expression of a variety of antiviral factors to inhibit viral replication. To establish effective infection, viruses need to develop strategies to evade the immune responses. A neurovirulent Sindbis virus strain with neuroinvasive pro...

journal_title：Journal of virology

authors： Wang X,Li MMH,Zhao J,Li S,MacDonald MR,Rice CM,Gao X,Gao G

更新日期：2016-10-28 00:00:00