Abstract:
:Chick embryo cells became more sensitive to the action of interferon the longer they remained in culture. This phenomenon was found even before confluency had been reached. The relative insensitivity of newly seeded cells was not due to a loss of receptors. Cells synthesizing deoxyribonucleic acid (DNA) at a high rate were less sensitive to interferon action than cells synthesizing DNA at a low rate, but the inhibition of DNA synthesis had no effect on interferon action. An increase in the number of cells used for seeding resulted in an earlier appearance of increased sensitivity to interferon action. These results are discussed in relation to the induction process in animal cells.
journal_name
J Viroljournal_title
Journal of virologyauthors
Rossman TG,Vilcek Jdoi
10.1128/JVI.4.1.7-11.1969subject
Has Abstractpub_date
1969-07-01 00:00:00pages
7-11issue
1eissn
0022-538Xissn
1098-5514journal_volume
4pub_type
杂志文章abstract::Proteins located in the tegument layer of herpesvirus particles play important roles in the replicative cycle at both early and late times after infection. As major constituents of the virion, they execute important functions in particular during formation of progeny virions. These functions have mostly been elucidate...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.3.1332-1339.2006
更新日期:2006-02-01 00:00:00
abstract::We have measured growth of West Nile virus in mouse primary peritoneal macrophages (resident, thioglycolate elicited, and Mycobacterium bovis BCG activated) and in macrophagelike (P338D1) and nonmacrophage (L929, PS clone D) cell lines infected in the absence or presence of specific antibodies (immunoglobulin G ([IgG]...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.57.3.952-959.1986
更新日期:1986-03-01 00:00:00
abstract::Transcription of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) is activated through binding of the viral Tat protein to the trans-activating response (TAR) element at the 5' end of the nascent transcript. Whereas HIV type 1 (HIV-1) TAR folds a simple hairpin structure, the corresponding do...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00530-08
更新日期:2008-09-01 00:00:00
abstract:UNLABELLED:Equine influenza viruses (EIV) are responsible for rapidly spreading outbreaks of respiratory disease in horses. Although natural infections of humans with EIV have not been reported, experimental inoculation of humans with these viruses can lead to a productive infection and elicit a neutralizing antibody r...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02449-14
更新日期:2015-02-01 00:00:00
abstract::The Epstein-Barr virus (EBV) genome contains an open reading frame, BHRF1, that encodes a presumptive membrane protein with sequence similarity to the proto-oncogene bcl2, which is linked to human B-cell follicular lymphoma. Potential roles for BHRF1 in EBV's ability to growth transform human B cells and to replicate ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.4.1899-1906.1992
更新日期:1992-04-01 00:00:00
abstract::Herpesvirus nucleocapsids traverse the nuclear envelope into the cytoplasm in a process called nuclear egress that includes disruption of the nuclear lamina. In several herpesviruses, a key player in nuclear egress is a complex of two proteins, whose homologs in human cytomegalovirus (HCMV) are UL50 and UL53. However,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02358-13
更新日期:2014-01-01 00:00:00
abstract::The recently developed subgenomic hepatitis C virus (HCV) replicons were limited by the fact that the sequence encoding the structural proteins was missing. Therefore, important information about a possible influence of these proteins on replication and pathogenesis and about the mechanism of virus formation could not...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.8.4008-4021.2002
更新日期:2002-04-01 00:00:00
abstract::The nucleotide and deduced amino acid sequences of the P1 region of the genomes of 10 independent equine rhinitis A virus (ERAV) isolates were determined and found to be very closely related. A panel of seven monoclonal antibodies to the prototype virus ERAV.393/76 that bound to nonneutralization epitopes conserved am...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.21.10550-10556.2001
更新日期:2001-11-01 00:00:00
abstract::We have used deletion and recombinant long terminal repeat (LTR) mutants to examine enhancer activity differences between LTRs of the nonpathogenic Akv and the thymus lymphomagenic MCF13 murine retroviruses. Deletion mutant analysis revealed that major control regions for MCF13 and Akv LTR enhancer activity were simil...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.8.3353-3361.1989
更新日期:1989-08-01 00:00:00
abstract::The intracellular assembly site for flaviviruses in currently not known but is presumed to be located within the lumen of the rough endoplasmic reticulum (RER). Building on previous studies involving immunofluorescence (IF) and cryoimmunoelectron microscopy of Kunjin virus (KUN)-infected cells, we sought to identify t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.22.10787-10799.2001
更新日期:2001-11-01 00:00:00
abstract::The bovine papillomavirus type 1 (BPV-1) E7 oncoprotein is required for the full transformation activity of the virus. Although BPV-1 E7 by itself is not sufficient to induce cellular transformation, it enhances the abilities of the other BPV-1 oncogenes to induce anchorage independence. We have been exploring the mec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00422-07
更新日期:2007-09-01 00:00:00
abstract::Previous work demonstrated that a herpes simplex virus type 1 (HSV-1) immediate-early function up-regulates beta interferon but not chloramphenicol acetyltransferase reporter genes driven by the strong simian virus 40 (SV40) or cytomegalovirus promoter-enhancer regions in both transient assays and stable cell lines. T...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.11.7187-7195.1995
更新日期:1995-11-01 00:00:00
abstract::The hepatitis E virus (HEV), a nonenveloped RNA virus, is the causative agent of hepatitis E. The mode by which HEV attaches to and enters into target cells for productive infection remains unidentified. Open reading frame 2 (ORF2) of HEV encodes its major capsid protein, pORF2, which is likely to have the determinant...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00717-09
更新日期:2009-12-01 00:00:00
abstract::Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together wi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.4.2650-2657.1999
更新日期:1999-04-01 00:00:00
