Involvement of multiple epitope-specific cytotoxic T-lymphocyte responses in vaccine-based control of simian immunodeficiency virus replication in rhesus macaques.

abstract：:The relative contribution of measles virus hemagglutinin (H)- or fusion protein (F)-specific antibodies to virus neutralization (VN) has not been demonstrated. We have depleted these specific antibodies from sera collected from young adults, who had been vaccinated during childhood, by prolonged incubation with viable...

journal_title：Journal of virology

authors： de Swart RL,Yüksel S,Osterhaus AD

更新日期：2005-09-01 00:00:00

abstract：:Several different forms of progeny viral DNA can be identified in polyoma virus (Py)-infected mouse L-cells. The majority comprise mature form I superhelical DNA and the circular, double-stranded "theta" replicating intermediates in which the progeny DNA strands never exceed the unit genome length of the template. The...

journal_title：Journal of virology

authors： Ganz PR,Sheinin R

更新日期：1983-06-01 00:00:00

abstract：:Identification of cell surface viral binding proteins is important for understanding viral attachment and internalization. We have fused the pre-S domain of the duck hepatitis B virus (DHBV) large envelope protein to glutathione S-transferase and demonstrated a 170-kDa binding protein (p170) in [35S]methionine-labeled...

journal_title：Journal of virology

authors： Tong S,Li J,Wands JR

更新日期：1995-11-01 00:00:00

abstract：:Rabies, caused by rabies virus (RABV), is a fatal encephalitis in humans and other mammals, which continues to present a public health threat in most parts of the world. Our previous study demonstrated that Toll-like receptor 7 (TLR7) is essential in the induction of anti-RABV antibodies via the facilitation of germin...

journal_title：Journal of virology

authors： Luo Z,Lv L,Li Y,Sui B,Wu Q,Zhang Y,Pei J,Li M,Zhou M,Hooper DC,Fu ZF,Zhao L

更新日期：2020-04-16 00:00:00

abstract：:We characterized a number of important features of the structure of the cohesive overlap region of the DNA genome of duck hepatitis B virus. The 5'-terminal nucleotide of minus-strand DNA was localized to nucleotide 2537, a G residue within the 12-base repeat sequence DR1. This G residue was shown to be the site of a ...

journal_title：Journal of virology

authors： Lien JM,Petcu DJ,Aldrich CE,Mason WS

更新日期：1987-12-01 00:00:00

abstract：:The phenomenon of prion strains with distinct biological characteristics has been hypothesized to be involved in the structural diversity of abnormal prion protein (PrP(Sc)). However, the molecular basis of the transmission of strain properties remains poorly understood. Real-time quaking-induced conversion (RT-QUIC) ...

journal_title：Journal of virology

authors： Sano K,Atarashi R,Ishibashi D,Nakagaki T,Satoh K,Nishida N

更新日期：2014-10-01 00:00:00

abstract：:Recently, novel arenaviruses were found in snakes with boid inclusion body disease (BIBD); these form the new genus Reptarenavirus within the family Arenaviridae. We used next-generation sequencing and de novo sequence assembly to investigate reptarenavirus isolates from our previous study. Four of the six isolates an...

journal_title：Journal of virology

authors： Hepojoki J,Salmenperä P,Sironen T,Hetzel U,Korzyukov Y,Kipar A,Vapalahti O

更新日期：2015-08-01 00:00:00

abstract：:The phenotypic defects of two mutants of vaccinia virus, the lesions of which map to gene G2R, were characterized in vivo, and the results suggest a role for the G2R protein in viral transcription elongation. Both a temperature-sensitive mutant, Cts56, and an isatin-beta-thiosemicarbazone-dependent deletion mutant, G2...

journal_title：Journal of virology

authors： Black EP,Condit RC

更新日期：1996-01-01 00:00:00

abstract：UNLABELLED:Of the various genetic subtypes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), only in subtype C of HIV-1 is a genetically variant NF-κB binding site found at the core of the viral promoter in association with a subtype-specific Sp1III motif. How the ...

journal_title：Journal of virology

authors： Verma A,Rajagopalan P,Lotke R,Varghese R,Selvam D,Kundu TK,Ranga U

更新日期：2016-07-27 00:00:00

abstract：:Several domains of CD4 have been suggested to play a critical role in events that follow its binding to the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120-gp41). It has been reported previously that cells expressing a chimeric molecule consisting of the first 177 residues of human CD4 attache...

