Strain-specific barriers against bovine prions in hamsters.

abstract：:There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-cell leukemia virus type I (HTLV-I), although the sequence variation between patients is small compared with that of human immunodeficiency virus type 1. In the present study, we investigated whether naturally occurring amino acid...

journal_title：Journal of virology

authors： Niewiesk S,Daenke S,Parker CE,Taylor G,Weber J,Nightingale S,Bangham CR

更新日期：1995-04-01 00:00:00

abstract：:The NS5A nonstructural protein of hepatitis C virus (HCV) has been shown to inhibit the cellular interferon (IFN)-induced protein kinase R (PKR). PKR mediates the host IFN-induced antiviral response at least in part by inhibiting mRNA translation initiation through phosphorylation of the alpha subunit of eukaryotic in...

journal_title：Journal of virology

authors： He Y,Tan SL,Tareen SU,Vijaysri S,Langland JO,Jacobs BL,Katze MG

更新日期：2001-06-01 00:00:00

abstract：:A coxsackievirus B3 (CB3) isolate adapted to growth in RD cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kDa cell surface molecule expressed on these cells. We now show that this molecule is the complement regulatory protein, decay-accelerating factor (DAF) (CD55). Anti-DAF antibodi...

journal_title：Journal of virology

authors： Bergelson JM,Mohanty JG,Crowell RL,St John NF,Lublin DM,Finberg RW

更新日期：1995-03-01 00:00:00

abstract：:The E1 helicase of papillomaviruses is required for replication of the viral double-stranded DNA genome, in conjunction with cellular factors. DNA replication is initiated at the viral origin by the assembly of E1 monomers into oligomeric complexes that have unwinding activity. In vivo, this process is catalyzed by th...

journal_title：Journal of virology

authors： Titolo S,Brault K,Majewski J,White PW,Archambault J

更新日期：2003-05-01 00:00:00

abstract：:Cytotoxic T-lymphocyte (CTL) responses are crucial for the control of immunodeficiency virus replication. Possible involvement of a dominant single epitope-specific CTL in control of viral replication has recently been indicated in preclinical AIDS vaccine trials, but it has remained unclear if multiple epitope-specif...

journal_title：Journal of virology

authors： Kawada M,Igarashi H,Takeda A,Tsukamoto T,Yamamoto H,Dohki S,Takiguchi M,Matano T

更新日期：2006-02-01 00:00:00

abstract：:The Tax transactivator protein of human T-cell leukemia virus type 1 (HTLV-1) plays a central role in the activation of viral gene expression. In addition, Tax is capable of activating the expression of specific cellular genes and is involved in the transformation of T-lymphocytes resulting in the development of adult...

journal_title：Journal of virology

authors： Bex F,Murphy K,Wattiez R,Burny A,Gaynor RB

更新日期：1999-01-01 00:00:00

abstract：:Several domains of CD4 have been suggested to play a critical role in events that follow its binding to the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120-gp41). It has been reported previously that cells expressing a chimeric molecule consisting of the first 177 residues of human CD4 attache...

journal_title：Journal of virology

authors： Golding H,Blumenthal R,Manischewitz J,Littman DR,Dimitrov DS

更新日期：1993-11-01 00:00:00

abstract：:The feline immunodeficiency virus (FIV) cat model is extensively used to investigate possible vaccination approaches against AIDS in humans. Although consistent levels of protection have been achieved with FIV, as with other model systems, by immunizing with whole inactivated virus or fixed infected cells, the mechani...

journal_title：Journal of virology

authors： Mazzetti P,Giannecchini S,Del Mauro D,Matteucci D,Portincasa P,Merico A,Chezzi C,Bendinelli M

更新日期：1999-01-01 00:00:00

abstract：:Data showing that an apoptotic reaction (the exit into the cytoplasm and nucleolytic internucleosomal degradation of chromosomal DNA, compaction and fragmentation of chromatin, cellular shrinkage, and cytoplasmic blebbing) developed in a subline of HeLa-S3 cells upon nonpermissive poliovirus infection with either a gu...

journal_title：Journal of virology

authors： Tolskaya EA,Romanova LI,Kolesnikova MS,Ivannikova TA,Smirnova EA,Raikhlin NT,Agol VI

更新日期：1995-02-01 00:00:00

abstract：:Levels of the p53 tumor suppressor protein are increased in human cytomegalovirus (HCMV)-infected cells and may be important for HCMV pathogenesis. In normal cells p53 levels are kept low due to an autoregulatory feedback loop where p53 activates the transcription of mdm2 and mdm2 binds and ubiquitinates p53, targetin...

