Complete genome sequence and analyses of the subgenomic RNAs of sweet potato chlorotic stunt virus reveal several new features for the genus Crinivirus.

abstract：:CtBP has been shown to be a highly conserved corepressor of transcription. E1A and all the various transcription factors to which CtBP binds contain a conserved PLDLS CtBP-interacting domain, and EBNA3C includes a PLDLS motif (amino acids [aa] 728 to 732). Here we show that EBNA3C binds to CtBP both in vitro and in vi...

journal_title：Journal of virology

authors： Touitou R,Hickabottom M,Parker G,Crook T,Allday MJ

更新日期：2001-08-01 00:00:00

abstract：:A recombinant Epstein-Barr virus (EBV) was constructed, with a positive-selection marker inserted at the site of a deletion of a DNA segment which encodes the first five transmembrane domains of LMP2A and LMP2B. Despite the mutation, the mutant recombinant EBV was able to initiate and maintain primary B-lymphocyte gro...

journal_title：Journal of virology

authors： Longnecker R,Miller CL,Tomkinson B,Miao XQ,Kieff E

更新日期：1993-08-01 00:00:00

abstract：:The activity and epithelial tropism of the human papillomavirus type 18 P105 early promoter, which directs the synthesis of the E6 and E7 transforming genes, are controlled by cis elements included in the viral long control region. To identify potential cellular regulators of this promoter, we mutagenized one or both ...

journal_title：Journal of virology

authors： Thierry F,Spyrou G,Yaniv M,Howley P

更新日期：1992-06-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：:The morphology of Safferman's virus of blue-green algae (phycovirus LPP-1) has been studied by electron microscopy and physicochemical methods. The virion has a short (100 to 200 A long, 150 A in diameter) forked tail, with an outer sheath, an inner core, and a capital attached to one of the vertices of a polyhedral h...

journal_title：Journal of virology

authors： Luftig R,Haselkorn R

更新日期：1967-04-01 00:00:00

abstract：:The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced foll...

journal_title：Journal of virology

authors： Yurochko AD,Hwang ES,Rasmussen L,Keay S,Pereira L,Huang ES

更新日期：1997-07-01 00:00:00

abstract：:The contributions of the glycoproteins gI (ORF67) and gE (ORF68) to varicella-zoster virus (VZV) replication were investigated in deletion mutants made by using cosmids with VZV DNA derived from the Oka strain. Deletion of both gI and gE prevented virus replication. Complete deletion of gI or deletions of 60% of the N...

journal_title：Journal of virology

authors： Mallory S,Sommer M,Arvin AM

更新日期：1997-11-01 00:00:00

abstract：:Our previous studies with influenza A viruses indicated that the association of M1 with viral RNA and nucleoprotein (NP) is required for the efficient formation of helical ribonucleoprotein (RNP) and for the nuclear export of RNPs. RNA-binding domains of M1 map to the following two independent regions: a zinc finger m...

journal_title：Journal of virology

authors： Liu T,Ye Z

更新日期：2004-09-01 00:00:00

abstract：:The processes that facilitate transport of integral membrane proteins though the secretory pathway and subsequently target them to particular cellular membranes are relevant to almost every field of biology. These transport processes involve integration of proteins into the membrane of the endoplasmic reticulum (ER), ...

journal_title：Journal of virology

authors： Brock SC,Heck JM,McGraw PA,Crowe JE Jr

更新日期：2005-10-01 00:00:00

abstract：:Penetration of the nervous systems of suckling mice by prototype strains of the three mammalian reovirus serotypes was studied after footpad inoculation of a dose (10(7) PFU) representing 3.5 x 10(3) 50% lethal doses (LD50) for reovirus type 3 Dearing and less than 1 LD50 for reoviruses type 1 Lang and type 2 Jones. T...

journal_title：Journal of virology

authors： Flamand A,Gagner JP,Morrison LA,Fields BN

更新日期：1991-01-01 00:00:00

abstract：:We previously described a preleukemic state induced by Moloney murine leukemia virus (Mo-MuLV) characterized by hematopoietic hyperplasia in the spleen. Further experiments suggested that splenic hyperplasia results from inhibitory effects in the bone marrow, leading to compensatory extramedullary hematopoiesis. An en...

