A live attenuated equine H3N8 influenza vaccine is highly immunogenic and efficacious in mice and ferrets.

abstract：:The avian adenovirus CELO is a promising vector for gene transfer applications. In order to study this potentiality, we developed an improved method for construction of adenovirus vectors in cosmids that was used to engineer the CELO genome. For all the recombinant viruses constructed by this method, the ability to pr...

journal_title：Journal of virology

authors： François A,Eterradossi N,Delmas B,Payet V,Langlois P

更新日期：2001-06-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. In other picornaviruses, homodimerization of 3A has been shown to be relevant for its biological activity. In this work, FMDV 3A homodimerization was evidenced by an in situ protein fluor...

journal_title：Journal of virology

authors： González-Magaldi M,Postigo R,de la Torre BG,Vieira YA,Rodríguez-Pulido M,López-Viñas E,Gómez-Puertas P,Andreu D,Kremer L,Rosas MF,Sobrino F

更新日期：2012-10-01 00:00:00

abstract：:The mechanisms of cell death in CD4+ T cells mediated by human herpesvirus 6 (HHV-6) were investigated. The frequency of cell death in the human CD4+ T-cell line JJHAN, which had been inoculated with HHV-6 variant A or B, appeared to be augmented by tumor necrosis factor alpha (TNF-alpha). Agarose gel electrophoresis ...

journal_title：Journal of virology

authors： Inoue Y,Yasukawa M,Fujita S

更新日期：1997-05-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 Tax protein activates the expression of cellular immediate early genes controlled by the serum response element (SRE), which contains both the serum response factor (SRF) binding element (CArG box) and the ternary complex factor (TCF) binding element (Ets box). We show that TCF b...

journal_title：Journal of virology

authors： Shuh M,Derse D

更新日期：2000-12-01 00:00:00

abstract：:Passage of native classical swine fever virus (CSFV) in cultured swine kidney cells (SK6 cells) selects virus variants that attach to the surface of cells by interaction with membrane-associated heparan sulfate (HS). A Ser-to-Arg change in the C terminus of envelope glycoprotein E(rns) (amino acid 476 in the open read...

journal_title：Journal of virology

authors： Hulst MM,van Gennip HG,Vlot AC,Schooten E,de Smit AJ,Moormann RJ

更新日期：2001-10-01 00:00:00

abstract：:The tax gene of the human T-cell leukemia virus types I and II (HTLV-I and HTLV-II) is essential for viral replication and acts by increasing the level of RNA transcription. The tax genes of HTLV-I and HTLV-II encode proteins of 40 and 37 kilodaltons, respectively. By in vitro mutagenesis of the tax gene, we have inve...

journal_title：Journal of virology

authors： Cann AJ,Rosenblatt JD,Wachsman W,Chen IS

更新日期：1989-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) requires that its genome be reverse transcribed into double-stranded DNA for productive infection of cells. This process requires not only reverse transcriptase but also the nucleocapsid protein (NC), which functions as a nucleic acid chaperone. Reverse transcription general...

journal_title：Journal of virology

authors： Thomas JA,Bosche WJ,Shatzer TL,Johnson DG,Gorelick RJ

更新日期：2008-10-01 00:00:00

abstract：:We used 18 monoclonal antibodies against B19 parvovirus to identify neutralizing epitopes on the viral capsid. Of the 18 antibodies, 9 had in vitro neutralizing activity in a bone marrow colony culture assay. The overlapping polypeptide fragments spanning the B19 structural proteins were produced in a pMAL-c Escherich...

journal_title：Journal of virology

authors： Yoshimoto K,Rosenfeld S,Frickhofen N,Kennedy D,Hills R,Kajigaya S,Young NS

更新日期：1991-12-01 00:00:00

abstract：:The EFII cis element is a 38-bp sequence at the 5' end of the Rous sarcoma virus long terminal repeat, extending from nucleotides -229 to -192 (with respect to the viral transcription start site), which is recognized by sequence-specific DNA-binding proteins in avian fibroblast nuclear extracts (L. Sealy and R. Chalkl...

journal_title：Journal of virology

authors： Sears RC,Sealy L

更新日期：1992-11-01 00:00:00

abstract：:The effectiveness and potential immunosuppressive effects of anti-inflammatory glucocorticoids in the lungs of severe acute respiratory syndrome (SARS) patients are undefined. We treated porcine respiratory coronavirus (PRCV)-infected conventional pigs with the corticosteroid dexamethasone (DEX) as a model for SARS. I...

