Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants.

abstract：:Equine infectious anemia virus (EIAV) is an equine lentivirus similar to HIV-1, targets host immune cells, and causes a life-long infection in horses. The Chinese live EIAV vaccine is attenuated from long-term passaging of a highly virulent strain in vitro The parent pathogenic strain (EIAVDLV34) induces a host inflam...

journal_title：Journal of virology

authors： Du C,Duan Y,Wang XF,Lin Y,Na L,Wang X,Chen K,Wang X

更新日期：2019-10-15 00:00:00

abstract：:We tested the ability of human monoclonal antibodies (immunoglobulin G1b12 [IgG1b12] and 19b) and CD4-based molecules (CD4-IgG2 and soluble CD4 [sCD4]) to neutralize human immunodeficiency virus type 1 directly from the plasma of seropositive donors in an ex vivo neutralization assay. IgG1b12 and CD4-IgG2, at concentr...

journal_title：Journal of virology

authors： Gauduin MC,Allaway GP,Maddon PJ,Barbas CF 3rd,Burton DR,Koup RA

更新日期：1996-04-01 00:00:00

abstract：:The plus strand of virion DNA of duck hepatitis B virus possessed, at its 5' terminus, a capped oligoribonucleotide 18 to 19 bases in length. This oligoribonucleotide had a unique 5' end, the heterogeneity in length reflecting two distinct junctions with plus-strand DNA that were 1 base apart. The sequence of the RNA ...

journal_title：Journal of virology

authors： Lien JM,Aldrich CE,Mason WS

更新日期：1986-01-01 00:00:00

abstract：:Production of a vesicular stomatitis virus spike protein G (VSVG)-pseudotyped lentiviral expression vector in HEK293 cells decreased on overexpression of low-density lipoprotein receptor (LDLR) but not that of ICAM1 or TfR1. Reverse transcription-quantitative PCR (RT-qPCR) revealed a reduction in vector RNA as a funct...

journal_title：Journal of virology

authors： Otahal A,Fuchs R,Al-Allaf FA,Blaas D

更新日期：2015-11-01 00:00:00

abstract：:Mutations introduced into the capsid gene of duck hepatitis B virus (DHBV) were tested for their effects on viral DNA synthesis and assembly of enveloped viruses. Four classes of mutant phenotypes were observed among a series of deletions of covering the 3' end of the capsid open reading frame. Class I mutant capsids ...

journal_title：Journal of virology

authors： Yu M,Summers J

更新日期：1991-05-01 00:00:00

abstract：:The intracellular assembly site for flaviviruses in currently not known but is presumed to be located within the lumen of the rough endoplasmic reticulum (RER). Building on previous studies involving immunofluorescence (IF) and cryoimmunoelectron microscopy of Kunjin virus (KUN)-infected cells, we sought to identify t...

journal_title：Journal of virology

authors： Mackenzie JM,Westaway EG

更新日期：2001-11-01 00:00:00

abstract：:The gene encoding glycoprotein B (gB) of murine cytomegalovirus (MCMV) strain Smith was identified, sequenced, and expressed by recombinant vaccinia virus. The gB gene was found adjacent to the polymerase gene, as it is in the genome of human cytomegalovirus (HCMV). The open reading frame consists of 2,784 nucleotides...

journal_title：Journal of virology

authors： Rapp M,Messerle M,Bühler B,Tannheimer M,Keil GM,Koszinowski UH

更新日期：1992-07-01 00:00:00

abstract：:The inhibition of multilineage hematopoiesis which occurs in the severe combined immunodeficiency mouse with transplanted human fetal thymus and liver tissues (SCID-hu Thy/Liv) due to human immunodeficiency virus type 1 (HIV-1) infection is also accompanied by a severe loss of c-Mpl expression on these progenitor cell...

journal_title：Journal of virology

authors： Koka PS,Kitchen CM,Reddy ST

更新日期：2004-10-01 00:00:00

abstract：:Harvard Medical School convened a meeting of biomedical and clinical experts on 5 March 2015 on the topic of "Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era," with the goals of discussing the lessons from the recent Ebola outbreak and using those lessons as a case study to aid...

