Varicella-zoster viral glycoproteins analyzed with monoclonal antibodies.

abstract：:The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Rorgamma isoforms in >77% of the tumors tested may complement apoptotic effects of c-myc overexpression. ...

journal_title：Journal of virology

authors： Broussard DR,Lozano MM,Dudley JP

更新日期：2004-05-01 00:00:00

abstract：:Particular interest in human T lymphocyte lymphoma/leukemia virus (HTLV) derives from the close association of HTLV with several types of human mature T lymphocyte malignancies and the strong possibility that HTLV is the causative agent of this group of leukemias and lymphomas. This is the first report to show that HT...

journal_title：Journal of virology

authors： Moore JL,Poiesz BJ,Zamkoff KW,Merl SA,Hanna S,Gazdar AF,Comis RL

更新日期：1985-02-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) BMRF1 protein is a DNA polymerase processivity factor. We have deleted the BMRF1 open reading frame from the EBV genome and assessed the DeltaBMRF1 EBV phenotype. DeltaBMRF1 viruses were replication deficient, but the wild-type phenotype could be restored by BMRF1 trans-complementation. Th...

journal_title：Journal of virology

authors： Neuhierl B,Delecluse HJ

更新日期：2006-05-01 00:00:00

abstract：:cis-Acting elements in the viral genome RNA (vRNA) are essential for the translation, replication, and/or encapsidation of RNA viruses. In this study, a novel conserved cis-acting element was identified in the capsid-coding region of mosquito-borne flavivirus. The downstream of 5' cyclization sequence (5'CS) pseudokno...

journal_title：Journal of virology

authors： Liu ZY,Li XF,Jiang T,Deng YQ,Zhao H,Wang HJ,Ye Q,Zhu SY,Qiu Y,Zhou X,Qin ED,Qin CF

更新日期：2013-06-01 00:00:00

abstract：:Viral particles infecting some stocks of the protozoan parasite Leishmania braziliensis subsp. guyanensis contain a double-stranded RNA genome of ca. 5 kbp and are associated with an RNA-dependent RNA polymerase which synthesizes in vitro double-stranded and single-stranded, genome-length transcripts. The majority of ...

journal_title：Journal of virology

authors： Widmer G,Patterson JL

更新日期：1991-08-01 00:00:00

abstract：:With the aid of three monoclonal antibodies (MAbs), a glycoprotein specifically localized to the outer envelope of vaccinia virus was shown to be encoded by the A33R gene. These MAbs reacted with a glycosylated protein that migrated as 23- to 28-kDa and 55-kDa species under reducing and nonreducing conditions, respect...

journal_title：Journal of virology

authors： Roper RL,Payne LG,Moss B

更新日期：1996-06-01 00:00:00

abstract：:Alkylation of T7 bacteriophage by methyl methane sulfonate blocked superinfection exclusion. This blockage could be correlated with a delay in the synthesis of phage-specific proteins. Therefore we conclude that protein synthesis directed by the primary infecting phage is required for efficient exclusion of superinfec...

journal_title：Journal of virology

authors： Karska-Wysocki B,Racine JF,Mamet-Bratley MD

更新日期：1982-11-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an essential regulatory protein that localizes to the nuclei of infected cells. The strong nuclear localization signal (NLS) of ICP27 was identified recently and shown to reside in the amino-terminal portion of the polypeptide from residues 110 t...

journal_title：Journal of virology

authors： Hibbard MK,Sandri-Goldin RM

更新日期：1995-08-01 00:00:00

abstract：:Waterfowl are the natural reservoir of all influenza A viruses, which are usually nonpathogenic in wild aquatic birds. However, in late 2002, outbreaks of highly pathogenic H5N1 influenza virus caused deaths among wild migratory birds and resident waterfowl, including ducks, in two Hong Kong parks. In February 2003, a...

journal_title：Journal of virology

authors： Sturm-Ramirez KM,Ellis T,Bousfield B,Bissett L,Dyrting K,Rehg JE,Poon L,Guan Y,Peiris M,Webster RG

更新日期：2004-05-01 00:00:00

abstract：:Tryptic digests of the internal proteins p30, p15, p12, and p10 of mouse xenotropic, ecotropic, and amphotropic type C viruses were subjected to cation-exchange chromatography. Analysis of these maps revealed that the p30 proteins from representative isolates of all three viral subgroups were distinguishable. The p15 ...

