Synthesis of multimeric polyoma virus DNA in mouse L-cells: role of the tsA1S9 gene product.

abstract：:The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing antibodies and is presently being evaluated as an HCV vaccine candidate. HCV binds to human cells through the interaction of E2 with the tetraspanin CD81, a putative viral receptor component. We have analyzed four different E2 protei...

journal_title：Journal of virology

authors： Roccasecca R,Ansuini H,Vitelli A,Meola A,Scarselli E,Acali S,Pezzanera M,Ercole BB,McKeating J,Yagnik A,Lahm A,Tramontano A,Cortese R,Nicosia A

更新日期：2003-02-01 00:00:00

abstract：:Previous studies identified a common site (Sfpi-1) for proviral integration in immortalized Friend erythroleukemias. cDNAs corresponding to a 1.5-kb Sfpi-1 mRNA were isolated and sequenced. These were larger than an independently isolated Sfpi-1 cDNA described by researchers from another laboratory, and they contained...

journal_title：Journal of virology

authors： Paul R,Schuetze S,Kozak SL,Kozak CA,Kabat D

更新日期：1991-01-01 00:00:00

abstract：:Natural killer (NK) cells serve as a crucial first-line defense against tumors and virus-infected cells. We previously showed that lysis of influenza virus (IV)-infected cells is mediated by the interaction between the NK receptor, NKp46, and the IV hemagglutinin (HA) type 1 expressed by the infected cells. This inter...

journal_title：Journal of virology

authors： Mendelson M,Tekoah Y,Zilka A,Gershoni-Yahalom O,Gazit R,Achdout H,Bovin NV,Meningher T,Mandelboim M,Mandelboim O,David A,Porgador A

更新日期：2010-04-01 00:00:00

abstract：UNLABELLED:The role of NF-κB in influenza A virus (IAV) infection does not reveal a coherent picture, as pro- and also antiviral functions of this transcription factor have been described. To address this issue, we used clustered regularly interspaced short palindromic repeat with Cas9 (CRISPR-Cas9)-mediated genome eng...

journal_title：Journal of virology

authors： Dam S,Kracht M,Pleschka S,Schmitz ML

更新日期：2016-08-12 00:00:00

abstract：:A significant difference in the recombination rates between human immunodeficiency virus type 1 (HIV-1) and the gammaretroviruses was previously reported, with the former being 10 to 100 times more recombinogenic. It is possible that preferential copackaging of homodimers in the case of gammaretroviruses, like murine ...

journal_title：Journal of virology

authors： Zhuang J,Mukherjee S,Ron Y,Dougherty JP

更新日期：2006-07-01 00:00:00

abstract：:Glycoprotein H (gH) is conserved among all herpesviruses and is essential for virus entry and cell fusion along with gL, gB, and, in most alphaherpesviruses, gD. Within the gH/gL heterodimer, it is thought that gH accounts for the fusion function and gL acts as a chaperone for the folding and transport of gH. Here, we...

journal_title：Journal of virology

authors： Cairns TM,Friedman LS,Lou H,Whitbeck JC,Shaner MS,Cohen GH,Eisenberg RJ

更新日期：2007-05-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 Tax protein activates the expression of cellular immediate early genes controlled by the serum response element (SRE), which contains both the serum response factor (SRF) binding element (CArG box) and the ternary complex factor (TCF) binding element (Ets box). We show that TCF b...

journal_title：Journal of virology

authors： Shuh M,Derse D

更新日期：2000-12-01 00:00:00

abstract：:Studies of rotavirus morphogenesis, transport, and release have shown that although these viruses are released from the apical surface of polarized intestinal cells before cellular lysis, they do not follow the classic exocytic pathway. Furthermore, increasing evidence suggests that lipid rafts actively participate in...

journal_title：Journal of virology

authors： Cuadras MA,Bordier BB,Zambrano JL,Ludert JE,Greenberg HB

更新日期：2006-04-01 00:00:00

abstract：:While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of...

journal_title：Journal of virology

authors： Denkers ND,Hayes-Klug J,Anderson KR,Seelig DM,Haley NJ,Dahmes SJ,Osborn DA,Miller KV,Warren RJ,Mathiason CK,Hoover EA