journal_title：Journal of virology

authors： Li QX,Fan H

更新日期：1991-08-01 00:00:00

abstract：:The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses ...

journal_title：Journal of virology

authors： Kim J,Zhang X,Centonze VE,Bowman VD,Noble S,Baker TS,Nibert ML

更新日期：2002-12-01 00:00:00

abstract：:The Nef proteins of human immunodeficiency virus and simian immunodeficiency virus (SIV) bind the AP-1 and AP-2 clathrin adaptors to downmodulate the expression of CD4 and CD28 by recruiting them to sites of AP-2 clathrin-dependent endocytosis. Additionally, SIV Nef directly binds the CD3-zeta subunit of the CD3 compl...

journal_title：Journal of virology

authors： Swigut T,Greenberg M,Skowronski J

更新日期：2003-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 Tat exerts prominent angiogenic effects which may lead to a variety of vasculopathic conditions in AIDS patients. Because endothelial cells undergo prominent cytoskeletal rearrangement during angiogenesis, we investigated the specific effects of Tat on the endothelial cell actin cyt...

journal_title：Journal of virology

authors： Wu RF,Gu Y,Xu YC,Mitola S,Bussolino F,Terada LS

更新日期：2004-01-01 00:00:00

abstract：:Due to various advantageous features there is current interest in retroviral vectors derived from primate foamy viruses (PFVs). Two PFV cis-acting sequences have been mapped in the 5' region of the RNA (pre-)genome and in the 3' pol genomic region. In order to genetically separate PFV packaging constructs from vector ...

journal_title：Journal of virology

authors： Heinkelein M,Thurow J,Dressler M,Imrich H,Neumann-Haefelin D,McClure MO,Rethwilm A

更新日期：2000-04-01 00:00:00

abstract：:Chick embryo cells became more sensitive to the action of interferon the longer they remained in culture. This phenomenon was found even before confluency had been reached. The relative insensitivity of newly seeded cells was not due to a loss of receptors. Cells synthesizing deoxyribonucleic acid (DNA) at a high rate...

journal_title：Journal of virology

authors： Rossman TG,Vilcek J

更新日期：1969-07-01 00:00:00

abstract：:Since most human immunodeficiency virus (HIV) infections are initiated following mucosal exposure to the virus, the anatomic containment or abortion of an HIV infection is likely to require vaccine-elicited cellular immune responses in those mucosal sites. Studying vaccine-elicited mucosal immune responses has been pr...

journal_title：Journal of virology

authors： Baig J,Levy DB,McKay PF,Schmitz JE,Santra S,Subbramanian RA,Kuroda MJ,Lifton MA,Gorgone DA,Wyatt LS,Moss B,Huang Y,Chakrabarti BK,Xu L,Kong WP,Yang ZY,Mascola JR,Nabel GJ,Carville A,Lackner AA,Veazey RS,Letvin N

更新日期：2002-11-01 00:00:00

abstract：:By pretreating simian virus 40-infected BSC-1 cells with glucosamine, [(3)H]uridine labeling of both cellular and viral RNA can be halted instantaneously by addition of cold uridine. We have studied the fate of pulse-labeled viral RNA from cells at 45 h postinfection under these conditions. During a 5-min period of la...

journal_title：Journal of virology

authors： Chiu NH,Radonovich MF,Thoren MM,Salzman NP

更新日期：1978-11-01 00:00:00

abstract：:Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues, such as the liver. ...

journal_title：Journal of virology

authors： Ylösmäki E,Martikainen M,Hinkkanen A,Saksela K

更新日期：2013-01-01 00:00:00

abstract：:The UL11 tegument protein of herpes simplex virus plays a critical role in the secondary envelopment; however, the mechanistic details remain elusive. Here, we report a new function of UL11 in the budding process in which it directs efficient acquisition of glycoprotein E (gE) via a direct interaction. In vitro bindin...

journal_title：Journal of virology

authors： Han J,Chadha P,Meckes DG Jr,Baird NL,Wills JW

更新日期：2011-09-01 00:00:00

abstract：:A majority of species B adenoviruses (Ads) use CD46 as their primary receptor; however, the precise mechanisms involved in the binding of different Ad types to CD46 have not been resolved. Although previous studies indicate close similarities between two members of species B2 Ads in their usage of CD46, our current in...

