A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.

abstract：:Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside reverse transcriptase (RT...

journal_title：Journal of virology

authors： Pelemans H,Esnouf R,Dunkler A,Parniak MA,Vandamme AM,Karlsson A,De Clercq E,Kleim JP,Balzarini J

更新日期：1997-11-01 00:00:00

abstract：UNLABELLED:The ATR kinase has essential functions in maintenance of genome integrity in response to replication stress. ATR is recruited to RPA-coated single-stranded DNA at DNA damage sites via its interacting partner, ATRIP, which binds to the large subunit of RPA. ATR activation typically leads to activation of the ...

journal_title：Journal of virology

authors： Adeyemi RO,Pintel DJ

更新日期：2014-09-01 00:00:00

abstract：:The rotavirus nonstructural phosphoprotein NSP5 is encoded by a gene in RNA segment 11. Immunofluorescence analysis of fixed cells showed that NSP5 polypeptides remained confined to viroplasms even at a late stage when provirions migrated from these structures. When NSP5 was expressed in COS-7 cells in the absence of ...

journal_title：Journal of virology

authors： Blackhall J,Muñoz M,Fuentes A,Magnusson G

更新日期：1998-08-01 00:00:00

abstract：:In humans, homologous to the E6-AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-like domain-containing protein 5 (HERC5) is an interferon-induced protein that inhibits replication of evolutionarily diverse viruses, including human immunodeficiency virus type 1 (HIV-1). To better understan...

journal_title：Journal of virology

authors： Paparisto E,Woods MW,Coleman MD,Moghadasi SA,Kochar DS,Tom SK,Kohio HP,Gibson RM,Rohringer TJ,Hunt NR,Di Gravio EJ,Zhang JY,Tian M,Gao Y,Arts EJ,Barr SD

更新日期：2018-06-13 00:00:00

abstract：:Many replication events are involved in the influenza A virus life cycle, and they are accomplished by different virus proteins with specific functions. However, because the size of the influenza virus genome is limited, the virus uses different mechanisms to express multiple viral proteins from a single gene segment....

journal_title：Journal of virology

authors： Muramoto Y,Noda T,Kawakami E,Akkina R,Kawaoka Y

更新日期：2013-03-01 00:00:00

abstract：:Recombinant retroviruses containing the trans activator genes of human T-cell leukemia virus (HTLV) type II and human T-cell lymphotropic virus type III were constructed. The trans activator genes tat II and tat III were inserted into the murine retroviral vector pZIPNEOSV(X)1. Recombinant plasmids were transfected in...

journal_title：Journal of virology

authors： Rosen CA,Sodroski JG,Campbell K,Haseltine WA

更新日期：1986-01-01 00:00:00

abstract：:In clinical trials, HIV-1 broadly neutralizing antibodies (bnAbs) effectively lower plasma viremia and delay virus reemergence. The presence of less neutralization-susceptible strains prior to treatment decreases the efficacy of these antibody-based treatments, but neutralization sensitivity often cannot be predicted ...

journal_title：Journal of virology

authors： Registre L,Moreau Y,Ataca ST,Pulukuri S,Henrich TJ,Lin N,Sagar M

更新日期：2020-01-06 00:00:00

abstract：:Genotype 1 hepatitis E viruses (HEVs) are restricted to primate hosts, whereas genotype 3 HEVs predominantly infect swine, in addition to primates. In order to identify possible determinants of the host range, infectious recombinant viruses and chimeras of a genotype 1 isolate and a genotype 3 isolate were compared fo...

journal_title：Journal of virology

authors： Nguyen HT,Shukla P,Torian U,Faulk K,Emerson SU

更新日期：2014-01-01 00:00:00

abstract：:Nevirapine forms the mainstay of our efforts to curtail the pediatric AIDS epidemic through prevention of mother-to-child transmission of HIV-1. A key limitation, however, is the rapid selection of HIV-1 strains resistant to nevirapine following the administration of a single dose. This rapid selection of resistance s...

journal_title：Journal of virology

authors： Gadhamsetty S,Dixit NM

更新日期：2010-10-01 00:00:00

abstract：:Poliovirus infection of HeLa cells results in a rapid inhibition of host protein synthesis by a mechanism that does not affect the translation of poliovirus RNA. It has been suggested that this virus-induced translational control results from inactivation of the cap-binding protein complex, and it has been shown that ...