journal_title：Journal of virology

authors： Zhang X,Alekseev K,Jung K,Vlasova A,Hadya N,Saif LJ

更新日期：2008-05-01 00:00:00

abstract：:For viruses with segmented genomes, genetic diversity is generated by genetic drift, reassortment, and recombination. Recombination produces RNA populations distinct from full-length gene segments and can influence viral population dynamics, persistence, and host immune responses. Viruses in the Reoviridae family, inc...

journal_title：Journal of virology

authors： Smith SC,Gribble J,Diller JR,Wiebe MA,Thoner TW Jr,Denison MR,Ogden KM

更新日期：2021-01-20 00:00:00

abstract：:Nonenveloped viruses often invade membranes by exposing hydrophobic or amphipathic peptides generated by a proteolytic maturation step that leaves a lytic peptide noncovalently associated with the viral capsid. Since multiple copies of the same protein form many nonenveloped virus capsids, it is unclear if lytic pepti...

journal_title：Journal of virology

authors： Domitrovic T,Matsui T,Johnson JE

更新日期：2012-09-01 00:00:00

abstract：:We report the discovery and analysis of an endogenous foamy virus (PSFVaye) within the genome of the aye-aye (Daubentonia madagascariensis), a strepsirrhine primate from Madagascar. Phylogenetic analyses indicate that PSFVaye is divergent from all known simian foamy viruses, suggesting an association between foamy vir...

journal_title：Journal of virology

authors： Han GZ,Worobey M

更新日期：2012-07-01 00:00:00

abstract：:Retroviruses have been isolated from the tissues of human leukemia patients. Previous studies have shown that these isolates share some antigenic determinants with the family of viruses isolated from the woolly monkey and gibbon ape and that they exhibit partial nuclei acid homology with this same group of viruses. We...

journal_title：Journal of virology

authors： Sahagan BG,Haseltine WA

更新日期：1980-05-01 00:00:00

abstract：:We have obtained a polyclonal antiserum, N-BE, against the denatured, amino-terminal half of the measles virus (MV) nucleocapsid (N) protein and a monoclonal antibody (MAb), N46, which recognizes a conformation-dependent epitope in the same region. Amino acid residues 23 to 239 were required and sufficient for the for...

journal_title：Journal of virology

authors： Gombart AF,Hirano A,Wong TC

更新日期：1993-07-01 00:00:00

abstract：:Rice yellow mottle virus is classified in five major serotypes; the molecular diversity of the coat protein (CP) is well established, but the amino acids involved in the recognition by discriminant monoclonal antibodies (MAbs) remain unknown. Reconstruction of a phylogenetic tree and sequence alignment of the CP gene ...

journal_title：Journal of virology

authors： Hébrard E,Pinel-Galzi A,Catherinot V,Labesse G,Brugidou C,Fargette D

更新日期：2005-04-01 00:00:00

abstract：:In most prion diseases, infectivity accumulates in lymphoreticular organs early after infection. Defects in hematopoietic compartments, such as impaired B-cell maturation, or in stromal compartments, such as abrogation of follicular dendritic cells, can delay or prevent lymphoreticular prion colonization. However, the...

journal_title：Journal of virology

authors： Kaeser PS,Klein MA,Schwarz P,Aguzzi A

更新日期：2001-08-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) infects alveolar macrophages (AMϕ), causing dysregulated alpha interferon (IFN-α) and tumor necrosis factor alpha (TNF-α) production through a mechanism(s) yet to be resolved. Here, we show that AMϕ infected with PRRSV secreted a reduced quantity of IFN-α fol...

journal_title：Journal of virology

authors： Chen WY,Schniztlein WM,Calzada-Nova G,Zuckermann FA

更新日期：2018-01-02 00:00:00

abstract：:MxA is an abundant and ubiquitous cytoplasmic protein induced by alpha/beta interferon in human cells. Upon full induction, it can constitute 0.5 to 1% of cytosolic proteins. MxA can bind elements of the cytoskeleton, such as actin and tubulins, and several larger cellular proteins. However, these protein-protein inte...

journal_title：Journal of virology

authors： Horisberger MA

更新日期：1992-08-01 00:00:00

abstract：:Poliovirus (PV) modifies membrane-trafficking machinery in host cells for its viral RNA replication. To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), including PV, involved in membrane traffic. In this study, we performed small interfering RNA (siRNA) scr...

journal_title：Journal of virology

authors： Arita M,Wakita T,Shimizu H

更新日期：2012-05-01 00:00:00

abstract：:In this study, we have identified an internal ribosome entry site (IRES) from the highly infectious herpesvirus Marek's disease virus (MDV). The IRES was mapped to the intercistronic region (ICR) of a bicistronic mRNA that we cloned from the MDV-transformed CD4(+) T-cell line MSB-1. The transcript is a member of a fam...