journal_title：Journal of virology

authors： Golding H,Blumenthal R,Manischewitz J,Littman DR,Dimitrov DS

更新日期：1993-11-01 00:00:00

abstract：:Mucosal surfaces are the primary portals for human immunodeficiency virus (HIV) transmission. Because systemic immunization, in general, does not induce effective mucosal immune responses, a mucosal HIV vaccine is urgently needed. For this study, we developed papillomavirus pseudoviruses that express HIV-1 Gag. The ps...

journal_title：Journal of virology

authors： Zhang H,Fayad R,Wang X,Quinn D,Qiao L

更新日期：2004-10-01 00:00:00

abstract：:Monoclonal antibodies to varicella-zoster virus were used to study viral glycoproteins by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Based on the viral glycoproteins immunoprecipitated, the five monoclonal antibodies fell into three groups. Two antibodies, 4B7 and 8G9 (group 1),...

journal_title：Journal of virology

authors： Forghani B,Dupuis KW,Schmidt NJ

更新日期：1984-10-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) specifically incorporates the host cell peptidyl-prolyl isomerase cyclophilin A into virions via contacts with the capsid (CA) domain of the Gag polyprotein Pr55gag. The immunosuppressant drug cyclosporin A and the nonimmunosuppressive cyclosporin A analog SDZ NIM 811 bind t...

journal_title：Journal of virology

authors： Dorfman T,Göttlinger HG

更新日期：1996-09-01 00:00:00

abstract：:Polyamine depletion produced by exogenous arginine in Escherichia coliK-12 cultures defective in agmatine ureohydrolase activity resulted in a marked inhibition of the rates of growth and nucleic acid synthesis. Addition of putrescine or spermidine to such depleted cultures restored the control rate of growth and nucl...

journal_title：Journal of virology

authors： Dion AS,Cohen SS

更新日期：1972-03-01 00:00:00

abstract：:Cytotoxic CD8+ T lymphocytes (CTL) directed against the matrix protein pp65 are major effectors in controlling infection against human cytomegalovirus (HCMV), a persistent virus of the Betaherpesvirus family. We previously suggested that cross-presentation of pp65 by nonpermissive dendritic cells (DCs) could overcome ...

journal_title：Journal of virology

authors： Arrode G,Boccaccio C,Abastado JP,Davrinche C

更新日期：2002-01-01 00:00:00

abstract：:The Birnaviridae family, responsible for major economic losses to poultry and aquaculture, is composed of nonenveloped viruses with a segmented double-stranded RNA (dsRNA) genome that replicate in discrete cytoplasmic virus factories (VFs). Reassortment is common; however, the underlying mechanism remains unknown give...

journal_title：Journal of virology

authors： Campbell EA,Reddy VRAP,Gray AG,Wells J,Simpson J,Skinner MA,Hawes PC,Broadbent AJ

更新日期：2020-06-16 00:00:00

abstract：UNLABELLED:Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients, underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular microRNAs (miRNAs) in cells that promote latency to regulate exp...

journal_title：Journal of virology

authors： O'Connor CM,Vanicek J,Murphy EA

更新日期：2014-05-01 00:00:00

abstract：:The intracellular assembly site for flaviviruses in currently not known but is presumed to be located within the lumen of the rough endoplasmic reticulum (RER). Building on previous studies involving immunofluorescence (IF) and cryoimmunoelectron microscopy of Kunjin virus (KUN)-infected cells, we sought to identify t...

journal_title：Journal of virology

authors： Mackenzie JM,Westaway EG

更新日期：2001-11-01 00:00:00

abstract：:Previous studies have suggested that coxsackievirus B (CVB) activates CD8(+) T cells in vivo, but the extent of this activation and the antigen specificity of the CD8(+) T cells remain uncertain. Furthermore, CVB-induced CD4(+) T-cell responses have not been carefully investigated. Herein, we evaluate CD8(+) and CD4(+...

journal_title：Journal of virology

authors： Kemball CC,Harkins S,Whitton JL

更新日期：2008-05-01 00:00:00

abstract：:Gene therapy is proposed as a novel therapeutic strategy for treating glioblastoma multiforme (GBM), a devastating brain cancer. In the clinic, antivector immune responses pose formidable challenges. Herein we demonstrate that high-capacity adenovirus vectors (HC-Ads) carrying the conditional cytotoxic gene herpes sim...

journal_title：Journal of virology

authors： King GD,Muhammad AK,Xiong W,Kroeger KM,Puntel M,Larocque D,Palmer D,Ng P,Lowenstein PR,Castro MG

更新日期：2008-05-01 00:00:00

abstract：:The active site serine of the acetylesterase of influenza C virus was localized to amino acid 71 of the hemagglutinin-esterase protein by affinity labeling with 3H-labeled diisopropylfluorophosphate. This serine and the adjacent amino acids (Phe-Gly-Asp-Ser) are part of a consensus sequence motif found in serine hydro...