journal_title：Journal of virology

authors： Lloyd RE,Jense HG,Ehrenfeld E

更新日期：1987-08-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) immediate-early 2 (IE2) transactivator has previously been shown to form intranuclear, dot-like accumulations in association with subnuclear structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10. We recently observed that IE2 can form dot-like structures even ...

journal_title：Journal of virology

authors： Sourvinos G,Tavalai N,Berndt A,Spandidos DA,Stamminger T

更新日期：2007-09-01 00:00:00

abstract：:The roles of the capsid protein (CP) and the CP coding sequence of tobacco etch potyvirus (TEV) in genome amplification were analyzed. A series of frameshift-stop codon mutations that interrupted translation of the CP coding sequence at various positions were introduced into the TEV genome. A series of 3' deletion mut...

journal_title：Journal of virology

authors： Mahajan S,Dolja VV,Carrington JC

更新日期：1996-07-01 00:00:00

abstract：:A widespread porcine epidemic diarrhea virus (PEDV) occurred in southern China during 2010 to 2012. A virulent field PEDV strain, GD-B, was isolated from a sucking piglet suffering from severe diarrhea in Guangdong, China. We sequenced and analyzed the complete genome of strain GD-B, which will promote a better unders...

journal_title：Journal of virology

authors： Luo Y,Zhang J,Deng X,Ye Y,Liao M,Fan H

更新日期：2012-09-01 00:00:00

abstract：:When influenza virus monoclonal antibody-resistant (mar) mutants are selected by incubation in vitro with excess antibody, 90 to 99% of the mutants are not detectable. This observation may be explained by encapsidation of mar mutant RNAs within phenotypically wild-type envelopes. This phenotypic hiding can be revealed...

journal_title：Journal of virology

authors： Valcárcel J,Ortín J

更新日期：1989-09-01 00:00:00

abstract：:We investigated the susceptibilities of Syrian golden hamsters to transmissible spongiform encephalopathy agents from cattle. We report efficient transmission of the L-type atypical bovine spongiform encephalopathy (BSE) agent into hamsters. Importantly, hamsters were also susceptible to the transmissible mink encepha...

journal_title：Journal of virology

authors： Nicot S,Baron T

更新日期：2011-02-01 00:00:00

abstract：:The antiviral effects of nitric oxide (NO) on Japanese encephalitis virus (JEV), a member of the family Flaviviridae, were investigated in this study. In vitro, inhibition of replication of JEV in gamma interferon-activated RAW 264.7 murine macrophages was correlated to cellular NO production. When cocultured with inf...

journal_title：Journal of virology

authors： Lin YL,Huang YL,Ma SH,Yeh CT,Chiou SY,Chen LK,Liao CL

更新日期：1997-07-01 00:00:00

abstract：:Influenza virus nucleoprotein (NP) is associated with the genome RNA, forming ribonucleoprotein cores. To identify the amino acid sequence involved in RNA binding, we performed Northwestern blot analysis with a set of N- and C-terminal deletion mutants of NP produced in Escherichia coli. The RNA binding region has bee...

journal_title：Journal of virology

authors： Kobayashi M,Toyoda T,Adyshev DM,Azuma Y,Ishihama A

更新日期：1994-12-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) infects >90% of the population and establishes a latent infection with asymptomatic episodes of reactivation. However, HHV-6 reactivation is associated with morbidity and sometimes mortality in immunocompromised patients. To date, control of the virus in healthy virus carriers and the failu...

journal_title：Journal of virology

authors： Fastenackels S,Bayard C,Larsen M,Magnier P,Bonnafous P,Seddiki N,Appay V,Gautheret-Dejean A,Sauce D

更新日期：2019-06-14 00:00:00

abstract：:Here, we report a novel porcine circovirus type 2a (PCV2a) strain with 11 nucleotides (nt) inserted in the origin of genome replication (Ori). This is the first report of a PCV2a strain with nucleotide insertion in Ori. Our study will help further epidemiological studies and extend our knowledge of evolutionary charac...

journal_title：Journal of virology

authors： Cai L,Han X,Hu D,Li X,Wang B,Ni J,Zhou Z,Yu X,Zhai X,Tian K

更新日期：2012-06-01 00:00:00

abstract：:Human cytomegalovirus (CMV) is the leading cause of prenatal viral infection. Affected infants may suffer intrauterine growth retardation and serious neurologic impairment. Analysis of spontaneously aborted conceptuses shows that CMV infects the placenta before the embryo or fetus. In the human hemochorial placenta, m...

