Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.

abstract：:Mother-to-child transmission can occur in utero, mainly intrapartum and postpartum in case of breastfeeding. In utero transmission is highly restricted and results in selection of viral variant from the mother to the child. We have developed an in vitro system that mimics the interaction between viruses, infected cell...

journal_title：Journal of virology

authors： Lagaye S,Derrien M,Menu E,Coïto C,Tresoldi E,Mauclère P,Scarlatti G,Chaouat G,Barré-Sinoussi F,Bomsel M,European Network for the Study of In Utero Transmission of HIV-1.

更新日期：2001-05-01 00:00:00

abstract：:We report here the complete genomic sequence of the duck Tembusu virus (DTMUV) WJ-1 strain, isolated from Muscovy ducks. This is the first complete genome sequence of DTMUV reported in southern China. Compared with the other strains (TA, GH-2, YY5, and ZJ-407) that were previously found in eastern China, WJ-1 bears a ...

journal_title：Journal of virology

authors： Zhu W,Chen J,Wei C,Wang H,Huang Z,Zhang M,Tang F,Xie J,Liang H,Zhang G,Su S

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:The genus beta human papillomaviruses (beta HPVs) cause cutaneous lesions and are thought to be involved in the initiation of some nonmelanoma skin cancers (NMSCs), particularly in patients with the genetic disorder epidermodysplasia verruciformis (EV). We have previously reported that at least two of the ge...

journal_title：Journal of virology

authors： White EA,Walther J,Javanbakht H,Howley PM

更新日期：2014-08-01 00:00:00

abstract：:Because immunologic classification of human immunodeficiency virus type 1 (HIV) might be more relevant than genotypic classification for designing polyvalent vaccines, studies were undertaken to determine whether immunologically defined groups of HIV ("immunotypes") could be identified. For these experiments, the V3 r...

journal_title：Journal of virology

authors： Zolla-Pazner S,Gorny MK,Nyambi PN,VanCott TC,Nádas A

更新日期：1999-05-01 00:00:00

abstract：:The pathway of envelopment and egress of the varicella-zoster virus (VZV) and the primary site of viral production within the epidermal layer of the skin are not fully understood. There are several hypotheses to explain how the virus may receive an envelope as it travels to the surface of the monolayer. In this study,...

journal_title：Journal of virology

authors： Harson R,Grose C

更新日期：1995-08-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) is likely to be involved in the pathogenesis of Kaposi's sarcoma (KS) and body cavity-based lymphomas (BCBLs). The HHV-8 genome is primarily in a latent state in BCBL-derived cell lines like BCBL-1, but lytic replication can be induced by phorbol esters (R. Renne, W. Zhang, B. Herndier, M. ...

journal_title：Journal of virology

authors： Raab MS,Albrecht JC,Birkmann A,Yağuboğlu S,Lang D,Fleckenstein B,Neipel F

更新日期：1998-08-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease. In this study, we investigated the phylogenetic origins of its genome segments and estimated...

journal_title：Journal of virology

authors： Hon CC,Lam TY,Drummond A,Rambaut A,Lee YF,Yip CW,Zeng F,Lam PY,Ng PT,Leung FC

更新日期：2006-09-01 00:00:00

abstract：:Acute measles in children can be prevented by immunization with the live attenuated measles vaccine virus. Although immunization is able to induce CD4 and CD8 T cells as well as neutralizing antibodies, only the latter have been correlated with protective immunity. CD8 T cells, however, have been documented to be impo...

journal_title：Journal of virology

authors： Pueschel K,Tietz A,Carsillo M,Steward M,Niewiesk S

更新日期：2007-08-01 00:00:00

abstract：:Combined Southern blot hybridization analyses of DNA digests of several clinical strains of Streptococcus pneumoniae have revealed the presence of a gene (hblR), or part of it, similar to the hbl7 gene coding for the cell wall lytic enzyme of the temperate HB-746 phage. The results confirmed that the genome of HB-746,...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1992-05-01 00:00:00

abstract：:The papillomavirus (PV) E2 protein is a critical regulator of viral transcription and genome replication. We previously reported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by the fibroblast growth factor receptor 3 (FGFR3) kinase. In this study, we generated quasiviruses containing G418-selectable HPV-31 gen...

