Initiation of baculovirus DNA replication: early promoter regions can function as infection-dependent replicating sequences in a plasmid-based replication assay.

abstract：:A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change ...

journal_title：Journal of virology

authors： Mariani R,Wong S,Mulder LC,Wilkinson DA,Reinhart AL,LaRosa G,Nibbs R,O'Brien TR,Michael NL,Connor RI,Macdonald M,Busch M,Koup RA,Landau NR

更新日期：1999-03-01 00:00:00

abstract：:Establishment of persistent Epstein-Barr virus (EBV) infection requires transition from a program of full viral latency gene expression (latency III) to one that is highly restricted (latency I and 0) within memory B lymphocytes. It is well established that DNA methylation plays a critical role in EBV gene silencing, ...

journal_title：Journal of virology

authors： Hughes DJ,Marendy EM,Dickerson CA,Yetming KD,Sample CE,Sample JT

更新日期：2012-01-01 00:00:00

abstract：:The temporal regulation of DNA replication is thought to be important for chromosome organization and genome stability. We show here that Epstein-Barr virus (EBV) genomes replicate in mid- to late S phase and that agents that accelerate replication timing of EBV reduce viral genome stability. Hydroxyurea (HU) treatmen...

journal_title：Journal of virology

authors： Zhou J,Snyder AR,Lieberman PM

更新日期：2009-03-01 00:00:00

abstract：:The distantly related lentiviruses human immunodeficiency virus type 1 (HIV-1) and visna virus each encode a posttranscriptional regulatory protein, termed Rev, that is critical for expression of the viral structural proteins. We genetically mapped the cis-acting target sequence for visna virus Rev, the visna virus Re...

journal_title：Journal of virology

authors： Tiley LS,Cullen BR

更新日期：1992-06-01 00:00:00

abstract：:Our previous observations indicated that upon infection with minute virus of mice (MVM), Ehrlich ascites cells lose a transcription elongation activity which is essential for the readthrough of the MVM attenuator. This was monitored by the ability of extracts from uninfected but not from infected cells to support read...

journal_title：Journal of virology

authors： Krauskopf A,Ben-Asher E,Aloni Y

更新日期：1994-04-01 00:00:00

abstract：:Human cytomegalovirus (CMV) is the leading cause of prenatal viral infection. Affected infants may suffer intrauterine growth retardation and serious neurologic impairment. Analysis of spontaneously aborted conceptuses shows that CMV infects the placenta before the embryo or fetus. In the human hemochorial placenta, m...

journal_title：Journal of virology

authors： Fisher S,Genbacev O,Maidji E,Pereira L

更新日期：2000-08-01 00:00:00

abstract：:Characterization of immune responses induced by live attenuated simian immunodeficiency virus (SIV) strains may yield clues to the nature of protective immunity induced by this vaccine approach. We investigated the ability of CD8(+) T lymphocytes from rhesus macaques immunized with the live, attenuated SIV strain SIVm...

journal_title：Journal of virology

authors： Gauduin MC,Glickman RL,Means R,Johnson RP

更新日期：1998-08-01 00:00:00

abstract：:The major envelope glycoproteins gp120 and gp41 of human immunodeficiency virus type 1, the causative agent for human AIDS, contain numerous N-linked oligosaccharides. We report here our discovery that N-acetylglucosamine residues within the complex-type N-linked oligosaccharides of both gp120 and its precursor, gp160...

journal_title：Journal of virology

authors： Shilatifard A,Merkle RK,Helland DE,Welles JL,Haseltine WA,Cummings RD

更新日期：1993-02-01 00:00:00

abstract：:We constructed a matched set of plasmids to investigate the interactions of essential core sequences of the simian virus 40 replication origin with flanking regulatory sequences. Deletions of either T-antigen-binding region I or the 21-base-pair repeated promoter elements reduced replication to 50 to 70% of wild-type ...

journal_title：Journal of virology

authors： DeLucia AL,Deb S,Partin K,Tegtmeyer P

更新日期：1986-01-01 00:00:00

abstract：:In vitro transcriptase activity of three group I temperature-sensitive (ts) mutants of vesicular stomatitis virus restricted at 39 C was restored by L-protein fractions derived from wild-type (wt) vesicular stomatitis virion nucleo-capsids. Soluble NS protein from wt nucleocapsids did not reconstitute restricted trans...

journal_title：Journal of virology

authors： Hunt DM,Emerson SU,Wagner RR

更新日期：1976-05-01 00:00:00

abstract：:Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did ...

