Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24.


:HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains unknown. We therefore assessed the nature of HLA-B*57 selection in a large, observational Kenyan cohort where clades A1 and D predominate. While T242N was ubiquitous in clade D HLA-B*57(+) subjects, this mutation was rare (15%) in clade A1. Instead, P243T and I247L were selected by clade A1-infected HLA-B*57 subjects but not by HLA-B*5801(+) subjects. Our data suggest that clade A1 consensus proline at Gag residue 243 might represent an inherent block to T242N escape in clade A1. We confirmed immunologically that P243T and I247L likely represent escape mutations. HLA-B*57 evolution also differed between clades in the KF11 and IW9 epitopes. A better understanding of clade-specific evolution is important for the development of HIV vaccines in regions with multiple clades.


J Virol


Journal of virology


McKinnon LR,Capina R,Peters H,Mendoza M,Kimani J,Wachihi C,Kariri A,Kimani M,Richmond M,Kiazyk SK,Fowke KR,Jaoko W,Luo M,Ball TB,Plummer FA




Has Abstract


2009-12-01 00:00:00














  • Human cytomegalovirus immediate-early 2 (IE2) protein can transactivate the human hsp70 promoter by alleviation of Dr1-mediated repression.

    abstract::The immediate-early 1 and 2 (IE1 and IE2, respectively) proteins of human cytomegalovirus are known transcription factors, which regulate the expression of viral and cellular genes. Transcriptional activation by IE2 is dependent on the presence of a TATA motif in target promoters, and IE2 can interact directly with th...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Caswell R,Bryant L,Sinclair J

    更新日期:1996-06-01 00:00:00

  • Pseudorabies virus glycoprotein gIII is required for efficient virus growth in tissue culture.

    abstract::Glycoprotein gIII of pseudorabies virus is a major antigen found in the envelopes of virus particles as well as in and on the surfaces of infected cells. It is not an essential gene product for virus growth in tissue culture. In this report, we provide evidence that, although it is not essential, the gIII protein is r...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Whealy ME,Robbins AK,Enquist LW

    更新日期:1988-07-01 00:00:00

  • Complexity of Neutralizing Antibodies against Multiple Dengue Virus Serotypes after Heterotypic Immunization and Secondary Infection Revealed by In-Depth Analysis of Cross-Reactive Antibodies.

    abstract:UNLABELLED:The four serotypes of dengue virus (DENV) cause the most important and rapidly emerging arboviral diseases in humans. The recent phase 2b and 3 studies of a tetravalent dengue vaccine reported a moderate efficacy despite the presence of neutralizing antibodies, highlighting the need for a better understandin...

    journal_title:Journal of virology

    pub_type: 杂志文章,随机对照试验


    authors: Tsai WY,Durbin A,Tsai JJ,Hsieh SC,Whitehead S,Wang WK

    更新日期:2015-07-01 00:00:00

  • High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.

    abstract::A protocol was designed to measure the forward mutation rate over an entire gene replicated as part of a Moloney murine leukemia virus-based vector. For these studies, the herpes simplex virus thymidine kinase (tk) gene under the control of the spleen necrosis virus U3 promoter was used as target sequence since it all...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Varela-Echavarría A,Prorock CM,Ron Y,Dougherty JP

    更新日期:1993-11-01 00:00:00

  • Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody.

    abstract::We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ohnuma K,Haagmans BL,Hatano R,Raj VS,Mou H,Iwata S,Dang NH,Bosch BJ,Morimoto C

    更新日期:2013-12-01 00:00:00

  • Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity.

    abstract::Rotavirus nonstructural protein 4 (NSP4) induces dramatic changes in cellular calcium homeostasis. These include increased endoplasmic reticulum (ER) permeability, resulting in decreased ER calcium stores and activation of plasma membrane (PM) calcium influx channels, ultimately causing a 2- to 4-fold elevation in cyt...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Hyser JM,Utama B,Crawford SE,Broughman JR,Estes MK

    更新日期:2013-12-01 00:00:00

  • Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes.