更新日期：2013-02-01 00:00:00

abstract：:The hepatitis C virus (HCV) encodes a large polyprotein; therefore, all viral proteins are produced in equimolar amounts regardless of their function. The aim of our study was to determine the ratio of nonstructural proteins to RNA that is required for HCV RNA replication. We analyzed Huh-7 cells harboring full-length...

journal_title：Journal of virology

authors： Quinkert D,Bartenschlager R,Lohmann V

更新日期：2005-11-01 00:00:00

abstract：:The subgroup A to E avian sarcoma and leukosis viruses (ASLVs) are highly related and are thought to have evolved from a common ancestor. These viruses use distinct cell surface proteins as receptors to gain entry into avian cells. Chickens have evolved resistance to infection by the ASLVs. We have identified the muta...

journal_title：Journal of virology

authors： Elleder D,Melder DC,Trejbalova K,Svoboda J,Federspiel MJ

更新日期：2004-12-01 00:00:00

abstract：:The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II)...

journal_title：Journal of virology

authors： O'Carroll IP,Thappeta Y,Fan L,Ramirez-Valdez EA,Smith S,Wang YX,Rein A

更新日期：2017-10-13 00:00:00

abstract：:A rapid assay for retroviral reverse transcriptase activity released into the culture medium by infected cells was developed. With the assay, 4,000 clonally infected cell lines could be tested in a few hours. We have adapted the assay for use as a screen for the detection of spontaneous viral mutants. Mutants of Molon...

journal_title：Journal of virology

authors： Goff S,Traktman P,Baltimore D

更新日期：1981-04-01 00:00:00

abstract：:Recombinant Epstein-Barr viruses (EBVs) were made with mutated latent membrane protein 1 (LMP1) genes that express only the LMP1 amino-terminal cytoplasmic and six transmembrane domains (MS187) or these domains and the first 44 amino acids of the 200-residue LMP1 carboxy-terminal domain (MS231). After infection of pri...

journal_title：Journal of virology

authors： Kaye KM,Izumi KM,Mosialos G,Kieff E

更新日期：1995-02-01 00:00:00

abstract：:Despite differences in the pathogenesis and host range of alphaherpesviruses, many stages of their morphogenesis are thought to be conserved. Here, an ultrastructural study of bovine herpesvirus 1 (BoHV-1) envelopment revealed profiles similar to those previously found for herpes simplex virus 1 (HSV-1), with BoHV-1 c...

journal_title：Journal of virology

authors： Russell T,Bleasdale B,Hollinshead M,Elliott G

更新日期：2018-10-29 00:00:00

abstract：UNLABELLED:Adeno-associated virus (AAV) has long been known to inhibit helper adenovirus (Ad) replication independently of AAV Rep protein expression. More recently, replication of Ad serotype 5 (Ad5)/AAV serotype 2 (AAV-2) hybrid vectors was shown to be inhibited incisby a sequence near the 3' end of AAVrep, termed th...

journal_title：Journal of virology

authors： Weger S,Hammer E,Gonsior M,Stutika C,Heilbronn R

更新日期：2016-03-28 00:00:00

abstract：:The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and th...

journal_title：Journal of virology

authors： Xiao H,Killip MJ,Staeheli P,Randall RE,Jackson D

更新日期：2013-12-01 00:00:00

abstract：UNLABELLED:One of the first lines of host defense against many viruses in vertebrates is the innate immune system, which detects pathogen-associated molecular patterns (PAMPs) using pathogen recognition receptors (PRR). The dynamic interactions between pathogens and hosts create, in some cases, species-specific relatio...

journal_title：Journal of virology

authors： Eichholz K,Mennechet FJ,Kremer EJ

更新日期：2015-03-01 00:00:00

abstract：:An adeno-associated virus (AAV) genome with a Lys-to-His (K340H) mutation in the consensus nucleotide triphosphate binding site of the rep gene has a dominant-negative DNA replication phenotype in vivo. We expressed both wild-type (Rep78) and mutant (Rep78NTP) proteins in two helper-free expression systems consisting ...

journal_title：Journal of virology

authors： Owens RA,Carter BJ

更新日期：1992-02-01 00:00:00

abstract：:Treatment of patients with lamivudine (3TC) results in loss of detectable levels of hepatitis B virus (HBV) DNA from serum; however, the relapse rate, with regard to both reappearance of virus in the bloodstream and hepatic inflammation, is high when therapy is terminated. Although the rebound observed in patients has...

