Viral multiplicity of attachment and its implications for human immunodeficiency virus therapies.

abstract：:Six monoclonal antibodies were isolated that exhibited specificity for a furin cleavage site deletion mutant (V3526) of Venezuelan equine encephalitis virus (VEEV). These antibodies comprise a single competition group and bound the E3 glycoprotein of VEEV subtype I viruses but failed to bind the E3 glycoprotein of oth...

journal_title：Journal of virology

authors： Parker MD,Buckley MJ,Melanson VR,Glass PJ,Norwood D,Hart MK

更新日期：2010-12-01 00:00:00

abstract：:Viral hemorrhagic septicemia virus (VHSV) infections cause high losses in cultured rainbow trout in Europe. Attempts to produce a recombinant vaccine based on the transmembrane glycoprotein (G protein) have indicated that proper folding is important for the antigenicity and immunogenicity of the protein. The present s...

journal_title：Journal of virology

authors： Einer-Jensen K,Krogh TN,Roepstorff P,Lorenzen N

更新日期：1998-12-01 00:00:00

abstract：:Cytomegalovirus (CMV) is acquired by the oral route in children, and primary infection is associated with abundant mucosal replication, as well as the establishment of latency in myeloid cells that results in lifelong infection. The efficiency of primary CMV infection in humans following oral exposure, however, is unk...

journal_title：Journal of virology

authors： Mayer BT,Krantz EM,Swan D,Ferrenberg J,Simmons K,Selke S,Huang ML,Casper C,Corey L,Wald A,Schiffer JT,Gantt S

更新日期：2017-05-26 00:00:00

abstract：:The vast majority of studies with candidate immunogens based on the human immunodeficiency virus envelope (Env) have been conducted with Env proteins derived from clade B viruses isolated during chronic infection. Whether non-clade B Env protein immunogens will elicit antibodies with epitope specificities that are sim...

journal_title：Journal of virology

authors： Kraft Z,Strouss K,Sutton WF,Cleveland B,Tso FY,Polacino P,Overbaugh J,Hu SL,Stamatatos L

更新日期：2008-06-01 00:00:00

abstract：:This paper reports the use of zonal ultracentrifuge techniques to conduct biophysical studies of rhinoviruses grown with WI-38 cells. Good clean-out of infectivity from rhinovirus harvests was obtained with the continuous-flow B-V and B-IX rotors. Use of the B-V rotor resulted in the successful concentration of rhinov...

journal_title：Journal of virology

authors： Gerin JL,Richter WR,Fenters JD,Holper JC

更新日期：1968-09-01 00:00:00

abstract：:Three serial passage series of simian virus 40 (SV40) in CV-1 cells were initiated by infection directly from the same wild-type plaque isolate, three series were initiated by infection with another plaque isolate, and two series were initiated with each of two other plaque isolates. Aberrant SV40 genomes were not det...

journal_title：Journal of virology

authors： Norkin LC,Tirrell SM

更新日期：1982-05-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infections in sub-Saharan Africa represent about 56% of global infections. Study of active-site mutations (the V82A single mutation and the V82F I84V double mutation) in the less-studied South African HIV type 1 subtype C (C-SA) protease indicated that neither mutation had a signific...

journal_title：Journal of virology

authors： Mosebi S,Morris L,Dirr HW,Sayed Y

更新日期：2008-11-01 00:00:00

abstract：:Reduction of major histocompatibility complex class I cell surface expression occurs in adenovirus-, herpes simplex virus-, human cytomegalovirus (HCMV)-, and murine cytomegalovirus-infected cell systems. Recently, it was demonstrated that the down-regulation mediated by HCMV infection is posttranslational, as a resul...

journal_title：Journal of virology

authors： Jones TR,Hanson LK,Sun L,Slater JS,Stenberg RM,Campbell AE

更新日期：1995-08-01 00:00:00

abstract：:Rotavirus NSP1 has been shown to function as an E3 ubiquitin ligase that mediates proteasome-dependent degradation of interferon (IFN) regulatory factors (IRF), including IRF3, -5, and -7, and suppresses the cellular type I IFN response. However, the effect of rotavirus NSP1 on viral replication is not well defined. P...

journal_title：Journal of virology

authors： Feng N,Sen A,Nguyen H,Vo P,Hoshino Y,Deal EM,Greenberg HB

更新日期：2009-07-01 00:00:00

abstract：:Macrophage adherence, an important regulatory signal, has the potential to affect human immunodeficiency virus (HIV) production either directly or by priming monocytes to respond to other activating signals. We have investigated the role of adherence as an activator of HIV-1 transcription and release. The effects of a...