journal_title：Journal of virology

authors： Knipe DM,Whelan SP

更新日期：2015-08-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV-68) is a naturally occurring rodent pathogen with significant homology to human pathogens Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. T cells are essential for primary clearance of MHV-68 and survival of mice following intranasal infection. Previous reports have sugg...

journal_title：Journal of virology

authors： Giannoni F,Lyon AB,Wareing MD,Dias PB,Sarawar SR

更新日期：2005-06-01 00:00:00

abstract：:Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order Nidovirales In this study, we aimed to identify arterivirus proteins involved in the mode of action of ...

journal_title：Journal of virology

authors： de Wilde AH,Boomaars-van der Zanden AL,de Jong AWM,Bárcena M,Snijder EJ,Posthuma CC

更新日期：2019-08-28 00:00:00

abstract：:Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in...

journal_title：Journal of virology

authors： Miura T,Brumme CJ,Brockman MA,Brumme ZL,Pereyra F,Block BL,Trocha A,John M,Mallal S,Harrigan PR,Walker BD

更新日期：2009-04-01 00:00:00

abstract：:Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally due to antibodies directed toward a hypervariable region of gp120 between cysteine residues 302 and 337 and is virus isol...

journal_title：Journal of virology

authors： Skinner MA,Langlois AJ,McDanal CB,McDougal JS,Bolognesi DP,Matthews TJ

更新日期：1988-11-01 00:00:00

abstract：:Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products al...

journal_title：Journal of virology

authors： Maruo S,Nanbo A,Takada K

更新日期：2001-10-01 00:00:00

abstract：:Herpesviruses establish latency in suitable host cells after primary infection and persist in their host organisms for life. Most of the viral genes are silenced during latency, also enabling the virus to escape from an immune response. This study addresses the control of viral gene silencing by epigenetic mechanisms,...

journal_title：Journal of virology

authors： Alberter B,Vogel B,Lengenfelder D,Full F,Ensser A

更新日期：2011-06-01 00:00:00

abstract：:The structures of canine parvovirus (CPV) and feline parvovirus (FPV) complexed with antibody fragments from eight different neutralizing monoclonal antibodies were determined by cryo-electron microscopy (cryoEM) reconstruction to resolutions varying from 8.5 to 18 A. The crystal structure of one of the Fab molecules ...

journal_title：Journal of virology

authors： Hafenstein S,Bowman VD,Sun T,Nelson CD,Palermo LM,Chipman PR,Battisti AJ,Parrish CR,Rossmann MG

更新日期：2009-06-01 00:00:00

abstract：:Selecting human immunodeficiency virus (HIV) sequences for inclusion within vaccines has been a difficult problem, as circulating HIV strains evolve relentlessly and become increasingly divergent over time. We report an assessment of this divergence from three perspectives: (i) across different hosts as a function of ...

journal_title：Journal of virology

authors： Herbeck JT,Nickle DC,Learn GH,Gottlieb GS,Curlin ME,Heath L,Mullins JI

更新日期：2006-02-01 00:00:00

abstract：:The presence of complement-fixing (CF) antibody reactive with T antigen and with viral C antigen in hamsters bearing adenovirus 12-induced tumors has been confirmed. Antibody activity in serum obtained at a time when the host was bearing large tumors was found to be associated exclusively with 7S immunoglobulins. Two ...

journal_title：Journal of virology

authors： Fugmann RA,Sigel MM

更新日期：1967-08-01 00:00:00

abstract：UNLABELLED:Paramyxoviruses and other negative-strand RNA viruses encode matrix proteins that coordinate the virus assembly process. The matrix proteins link the viral glycoproteins and the viral ribonucleoproteins at virus assembly sites and often recruit host machinery that facilitates the budding process. Using a co-...

journal_title：Journal of virology

authors： Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

更新日期：2014-11-01 00:00:00

abstract：:Our study was designed to investigate the nature of an antigen-specific suppressor factor generated by antigen-stimulated herpes simplex virus (HSV)-immune splenocytes. Factor SF-200, a 90,000- to 100,000-dalton fraction obtained after Sephacryl gel filtration, suppressed the generation of HSV-specific cytotoxic T-lym...