    abstract:UNLABELLED:The genus beta human papillomaviruses (beta HPVs) cause cutaneous lesions and are thought to be involved in the initiation of some nonmelanoma skin cancers (NMSCs), particularly in patients with the genetic disorder epidermodysplasia verruciformis (EV). We have previously reported that at least two of the ge...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: White EA,Walther J,Javanbakht H,Howley PM

    更新日期:2014-08-01 00:00:00

  • Nucleotide sequence analysis of a variant human T-cell leukemia virus (HTLV-Ib) provirus with a deletion in pX-I.

    abstract::A variant of human T-cell leukemia virus subgroup I (HTLV-I), designated HTLV-Ib, has been isolated from a transformed T-lymphocytic cell line established from a Zairian patient with adult T-cell lymphoma. A recombinant phage clone of the variant provirus, denoted lambda MC-1, hybridizes under high stringency to HTLV-...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ratner L,Josephs SF,Starcich B,Hahn B,Shaw GM,Gallo RC,Wong-Staal F

    更新日期:1985-06-01 00:00:00

  • Induction and maintenance of autonomous flock house virus RNA1 replication.

    abstract::The nodavirus flock house virus (FHV) has a bipartite, positive-sense, RNA genome that encodes the catalytic subunit of the RNA replicase and the viral capsid protein precursor on separate genomic segments (RNA1 and RNA2, respectively). RNA1 can replicate autonomously when transfected into permissive cells, allowing s...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Johnson KL,Ball LA

    更新日期:1999-10-01 00:00:00

  • Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance.

    abstract::Broadly neutralizing antibodies have been isolated that bind the glycan shield of the HIV-1 envelope spike. One such antibody, PGT135, contacts the intrinsic mannose patch of gp120 at the Asn332, Asn392, and Asn386 glycosylation sites. Here, site-specific glycosylation analysis of recombinant gp120 revealed glycan mic...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Pritchard LK,Spencer DI,Royle L,Vasiljevic S,Krumm SA,Doores KJ,Crispin M

    更新日期:2015-07-01 00:00:00

  • Antibody-forming cell response to virus challenge in mice immunized with DNA encoding the influenza virus hemagglutinin.

    abstract::Immunization of mice with DNA encoding the influenza virus hemagglutinin (HA) affords complete protection against lethal influenza virus infection and the means to investigate the mechanisms of B-cell responsiveness to virus challenge. Using a single-cell enzyme-linked immunospot assay, we sought to determine the loca...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Justewicz DM,Morin MJ,Robinson HL,Webster RG

    更新日期:1995-12-01 00:00:00

  • The comparative genomics of human respiratory syncytial virus subgroups A and B: genetic variability and molecular evolutionary dynamics.

    abstract::Genomic variation and related evolutionary dynamics of human respiratory syncytial virus (RSV), a common causative agent of severe lower respiratory tract infections, may affect its transmission behavior. RSV evolutionary patterns are likely to be influenced by a precarious interplay between selection favoring variant...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Tan L,Coenjaerts FE,Houspie L,Viveen MC,van Bleek GM,Wiertz EJ,Martin DP,Lemey P

    更新日期:2013-07-01 00:00:00

  • A chimeric vesiculo/alphavirus is an effective alphavirus vaccine.

    abstract::While a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever. This virus has the potential to cause a wor...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Chattopadhyay A,Wang E,Seymour R,Weaver SC,Rose JK

    更新日期:2013-01-01 00:00:00

  • Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.

    abstract::Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting patients infected with virus bearing the T215Y/F amino acid substitution associated with zidovudine (ZDV) resistance. A...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Yerly S,Rakik A,De Loes SK,Hirschel B,Descamps D,Brun-Vézinet F,Perrin L

    更新日期:1998-05-01 00:00:00

  • Terminal repetitive sequences in herpesvirus saimiri virion DNA.

    abstract::The H-DNA repeat unit of Herpesvirus saimiri strain 11 was cloned in plasmid vector pAGO, and the nucleotide sequence was determined by the dideoxy chain termination method. One unit of repetitive DNA has 1,444 base pairs with 70.8% G+C content. The structural features of repeat DNA sequences at the termini of intact ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Bankier AT,Dietrich W,Baer R,Barrell BG,Colbère-Garapin F,Fleckenstein B,Bodemer W

