Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins.

abstract：:New zonal centrifuges can conveniently process as much as five orders of magnitude (10(5)) greater sample volumes than conventional swinging-bucket rotors. The continuous-sample-flow-with-banding versions may be used in series with ancillary purification procedures. Here we have studied the combined process: absorptio...

journal_title：Journal of virology

authors： Reimer CB,Baker RS,Van Frank RM,Newlin TE,Cline GB,Anderson NG

更新日期：1967-12-01 00:00:00

abstract：:Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed during latent Epstein-Barr virus (EBV) infections in human peripheral B cells. LMP2A blocks B-cell receptor (BCR) signal transduction in vitro by modulation of the Syk and Lyn protein tyrosine kinases. Five genetically unique LMP2A transgen...

journal_title：Journal of virology

authors： Caldwell RG,Brown RC,Longnecker R

更新日期：2000-02-01 00:00:00

abstract：:It has previously been shown that: (i) during infection of its host, the DNA bacteriophage T7 assembles a DNA-free procapsid (capsid I), a capsid with an envelope differing physically and chemically from the capsid of the mature bacteriophage, and (ii) capsid I converts to a capsid (capsid II) with a bacteriophage-lik...

journal_title：Journal of virology

authors： Serwer P,Watson RH,Hayes SJ

更新日期：1982-05-01 00:00:00

abstract：:Ribonucleic acid extracted from influenza virus was labeled at the 3' termini with (3)H and analyzed by polyacrylamide gel electrophoresis. Influenza virus was found to contain a minimum of seven and possibly as many as 10 polynucleotide chains, most of which appear to terminate at the 3' end in uridine. ...

journal_title：Journal of virology

authors： Lewandowski LJ,Content J,Leppla SH

更新日期：1971-11-01 00:00:00

abstract：:Herpes simplex virus 1 replication initiates angiogenesis and inflammation in the cornea. This can result in herpetic stromal keratitis (HSK), which is a leading cause of infection-induced corneal blindness. Host cellular factors mediate the progression of HSK, but little is known about these cellular factors and thei...

journal_title：Journal of virology

authors： Yao HW,Chen SH,Li C,Tung YY,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:With the rationale that the neuropathological similarities between scrapie and Alzheimer's disease reflect convergent pathological mechanisms involving altered gene expression, we set out to identify molecular events involved in both processes, using scrapie as a model to study the time course of these changes. We dif...

journal_title：Journal of virology

authors： Diedrich JF,Minnigan H,Carp RI,Whitaker JN,Race R,Frey W 2nd,Haase AT

更新日期：1991-09-01 00:00:00

abstract：:Here, we report a novel porcine circovirus type 2a (PCV2a) strain with 11 nucleotides (nt) inserted in the origin of genome replication (Ori). This is the first report of a PCV2a strain with nucleotide insertion in Ori. Our study will help further epidemiological studies and extend our knowledge of evolutionary charac...

journal_title：Journal of virology

authors： Cai L,Han X,Hu D,Li X,Wang B,Ni J,Zhou Z,Yu X,Zhai X,Tian K

更新日期：2012-06-01 00:00:00

abstract：:This study reports the identification and initial characterization of the precursors, modified forms, and oligomers of bovine herpesvirus 1 (BHV-1) gI and gE proteins with polyvalent rabbit serum specific for gI or gE. Our experiments used the Colorado strain of BHV-1 and mutant viruses with insertions of the Escheric...

journal_title：Journal of virology

authors： Whitbeck JC,Knapp AC,Enquist LW,Lawrence WC,Bello LJ

更新日期：1996-11-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) UL25 gene contains a 580-amino-acid open reading frame that codes for an essential protein. Previous studies have shown that the UL25 gene product is a virion component (M. A. Ali et al., Virology 216:278-283, 1996) involved in virus penetration and capsid assembly (C. Addison e...

journal_title：Journal of virology

authors： McNab AR,Desai P,Person S,Roof LL,Thomsen DR,Newcomb WW,Brown JC,Homa FL

更新日期：1998-02-01 00:00:00

abstract：:The N-terminal domain of the bovine papillomavirus type 1 E2 protein is important for viral DNA replication, for transcriptional transactivation, and for interaction with the E1 protein. To determine which residues of this 200-amino-acid domain are important for these activities, single conservative amino acid substit...