journal_title：Journal of virology

authors： Horohov DW,Wyckoff JH 3rd,Moore RN,Rouse BT

更新日期：1986-05-01 00:00:00

abstract：:The major adenovirus (Ad) capsid proteins hexon, penton, and fiber influence the efficiency and tropism of gene transduction by Ad vectors. Fiber is the high-affinity receptor binding protein that serves to mediate cell attachment in vitro when using coxsackie-adenovirus receptor (CAR)-containing cell lines. This cont...

journal_title：Journal of virology

authors： Schoggins JW,Nociari M,Philpott N,Falck-Pedersen E

更新日期：2005-09-01 00:00:00

abstract：:The principal neutralizing epitope of the human immunodeficiency virus type 1 (HIV-1) lies between two invariant cysteines in the third variable region (V3) of the viral envelope (gp120), and its amino acid sequence varies among different HIV-1 isolates. HIV-2 carries an analogous amino acid sequence between two cyste...

journal_title：Journal of virology

authors： Boeri E,Giri A,Lillo F,Ferrari G,Varnier OE,Ferro A,Sabbatani S,Saxinger WC,Franchini G

更新日期：1992-07-01 00:00:00

abstract：:We have constructed a series of vectors based on simian foamy virus type 1 (SFV-1) to define the minimum cis-acting elements required for gene transfer. To characterize these vectors, we inserted the coding sequence of the bacterial lacZ gene linked to the cytomegalovirus immediate-early gene promoter. Introduction of...

journal_title：Journal of virology

authors： Wu M,Chari S,Yanchis T,Mergia A

更新日期：1998-04-01 00:00:00

abstract：:Picornavirus-infected cells contain a double-stranded RNA (replicative form [RF] RNA), composed of viral genomic RNA hydrogen bonded to cRNA of similar nucleotide length. Mengovirus RF RNA reacted with a succinimide ester of biotin was shown by electron microscopy to bind avidin-coupled polymethacrylate spheres. These...

journal_title：Journal of virology

authors： Thornton GB,Robberson DL,Arlinghaus RB

更新日期：1981-07-01 00:00:00

abstract：:Assembly and maturation of retroviral particles requires the aggregation and controlled proteolytic cleavage of polyprotein core precursors by a precursor-encoded protease (PR). Active, mature retroviral PR is a dimer, and the accumulation of precursors at sites of assembly may facilitate subunit interaction and subse...

journal_title：Journal of virology

authors： Burstein H,Bizub D,Skalka AM

更新日期：1991-11-01 00:00:00

abstract：:We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replication of DNAs containin...

journal_title：Journal of virology

authors： Tang WJ,Folk WR

更新日期：1989-01-01 00:00:00

abstract：:Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) cells are predominantly infected with latent Kaposi's sarcoma-associated herpesvirus (KSHV), presenting a barrier to the destruction of tumor cells. Latent KSHV can be reactivated to undergo lytic replication. Here we report that in PEL cells, oxidative stress ...

journal_title：Journal of virology

authors： Li X,Feng J,Sun R

更新日期：2011-01-01 00:00:00

abstract：:A streptomycin-resistant Escherichia coli mutant has been isolated that is temperature sensitive for Qbeta phage, but not for the group I RNA phages f2, MS2, and R17. The growth of Qbeta in the mutant at the nonpermissive temperature (42 degrees C) results in the release of a near-normal burst of noninfectious particl...

journal_title：Journal of virology

authors： Engelberg-Kulka H,Dekel L,Israeli-Reches M

更新日期：1977-01-01 00:00:00

abstract：:The major envelope glycoproteins gp120 and gp41 of human immunodeficiency virus type 1, the causative agent for human AIDS, contain numerous N-linked oligosaccharides. We report here our discovery that N-acetylglucosamine residues within the complex-type N-linked oligosaccharides of both gp120 and its precursor, gp160...

journal_title：Journal of virology

authors： Shilatifard A,Merkle RK,Helland DE,Welles JL,Haseltine WA,Cummings RD

更新日期：1993-02-01 00:00:00

abstract：:Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings s...

journal_title：Journal of virology

authors： Meckes DG Jr

更新日期：2015-05-01 00:00:00