Emergence of simian virus 40 variants during serial passage of plaque isolates.

abstract：:Vaccinia virus replication is inhibited by etoposide and mitoxantrone even though poxviruses do not encode the type II topoisomerases that are the specific targets of these drugs. Furthermore, one can isolate drug-resistant virus carrying mutations in the viral DNA ligase and yet the ligase is not known to exhibit sen...

journal_title：Journal of virology

authors： Lin YC,Li J,Irwin CR,Jenkins H,DeLange L,Evans DH

更新日期：2008-06-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of rhesus macaques causes immune depletion and disease closely resembling human AIDS and is well recognized as the most relevant animal model for the human disease. Experimental investigations of viral pathogenesis and vaccine protection primarily involve a limited set of ...

journal_title：Journal of virology

authors： Fischer W,Apetrei C,Santiago ML,Li Y,Gautam R,Pandrea I,Shaw GM,Hahn BH,Letvin NL,Nabel GJ,Korber BT

更新日期：2012-12-01 00:00:00

abstract：:In view of the concern over potential infection hazards in the use of porcine tissues and organs for xenotransplantation to humans, we investigated the diversity of porcine endogenous retrovirus (PERV) genomes in the DNA of domestic pigs and related species. In addition to the three known envelope subgroups of infecti...

journal_title：Journal of virology

authors： Patience C,Switzer WM,Takeuchi Y,Griffiths DJ,Goward ME,Heneine W,Stoye JP,Weiss RA

更新日期：2001-03-01 00:00:00

abstract：UNLABELLED:Susceptibility to alphavirus infection is age dependent, and host maturation is associated with decreased virus replication and less severe encephalitis. To identify factors associated with maturation-dependent restriction of virus replication, we studied AP-7 rat olfactory bulb neuronal cells, which can dif...

journal_title：Journal of virology

authors： Schultz KL,Vernon PS,Griffin DE

更新日期：2015-01-01 00:00:00

abstract：:Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green mon...

journal_title：Journal of virology

authors： Campillo-Gimenez L,Laforge M,Fay M,Brussel A,Cumont MC,Monceaux V,Diop O,Lévy Y,Hurtrel B,Zaunders J,Corbeil J,Elbim C,Estaquier J

更新日期：2010-02-01 00:00:00

abstract：:Adeno-associated virus type 2 (AAV-2) gene expression is tightly controlled by functions of the helper virus as well as by the products of its own viral rep gene. Double-immunofluorescence studies of Rep and VP protein expression in cells coinfected with AAV-2 and adenovirus type 2 showed that a large proportion of th...

journal_title：Journal of virology

authors： Weger S,Wistuba A,Grimm D,Kleinschmidt JA

更新日期：1997-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) has evolved multiple strategies for suppression of the antiviral response of the infected cell. DNA array technology has revealed that HCMV clearly regulates host gene expression during the course of a productive infection by enhancing, sustaining, or suppressing steady-state levels of cel...

journal_title：Journal of virology

authors： Gealy C,Denson M,Humphreys C,McSharry B,Wilkinson G,Caswell R

更新日期：2005-01-01 00:00:00

abstract：:Superinfection of Corynebacterium diphtheriae C7(beta) by heteroimmune phage gamma is productive, whereas superinfection by gamma-bin mutants is for the most part nonproductive. Exclusion of gamma-bin phage occurred after its DNA had penetrated and was partially expressed in the heteroimmune lysogen. All of the infect...

journal_title：Journal of virology

authors： Groman NB,Rabin M

更新日期：1980-11-01 00:00:00

abstract：:Virus-specific cytotoxic T lymphocytes (CTL) exert intense selection pressure on replicating simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) in infected individuals. The immunodominant Mamu-A(*)01-restricted Gag p11C, C-M epitope is highly conserved among all sequenced isolates of S...

journal_title：Journal of virology

authors： Peyerl FW,Barouch DH,Yeh WW,Bazick HS,Kunstman J,Kunstman KJ,Wolinsky SM,Letvin NL

更新日期：2003-12-01 00:00:00

abstract：UNLABELLED:Influenza A virus (IAV) entry is a multistep process that requires the interaction of the virus with numerous host factors. In this study, we demonstrate that prolidase (PEPD) is a cellular factor required by IAV for successful entry into target cells. PEPD was selected as a candidate during an entry screen ...

journal_title：Journal of virology

authors： Pohl MO,Edinger TO,Stertz S

更新日期：2014-10-01 00:00:00

abstract：:BALB/c mice treated with pristane and Abelson virus have been used as an animal model system for the rapid induction of plasmacytomas. Myelomonocytic tumors with helper Moloney murine leukemia virus clonally inserted into the c-myb locus were observed in about 10% of pristane-primed BALB/c mice infected with Abelson v...

