New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1.

abstract：:An E1-E3-deleted recombinant adenovirus vector expressing the hybrid protein TetR-KRAB has been produced. In this virus, AdTG9562, the E2 transcription is regulated by TetR-KRAB and tetO sequences inserted in cis. In the absence of tetracycline, a strong reduction in E2A gene expression, viral DNA replication, and lat...

journal_title：Journal of virology

authors： Rittner K,Schultz H,Pavirani A,Mehtali M

更新日期：1997-04-01 00:00:00

abstract：:We previously demonstrated that human cytomegalovirus (HCMV) infection induced the activation of the cellular transcription factor NF-kappaB. Here, we investigate the mechanism for the HCMV-induced NF-kappaB activation and the role that the induced NF-kappaB plays in transactivation of the major immediate-early promot...

journal_title：Journal of virology

authors： DeMeritt IB,Milford LE,Yurochko AD

更新日期：2004-05-01 00:00:00

abstract：:Polymerase basic protein 2 (PB2), a component of the influenza virus polymerase complex, when expressed alone from cloned cDNA in the absence of other influenza virus proteins, is transported into the nucleus. In this study, we have examined the nuclear translocation signal of PB2 by making deletions and mutations in ...

journal_title：Journal of virology

authors： Mukaigawa J,Nayak DP

更新日期：1991-01-01 00:00:00

abstract：:The mechanism whereby picornaviruses inhibit host protein synthesis while their own synthetic processes proceed unabated has remained elusive. One of our approaches to this problem was to study the ability of cell-free extracts derived from uninfected and mengovirus-infected Ehrlich ascites tumor cells to translate vi...

journal_title：Journal of virology

authors： Abreu SL,Lucas-Lenard J

更新日期：1976-04-01 00:00:00

abstract：:A window of opportunity for immune responses to extinguish human immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through establishment of the latent pool of HIV-1-infected cells. A critical time to study the initial immune responses to the transmitted/founder virus is the eclipse phase of ...

journal_title：Journal of virology

authors： Tomaras GD,Yates NL,Liu P,Qin L,Fouda GG,Chavez LL,Decamp AC,Parks RJ,Ashley VC,Lucas JT,Cohen M,Eron J,Hicks CB,Liao HX,Self SG,Landucci G,Forthal DN,Weinhold KJ,Keele BF,Hahn BH,Greenberg ML,Morris L,Karim S

更新日期：2008-12-01 00:00:00

abstract：:High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative agents of cervical carcinomas and are linked to several other tumors of the anogenital and oropharyngeal regions. The majority of HPV-induced tumors contain integrated copies of the normally episomal HPV genome that invariably reta...

journal_title：Journal of virology

authors： Kennedy EM,Kornepati AV,Goldstein M,Bogerd HP,Poling BC,Whisnant AW,Kastan MB,Cullen BR

更新日期：2014-10-01 00:00:00

abstract：:Two herpes simplex virus type 1 glycoproteins, gE and gI, have been shown to form a complex that binds the Fc domain of immunoglobulin G (IgG). We demonstrate that this complex is required for the binding of monomeric nonimmune IgG but that gE alone is sufficient for binding polymeric IgG in the form of IgG complexes....

journal_title：Journal of virology

authors： Dubin G,Frank I,Friedman HM

更新日期：1990-06-01 00:00:00

abstract：:One common attribute of herpesviruses is the ability to establish latent, life-long infections. The role of virus-virus interaction in viral reactivation between or among herpesviruses has not been studied. Preliminary experiments in our laboratory had indicated that infection of Epstein-Barr virus (EBV) genome-positi...

journal_title：Journal of virology

authors： Flamand L,Stefanescu I,Ablashi DV,Menezes J

更新日期：1993-11-01 00:00:00

abstract：:Spleen necrosis virus productively infects avian and rat cells. The average number of molecules of unintegrated and integrated viral DNA in cells at different times after infection was determined by hybridization and transfection assays. Shortly after infection, there was a transient accumulation of an average of abou...

journal_title：Journal of virology

authors： Keshet E,Temin HM

更新日期：1979-08-01 00:00:00

abstract：:Adenovirus type 2 (Ad2) and Ad5 enter epithelial cells via the coxsackievirus B Ad receptor (CAR) and alpha(v) integrin coreceptors. In the absence of CAR, they can be directed to the Fcgamma receptor 1 of hematopoietic cells by an adaptor comprising the extracellular CAR domain and the Fc portion of a human immunoglo...