journal_title：Journal of virology

authors： Shattock RJ,Friedland JS,Griffin GE

更新日期：1993-06-01 00:00:00

abstract：:The major human tRNA(Lys) isoacceptors, and, are selectively packaged into human immunodeficiency virus type 1 (HIV-1) during assembly, where acts as a primer for reverse transcription. Lysyl-tRNA synthetase (LysRS) is also incorporated into HIV-1, independently of tRNA(Lys), via its interaction with Gag, and is a str...

journal_title：Journal of virology

authors： Guo F,Cen S,Niu M,Javanbakht H,Kleiman L

更新日期：2003-09-01 00:00:00

abstract：:The adenovirus E1A 243R oncoprotein is capable of transactivating the expression of the human proliferating cell nuclear antigen (PCNA) promoter. Mutational analysis of the E1A 243R protein suggested that both its p300/CBP- and p107-binding regions are required for optimal induction of the PCNA promoter (C. Kannabiran...

journal_title：Journal of virology

authors： Lee BH,Liu M,Mathews MB

更新日期：1998-02-01 00:00:00

abstract：:Andes virus (ANDV) causes a fatal hantavirus pulmonary syndrome (HPS) in humans and Syrian hamsters. Human alpha(v)beta(3) integrins are receptors for several pathogenic hantaviruses, and the function of alpha(v)beta(3) integrins on endothelial cells suggests a role for alpha(v)beta(3) in hantavirus directed vascular ...

journal_title：Journal of virology

authors： Matthys VS,Gorbunova EE,Gavrilovskaya IN,Mackow ER

更新日期：2010-01-01 00:00:00

abstract：:The RNA polymerase of the influenza virus is responsible for the transcription and replication of the segmented RNA viral genome during infection of host cells. Polymerase function is known to be strictly dependent on interaction with its RNA promoter, but no attempts to investigate whether the virion RNA (vRNA) promo...

journal_title：Journal of virology

authors： Brownlee GG,Sharps JL

更新日期：2002-07-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) to human immunodeficiency virus type 1 were produced. Two antibodies reacted with the 17-kilodalton core protein (p17) of the virus and with its polyprotein precursor. To various degrees, each MAb neutralized infection by the cell-free virus. With a series of sequential overlapping hexapep...

journal_title：Journal of virology

authors： Papsidero LD,Sheu M,Ruscetti FW

更新日期：1989-01-01 00:00:00

abstract：:The E8 open reading frame of bovine papillomavirus type 4 encodes a small hydrophobic polypeptide which contributes to cell transformation by conferring anchorage-independent growth. Using an in vitro translation system, we show that the E8 polypeptide binds to ductin, the 16-kDa proteolipid that forms transmembrane c...

journal_title：Journal of virology

authors： Faccini AM,Cairney M,Ashrafi GH,Finbow ME,Campo MS,Pitts JD

更新日期：1996-12-01 00:00:00

abstract：:HIV-1 Nef promotes virus spread and disease progression by altering host cell transport and signaling processes through interaction with multiple host cell proteins. The N-terminal region in HIV-1 Nef encompassing residues 12 to 39 has been implicated in many Nef activities, including disruption of CD4 T lymphocyte po...

journal_title：Journal of virology

authors： Ananth S,Morath K,Trautz B,Tibroni N,Shytaj IL,Obermaier B,Stolp B,Lusic M,Fackler OT

更新日期：2019-12-12 00:00:00

abstract：:Q beta phage RNAs with inactivating insertion (8-base) or deletion (17-base) mutations within their replicase genes were prepared from modified Q beta cDNAs and transfected into Escherichia coli spheroplasts containing Q beta replicase provided in trans by a resident plasmid. Replicase-defective (Rep-) Q beta phage pr...

journal_title：Journal of virology

authors： Palasingam K,Shaklee PN

更新日期：1992-04-01 00:00:00

abstract：:Many of the approximately 165 proteins encoded by the African swine fever virus (ASFV) genome do not have significant similarity to known proteins and have not been studied experimentally. One such protein is DP148R. We showed that the DP148R gene is transcribed at early times postinfection. Deletion of this gene did ...

journal_title：Journal of virology

authors： Reis AL,Goatley LC,Jabbar T,Sanchez-Cordon PJ,Netherton CL,Chapman DAG,Dixon LK

更新日期：2017-11-30 00:00:00

abstract：:DNA sequences encoding the surface envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) were amplified by PCR from uncultured peripheral blood mononuclear cells obtained from patients with serologically defined HIV-1/HIV-2 mixed infections from Bombay, India. HIV-1-specific PCR prod...

journal_title：Journal of virology

authors： Grez M,Dietrich U,Balfe P,von Briesen H,Maniar JK,Mahambre G,Delwart EL,Mullins JI,Rübsamen-Waigmann H

