Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.

abstract：:Rotavirus NSP1 has been shown to function as an E3 ubiquitin ligase that mediates proteasome-dependent degradation of interferon (IFN) regulatory factors (IRF), including IRF3, -5, and -7, and suppresses the cellular type I IFN response. However, the effect of rotavirus NSP1 on viral replication is not well defined. P...

journal_title：Journal of virology

authors： Feng N,Sen A,Nguyen H,Vo P,Hoshino Y,Deal EM,Greenberg HB

更新日期：2009-07-01 00:00:00

abstract：:The E7 proteins of human papillomaviruses (HPVs) promote S-phase reentry in differentiated keratinocytes of the squamous epithelia to support viral DNA amplification. In this study, we showed that nuclear p130 was present in the differentiated strata of several native squamous epithelia susceptible to HPV infection. I...

journal_title：Journal of virology

authors： Genovese NJ,Banerjee NS,Broker TR,Chow LT

更新日期：2008-05-01 00:00:00

abstract：:Neurons of the sensory ganglia are the major site of varicella-zoster virus (VZV) latency and may undergo productive infection during reactivation. Although the VZV glycoprotein E/glycoprotein I (gE/gI) complex is known to be critical for neurovirulence, few studies have assessed the roles of these proteins during inf...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2013-12-01 00:00:00

abstract：:We have demonstrated that Epstein-Barr virus (EBV) confers enhanced growth capability in soft agarose, tumorigenesis in the SCID mouse, and resistance to apoptosis in the Burkitt's lymphoma cell line Akata. Subsequently, we have shown that EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. We constan...

journal_title：Journal of virology

authors： Komano J,Takada K

更新日期：2001-02-01 00:00:00

abstract：:Three mRNAs from the murine polyomavirus early region encode the three well-characterized tumor antigens. We report the existence of a fourth alternatively spliced mRNA which encodes a fourth tumor antigen, tiny T antigen, which comprises the amino-terminal domain common to all of the T antigens but is extended by six...

journal_title：Journal of virology

authors： Riley MI,Yoo W,Mda NY,Folk WR

更新日期：1997-08-01 00:00:00

abstract：:The product of the v-myb oncogene of avian myeloblastosis virus is a nuclear protein with an associated DNA-binding activity. We demonstrated that the highly conserved amino-terminal domain of p48v-myb is required for its associated DNA-binding activity. This activity is not required for the nuclear localization of p4...

journal_title：Journal of virology

authors： Ibanez CE,Garcia A,Stober-Grässer U,Lipsick JS

更新日期：1988-11-01 00:00:00

abstract：:Bicistronic RNAs containing the 373-nucleotide-long 5' nontranslated region (NTR) of the classical swine fever virus (CSFV) genome as intercistronic spacer were used to show the presence of an internal ribosome entry site (IRES) in the 5' end of the CSFV genome. By coexpression of the poliovirus 2A protease it was dem...

journal_title：Journal of virology

authors： Rijnbrand R,van der Straaten T,van Rijn PA,Spaan WJ,Bredenbeek PJ

更新日期：1997-01-01 00:00:00

abstract：:The human antibody response to flavivirus infection is dominantly directed against a cross-reactive epitope on the fusion loop of domain II (DII-FL) of the envelope (E) protein. Although antibodies against this epitope fail to recognize fully mature West Nile virus (WNV) virions and accordingly neutralize infection po...

journal_title：Journal of virology

authors： Vogt MR,Dowd KA,Engle M,Tesh RB,Johnson S,Pierson TC,Diamond MS

更新日期：2011-11-01 00:00:00

abstract：:A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against c...

journal_title：Journal of virology

authors： Berhe G,Minet C,Le Goff C,Barrett T,Ngangnou A,Grillet C,Libeau G,Fleming M,Black DN,Diallo A

更新日期：2003-01-01 00:00:00

abstract：:Recombinant vaccinia viruses expressing C-terminally truncated E's that ranged in length from 9 to 99% of the N-terminal sequence were constructed. The overall antigenicity of the E products was analyzed by radioimmunoprecipitation, using dengue virus hyperimmune mouse ascitic fluid (HMAF) or an anti-E peptide serum. ...