journal_title：Journal of virology

authors： Shen-Ong GL,Wolff L

更新日期：1987-12-01 00:00:00

abstract：:Vaccinia virus has a wide host range and infects mammalian cells of many different species. This suggests that the cell surface receptors for vaccinia virus are ubiquitously expressed and highly conserved. Alternatively, different receptors are used for vaccinia virus infection of different cell types. Here we report ...

journal_title：Journal of virology

authors： Chung CS,Hsiao JC,Chang YS,Chang W

更新日期：1998-02-01 00:00:00

abstract：UNLABELLED:The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from ...

journal_title：Journal of virology

authors： Koel BF,Mögling R,Chutinimitkul S,Fraaij PL,Burke DF,van der Vliet S,de Wit E,Bestebroer TM,Rimmelzwaan GF,Osterhaus AD,Smith DJ,Fouchier RA,de Graaf M

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:Major histocompatibility complex class II (MHC-II) molecules play a central role in adaptive antiviral immunity by presenting viral peptides to CD4(+) T cells. Due to their key role in adaptive immunity, many viruses, including Kaposi's sarcoma-associated herpesvirus (KSHV), have evolved multiple strategies ...

journal_title：Journal of virology

authors： Thakker S,Purushothaman P,Gupta N,Challa S,Cai Q,Verma SC

更新日期：2015-05-01 00:00:00

abstract：:There is an open reading frame in the E3 transcription unit of adenovirus type 3 (Ad3) and Ad7 that could encode a protein of 16 kDa (16K protein). Ad3 and Ad7 are members of subgroup B of human adenoviruses. Using a rabbit antipeptide antiserum, we show that the 16K protein is expressed in Ad3- and Ad7-infected cells...

journal_title：Journal of virology

authors： Hawkins LK,Wilson-Rawls J,Wold WS

更新日期：1995-07-01 00:00:00

abstract：:The infection of cells which belong to the B-cell lineage is thought to be the primary event leading to the phenotypic and functional alterations seen in the murine AIDS (M. Huang, C. Simard, D. Kay, and P. Jolicoeur, J. Virol. 65:6562-6571, 1991). Using in situ hybridization, we studied the time course of the anatomi...

journal_title：Journal of virology

authors： Simard C,Huang M,Jolicoeur P

更新日期：1994-03-01 00:00:00

abstract：:The iridovirus frog virus 3 (FV3) can replicate in culture in fat head minnow (FHM) fish cells or in BHK-21 hamster cells. Viral DNA replication commences about 3 h after infection of FHM cells with FV3. Between 3 and 6 h postinfection (p.i.), a portion of the intranuclear FV3 DNA is partly unmethylated. At later time...

journal_title：Journal of virology

authors： Schetter C,Grünemann B,Hölker I,Doerfler W

更新日期：1993-12-01 00:00:00

abstract：:Poliovirus proteins, except P3-7c, are associated with the endoplasmic reticulum after extraction of the cytoplasm and centrifugation of membranes to equilibrium in sucrose gradients. Proteins P3-2, P2-X, and P3-9 are found preferentially among the rough endoplasmic reticulum, whereas P3-7c is located in smooth endopl...

journal_title：Journal of virology

authors： Tershak DR

更新日期：1984-12-01 00:00:00

abstract：:HIV-1 transmission occurs mainly through mucosal tissues. During mucosal transmission, HIV-1 preferentially infects α4β7+ gut-homing CCR7- CD4+ effector/effector memory T cells (TEM) and results in massive depletion of these cells and other subsets of TEM in gut-associated lymphoid tissues. However, besides being elim...

journal_title：Journal of virology

authors： Cheung KW,Wu T,Ho SF,Wong YC,Liu L,Wang H,Chen Z

更新日期：2018-03-28 00:00:00

abstract：:An in vitro poliovirus RNA-synthesizing system derived from a crude membrane fraction of infected HeLa cells was used to analyze the mechanism of initiation of poliovirus plus-strand RNA synthesis. This system contains an activity that synthesizes the nucleotidyl proteins VPg-pU and VPg-pUpU. These molecules represent...

journal_title：Journal of virology

authors： Takeda N,Kuhn RJ,Yang CF,Takegami T,Wimmer E

更新日期：1986-10-01 00:00:00

abstract：:The human T-cell leukemia virus type I (HTLV-I) envelope protein is synthesized as a gp61 precursor product cleaved into two mature proteins, a gp45 exterior protein and a gp20 anchoring the envelope at the cell membrane. Using N-glycosylation inhibitors and site-directed mutagenesis of the potential glycosylation sit...