journal_title：Journal of virology

authors： Zhang Z,Evers DL,McCarville JF,Dantonel JC,Huong SM,Huang ES

更新日期：2006-04-01 00:00:00

abstract：:Both CD4(+) and CD8(+) T cells are required for clearance of the murine coronavirus mouse hepatitis virus (MHV) during acute infection. We investigated the effects of an epitope-specific CD8(+) T-cell response on acute infection of MHV, strain A59, in the murine CNS. Mice with CD8(+) T cells specific for gp33-41 (an H...

journal_title：Journal of virology

authors： Chua MM,MacNamara KC,San Mateo L,Shen H,Weiss SR

更新日期：2004-02-01 00:00:00

abstract：:Deer mice are the principal reservoir hosts of Sin Nombre virus, the etiologic agent of most hantavirus cardiopulmonary syndrome cases in North America. Infection of deer mice results in persistence without conspicuous pathology, and most, if not all, infected mice remain infected for life, with periods of viral shedd...

journal_title：Journal of virology

authors： Schountz T,Acuña-Retamar M,Feinstein S,Prescott J,Torres-Perez F,Podell B,Peters S,Ye C,Black WC 4th,Hjelle B

更新日期：2012-09-01 00:00:00

abstract：:Polymerase basic protein 2 (PB2), a component of the influenza virus polymerase complex, when expressed alone from cloned cDNA in the absence of other influenza virus proteins, is transported into the nucleus. In this study, we have examined the nuclear translocation signal of PB2 by making deletions and mutations in ...

journal_title：Journal of virology

authors： Mukaigawa J,Nayak DP

更新日期：1991-01-01 00:00:00

abstract：:The oligosaccharide processing and secretion of hepatitis B surface antigen (HBsAg) was studied in Chinese hamster ovary cells stably transfected with the gene coding HBsAg. HBsAg was secreted from cells with a relatively long half time (ca. 5 h). This appeared to be a characteristic of HBsAg itself, since HBsAg-produ...

journal_title：Journal of virology

authors： Patzer EJ,Nakamura GR,Yaffe A

更新日期：1984-08-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) UL138 protein downregulates the cell surface expression of the multidrug resistance-associated protein 1 (MRP1) transporter. We examined the genetic requirements within UL138 for MRP1 downregulation. We determined that the acidic cluster dileucine motif is essential for UL138-mediated ...

journal_title：Journal of virology

authors： Gelbmann CB,Kalejta RF

更新日期：2019-05-15 00:00:00

abstract：:Both the RNase H domain of Moloney murine leukemia virus (Mo-MLV) reverse transcriptase (RT) and Escherichia coli RNase H possess a positively charged alpha-helix (C helix) and a loop that are not present in the RNase H domains of human immunodeficiency virus (HIV) RT or avian sarcoma virus RT. Although a mutant Mo-ML...

journal_title：Journal of virology

authors： Lim D,Orlova M,Goff SP

更新日期：2002-08-01 00:00:00

abstract：:The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves as the messenger for both core and P proteins, with the downstream P gene translated by ribosomal leaky scanning. HBV replication begins with packaging of the pgRNA and P protein into core protein particles, followed by conversion of RNA into DNA. Genotype G...

journal_title：Journal of virology

authors： Gutelius D,Li J,Wands J,Tong S

更新日期：2011-12-01 00:00:00

abstract：:Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. The results of nucle...

journal_title：Journal of virology

authors： Zulianello L,Kaneko K,Scott M,Erpel S,Han D,Cohen FE,Prusiner SB

更新日期：2000-05-01 00:00:00

abstract：:Picornavirus genomes encode unique 5' noncoding regions (5' NCRs) which are approximately 600 to 1,300 nucleotides in length, contain multiple upstream AUG codons, and display the ability to form extensive secondary structures. A number of recent reports have shown that picornavirus 5' NCRs are able to facilitate cap-...

journal_title：Journal of virology

authors： Dildine SL,Semler BL

更新日期：1992-07-01 00:00:00

abstract：:Translation of early RNA specific for the leftmost early region 1 of adenovirus type 5 DNA in a rabbit reticulocyte cell-free system resulted in the synthesis of proteins with the following molecular weights: 65,000 (65K), 54K, 42 to 34K, 29K, 25K, 19K, and 18K. All of these proteins could be immunoprecipitated with h...

journal_title：Journal of virology

authors： Lupker JH,Davis A,Jochemsen H,van der Eb AJ

更新日期：1981-01-01 00:00:00

abstract：:Endocytosis and endosomal trafficking regulate the proteins targeted to the plasma membrane and play essential roles in diverse cellular processes, including responses to pathogen attack. Here, we report the identification of Glycine max (soybean) endocytosis dynamin-like protein 5A (GmSDL5A) associated with purified ...