journal_title：Journal of virology

authors： Markine-Goriaynoff D,Coutelier JP

更新日期：2002-01-01 00:00:00

abstract：:Molecular clones of closed circular DNA molecules of a mink cell focus-inducing murine leukemia virus (MCF-13 MuLV) were generated. Closed circular DNA molecules isolated from a Hirt extraction of recently infected NIH/3T3 cells were inserted at their unique EcoRI site into lambda gtWES.lambda B. Restriction endonucle...

journal_title：Journal of virology

authors： Yoshimura FK

更新日期：1982-07-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) directed against the E2 glycoprotein of mouse hepatitis virus (MHV) have been classified according to their ability to bind to either of the two purified 90,000-molecular-weight subunits (90K subunits) of the 180K peplomeric glycoprotein E2. Correlation with previously reported information...

journal_title：Journal of virology

authors： Weismiller DG,Sturman LS,Buchmeier MJ,Fleming JO,Holmes KV

更新日期：1990-06-01 00:00:00

abstract：:In this paper, we report that the DNA of bovine mammillitis virus (BMV) consists of two covalently linked components that are 71.5 x 10(6) and 15.7 x 10(6) in molecular weight and designated L and S, respectively. We further report that the BMV DNA consists of four equimolar populations differing only in the orientati...

journal_title：Journal of virology

authors： Buchman TG,Roizman B

更新日期：1978-01-01 00:00:00

abstract：:Latency is an integral feature of the pathogenesis of cytomegalovirus infection and disease. Using in situ hybridization, we detected viral DNA in the splenic stroma of mice with acute murine cytomegalovirus (MCMV) infection but could not detect latent infection. By using enzymatic amplification of a 700-bp region of ...

journal_title：Journal of virology

authors： Pomeroy C,Hilleren PJ,Jordan MC

更新日期：1991-06-01 00:00:00

abstract：:Several different forms of progeny viral DNA can be identified in polyoma virus (Py)-infected mouse L-cells. The majority comprise mature form I superhelical DNA and the circular, double-stranded "theta" replicating intermediates in which the progeny DNA strands never exceed the unit genome length of the template. The...

journal_title：Journal of virology

authors： Ganz PR,Sheinin R

更新日期：1983-06-01 00:00:00

abstract：:Accumulation of the interferon-stimulated gene 15 (ISG15) protein product, which is reversibly conjugated to numerous polypeptide targets, impacts the proteome and physiology of uninfected and infected cells. While many viruses, including human cytomegalovirus (HCMV), blunt host antiviral defenses by limiting ISG expr...

journal_title：Journal of virology

authors： Bianco C,Mohr I

更新日期：2017-04-13 00:00:00

abstract：:Antiviral effects were characterized for two oligodeoxyribonucleoside methylphosphonates synthesized in an antisense (3'-TCTTAACC-5') or a sense (5'-AGAATTGG-3') orientation, based on the RNA sequence of the first splice acceptor site of the tat-3 gene of human immunodeficiency virus (HIV) (5'...AGAAUUGG...3'). The de...

journal_title：Journal of virology

authors： Zaia JA,Rossi JJ,Murakawa GJ,Spallone PA,Stephens DA,Kaplan BE,Eritja R,Wallace RB,Cantin EM

更新日期：1988-10-01 00:00:00

abstract：:Glycosylated, membrane-associated E1 (58-kDa) and E2 (47- to 49-kDa) rubella virus proteins and unglycosylated nucleoprotein C (33 kDa), from separately expressed vaccinia virus recombinants, were injected into golden Syrian hamsters. Rubella virus E1 and E2 glycoproteins consistently induced an organ-specific autoimm...

journal_title：Journal of virology

authors： Yoon JW,Choi DS,Liang HC,Baek HS,Ko IY,Jun HS,Gillam S

更新日期：1992-02-01 00:00:00

abstract：:Viral particles infecting some stocks of the protozoan parasite Leishmania braziliensis subsp. guyanensis contain a double-stranded RNA genome of ca. 5 kbp and are associated with an RNA-dependent RNA polymerase which synthesizes in vitro double-stranded and single-stranded, genome-length transcripts. The majority of ...

journal_title：Journal of virology

authors： Widmer G,Patterson JL

更新日期：1991-08-01 00:00:00

abstract：:The activity and epithelial tropism of the human papillomavirus type 18 P105 early promoter, which directs the synthesis of the E6 and E7 transforming genes, are controlled by cis elements included in the viral long control region. To identify potential cellular regulators of this promoter, we mutagenized one or both ...