journal_title：Journal of virology

authors： Pique C,Pham D,Tursz T,Dokhélar MC

更新日期：1992-02-01 00:00:00

abstract：:The current therapy for hepatitis B and C is based on systemic administration of recombinant human alpha interferon (r-hIFN-alpha). However, systemic delivery of r-hIFN-alpha is associated with severe side effects, but more importantly, it is effective in only a small percentage of patients. In an effort to maximize I...

journal_title：Journal of virology

authors： Aurisicchio L,Delmastro P,Salucci V,Paz OG,Rovere P,Ciliberto G,La Monica N,Palombo F

更新日期：2000-05-01 00:00:00

abstract：:Measles virus (MeV) is an enveloped RNA virus bearing two envelope glycoproteins, the hemagglutinin (H) and fusion (F) proteins. Upon receptor binding, the H protein triggers conformational changes of the F protein, causing membrane fusion and subsequent virus entry. MeV may persist in the brain, infecting neurons and...

journal_title：Journal of virology

authors： Shirogane Y,Hashiguchi T,Yanagi Y

更新日期：2020-01-06 00:00:00

abstract：:CaM kinase-Gr is a multifunctional Ca2+/calmodulin-dependent protein kinase which is enriched in neurons and T lymphocytes. The kinase is absent from primary human B lymphocytes but is expressed in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cell lines, suggesting that expression of the kinase can be upregul...

journal_title：Journal of virology

authors： Mosialos G,Hanissian SH,Jawahar S,Vara L,Kieff E,Chatila TA

更新日期：1994-03-01 00:00:00

abstract：:Luteoviruses avoid degradation in the hemolymph of their aphid vector by interacting with a GroEL homolog from the aphid's primary endosymbiotic bacterium (Buchnera sp.). Mutational analysis of GroEL from the primary endosymbiont of Myzus persicae (MpB GroEL) revealed that the amino acids mediating binding of Potato l...

journal_title：Journal of virology

authors： Hogenhout SA,van der Wilk F,Verbeek M,Goldbach RW,van den Heuvel JF

更新日期：2000-05-01 00:00:00

abstract：:An unusual set of 3' coterminal, spliced mRNAs transcribed through the BamHI A fragment have been previously identified in nasopharyngeal carcinoma (NPC) tissues. These RNAs have also been detected at low levels in Burkitt's lymphoma (BL) cell lines and Epstein-Barr virus (EBV)-transformed lymphocytes. Sequence analys...

journal_title：Journal of virology

authors： Fries KL,Sculley TB,Webster-Cyriaque J,Rajadurai P,Sadler RH,Raab-Traub N

更新日期：1997-04-01 00:00:00

abstract：:A human cell line (293) transformed by adenovirus type 5 encodes mRNA's and proteins from the early region 1 (E1) of the viral genome. These products correspond to those synthesized early after adenovirus infection of normal cells. This pattern of expression is different from that observed at later times in the lytic ...

journal_title：Journal of virology

authors： Spector DJ,Halbert DN,Raskas HJ

更新日期：1980-12-01 00:00:00

abstract：:Glycoprotein B (gB) of herpes simplex virus (HSV) is one of four glycoproteins essential for viral entry and cell fusion. Recently, paired immunoglobulin-like type 2 receptor (PILRalpha) was identified as a receptor for HSV type 1 (HSV-1) gB. Both PILRalpha and a gD receptor were shown to participate in HSV-1 entry in...

journal_title：Journal of virology

authors： Fan Q,Lin E,Satoh T,Arase H,Spear PG

更新日期：2009-08-01 00:00:00

abstract：UNLABELLED:Ebola virus (EBOV) causes hemorrhagic fevers with high mortality rates. During cellular entry, the virus is internalized by macropinocytosis and trafficked through endosomes until fusion between the viral and an endosomal membrane is triggered, releasing the RNA genome into the cytoplasm. We found that while...

journal_title：Journal of virology

authors： Mingo RM,Simmons JA,Shoemaker CJ,Nelson EA,Schornberg KL,D'Souza RS,Casanova JE,White JM

更新日期：2015-03-01 00:00:00

abstract：:The cytotoxic T-lymphocyte (CTL) response to lymphocytic choriomeningitis virus infection determines the outcome of infection. Here we show that this response in BALB/c mice (H-2d), when analyzed both at the primary CTL level and using CTL clones, is predominantly monospecific. The vast majority of CTL have a common s...

journal_title：Journal of virology

authors： Whitton JL,Tishon A,Lewicki H,Gebhard J,Cook T,Salvato M,Joly E,Oldstone MB

更新日期：1989-10-01 00:00:00