journal_title：Journal of virology

authors： Brokaw JL,Blanco M,McBride AA

更新日期：1996-01-01 00:00:00

abstract：:Resistance to human immunodeficiency virus type 1 protease (HIV PR) inhibitors results primarily from the selection of multiple mutations in the protease region. Because many of these mutations are selected for the ability to decrease inhibitor binding in the active site, they also affect substrate binding and potenti...

journal_title：Journal of virology

authors： Dauber DS,Ziermann R,Parkin N,Maly DJ,Mahrus S,Harris JL,Ellman JA,Petropoulos C,Craik CS

更新日期：2002-02-01 00:00:00

abstract：:Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to restriction in animal movements. Therefore, many new types of vaccines, par...

journal_title：Journal of virology

authors： Celma CC,Boyce M,van Rijn PA,Eschbaumer M,Wernike K,Hoffmann B,Beer M,Haegeman A,De Clercq K,Roy P

更新日期：2013-09-01 00:00:00

abstract：:Attempts to elicit broadly neutralizing antibody responses by human immunodeficiency virus type 1 (HIV-1) vaccine antigens have been met with limited success. To better understand the requirements for cross-neutralization of HIV-1, we have characterized the neutralizing antibody specificities present in the sera of th...

journal_title：Journal of virology

authors： Dhillon AK,Donners H,Pantophlet R,Johnson WE,Decker JM,Shaw GM,Lee FH,Richman DD,Doms RW,Vanham G,Burton DR

更新日期：2007-06-01 00:00:00

abstract：:Recognition of viruses by germ line-encoded pattern recognition receptors of the innate immune system is essential for rapid production of type I interferon (IFN) and early antiviral defense. We investigated the mechanisms of viral recognition governing production of type I IFN during herpes simplex virus (HSV) infect...

journal_title：Journal of virology

authors： Rasmussen SB,Sørensen LN,Malmgaard L,Ank N,Baines JD,Chen ZJ,Paludan SR

更新日期：2007-12-01 00:00:00

abstract：:Genetic bottlenecks are important events in the genetic diversification of organisms and colonization of new ecological niches. Repeated bottlenecking of RNA viruses often leads to fitness losses due to the operation of Muller's ratchet. Herein we use vesicular stomatitis virus to determine the transmission population...

journal_title：Journal of virology

authors： Novella IS,Elena SF,Moya A,Domingo E,Holland JJ

更新日期：1995-05-01 00:00:00

abstract：:Latency-associated transcript (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in the rabbit eye model. We have mapped a reactivation phenotype within LAT and describe the construction of recombinants in which poly(A) addition sites hav...

journal_title：Journal of virology

authors： Bloom DC,Hill JM,Devi-Rao G,Wagner EK,Feldman LT,Stevens JG

更新日期：1996-04-01 00:00:00

abstract：:p60src, the transforming protein of Rous sarcoma virus, was found to contain 0.5 to 0.9 mol of total phosphate per mol of polypeptide. The protein is known to be phosphorylated at two sites, a serine in the amino-terminal domain and a tyrosine in the carboxy-terminal domain. Because our indirect analysis suggests that...

journal_title：Journal of virology

authors： Sefton BM,Patschinsky T,Berdot C,Hunter T,Elliott T

更新日期：1982-03-01 00:00:00

abstract：:A number of naturally occurring hepatitis B virus mutants that cannot synthesize the virus precore protein have been identified. Such mutants have been associated with more severe forms of hepatitis, including fulminant hepatitis. The most common mutation observed is a substitution of G to A in the distal precore gene...

journal_title：Journal of virology

authors： Chen HS,Kew MC,Hornbuckle WE,Tennant BC,Cote PJ,Gerin JL,Purcell RH,Miller RH

更新日期：1992-09-01 00:00:00

abstract：:Herpes simplex virus (HSV) has often been suggested for development as a vector, particularly for the nervous system. Considerable evidence has shown that for use of HSV as a vector, immediate-early (IE) gene expression must be minimized or abolished, otherwise such vectors are likely to be highly cytotoxic. Mutations...

journal_title：Journal of virology

authors： Thomas SK,Lilley CE,Latchman DS,Coffin RS

更新日期：1999-09-01 00:00:00

abstract：:Purified retrovirus Gag proteins can assemble in vitro into virus-like particles (VLPs) in the presence of RNA. It was shown previously that a Rous sarcoma virus Gag protein missing only the protease domain forms spherical particles resembling immature virions lacking a membrane but that a similar protein missing the ...