journal_title：Journal of virology

authors： Jose L,Androphy EJ,DeSmet M

更新日期：2020-07-01 00:00:00

abstract：:We have found that interleukin-4 (IL-4) abrogated constitutive beta interferon (IFN-beta) synthesis in mouse macrophages. Analysis of endogenous IFN mRNA by reverse transcription-PCR clearly documented the presence of IFN-beta but not of IFN-alpha transcripts in RNA from bone marrow-derived macrophages (BMM). Culture ...

journal_title：Journal of virology

authors： Nickolaus P,Zawatzky R

更新日期：1994-10-01 00:00:00

abstract：:Although the genetic organization of tobacco mosaic virus (TMV) differs considerably from that of the tripartite viruses (alfalfa mosaic virus [AlMV] and brome mosaic virus [BMV]), all of these RNA plant viruses share three domains of homology among their nonstructural proteins. One such domain, common to the AlMV and...

journal_title：Journal of virology

authors： Ahlquist P,Strauss EG,Rice CM,Strauss JH,Haseloff J,Zimmern D

更新日期：1985-02-01 00:00:00

abstract：:The synthesis of viral RNA by wild-type vesicular stomatitis virus (L(1)VSV) and a small, plaque-size mutant (S(2)VSV) was studied in vitro and in chicken embryo (CE) and mouse L-cell cultures. Virus-specific RNA synthesized in CE or L cells infected with either L(1) or S(2)VSV at low multiplicity was of the same size...

journal_title：Journal of virology

authors： Wertz GW,Levine M

更新日期：1973-08-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) glycoprotein C (gC) gene was altered so that it encoded a truncated glycoprotein lacking a cytoplasmic domain but retaining 20 of 23 amino acids of the transmembrane domain. No additional amino acid residues were introduced into the glycoprotein encoded by the altered gene. The ...

journal_title：Journal of virology

authors： Holland TC,Lerch RJ,Earhart K

更新日期：1988-05-01 00:00:00

abstract：:We have developed a complementation assay, using transiently transfected COS cells, to facilitate a molecular analysis of the herpes simplex virus type 1 glycoprotein gH. When infected by a gH-null syncytial virus, COS cells expressing wild-type gH generate infectious progeny virions and form a syncytium with neighbor...

journal_title：Journal of virology

authors： Wilson DW,Davis-Poynter N,Minson AC

更新日期：1994-11-01 00:00:00

abstract：:We have used an antisense RNA approach in the analysis of gene function in human cytomegalovirus (HCMV). An astrocytoma cell line (U373-MG) that is permissive for virus replication was permanently transfected with a construct bearing sequence from HCMV UL44 (coding for the major late DNA-binding protein, ppUL44, also ...

journal_title：Journal of virology

authors： Ripalti A,Boccuni MC,Campanini F,Landini MP

更新日期：1995-04-01 00:00:00

abstract：:The effects of human papillomavirus type 18 (HPV-18) E6 and E7 proteins on global patterns of host gene expression in primary human keratinocytes grown in organotypic raft culture system were assessed. Primary human keratinocytes were infected with retroviruses that express the wild-type HPV-18 E6 and E7 genes from th...

journal_title：Journal of virology

authors： Garner-Hamrick PA,Fostel JM,Chien WM,Banerjee NS,Chow LT,Broker TR,Fisher C

更新日期：2004-09-01 00:00:00

abstract：:DNA of the avian hepadnavirus, duck hepatitis B virus, was found to be integrated at low abundance into the cellular DNA extracted from the livers of infected ducklings. The frequency of integration was estimated to be at least one viral genome per 10(3) to 10(4) cells by 6 days postinfection. The structures of virus-...

journal_title：Journal of virology

authors： Yang W,Summers J

更新日期：1999-12-01 00:00:00

abstract：:Eucaryotic, viral, and bacteriophage DNA polymerases of the alpha-like family share blocks of sequence similarity, the most conserved of which has been designated region I. Region I includes a YGDTDS motif that is almost invariant within the alpha-like family and that is similar to a motif conserved among RNA-directed...

journal_title：Journal of virology

authors： Marcy AI,Hwang CB,Ruffner KL,Coen DM

更新日期：1990-12-01 00:00:00

abstract：:Molecularly defined vaccine formulations capable of inducing antiviral CD8+ T-cell-specific immunity in a manner compatible with human delivery are limited. Few molecules achieve this target without the support of an appropriate immunological adjuvant. In this study, we investigate the potential of totally synthetic p...