journal_title：Journal of virology

authors： Thierry F,Spyrou G,Yaniv M,Howley P

更新日期：1992-06-01 00:00:00

abstract：:Immature retroviral particles are assembled by self-association of the structural polyprotein precursor Gag. During maturation the Gag polyprotein is proteolytically cleaved, yielding mature structural proteins, matrix (MA), capsid (CA), and nucleocapsid (NC), that reassemble into a mature viral particle. Proteolytic ...

journal_title：Journal of virology

authors： Hadravová R,de Marco A,Ulbrich P,Stokrová J,Dolezal M,Pichová I,Ruml T,Briggs JA,Rumlová M

更新日期：2012-02-01 00:00:00

abstract：:The bovine leukemia virus (BLV) is an oncogenic retrovirus that is associated with the development of persistent lymphocytosis (PL) and lymphoma in cattle. While B lymphocytes have been shown to be the primary cellular target of BLV, recent studies suggest that some T lymphocytes and monocytes may be infected by the v...

journal_title：Journal of virology

authors： Mirsky ML,Olmstead CA,Da Y,Lewin HA

更新日期：1996-04-01 00:00:00

abstract：:Chronic infection by hepatitis C virus (HCV) can lead to severe hepatitis and cirrhosis and is closely associated with hepatocellular carcinoma. The replication cycle of HCV is poorly understood but is likely to involve interaction with host factors. In this report, we show that NS5B, the HCV RNA-dependent RNA polymer...

journal_title：Journal of virology

authors： Goh PY,Tan YJ,Lim SP,Tan YH,Lim SG,Fuller-Pace F,Hong W

更新日期：2004-05-01 00:00:00

abstract：:A cloned segment of the polyoma virus genome encoding the small T antigen has been fused, in the correct phase for translation, to the 5' end of the beta-galactosidase gene. The hybrid gene, cloned in Escherichia coli, produces a protein resembling the small T antigen. ...

journal_title：Journal of virology

authors： Horwich A,Koop AH,Eckhart W

更新日期：1980-10-01 00:00:00

abstract：:Little is known about the mechanisms used by enveloped viruses to separate themselves from the cell surface at the final step of budding. However, small sequences in the Gag proteins of several retroviruses (L domains) have been implicated in this process. A sequence has been identified in the M proteins of rhabdoviru...

journal_title：Journal of virology

authors： Craven RC,Harty RN,Paragas J,Palese P,Wills JW

更新日期：1999-04-01 00:00:00

abstract：:Nine pre-early polypeptides have been detected after infection with bacteriophage T5 and 10 pre-early polypeptides have been detected after infection with bacteriophage BF23. Only about one-half of the coding capacity of the redundant ends of the phage DNA, which code for pre-early proteins, is needed for these 9 to 1...

journal_title：Journal of virology

authors： McCorquodale DJ,Shaw AR,Shaw PK,Chinnadurai G

更新日期：1977-05-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus type 1 (HIV-1) Pr55Gag molecule with the plasma membrane of an infected cell is an essential step of the viral life cycle. Myristic acid and positively charged residues within the N-terminal portion of MA constitute the membrane-binding domain of Pr55Gag. A separate ...

journal_title：Journal of virology

authors： Sandefur S,Varthakavi V,Spearman P

更新日期：1998-04-01 00:00:00

abstract：:Immune activation is a major characteristic of human immunodeficiency virus type 1 (HIV-1) infection and a strong prognostic factor for HIV-1 disease progression. The underlying mechanisms leading to immune activation in viremic HIV-1 infection, however, are not fully understood. Here we show that, following the initi...

journal_title：Journal of virology

authors： Meier A,Alter G,Frahm N,Sidhu H,Li B,Bagchi A,Teigen N,Streeck H,Stellbrink HJ,Hellman J,van Lunzen J,Altfeld M

更新日期：2007-08-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is a major cause of liver disease. The HCV polyprotein contains a hypervariable region (HVR1) located at the N terminus of the second envelope glycoprotein E2. The strong variability of this 27-amino-acid region is due to its apparent tolerance of amino acid substitutions toge...

journal_title：Journal of virology

authors： Penin F,Combet C,Germanidis G,Frainais PO,Deléage G,Pawlotsky JM

更新日期：2001-06-01 00:00:00