journal_title：Journal of virology

authors： Fisher S,Genbacev O,Maidji E,Pereira L

更新日期：2000-08-01 00:00:00

abstract：:Purified Kunjin virus was disrupted with sodium dodecyl sulfate, urea, and mercaptoethanol or acetic acid. Electrophoresis on 7.5% polyacrylamide gel separated four proteins of high (120,000), intermediate (65,000) and low (18,000 and 13,000) molecular weights. A "core" particle was obtained by degradation of the viri...

journal_title：Journal of virology

authors： Westaway EG,Reedman BM

更新日期：1969-11-01 00:00:00

abstract：:To investigate the relation between the polyoma tumor-specific transplantation antigen and the virus-coded proteins, mice were immunized by inoculation of a variety of viable polyoma virus mutants and then challenged with polyoma virus-induced tumors. Two classes of early region mutants were used. One class produces a...

journal_title：Journal of virology

authors： Dalianis T,Magnusson G,Ito Y,Klein G

更新日期：1982-09-01 00:00:00

abstract：:It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E prot...

journal_title：Journal of virology

authors： To J,Surya W,Fung TS,Li Y,Verdià-Bàguena C,Queralt-Martin M,Aguilella VM,Liu DX,Torres J

更新日期：2017-02-14 00:00:00

abstract：:In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the...

journal_title：Journal of virology

authors： Takada A,Kuboki N,Okazaki K,Ninomiya A,Tanaka H,Ozaki H,Itamura S,Nishimura H,Enami M,Tashiro M,Shortridge KF,Kida H

更新日期：1999-10-01 00:00:00

abstract：:Upon cell entry, the genomes of herpes simplex virus type 1 (HSV-1) and adenovirus (Ad) associate with distinct nuclear structures termed ND10 or promyelocytic leukemia (PML) nuclear bodies (NBs). PML NB morphology is altered or disrupted by specific viral proteins as replication proceeds. We examined whether adeno-as...

journal_title：Journal of virology

authors： Fraefel C,Bittermann AG,Büeler H,Heid I,Bächi T,Ackermann M

更新日期：2004-01-01 00:00:00

abstract：:Some animal rotaviruses require the presence of sialic acid (SA) on the cell surface to infect the cell. We have isolated variants of rhesus rotavirus (RRV) whose infectivity no longer depends on SA. Both the SA-dependent and -independent interactions of these viruses with the cell are mediated by the virus spike prot...

journal_title：Journal of virology

authors： Zárate S,Espinosa R,Romero P,Méndez E,Arias CF,López S

更新日期：2000-01-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentric Castleman disease (MCD). The KSHV life cycle has two principal gene repertoires, latent and lytic. KSHV viral interleukin-6 (vIL-6), an analog of human ...

journal_title：Journal of virology

authors： Hu D,Wang V,Yang M,Abdullah S,Davis DA,Uldrick TS,Polizzotto MN,Veeranna RP,Pittaluga S,Tosato G,Yarchoan R

更新日期：2015-10-21 00:00:00

abstract：:The ORF3 protein of hepatitis E virus (HEV) is a multifunctional protein important for virus replication. The ORF3 proteins from human, swine, and avian strains of HEV contain a conserved PXXP amino acid motif, resembling either Src homology 3 (SH3) cell signaling interaction motifs or "late domains" involved in host ...

journal_title：Journal of virology

authors： Kenney SP,Pudupakam RS,Huang YW,Pierson FW,LeRoith T,Meng XJ

更新日期：2012-05-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, but no safe and effective RSV vaccine is yet available. For reasons that are not well understood, RSV is only weakly immunogenic, and reinfection occurs throughout life. This has complicated the sea...

journal_title：Journal of virology

authors： Martinez-Sobrido L,Gitiban N,Fernandez-Sesma A,Cros J,Mertz SE,Jewell NA,Hammond S,Flano E,Durbin RK,García-Sastre A,Durbin JE

更新日期：2006-02-01 00:00:00

abstract：:Influenza pandemic preparedness has focused on influenza virus H5 and H7 subtypes. However, it is not possible to predict with certainty which subtype of avian influenza virus will cause the next pandemic, and it is prudent to include other avian influenza virus subtypes in pandemic preparedness efforts. An H6 influen...

journal_title：Journal of virology

authors： Gillim-Ross L,Santos C,Chen Z,Aspelund A,Yang CF,Ye D,Jin H,Kemble G,Subbarao K

更新日期：2008-11-01 00:00:00