abstract::Sequences present at the genomic termini of herpesviruses become linked during lytic-phase replication and provide the substrate for cleavage and packaging of unit length viral genomes. We have previously shown that homologs of the consensus herpesvirus cleavage-packaging signals, pac1 and pac2, are located at the lef...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.1.320-329.1998
更新日期:1998-01-01 00:00:00
abstract::Equine rhinitis A virus (ERAV) has recently been classified as an aphthovirus, a genus otherwise comprised of the different serotypes of Foot-and-mouth disease virus (FMDV). FMDV initiates translation via a type II internal ribosomal entry site (IRES) and utilizes two in-frame AUG codons to produce the leader proteina...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.24.11708-11716.2000
更新日期:2000-12-01 00:00:00
abstract::Deoxyribonucleoside triphosphates are incorporated into T4 DNA in infected cells treated with toluene. Under the proper conditions the incorporation is controlled by the known T4 DNA polymerase and proceeds by a semiconservative mechanism. Both strands of the phage DNA are replicated into a high molecular weight proge...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.12.6.1195-1203.1973
更新日期:1973-12-01 00:00:00
abstract::Rhesus lymphocryptovirus (rLCV) and Epstein-Barr virus (EBV) are closely related gammaherpesviruses that infect and cause disease in rhesus monkeys and humans, respectively. Thus, rLCV is an important model system for EBV pathogenesis. Both rLCV and EBV express microRNAs (miRNAs), several conserved in sequence and gen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00110-10
更新日期:2010-05-01 00:00:00
abstract::We recently discovered an expanded family of adeno-associated viruses (AAVs) that show promise as improved gene therapy vectors. In this study we evaluated the potential of vectors based on several of these novel AAVs as vaccine carriers for human immunodeficiency virus type 1 Gag. Studies with mice indicated that vec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01253-07
更新日期:2007-11-01 00:00:00
abstract::Molluscum contagiosum virus (MCV), a member of the human poxvirus family, encodes the MC159 protein that inhibits Fas-, tumor necrosis factor (TNF)-, and TNF-related apoptosis-inducing ligant (TRAIL)-induced apoptosis. We used site-directed mutagenesis to change charged or hydrophobic amino acid residues to alanines t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.2.697-706.2002
更新日期:2002-01-01 00:00:00
abstract::Replication of all positive-strand RNA viruses is intimately associated with membranes. Here we utilize electron tomography and other methods to investigate the remodeling of membranes in poliovirus-infected cells. We found that the viral replication structures previously described as "vesicles" are in fact convoluted...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05937-11
更新日期:2012-01-01 00:00:00
abstract::The vaccinia virus Western Reserve A38L protein is a hydrophobic integral membrane glycoprotein with amino acid similarity to mammalian integrin-associated protein. The protein has an N-terminal immunoglobulin superfamily domain, followed by five membrane-spanning domains and a short cytoplasmic tail. Deletion of the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.2.905-914.1996
更新日期:1996-02-01 00:00:00
abstract::The human herpes simplex virus (HSV) protein VP16 induces formation of a transcriptional regulatory complex with two cellular factors-the POU homeodomain transcription factor Oct-1 and the cell proliferation factor HCF-1-to activate viral immediate-early-gene transcription. Although the cellular role of Oct-1 in trans...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.24.12402-12411.2001
更新日期:2001-12-01 00:00:00
abstract::The HIV-1 Vpr protein participates in the early steps of the virus life cycle by influencing the accuracy of reverse transcription. This role of Vpr was related to the recruitment of the nuclear form of the uracil DNA glycosylase (UNG2) enzyme into virus particles, but several conflicting findings have been reported r...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05163-11
更新日期:2012-03-01 00:00:00
abstract::Host cell-mediated proteolytic cleavage of the human immunodeficiency virus type 1 (HIV-1) gp160 precursor glycoprotein into gp120 and gp41 subunits is required to generate fusion-competent envelope glycoprotein (Env) spikes. The gp120-directed broadly neutralizing monoclonal antibodies (bNabs) isolated from HIV-infec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01247-13
更新日期:2013-12-01 00:00:00
abstract::There are no known RNA viruses that infect Archaea. Filling this gap in our knowledge of viruses will enhance our understanding of the relationships between RNA viruses from the three domains of cellular life and, in particular, could shed light on the origin of the enormous diversity of RNA viruses infecting eukaryot...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.07196-11
更新日期:2012-05-01 00:00:00
abstract::Since its detection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hosts, and bovines have been identified as its natural reservoir. However, it remains unclear how IDVs emerge, evolve, spread, and maintain in bovine populations. Through multiple years of virological and serological ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00240-20
更新日期:2020-08-31 00:00:00
abstract::The interaction of papillomavirus E2 proteins with cellular Brd4 protein is important for transcriptional regulation of viral genes and partitioning of viral genomes. Bovine papillomavirus type 1 (BPV-1) E2 binds cellular chromatin in complex with Brd4 in both mitotic and interphase cells. To identify specific sites o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02275-08
更新日期:2009-03-01 00:00:00
abstract::Single-envelope human immunodeficiency virus (HIV) vaccines have been studied for more than a decade, with some successes in homologous challenge experiments in nonhuman primates but with no clear successes in clinical trials. To gain insight into the breadth of the immunity elicited by such vaccines, we have dissecte...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.7.4231-4236.2003
更新日期:2003-04-01 00:00:00
abstract::Most of the viral DNA extracted from simian virus 40 (SV40)-infected African green monkey kidney cells consists of circular molecules about 5.3 kilobases in contour length. However, about 1% of the viral DNA was found to occur as closed circular dimers that appeared to be formed, preferentially, late in infection. The...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.24.1.295-302.1977
更新日期:1977-10-01 00:00:00