journal_title：Journal of virology

authors： Tahiri-Alaoui A,Smith LP,Baigent S,Kgosana L,Petherbridge LJ,Lambeth LS,James W,Nair V

更新日期：2009-06-01 00:00:00

abstract：:Mutations critical for the central nervous system (CNS) attenuation of the Sabin vaccine strains of poliovirus (PV) are located within the viral internal ribosome entry site (IRES). We examined the interaction of the IRESs of PV type 3 (PV3) and Sabin type 3 (Sabin3) with polypyrimidine tract-binding protein (PTB) and...

journal_title：Journal of virology

authors： Guest S,Pilipenko E,Sharma K,Chumakov K,Roos RP

更新日期：2004-10-01 00:00:00

abstract：:To analyze the biological activities of the alphavirus glycoproteins, eight different monoclonal antibodies against the two glycoproteins of western equine encephalitis virus were isolated. Five of the eight monoclonal antibodies were shown to be specific for E1 and three for E2 protein by an enzyme-linked immunosorbe...

journal_title：Journal of virology

authors： Yamamoto K,Hashimoto K,Chiba J,Simizu B

更新日期：1985-09-01 00:00:00

abstract：:The effects of human papillomavirus type 18 (HPV-18) E6 and E7 proteins on global patterns of host gene expression in primary human keratinocytes grown in organotypic raft culture system were assessed. Primary human keratinocytes were infected with retroviruses that express the wild-type HPV-18 E6 and E7 genes from th...

journal_title：Journal of virology

authors： Garner-Hamrick PA,Fostel JM,Chien WM,Banerjee NS,Chow LT,Broker TR,Fisher C

更新日期：2004-09-01 00:00:00

abstract：UNLABELLED:Epstein-Barr virus (EBV) is a well-established B-cell-tropic virus associated with various lymphoproliferative diseases of both B-cell and non-B-cell origin. EBV is associated with a number of T-cell lymphomas; however, in vitro studies utilizing prototypical EBV type 1 (EBV-1) laboratory strains have genera...

journal_title：Journal of virology

authors： Coleman CB,Wohlford EM,Smith NA,King CA,Ritchie JA,Baresel PC,Kimura H,Rochford R

更新日期：2015-02-01 00:00:00

abstract：:The vaccinia virus A16L open reading frame encodes a 378-amino-acid protein with a predicted C-terminal transmembrane domain and 20 invariant cysteine residues that is conserved in all sequenced members of the poxvirus family. The A16 protein was expressed late in infection and incorporated into intracellular virus pa...

journal_title：Journal of virology

authors： Ojeda S,Senkevich TG,Moss B

更新日期：2006-01-01 00:00:00

abstract：:Arenaviruses are rodent-borne viruses, with five members of the family capable of causing severe hemorrhagic fevers if transmitted to humans. To date, two distinct cellular receptors have been identified that are used by different pathogenic viruses, alpha-dystroglycan by Lassa fever virus and transferrin receptor 1 (...

journal_title：Journal of virology

authors： Flanagan ML,Oldenburg J,Reignier T,Holt N,Hamilton GA,Martin VK,Cannon PM

更新日期：2008-01-01 00:00:00

abstract：:Previous analyses have demonstrated that adenovirus DNA is packaged into virions in vivo in a polar, left-to-right fashion. The packaging of viral DNA is dependent on cis-acting elements at the left end of the genome. In this report, we describe a genetic analysis of the sequences that are required for efficient packa...

journal_title：Journal of virology

authors： Gräble M,Hearing P

更新日期：1990-05-01 00:00:00

abstract：:Human CD4(+) T-helper 1 cell responses to Epstein-Barr virus (EBV) infection are likely to be important in the maintenance of virus-specific CD8(+) memory and/or as antiviral effectors in their own right. The present work has used overlapping peptides as stimulators of gamma interferon release (i) to identify CD4(+) e...

journal_title：Journal of virology

authors： Leen A,Meij P,Redchenko I,Middeldorp J,Bloemena E,Rickinson A,Blake N

更新日期：2001-09-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine leads to a serious disease characterized by a delayed and defective adaptive immune response. It is hypothesized that a suboptimal innate immune response is responsible for the disease pathogenesis. In the study presented here we tested thi...

journal_title：Journal of virology

authors： Beura LK,Sarkar SN,Kwon B,Subramaniam S,Jones C,Pattnaik AK,Osorio FA

更新日期：2010-02-01 00:00:00