journal_title：Journal of virology

authors： Meier O,Gastaldelli M,Boucke K,Hemmi S,Greber UF

更新日期：2005-02-01 00:00:00

abstract：:The transforming proteins of the small DNA tumor viruses, simian virus 40 (SV40), adenovirus, and human papillomavirus (HPV) target a number of identical cellular regulators whose functional abrogation is required for transformation. However, while both adenovirus E1A and SV40 large T transforming properties also depe...

journal_title：Journal of virology

authors： Zimmermann H,Degenkolbe R,Bernard HU,O'Connor MJ

更新日期：1999-08-01 00:00:00

abstract：:Translation of aphthovirus RNA is initiated at an internal ribosome entry site (IRES) element, preceding the first functional AUG initiation codon. The effect of mutations at the base of domain 3 of the aphthovirus IRES on translation activity has been analyzed by site-directed mutagenesis and expression of bicistroni...

journal_title：Journal of virology

authors： Martínez-Salas E,Regalado MP,Domingo E

更新日期：1996-02-01 00:00:00

abstract：:The nature of the lesions involved in producing the fusiform phenotype of three mutants (WO101, WO201, and tsST529) of the Schmidt-Ruppin A strain of Rous sarcoma virus (RSV) was determined by molecular cloning and DNA sequencing. WO101 and WO201 contained an in-frame deletion of the v-src region coding for amino acid...

journal_title：Journal of virology

authors： Anderson SK,Fujita DJ

更新日期：1987-06-01 00:00:00

abstract：:Several viral determinants were shown to play a role in the ability of human immunodeficiency virus type 1 (HIV-1) to infect nondividing cells. In particular, Vpr and Gag matrix (MA) were recognized to be involved in the nuclear transport of the viral preintegration complex. The goal of the present study was to evalua...

journal_title：Journal of virology

authors： Nie Z,Bergeron D,Subbramanian RA,Yao XJ,Checroune F,Rougeau N,Cohen EA

更新日期：1998-05-01 00:00:00

abstract：:Fluorescent retroviral envelope (Env) proteins were developed for direct visualization of viral particles. By fusing the enhanced green fluorescent protein (eGFP) to the N terminus of the amphotropic 4070A envelope protein, extracellular presentation of eGFP was achieved. Viruses incorporated the modified Env protein ...

journal_title：Journal of virology

authors： Spitzer D,Dittmar KE,Rohde M,Hauser H,Wirth D

更新日期：2003-05-01 00:00:00

abstract：:Herpes B virus (BV) naturally infects macaque monkeys and is genetically similar to herpes simplex virus (HSV). Zoonotic infection of humans can cause encephalitis and if untreated has a fatality rate of ∼80%. The frequent use of macaques in biomedical research emphasizes the need to understand the molecular basis of ...

journal_title：Journal of virology

authors： Amen MA,Griffiths A

更新日期：2011-07-01 00:00:00

abstract：UNLABELLED:There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been solved, with the excep...

journal_title：Journal of virology

authors： Sun X,Li Q,Wu Y,Wang M,Liu Y,Qi J,Vavricka CJ,Gao GF

更新日期：2014-08-01 00:00:00

abstract：:In this study, we show that replication-competent subgenomic hepatitis C virus (HCV) RNA can be transferred to permissive Huh7 cells, leading to the establishment of viral RNA replication. Further, we show that these events are mediated by exosomes rather than infectious virus particles. If similar events occur in viv...

journal_title：Journal of virology

authors： Longatti A,Boyd B,Chisari FV

更新日期：2015-03-01 00:00:00

abstract：:Type I interferon is induced shortly following viral infection and represents a first line of host defense against a majority of viral pathogens. Not surprisingly, both replication and latency of gammaherpesviruses, ubiquitous cancer-associated pathogens, are attenuated by type I interferon, although the mechanism of ...

journal_title：Journal of virology

authors： Mounce BC,Mboko WP,Kanack AJ,Tarakanova VL

更新日期：2014-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) is one of five viral nuclear proteins that are essential for EBV-induced immortalization of primary human B lymphocytes in vitro. Previous studies have implied that EBNA-3C acts as a transcription factor. Using transient transfection assays, we demonstrate that EBN...

journal_title：Journal of virology

authors： Marshall D,Sample C

更新日期：1995-06-01 00:00:00

abstract：:The mechanism by which murine polyomavirus penetrates cells and arrives at the nucleus, the site of viral replication, is not well understood. Simian virus 40 and JC virus, two closely related members of the polyomavirus subfamily, use caveola- and clathrin-mediated uptake pathways for entry, respectively. The data pr...