journal_title：Journal of virology

authors： Joshi SM,Vogt VM

更新日期：2000-11-01 00:00:00

abstract：:Sequencing and reversion analysis of murine hepatitis virus (MHV) temperature-sensitive (ts) viruses has identified putative ts mutations in the replicase nonstructural proteins (nsp's) of these coronaviruses. In this study, reverse transcriptase PCR sequencing of the RNA genome of an isolate of the MHV ts virus Alb t...

journal_title：Journal of virology

authors： Sparks JS,Donaldson EF,Lu X,Baric RS,Denison MR

更新日期：2008-06-01 00:00:00

abstract：:DNA sequence analysis has revealed that the gene coding for the human cytomegalovirus (HCMV) DNA polymerase is present within the long unique region of the virus genome. Identification is based on extensive amino acid homology between the predicted HCMV open reading frame HFLF2 and the DNA polymerase of herpes simplex...

journal_title：Journal of virology

authors： Kouzarides T,Bankier AT,Satchwell SC,Weston K,Tomlinson P,Barrell BG

更新日期：1987-01-01 00:00:00

abstract：:A mutant which produces a small-headed ("petite") variant of bacteriophage T4 is described. The mutation (E920g) maps in a new gene (66) between genes 23 and 24. Petite phage particles composed up to 70% of the phage yield. The petite phage was nonviable upon single infection but produced progeny when two or more infe...

journal_title：Journal of virology

authors： Eiserling FA,Geiduschek EP,Epstein RH,Metter EJ

更新日期：1970-12-01 00:00:00

abstract：:Vaccine-induced memory T cells localized at mucosal sites can provide rapid protection from viral infection. All-trans-retinoic acid (ATRA) has been shown to act physiologically to induce the expression of gut-homing receptors on lymphocytes. We tested whether the administration of exogenous ATRA during a systemic vac...

journal_title：Journal of virology

authors： Tan X,Sande JL,Pufnock JS,Blattman JN,Greenberg PD

更新日期：2011-08-01 00:00:00

abstract：:The release of Bluetongue virus (BTV) and other members of the Orbivirus genus from infected host cells occurs predominantly by cell lysis, and in some cases, by budding from the plasma membrane. Two nonstructural proteins, NS3 and NS3A, have been implicated in this process. Here we show that both proteins bind to hum...

journal_title：Journal of virology

authors： Wirblich C,Bhattacharya B,Roy P

更新日期：2006-01-01 00:00:00

abstract：:The Kilham strain of polyomavirus (KV) infects vascular endothelial cells in vivo (J. E. Greenlee, Infect. Immun. 26:705-713, 1979), but no permissive cell type for growth of the virus in vitro has been identified. The failure of KV DNA to replicate in mouse fibroblast cells after transfection suggested that viral gen...

journal_title：Journal of virology

authors： Zhang S,Magnusson G

更新日期：2001-11-01 00:00:00

abstract：:The major envelope glycoproteins gp120 and gp41 of human immunodeficiency virus type 1, the causative agent for human AIDS, contain numerous N-linked oligosaccharides. We report here our discovery that N-acetylglucosamine residues within the complex-type N-linked oligosaccharides of both gp120 and its precursor, gp160...

journal_title：Journal of virology

authors： Shilatifard A,Merkle RK,Helland DE,Welles JL,Haseltine WA,Cummings RD

更新日期：1993-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) UL84 is a phosphoprotein that shuttles from the nucleus to the cytoplasm and is required for oriLyt-dependent DNA replication and viral growth. UL84 was previously shown to interact with IE2 (IE86) in infected cells, and this interaction down-regulates IE2-mediated transcriptional activati...

journal_title：Journal of virology

authors： Gao Y,Colletti K,Pari GS

更新日期：2008-01-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are closely related but pathogenically distinct human retroviruses. The antisense strand of the HTLV-1 genome encodes HTLV-1 basic leucine zipper (b-ZIP) protein (HBZ), a protein that inhibits Tax-mediated viral transcription, enhances T-cell proliferation, and pr...

journal_title：Journal of virology

authors： Yin H,Kannian P,Dissinger N,Haines R,Niewiesk S,Green PL

更新日期：2012-08-01 00:00:00

abstract：:Three serial passage series of simian virus 40 (SV40) in CV-1 cells were initiated by infection directly from the same wild-type plaque isolate, three series were initiated by infection with another plaque isolate, and two series were initiated with each of two other plaque isolates. Aberrant SV40 genomes were not det...

journal_title：Journal of virology

authors： Norkin LC,Tirrell SM

更新日期：1982-05-01 00:00:00