更新日期：1994-04-01 00:00:00

abstract：:Zika virus (ZIKV) has emerged as a cause of congenital brain anomalies and a range of placenta-related abnormalities, highlighting the need to unveil the modes of maternal-fetal transmission. The most likely route of vertical ZIKV transmission is via the placenta. The earliest events of ZIKV transmission in the matern...

journal_title：Journal of virology

authors： Weisblum Y,Oiknine-Djian E,Vorontsov OM,Haimov-Kochman R,Zakay-Rones Z,Meir K,Shveiky D,Elgavish S,Nevo Y,Roseman M,Bronstein M,Stockheim D,From I,Eisenberg I,Lewkowicz AA,Yagel S,Panet A,Wolf DG

更新日期：2017-01-31 00:00:00

abstract：:Five monoclonal antibodies to the matrix (M) protein of Newcastle disease virus (NDV) Australia-Victoria (AV) strain were generated and characterized. In competitive antibody-binding assays, the antibodies fell into three discrete groups. The antigenic sites described by these antibody groups were designated M1, M2, a...

journal_title：Journal of virology

authors： Faaberg KS,Peeples ME

更新日期：1988-02-01 00:00:00

abstract：:Replication of human papillomavirus type 11 (HPV-11) DNA requires the full-length viral E1 and E2 proteins (C.-M. Chiang, M. Ustav, A. Stenlund, T. F. Ho, T. R. Broker, and L. T. Chow, Proc. Natl. Acad. Sci. USA 89:5799-5803, 1992). Using transient transfection of subgenomic HPV DNA into hamster CHO and human 293 cell...

journal_title：Journal of virology

authors： Chiang CM,Dong G,Broker TR,Chow LT

更新日期：1992-09-01 00:00:00

abstract：:A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between ex...

journal_title：Journal of virology

authors： Benson SJ,Ruis BL,Garbers AL,Fadly AM,Conklin KF

更新日期：1998-12-01 00:00:00

abstract：:The relationship between immunosenescence and the host response to virus infection is poorly understood at the molecular level. Two different patterns of pulmonary host responses to virus were observed when gene expression profiles from severe acute respiratory syndrome coronavirus (SARS-CoV)-infected young mice that ...

journal_title：Journal of virology

authors： Baas T,Roberts A,Teal TH,Vogel L,Chen J,Tumpey TM,Katze MG,Subbarao K

更新日期：2008-10-01 00:00:00

abstract：:Amino acid analysis of [3H]proline-labeled polyomavirus major capsid protein VP1 by two-dimensional paper chromatography of the acid-hydrolyzed protein revealed the presence of 3H-labeled hydroxyproline. Addition of the proline analog L-azetidine-2-carboxylic acid to infected mouse kidney cell cultures prevented or gr...

journal_title：Journal of virology

authors： Ludlow JW,Consigli RA

更新日期：1989-06-01 00:00:00

abstract：:The precise roles of gamma interferon-inducible immunoproteasome-associated molecules in generation of cytotoxic T-lymphocyte (CTL) epitopes have yet to be fully elucidated. We describe here a unique epitope derived from the Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A) presented by HLA-A*2402 molecules....

journal_title：Journal of virology

authors： Ito Y,Kondo E,Demachi-Okamura A,Akatsuka Y,Tsujimura K,Tanimoto M,Morishima Y,Takahashi T,Kuzushima K

更新日期：2006-01-01 00:00:00

abstract：:Myeloid differentiation factor 88 (MyD88) is an essential adaptor protein in the Toll-like receptor-mediated innate signaling pathway, as well as in interleukin-1 receptor (IL-1R) and IL-18R signaling. The importance of MyD88 in the regulation of innate immunity to microbial pathogens has been well demonstrated. Howev...

journal_title：Journal of virology

authors： Zhou S,Kurt-Jones EA,Cerny AM,Chan M,Bronson RT,Finberg RW

更新日期：2009-02-01 00:00:00

abstract：:Several reports have shown that human cytomegalovirus (HCMV)-infected cells are resistant to NK lysis. These studies have focused on receptor-ligand interactions, and different HCMV proteins have been indicated to mediate inhibitory NK signals. Here, we report that the HCMV protein UL16 is of major importance for the ...

journal_title：Journal of virology

authors： Odeberg J,Browne H,Metkar S,Froelich CJ,Brandén L,Cosman D,Söderberg-Nauclér C

更新日期：2003-04-01 00:00:00

abstract：:We previously reported that human cytomegalovirus (HCMV) infection induces endoplasmic reticulum (ER) stress, resulting in activation of the unfolded protein response (UPR). Although some normal consequences of UPR activation (e.g., translation attenuation) are detrimental to viral infection, we have previously shown ...

journal_title：Journal of virology

authors： Isler JA,Maguire TG,Alwine JC

更新日期：2005-12-01 00:00:00