journal_title：Journal of virology

authors： Vlasak R,Muster T,Lauro AM,Powers JC,Palese P

更新日期：1989-05-01 00:00:00

abstract：:West Nile virus (WNV), currently the cause of a serious U.S. epidemic, is a mosquito-borne flavivirus and member of the Japanese encephalitis (JE) serocomplex. There is currently no approved human WNV vaccine, and treatment options remain limited, resulting in significant mortality and morbidity from human infection. ...

journal_title：Journal of virology

authors： Petrovsky N,Larena M,Siddharthan V,Prow NA,Hall RA,Lobigs M,Morrey J

更新日期：2013-09-01 00:00:00

abstract：:Passive transfer of neutralizing antibodies is effective in protecting rhesus macaques against simian/human immunodeficiency virus (SHIV) challenge. In addition to neutralization, effector functions of the crystallizable fragment (Fc) of antibodies are involved in antibody-mediated protection against a number of virus...

journal_title：Journal of virology

authors： Moldt B,Schultz N,Dunlop DC,Alpert MD,Harvey JD,Evans DT,Poignard P,Hessell AJ,Burton DR

更新日期：2011-10-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68) provides an important experimental model for understanding mechanisms of immune control of the latent human gammaherpesviruses. Antiviral CD8 T cells play a key role throughout three separate phases of the infection: clearance of lytic virus, control of the latency amplification ...

journal_title：Journal of virology

authors： Freeman ML,Lanzer KG,Cookenham T,Peters B,Sidney J,Wu TT,Sun R,Woodland DL,Sette A,Blackman MA

更新日期：2010-03-01 00:00:00

abstract：:Neurons of the sensory ganglia are the major site of varicella-zoster virus (VZV) latency and may undergo productive infection during reactivation. Although the VZV glycoprotein E/glycoprotein I (gE/gI) complex is known to be critical for neurovirulence, few studies have assessed the roles of these proteins during inf...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2013-12-01 00:00:00

abstract：:In vitro studies have suggested an important role for the minor capsid protein (VP1) unique region and the junction between VP1 and the major capsid protein (VP2) in the neutralizing immune response to B19 parvovirus. We investigated the role of the NH2-terminal region of the major structural protein in capsid structu...

journal_title：Journal of virology

authors： Kawase M,Momoeda M,Young NS,Kajigaya S

更新日期：1995-10-01 00:00:00

abstract：:2G12 is a broadly neutralizing anti-HIV-1 monoclonal human IgG1 antibody reactive with a high-mannose glycan cluster on the surface of glycoprotein gp120. A key feature of this very highly mutated antibody is domain exchange of the heavy-chain variable region (V(H)) with the V(H) of the adjacent Fab of the same immuno...

journal_title：Journal of virology

authors： Huber M,Le KM,Doores KJ,Fulton Z,Stanfield RL,Wilson IA,Burton DR

更新日期：2010-10-01 00:00:00

abstract：:Infection of cells with herpes simplex virus type 1 (HSV-1) results in a rapid alteration of phosphorylation on the large subunit of cellular RNA polymerase II (RNAP II), most likely on its C-terminal domain (S. A. Rice, M. C. Long, V. Lam, C. A. Spencer, J. Virol. 68:988-1001, 1994). This phosphorylation modification...

journal_title：Journal of virology

authors： Rice SA,Long MC,Lam V,Schaffer PA,Spencer CA

更新日期：1995-09-01 00:00:00

abstract：:Transient lymphopenia is a hallmark of measles virus (MV)-induced immunosuppression. To address to what extent replenishment of the peripheral lymphocyte compartment from bone marrow (BM) progenitor/stem cells might be affected, we analyzed the interaction of wild-type MV with hematopoietic stem and progenitor cells (...

journal_title：Journal of virology

authors： Boussaad I,Varagnolo L,Hornich V,Rieger L,Krockenberger M,Stuehmer T,Kranzfelder D,Mueller AM,Schneider-Schaulies S

更新日期：2011-08-01 00:00:00

abstract：:To analyze the proposed growth-inhibitory function of wild-type p53, we compared simian virus 40 (SV40) DNA replication in primary rhesus monkey kidney (PRK) cells, which express wild-type p53, and in the established rhesus monkey kidney cell line LLC-MK2, which expresses a mutated p53 that does not complex with large...

journal_title：Journal of virology

authors： von der Weth A,Deppert W

更新日期：1993-02-01 00:00:00