journal_title：Journal of virology

authors： Albino A,Korngold L,Mellors RC

更新日期：1979-01-01 00:00:00

abstract：:Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essenti...

journal_title：Journal of virology

authors： Moffat J,Ito H,Sommer M,Taylor S,Arvin AM

更新日期：2002-08-01 00:00:00

abstract：:Hepatitis A virus (HAV) 3C proteinase expressed in Escherichia coli was purified to homogeneity, and its cleavage specificity towards various parts of the viral polyprotein was analyzed. Intermolecular cleavage of the P2-P3 domain of the HAV polyprotein gave rise to proteins 2A, 2B, 2C, 3ABC, and 3D, suggesting that i...

journal_title：Journal of virology

authors： Schultheiss T,Sommergruber W,Kusov Y,Gauss-Müller V

更新日期：1995-03-01 00:00:00

abstract：:Synthesis of cytoplasmic viral RNA was studied during infection of cultured human (KB) cells with adenovirus 2. At 6 h, before viral DNA synthesis began 5% of the poly(A)-containing RNA hybridized to viral DNA; by 12 h and at later times more than 80% was virus specified. At 18 h after infection, four major size class...

journal_title：Journal of virology

authors： Tal J,Craig EA,Raskas HJ

更新日期：1975-01-01 00:00:00

abstract：:Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally due to antibodies directed toward a hypervariable region of gp120 between cysteine residues 302 and 337 and is virus isol...

journal_title：Journal of virology

authors： Skinner MA,Langlois AJ,McDanal CB,McDougal JS,Bolognesi DP,Matthews TJ

更新日期：1988-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) transactivates EBV genes in latently infected B cells. We have shown that mitotic hyperphosphorylation of EBNA2 suppresses its ability to transactivate the latent membrane protein 1 (LMP1) promoter. In this follow-up study, we identify EBNA2 Ser243 as a phosphorylatio...

journal_title：Journal of virology

authors： Yue W,Shackelford J,Pagano JS

更新日期：2006-02-01 00:00:00

abstract：:Recently, it was demonstrated that the coxsackievirus B3 variant PD (CVB3 PD) is able to infect coxsackievirus-adenovirus receptor (CAR)-lacking cells by using heparan sulfates (HS) as additional receptors (A. E. Zautner, U. Korner, A. Henke, C. Badorff, and M. Schmidtke, J. Virol. 77:10071-10077, 2003). For this stud...

journal_title：Journal of virology

authors： Zautner AE,Jahn B,Hammerschmidt E,Wutzler P,Schmidtke M

更新日期：2006-07-01 00:00:00

abstract：UNLABELLED:Increasing data suggest that NK cells can mediate antiviral activity in HIV-1-infected humans, and as such, novel approaches harnessing the anti-HIV-1 function of both T cells and NK cells represent attractive options to improve future HIV-1 immunotherapies. Chronic progressive HIV-1 infection has been assoc...

journal_title：Journal of virology

authors： Jost S,Tomezsko PJ,Rands K,Toth I,Lichterfeld M,Gandhi RT,Altfeld M

更新日期：2014-08-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect keratinocytes and induce proliferative lesions. In infected cells, viral gene products alter the activities of cellular proteins, such as Rb and p53, resulting in altered cell cycle response. It is likely that HPV gene products also alter expression of cellular genes. In this study...

journal_title：Journal of virology

authors： Chang YE,Laimins LA

更新日期：2000-05-01 00:00:00

abstract：:Using a method for freeze-drying intact cells, uninfected and murine leukemia virus (MuLV)-infected JLSV9 cell surfaces, as well as murine mammary tumor virus (MuMTV)-infected cell surfaces, were examined by electron microscopy. The 10-nm knobs of MuLV and the 5-nm spikes of MuMTV were clearly revealed on the surfaces...

journal_title：Journal of virology

authors： Demsey A,Kawka D,Stackpole CW

更新日期：1977-01-01 00:00:00

abstract：:Poliovirus infection of HeLa cells results in a rapid inhibition of host protein synthesis by a mechanism that does not affect the translation of poliovirus RNA. It has been suggested that this virus-induced translational control results from inactivation of the cap-binding protein complex, and it has been shown that ...

journal_title：Journal of virology

authors： Lloyd RE,Jense HG,Ehrenfeld E

更新日期：1987-08-01 00:00:00

abstract：:A covalently closed circular form of unintegrated viral DNA obtained from NIH 3T3 cells freshly infected with Moloney murine leukemia virus (M-MLV) and a port of the endogenous M-MLV from the BALB/Mo mouse strain have been cloned in bacteriophage lambda. The unintegrated viral DNA was cleaved with restriction endonucl...