journal_title：Journal of virology

authors： Gilbert JM,Benjamin TL

更新日期：2000-09-01 00:00:00

abstract：:The movement protein (MP) of Tobacco mosaic virus mediates the cell-to-cell transport of viral RNA through plasmodesmata, cytoplasmic cell wall channels for direct cell-to-cell communication between adjacent cells. Previous in vivo studies demonstrated that the RNA transport function of the protein correlates with its...

journal_title：Journal of virology

authors： Ferralli J,Ashby J,Fasler M,Boyko V,Heinlein M

更新日期：2006-06-01 00:00:00

abstract：:Upon inoculation into AKR mice, mink cell focus-forming murine leukemia virus (MCF MLV) accelerates thymic lymphoma formation. During the preleukemic phase of disease, we observed the induction of apoptosis in thymic lymphocytes. A similar induction of apoptosis was observed for cultured mink epithelial cells after MC...

journal_title：Journal of virology

authors： Nanua S,Yoshimura FK

更新日期：2004-05-01 00:00:00

abstract：:Identification of cellular receptors used by coronavirus (CoV) entry into the host cells is critical to an understanding of pathogenesis and to development of intervention strategies. The fourth CoV genus, Deltacoronavirus, evolutionarily related to the Gammacoronavirus, has just been defined recently. In the current ...

journal_title：Journal of virology

authors： Wang B,Liu Y,Ji CM,Yang YL,Liang QZ,Zhao P,Xu LD,Lei XM,Luo WT,Qin P,Zhou J,Huang YW

更新日期：2018-05-29 00:00:00

abstract：:From the results of transient plasmid-based replication assays, it has been postulated that homologous regions (hrs) of Autographa californica nuclear polyhedrosis virus (AcMNPV) function as origins of viral DNA replication. However, these assays vary in specificity according to the methodology used and may not be dep...

journal_title：Journal of virology

authors： Wu Y,Carstens EB

更新日期：1996-10-01 00:00:00

abstract：:In Epstein-Barr virus (EBV)-carrying nonproducer Raji cells, the induction of the viral replicative cycle by chemical treatment is limited to only the early stage and viral DNA synthesis is totally inhibited. We previously showed the absence of two messenger RNAs that are encoded by the BamHI-A fragment of the EBV gen...

journal_title：Journal of virology

authors： Decaussin G,Leclerc V,Ooka T

更新日期：1995-11-01 00:00:00

abstract：UNLABELLED:Hepatitis B, which caused by hepatitis B virus (HBV) infection, remains a major health threat worldwide. Hepatic injury and regeneration from chronic inflammation are the main driving factors of liver fibrosis and cirrhosis in chronic hepatitis B. Proinflammatory tumor necrosis factor alpha (TNF-α) has been ...

journal_title：Journal of virology

authors： Jia B,Guo M,Li G,Yu D,Zhang X,Lan K,Deng Q

更新日期：2015-02-01 00:00:00

abstract：:The ability of vaccinia virus to replicate in HeLa cells which had been previously infected with adenovirus type 2 (Ad2) was studied in order to gain insight into the mechanism by which adenovirus inhibits the expression of host cell functions. Vaccinia virus was employed in these studies because it replicates in the ...

journal_title：Journal of virology

authors： Giorno R,Kates JR

更新日期：1971-02-01 00:00:00

abstract：:We show here that the white spot syndrome virus (WSSV) immediate-early protein IE1 interacts with the Penaeus monodon TATA box-binding protein (PmTBP) and that this protein-protein interaction occurs in the absence of any other viral or cellular proteins or nucleic acids, both in vitro and in vivo. Mapping studies usi...

journal_title：Journal of virology

authors： Liu WJ,Chang YS,Huang WT,Chen IT,Wang KC,Kou GH,Lo CF

更新日期：2011-07-01 00:00:00

abstract：:All hepadnaviruses known so far have a very limited host range, restricted to their natural hosts and a few closely related species. This is thought to be due mainly to sequence divergence in the large envelope protein and species-specific differences in host components essential for virus propagation. Here we report ...

journal_title：Journal of virology

authors： Prassolov A,Hohenberg H,Kalinina T,Schneider C,Cova L,Krone O,Frölich K,Will H,Sirma H

更新日期：2003-02-01 00:00:00