journal_title：Journal of virology

authors： Wu G,Cui X,Chen H,Renaud JB,Yu K,Chen X,Wang A

更新日期：2018-11-12 00:00:00

abstract：UNLABELLED:MicroRNAs (miRNAs) are single-stranded small RNA molecules that regulate various cellular processes. miRNA 155 (miR-155) regulates various aspects of innate and adaptive immune responses and plays a key role in various viral infections and the resulting neuroinflammation. The present study evaluated the invo...

journal_title：Journal of virology

authors： Thounaojam MC,Kundu K,Kaushik DK,Swaroop S,Mahadevan A,Shankar SK,Basu A

更新日期：2014-05-01 00:00:00

abstract：:Ebola virus (EBOV) causes severe hemorrhagic fever, for which therapeutic options are not available. Preventing the entry of EBOV into host cells is an attractive antiviral strategy, which has been validated for HIV by the FDA approval of the anti-HIV drug enfuvirtide. To identify inhibitors of EBOV entry, the EBOV en...

journal_title：Journal of virology

authors： Basu A,Li B,Mills DM,Panchal RG,Cardinale SC,Butler MM,Peet NP,Majgier-Baranowska H,Williams JD,Patel I,Moir DT,Bavari S,Ray R,Farzan MR,Rong L,Bowlin TL

更新日期：2011-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) pathogenesis is dependent on the hematogenous spread of the virus to host tissue. While data suggest that infected monocytes are required for viral dissemination from the blood to the host organs, infected endothelial cells are also thought to contribute to this key step in viral pathogene...

journal_title：Journal of virology

authors： Bentz GL,Jarquin-Pardo M,Chan G,Smith MS,Sinzger C,Yurochko AD

更新日期：2006-12-01 00:00:00

abstract：:While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of...

journal_title：Journal of virology

authors： Denkers ND,Hayes-Klug J,Anderson KR,Seelig DM,Haley NJ,Dahmes SJ,Osborn DA,Miller KV,Warren RJ,Mathiason CK,Hoover EA

更新日期：2013-02-01 00:00:00

abstract：:Initiation of the Epstein-Barr virus (EBV) lytic cycle is dependent on expression of the viral transactivator Zta, which is encoded by the BZLF1 gene. Described here is an initial mapping of the regions of Zta involved in activating transcription. The data indicate that the amino-terminal 153 amino acids of Zta are im...

journal_title：Journal of virology

authors： Flemington EK,Borras AM,Lytle JP,Speck SH

更新日期：1992-02-01 00:00:00

abstract：:In order to study primate lentivirus evolution in the Colobinae subfamily, in which only one simian immunodeficiency virus (SIV) has been described to date, we screened additional species from the three different genera of African colobus monkeys for SIV infection. Blood was obtained from 13 West African colobids, and...

journal_title：Journal of virology

authors： Courgnaud V,Formenty P,Akoua-Koffi C,Noe R,Boesch C,Delaporte E,Peeters M

更新日期：2003-01-01 00:00:00

abstract：:We report the discovery and analysis of an endogenous foamy virus (PSFVaye) within the genome of the aye-aye (Daubentonia madagascariensis), a strepsirrhine primate from Madagascar. Phylogenetic analyses indicate that PSFVaye is divergent from all known simian foamy viruses, suggesting an association between foamy vir...

journal_title：Journal of virology

authors： Han GZ,Worobey M

更新日期：2012-07-01 00:00:00

abstract：:An adult horse infected with a virulent, cell culture-adapted strain of equine infectious anemia virus (EIAV) developed cyclical thrombocytopenia in which the nadir of platelet counts coincided with peak febrile responses. In order to investigate the mechanism of thrombocytopenia during acute febrile episodes, four ad...

journal_title：Journal of virology

authors： Clabough DL,Gebhard D,Flaherty MT,Whetter LE,Perry ST,Coggins L,Fuller FJ

更新日期：1991-11-01 00:00:00

abstract：:Recently it has been shown that kaposica, an immune evasion protein of Kaposi's sarcoma-associated herpesvirus, inactivates complement by acting on C3-convertases by accelerating their decay as well as by acting as a cofactor in factor I-mediated inactivation of their subunits C3b and C4b. Here, we have mapped the fun...

journal_title：Journal of virology

authors： Mullick J,Singh AK,Panse Y,Yadav V,Bernet J,Sahu A

更新日期：2005-05-01 00:00:00