journal_title：Journal of virology

authors： Men RH,Bray M,Lai CJ

更新日期：1991-03-01 00:00:00

abstract：:Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses. There are two ZAP isoforms arising from alternative splicing, which differ only at the C termini. It was recently reported that the long isoform (ZAPL) promotes proteasomal degradation of influenza A vir...

journal_title：Journal of virology

authors： Tang Q,Wang X,Gao G

更新日期：2017-01-03 00:00:00

abstract：:Members of the Paramyxovirinae subfamily rely on the concerted action of two envelope glycoprotein complexes, attachment protein H and the fusion (F) protein oligomer, to achieve membrane fusion for viral entry. Despite advances in X-ray information, the organization of the physiological attachment (H) oligomer in fun...

journal_title：Journal of virology

authors： Brindley MA,Plemper RK

更新日期：2010-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 Tat exerts prominent angiogenic effects which may lead to a variety of vasculopathic conditions in AIDS patients. Because endothelial cells undergo prominent cytoskeletal rearrangement during angiogenesis, we investigated the specific effects of Tat on the endothelial cell actin cyt...

journal_title：Journal of virology

authors： Wu RF,Gu Y,Xu YC,Mitola S,Bussolino F,Terada LS

更新日期：2004-01-01 00:00:00

abstract：:We have found that the burst size of bacteriophage T7 was decreased in two Escherichia coli temperature-sensitive gyrase mutants incubated at the restrictive temperature. This reduction in burst size indicates that gyrase may be required for T7 growth. ...

journal_title：Journal of virology

authors： Steck TR,Drlica K

更新日期：1985-01-01 00:00:00

abstract：:Here, we report a novel porcine circovirus type 2a (PCV2a) strain with 11 nucleotides (nt) inserted in the origin of genome replication (Ori). This is the first report of a PCV2a strain with nucleotide insertion in Ori. Our study will help further epidemiological studies and extend our knowledge of evolutionary charac...

journal_title：Journal of virology

authors： Cai L,Han X,Hu D,Li X,Wang B,Ni J,Zhou Z,Yu X,Zhai X,Tian K

更新日期：2012-06-01 00:00:00

abstract：:The entire measles virus (MV) hemagglutinin (HA)-coding region was reconstructed from cloned cDNAs and used as part of a hybrid transcription unit to replace a region of the adenovirus type 5 genome corresponding to the entire E1a transcription unit and most of the E1b transcription unit. The resulting recombinant vir...

journal_title：Journal of virology

authors： Alkhatib G,Briedis DJ

更新日期：1988-08-01 00:00:00

abstract：:APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the propensity to form homo-multimers. In the current study, we investigated the functional determinants for multimerization o...

journal_title：Journal of virology

authors： Opi S,Takeuchi H,Kao S,Khan MA,Miyagi E,Goila-Gaur R,Iwatani Y,Levin JG,Strebel K

更新日期：2006-05-01 00:00:00

abstract：:Recently, recombinant baculoviruses have been used to show that expression of six herpes simplex virus type 1 genes results in the formation of capsid-like particles. We have applied cryoelectron microscopy and three-dimensional image reconstruction to establish their structural authenticity to a resolution of approxi...

journal_title：Journal of virology

authors： Trus BL,Homa FL,Booy FP,Newcomb WW,Thomsen DR,Cheng N,Brown JC,Steven AC

更新日期：1995-11-01 00:00:00

abstract：:Deletion mutants of simian virus 40 (SV40) with lesions at the three DdeI sites near the 3' end of the early region were constructed. Mutants with deletions at 0.203 and 0.219 map units (mu) which did not change the large T antigen reading frame were viable. This extends slightly the upstream boundary for the location...

journal_title：Journal of virology

authors： Tornow J,Cole CN

更新日期：1983-09-01 00:00:00

abstract：:We recently found that a human T-cell leukemia virus type 1-infected cell line, MT-2, could support the replication of hepatitis C virus (HCV) (N. Kato, T. Nakazawa, T. Mizutani, and K. Shimotohno, Biochem. Biophys. Res. Commun. 206:863-869, 1995). In order to develop a culture system in which HCV replicates more effi...