    更新日期:1985-07-01 00:00:00

  • Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Frolov I,Agapov E,Hoffman TA Jr,Prágai BM,Lippa M,Schlesinger S,Rice CM

    更新日期:1999-05-01 00:00:00

  • In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Watson ZL,Washington SD,Phelan DM,Lewin AS,Tuli SS,Schultz GS,Neumann DM,Bloom DC

    更新日期:2018-07-31 00:00:00

  • Bacteriophage-host interaction and restriction of nonglucosylated T6.

    abstract::Nonglucosylated T6 phage (T6gtam 16am30, hereafter called T6alpha gt-) were found to have two structural anomalies when compared with wild-type T6. The DNA of T6alpha gt- phage contains single-strand interruptions. These can be seen both during infection, in the pool of replicating DNA, and in DNA extracted from purif...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Hewlett MJ,Mathews CK

    更新日期:1975-04-01 00:00:00

  • Glycopeptides of murine leukemia viruses. I. Comparison of two ecotropic viruses.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kemp MC,Basak S,Compans RW

    更新日期:1979-07-01 00:00:00

  • Genetic mapping of the mouse c-fms proto-oncogene to chromosome 18.

    abstract::Chinese hamster X mouse somatic cell hybrids were analyzed by Southern blot hybridization with a probe specific for the cellular c-fms proto-oncogene. Results demonstrate that Fms, the genetic locus containing this sequence, maps to mouse chromosome 18. Mouse Fms is thus not linked to the same set of genes involved in...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Hoggan MD,Halden NF,Buckler CE,Kozak CA

    更新日期:1988-03-01 00:00:00

  • Mechanistic insights into the enhancement of adeno-associated virus transduction by proteasome inhibitors.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Mitchell AM,Samulski RJ

    更新日期:2013-12-01 00:00:00

  • Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Zhang Y,Zhang Q,Gao Y,He X,Kong H,Jiang Y,Guan Y,Xia X,Shu Y,Kawaoka Y,Bu Z,Chen H

    更新日期:2012-09-01 00:00:00

  • Characterization of adenovirus type 2 transcriptional complexes isolated from infected HeLa cell nuclei.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Wilhelm J,Brison O,Kedinger C,Chambon P

    更新日期:1976-07-01 00:00:00

  • Ping-pong amplification of a retroviral vector achieves high-level gene expression: human growth hormone production.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kozak SL,Kabat D

    更新日期:1990-07-01 00:00:00

  • Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication.

    abstract:UNLABELLED:To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) regulatory protein ICP0 promotes viral gene expression and replication, we screened cells overexpressing ICP0 for ICP0-binding host cell proteins. Tandem affinity purification of transiently expressed ICP0 coupled with mass spe...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Sato Y,Kato A,Maruzuru Y,Oyama M,Kozuka-Hata H,Arii J,Kawaguchi Y

    更新日期:2016-01-06 00:00:00

  • An endonuclease switching mechanism in the virion RNA and cRNA promoters of Thogoto orthomyxovirus.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Leahy MB,Dessens JT,Pritlove DC,Nuttall PA

    更新日期:1998-03-01 00:00:00

  • The P1N-PISPO trans-Frame Gene of Sweet Potato Feathery Mottle Potyvirus Is Produced during Virus Infection and Functions as an RNA Silencing Suppressor.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Mingot A,Valli A,Rodamilans B,San León D,Baulcombe DC,García JA,López-Moya JJ

    更新日期:2016-01-20 00:00:00

  • Avian Influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection.

    abstract::Strong determinants of the host range of influenza A viruses have been identified on the polymerase complex formed by the PB1, PB2, and PA subunits and on the nucleoprotein (NP). In the present study, molecular mechanisms that may involve these four core proteins and contribute to the restriction of avian influenza vi...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Rameix-Welti MA,Tomoiu A,Dos Santos Afonso E,van der Werf S,Naffakh N

    更新日期:2009-02-01 00:00:00

  • Functional characterization of thermolabile DNA-binding proteins that affect adenovirus DNA replication.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Prelich G,Stillman BW

    更新日期:1986-03-01 00:00:00

  • Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Forrester A,Farrell H,Wilkinson G,Kaye J,Davis-Poynter N,Minson T

    更新日期:1992-01-01 00:00:00