journal_title：Journal of virology

authors： Abdelhamed AM,Kelley CM,Miller TG,Furman PA,Isom HC

更新日期：2002-08-01 00:00:00

abstract：:The E2 gene products of papillomavirus play key roles in viral replication, both as regulators of viral transcription and as auxiliary factors that act with E1 in viral DNA replication. We have carried out a detailed structure-function analysis of conserved amino acids within the N-terminal domain of the human papillo...

journal_title：Journal of virology

authors： Sakai H,Yasugi T,Benson JD,Dowhanick JJ,Howley PM

更新日期：1996-03-01 00:00:00

abstract：:We analyzed xenotropic murine leukemia virus-related virus (XMRV) integration site sequences previously identified from human prostate tissues for single-nucleotide polymorphisms (SNPs) to discriminate between patient and potential cell line sources of the proviruses. The SNPs of two integration sites were identical t...

journal_title：Journal of virology

authors： Rusmevichientong A,Das Gupta J,Elias PS,Silverman RH,Chow SA

更新日期：2011-12-01 00:00:00

abstract：:The entry of animal viruses into cells is associated with permeabilization of the infected cells to protein toxins such as alpha-sarcin (C. Fernández-Puentes and L. Carrasco, Cell 20:769-775, 1980). This phenomenon has been referred to as "the early permeabilization by animal viruses" (L. Carrasco, Virology 113:623-62...

journal_title：Journal of virology

authors： Almela MJ,González ME,Carrasco L

更新日期：1991-05-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are closely related but pathogenically distinct human retroviruses. The antisense strand of the HTLV-1 genome encodes HTLV-1 basic leucine zipper (b-ZIP) protein (HBZ), a protein that inhibits Tax-mediated viral transcription, enhances T-cell proliferation, and pr...

journal_title：Journal of virology

authors： Yin H,Kannian P,Dissinger N,Haines R,Niewiesk S,Green PL

更新日期：2012-08-01 00:00:00

abstract：:Vesicular stomatitis virus has the potential for very rapid evolution in the laboratory, but like many other arboviruses, it evolves at a relatively slow rate in the natural environment. Previous work showed that alternating replication in different cell types does not promote stasis. In order to determine whether oth...

journal_title：Journal of virology

authors： Zárate S,Novella IS

更新日期：2004-11-01 00:00:00

abstract：UNLABELLED:Marburg virus (MARV) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. Development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. In this study,...

journal_title：Journal of virology

authors： Lin KL,Twenhafel NA,Connor JH,Cashman KA,Shamblin JD,Donnelly GC,Esham HL,Wlazlowski CB,Johnson JC,Honko AN,Botto MA,Yen J,Hensley LE,Goff AJ

更新日期：2015-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based pseudoparticles (HCVpp) incorporating a panel of full-length E1E2 clon...

journal_title：Journal of virology

authors： Owsianka A,Tarr AW,Juttla VS,Lavillette D,Bartosch B,Cosset FL,Ball JK,Patel AH

更新日期：2005-09-01 00:00:00

abstract：:YY1 is a zinc finger transcription factor which acts as either a repressor or an activator dependent on the promoter context. YY1 is a potent activator of the genuine human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) in HeLa cells, which are known for high-level expression of the HPV-18 early gene...

journal_title：Journal of virology

authors： Bauknecht T,Jundt F,Herr I,Oehler T,Delius H,Shi Y,Angel P,Zur Hausen H

更新日期：1995-01-01 00:00:00

abstract：:Nonpermissive 3T3 cells were infected with purified superhelical simian virus 40 (SV40) deoxyribonucleic acid I (DNA I). One hour after infection, approximately 60% of the intracellular SV40 DNA was converted to relaxed forms. One day after infection, all intracellular SV40 DNA was present as slow-sedimenting material...

journal_title：Journal of virology

authors： Collins CJ,Sauer G

更新日期：1972-09-01 00:00:00

abstract：:The multiplicity of attachment (MOA) of a virion in any particular time interval is the average number of cellular attachment opportunities that must be blocked to keep the virion in suspension. MOA is usually proportional to incubation time and cell concentration. Low MOA (like low multiplicity of infection) is requi...

journal_title：Journal of virology

authors： Spouge JL

更新日期：1994-03-01 00:00:00