journal_title：Journal of virology

authors： Pache L,Venkataraman S,Reddy VS,Nemerow GR

更新日期：2008-08-01 00:00:00

abstract：UNLABELLED:The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we surveyed the interactome of ORF45 using a panel of monoc...

journal_title：Journal of virology

authors： Gillen J,Li W,Liang Q,Avey D,Wu J,Wu F,Myoung J,Zhu F

更新日期：2015-05-01 00:00:00

abstract：:By using in situ hybridization, we localized three endogenous chicken retrovirus loci associated with the gs- chf- phenotype to distinct regions on chromosome 1. These three loci, ev4, ev5, and ev8, along with the two other known gs- chf--associated loci in White Leghorn chickens, ev1 and ev13, appear to be evenly dis...

journal_title：Journal of virology

authors： Tereba A,Astrin SM

更新日期：1982-08-01 00:00:00

abstract：:Structural proteins designated p10gag, p21gag, p8gag, p3gag, p27gag, and p14gag from the C3H strain of mouse mammary tumor virus (MMTV) were purified by reversed-phase high-pressure liquid chromatography. The N- and C-terminal amino acid sequences and amino acid composition of each protein were determined and compared...

journal_title：Journal of virology

authors： Hizi A,Henderson LE,Copeland TD,Sowder RC,Krutzsch HC,Oroszlan S

更新日期：1989-06-01 00:00:00

abstract：UNLABELLED:Foreskin is the principal site of heterosexual HIV-1 infection in men. However, little is known about HIV-1-specific immune responses or inflammation in foreskin. To the best of our knowledge, no previous studies have assessed immune responses to candidate HIV-1 vaccines in foreskin. Using the rhesus monkey ...

journal_title：Journal of virology

authors： Balandya E,Miller AD,Beck M,Liu J,Li H,Borducchi E,Smith K,Cabral C,Stanley K,Maxfield LF,Barouch DH

更新日期：2014-04-01 00:00:00

abstract：:A viral mRNA of the late kinetic class expressed by murine cytomegalovirus (MCMV) contains an open reading frame (ORF) whose predicted protein, designated MCK-1, has homology to beta chemokines (M. R. MacDonald, X.-Y. Li, and H. W. Virgin IV, J. Virol. 71:1671-1678, 1997). The present study analyzed further the struct...

journal_title：Journal of virology

authors： MacDonald MR,Burney MW,Resnick SB,Virgin HW IV

更新日期：1999-05-01 00:00:00

abstract：:Viral manipulation of cellular proteins allows viruses to suppress host defenses and generate infectious progeny. Due to the linear double-stranded DNA nature of the adenovirus genome, the cellular DNA damage response (DDR) is considered a barrier to successful infection. The adenovirus genome is packaged with protein...

journal_title：Journal of virology

authors： Avgousti DC,Della Fera AN,Otter CJ,Herrmann C,Pancholi NJ,Weitzman MD

更新日期：2017-09-27 00:00:00

abstract：:Analyses, by construction of phage growth curves, indicated that the polysaccharide depolymerase was synthesized by Pseudomonas aeruginosa strains B and BI after infection with phage 2. The kinetics of biosynthesis of the depolymerase were found to parallel closely the rate of formation of phage-directed virions, and ...

journal_title：Journal of virology

authors： Bartell PF,Orr TE

更新日期：1969-03-01 00:00:00

abstract：:Innate immunity provides an immediate defense against infection after host cells sense danger signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of misfolded/unfolded proteins when protein load overwhelms the ER folding capacity, which activates the unfolded protein response (UPR) to res...

journal_title：Journal of virology

authors： Frabutt DA,Wang B,Riaz S,Schwartz RC,Zheng YH

更新日期：2017-12-14 00:00:00

abstract：:NF-kappaB signaling is critical to the survival and transformation of cells infected by the human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here we have examined how elimination of the NF-kappaB transcription factor p50 from mice affects the life cycle of murine gammaherpesviru...

journal_title：Journal of virology

authors： Krug LT,Collins CM,Gargano LM,Speck SH

更新日期：2009-05-01 00:00:00