journal_title：Journal of virology

authors： Mizutani T,Kato N,Saito S,Ikeda M,Sugiyama K,Shimotohno K

更新日期：1996-10-01 00:00:00

abstract：:A murine retrovirus encoding the middle T protein of polyomavirus infected and transformed nonestablished chicken embryo cells. The infected cultures formed colonies in soft agar-containing medium and released infectious transforming virus. Middle T protein expressed in the transformed chicken cells associated with p6...

journal_title：Journal of virology

authors： Kaplan PL,Simon S,Eckhart W

更新日期：1985-12-01 00:00:00

abstract：:Among the numerous immunological abnormalities observed in chronically human immunodeficiency virus (HIV)-infected individuals, perturbations in memory CD4 T cells are thought to contribute specifically to disease pathogenesis. Among these, functional imbalances in the frequencies of T regulatory cells (Tregs) and int...

journal_title：Journal of virology

authors： Lai SH,Starke CE,Flynn JK,Vinton CL,Ortiz AM,Mudd JC,Brenchley JM

更新日期：2019-04-17 00:00:00

abstract：:Infection by rat virus has been studied in cultures of rat embryo cells to evaluate the Margolis-Kilham hypothesis that the virus preferentially infects tissues with actively dividing cells. An enhancement of infection was seen in cultures infected 10 hr after fresh medium was added as compared to infection of station...

journal_title：Journal of virology

authors： Tennant RW,Layman KR,Hand RE

更新日期：1969-12-01 00:00:00

abstract：:Recombinant poxvirus vectors are undergoing intensive evaluation as vaccine candidates for a variety of infectious pathogens. Avipoxviruses, such as canarypox virus, are replication deficient in mammalian cells by virtue of a poorly understood species-specific restriction. Highly attenuated vaccinia virus strains such...

journal_title：Journal of virology

authors： Zhang X,Cassis-Ghavami F,Eller M,Currier J,Slike BM,Chen X,Tartaglia J,Marovich M,Spearman P

更新日期：2007-07-01 00:00:00

abstract：:HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains unknown. We therefore assessed the nature of HLA-B*57 selection in a large, observational Kenyan cohort where clade...

journal_title：Journal of virology

authors： McKinnon LR,Capina R,Peters H,Mendoza M,Kimani J,Wachihi C,Kariri A,Kimani M,Richmond M,Kiazyk SK,Fowke KR,Jaoko W,Luo M,Ball TB,Plummer FA

更新日期：2009-12-01 00:00:00

abstract：:Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of cholesterol to form a solub...

journal_title：Journal of virology

authors： Doms A,Sanabria T,Hansen JN,Altan-Bonnet N,Holm GH

更新日期：2018-08-29 00:00:00

abstract：:The transforming proteins of the small DNA tumor viruses, simian virus 40 (SV40), adenovirus, and human papillomavirus (HPV) target a number of identical cellular regulators whose functional abrogation is required for transformation. However, while both adenovirus E1A and SV40 large T transforming properties also depe...

journal_title：Journal of virology

authors： Zimmermann H,Degenkolbe R,Bernard HU,O'Connor MJ

更新日期：1999-08-01 00:00:00

abstract：:Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed during latent Epstein-Barr virus (EBV) infections in human peripheral B cells. LMP2A blocks B-cell receptor (BCR) signal transduction in vitro by modulation of the Syk and Lyn protein tyrosine kinases. Five genetically unique LMP2A transgen...

journal_title：Journal of virology

authors： Caldwell RG,Brown RC,Longnecker R

更新日期：2000-02-01 00:00:00

abstract：:While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of...

journal_title：Journal of virology

authors： Denkers ND,Hayes-Klug J,Anderson KR,Seelig DM,Haley NJ,Dahmes SJ,Osborn DA,Miller KV,Warren RJ,Mathiason CK,Hoover EA

更新日期：2013-02-01 00:00:00

abstract：:The adaptive immune system generates CD8 cytotoxic T lymphocytes (CTLs) as a major component of the protective response against viruses. Knowledge regarding the nature of the peptide sequences presented by HLA class I molecules and recognized by CTLs is thus important for understanding host-pathogen interactions. In t...

journal_title：Journal of virology

authors： Varela-Calvino R,Skowera A,Arif S,Peakman M

更新日期：2004-12-01 00:00:00