journal_title：Journal of virology

authors： Berns AJ,Lai MH,Bosselman RA,McKennett MA,Bacheler LT,Fan H,Maandag EC,van der Putten HV,Verma IM

更新日期：1980-10-01 00:00:00

abstract：:A herpes simplex virus type 1 (HSV-1) strain, B3, was found to have a short duplication on the left junction between the unique sequence (US) and the inverted repeat sequence (RS) in the S component of the genome DNA. A short region of RS contiguous to the left US-RS junction was duplicated in B3. Based on the nucleot...

journal_title：Journal of virology

authors： Umene K

更新日期：1989-05-01 00:00:00

abstract：:Inbred LSH hamster brain cells were transformed in vitro by the GS strain of BK virus (BKV), and transplantable tumors classified as undifferentiated glioblastomas were induced in the syngeneic host. The viral status in the transformed cells, designated LSH-BR-BK, was established. About 46 genome equivalents per cell ...

journal_title：Journal of virology

authors： Beth E,Giraldo G,Schmidt-Ullrich R,Pater MM,Pater A,di Mayorca G

更新日期：1981-10-01 00:00:00

abstract：UNLABELLED:The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use to prevent or to treat HIV-1 infection. Due to the antigenically diverse nature of the HIV-1 envelope (Env), no single antibody is highly active against all viral strains. ...

journal_title：Journal of virology

authors： Asokan M,Rudicell RS,Louder M,McKee K,O'Dell S,Stewart-Jones G,Wang K,Xu L,Chen X,Choe M,Chuang G,Georgiev IS,Joyce MG,Kirys T,Ko S,Pegu A,Shi W,Todd JP,Yang Z,Bailer RT,Rao S,Kwong PD,Nabel GJ,Mascola JR

更新日期：2015-12-01 00:00:00

abstract：:The susceptibility to tumors induced by raf and raf/myc retroviruses was investigated in BALB/c, C57BL/6, (BALB/c x C57BL/6)F1 and (BALB/c x C57BL/6) backcross mice. Newborn mice were susceptible to neoplasms generated by both viruses, but resistance to raf-induced leukemia developed rapidly in all mice as they mature...

journal_title：Journal of virology

authors： Klinken SP,Hartley JW,Fredrickson TN,Rapp UR,Morse HC 3rd

更新日期：1989-05-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 E6 (16E6) is an oncogenic, multifunctional nuclear protein that induces p53 degradation and perturbs normal cell cycle control, leading to immortalization and transformation of infected keratinocytes and epithelial cells. Although it is unclear how 16E6 disrupts the epigenetic profil...

journal_title：Journal of virology

authors： Tao M,Kruhlak M,Xia S,Androphy E,Zheng ZM

更新日期：2003-12-01 00:00:00

abstract：:The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and consequent activatio...

journal_title：Journal of virology

authors： Beretta L,Svitkin YV,Sonenberg N

更新日期：1996-12-01 00:00:00

abstract：:Extracellular murine leukemia virus (MLV) reverse transcriptase activity was decreased by interferon treatment in four interferon-sensitive mouse cell lines which were chronic MLV producers. In three cell lines which were relatively insensitive to interferon, extracellular enzyme activity remained unchanged by interfe...

journal_title：Journal of virology

authors： Friedman RM,Chang EH,Ramseur JM,Myers MW

更新日期：1975-09-01 00:00:00

abstract：:Two virus-specific species of newly synthesized DNA were isolated from rat fibroblast cell cultures infected with the Kilham rat virus (RV). These two DNA species were purified; their behavior on hydroxyapatite chromatography and their sedimentation coefficients in sucrose gradients were determined. One of the two spe...

journal_title：Journal of virology

authors： Gunther M,May P

更新日期：1976-10-01 00:00:00

abstract：:Recombinant Epstein-Barr viruses (EBV) with a translation termination codon mutation inserted into the nuclear protein 3A (EBNA-3A) or 3C (EBNA-3C) open reading frame were generated by second-site homologous recombination. These mutant viruses were used to infect primary B lymphocytes to assess the requirement of EBNA...

journal_title：Journal of virology

authors： Tomkinson B,Robertson E,Kieff E

更新日期：1993-04-01 00:00:00