Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralization.

Abstract:

:The relative contribution of measles virus hemagglutinin (H)- or fusion protein (F)-specific antibodies to virus neutralization (VN) has not been demonstrated. We have depleted these specific antibodies from sera collected from young adults, who had been vaccinated during childhood, by prolonged incubation with viable transfected human melanoma cells expressing H or F. Simultaneous depletion of antibodies of both specificities completely abrogated VN activity. Depletion of F-specific antibodies only had a minimal effect, whereas removal of H-specific antibodies resulted in almost complete reduction of VN activity. These results demonstrate that measles virus neutralizing antibodies are mainly directed to the H protein.

journal_name

J Virol

journal_title

Journal of virology

authors

de Swart RL,Yüksel S,Osterhaus AD

doi

10.1128/JVI.79.17.11547-11551.2005

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

11547-51

issue

17

eissn

0022-538X

issn

1098-5514

pii

79/17/11547

journal_volume

79

pub_type

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