Abstract:
:HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains unknown. We therefore assessed the nature of HLA-B*57 selection in a large, observational Kenyan cohort where clades A1 and D predominate. While T242N was ubiquitous in clade D HLA-B*57(+) subjects, this mutation was rare (15%) in clade A1. Instead, P243T and I247L were selected by clade A1-infected HLA-B*57 subjects but not by HLA-B*5801(+) subjects. Our data suggest that clade A1 consensus proline at Gag residue 243 might represent an inherent block to T242N escape in clade A1. We confirmed immunologically that P243T and I247L likely represent escape mutations. HLA-B*57 evolution also differed between clades in the KF11 and IW9 epitopes. A better understanding of clade-specific evolution is important for the development of HIV vaccines in regions with multiple clades.
journal_name
J Viroljournal_title
Journal of virologyauthors
McKinnon LR,Capina R,Peters H,Mendoza M,Kimani J,Wachihi C,Kariri A,Kimani M,Richmond M,Kiazyk SK,Fowke KR,Jaoko W,Luo M,Ball TB,Plummer FAdoi
10.1128/JVI.01236-09subject
Has Abstractpub_date
2009-12-01 00:00:00pages
12636-42issue
23eissn
0022-538Xissn
1098-5514pii
JVI.01236-09journal_volume
83pub_type
杂志文章abstract::The specificity of binding of wheat germ ribosomes to mRNA was greatly altered by cleavage of the message. Fragmentation of reovirus mRNA allowed wheat germ ribosomes to bind and protect a variety of internal sequences which were not accessible to ribosomes in the intact message. In experiments using the polycistronic...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.35.3.748-756.1980
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journal_title:Journal of virology
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doi:10.1128/JVI.2.3.182-191.1968
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.16.6.1608-1614.1975
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.5.1877-1883.1989
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.12.8645-8652.1996
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journal_title:Journal of virology
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.11.6387-6394.1993
更新日期:1993-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.1.513-521.2001
更新日期:2001-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.11.6.915-925.1973
更新日期:1973-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.8.6475-6481.1998
更新日期:1998-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.43.3.772-777.1982
更新日期:1982-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.24.11899-11910.2000
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journal_title:Journal of virology
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更新日期:2005-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.11.9659-9663.1999
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00