journal_title：Journal of virology

authors： Zhang X,Issagholian A,Berg EA,Fishman JB,Nesburn AB,BenMohamed L

更新日期：2005-12-01 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (pX) is implicated in hepatocarcinogenesis by an unknown mechanism. pX variants encoded by HBV genomes found integrated in genomic DNA from liver tumors of patients with hepatocellular carcinoma (HCC) generally lack amino acids 134 to 154. Since deregulation of mitogenic pathways ...

journal_title：Journal of virology

authors： Li H,Chi CY,Lee S,Andrisani OM

更新日期：2006-11-01 00:00:00

abstract：UNLABELLED:The latent infection of Epstein-Barr virus (EBV) is associated with 1% of human cancer incidence. Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification catalyzed by poly(ADP-ribose) polymerases (PARPs) that mediate EBV replication during latency. In this study, we detail the mechanisms that...

journal_title：Journal of virology

authors： Martin KA,Lupey LN,Tempera I

更新日期：2016-09-12 00:00:00

abstract：:Of the four required herpes simplex virus (HSV) entry glycoproteins, the precise role of gH-gL in fusion remains the most elusive. The heterodimer gH-gL has been proposed to mediate hemifusion after the interaction of another required glycoprotein, gD, with a receptor. To identify functional domains of HSV-1 gH, we ge...

journal_title：Journal of virology

authors： Jackson JO,Lin E,Spear PG,Longnecker R

更新日期：2010-02-01 00:00:00

abstract：:Increased lymphocyte turnover is a hallmark of pathogenic lentiviral infection. To investigate perturbations in lymphocyte dynamics in natural hosts with nonpathogenic simian immunodeficiency virus (SIV) infection, the nucleoside analog bromodeoxyuridine (BrdU) was administered to six naturally SIV-infected and five S...

journal_title：Journal of virology

authors： Kaur A,Di Mascio M,Barabasz A,Rosenzweig M,McClure HM,Perelson AS,Ribeiro RM,Johnson RP

更新日期：2008-02-01 00:00:00

abstract：:The combinatorial nature of genetic recombination can potentially provide organisms with immediate access to many more positions in sequence space than can be reached by mutation alone. Recombination features particularly prominently in the evolution of a diverse range of viruses. Despite rapid progress having been ma...

journal_title：Journal of virology

authors： Lefeuvre P,Lett JM,Varsani A,Martin DP

更新日期：2009-03-01 00:00:00

abstract：:Immunization of mice with DNA encoding the influenza virus hemagglutinin (HA) affords complete protection against lethal influenza virus infection and the means to investigate the mechanisms of B-cell responsiveness to virus challenge. Using a single-cell enzyme-linked immunospot assay, we sought to determine the loca...

journal_title：Journal of virology

authors： Justewicz DM,Morin MJ,Robinson HL,Webster RG

更新日期：1995-12-01 00:00:00

abstract：:Animals that naturally acquire the prion diseases have a well-developed olfactory sense that they utilize for a variety of basic behaviors. To assess the potential for the nasal cavity to serve as a point of entry for prion diseases, a small amount of prion-infected brain homogenate was placed inferior to the nostrils...

journal_title：Journal of virology

authors： Kincaid AE,Bartz JC

更新日期：2007-05-01 00:00:00

abstract：:Three serial passage series of simian virus 40 (SV40) in CV-1 cells were initiated by infection directly from the same wild-type plaque isolate, three series were initiated by infection with another plaque isolate, and two series were initiated with each of two other plaque isolates. Aberrant SV40 genomes were not det...

journal_title：Journal of virology

authors： Norkin LC,Tirrell SM

更新日期：1982-05-01 00:00:00

abstract：:Autophagy is now known to be an essential component of host innate and adaptive immunity. Several herpesviruses have developed various strategies to evade this antiviral host defense. Herpes simplex virus 1 (HSV-1) blocks autophagy in fibroblasts and in neurons, and the ICP34.5 protein is important for the resistance ...

journal_title：Journal of virology

authors： Lussignol M,Queval C,Bernet-Camard MF,Cotte-Laffitte J,Beau I,Codogno P,Esclatine A

更新日期：2013-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes lifelong infection in the host. Virus persistence is aided by extensive manipulation of the host immune system, particularly cytokine and chemokine signaling pathways. The HCMV UL111A gene encodes cmvIL-10, an ortholog of human interleukin-10 that h...

journal_title：Journal of virology

authors： Tu CC,Arnolds KL,O'Connor CM,Spencer JV

更新日期：2018-02-12 00:00:00