The Epstein-Barr virus BMRF1 gene is essential for lytic virus replication.

abstract：:RNA silencing is a potent means of antiviral defense in plants and animals. A hallmark of this defense response is the production of 21- to 24-nucleotide viral small RNAs via mechanisms that remain to be fully understood. Many viruses encode suppressors of RNA silencing, and some viral RNAs function directly as silenc...

journal_title：Journal of virology

authors： Itaya A,Zhong X,Bundschuh R,Qi Y,Wang Y,Takeda R,Harris AR,Molina C,Nelson RS,Ding B

更新日期：2007-03-01 00:00:00

abstract：:Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) transforms human T cells in vitro, and Tax, a potent transactivator of viral and cellular genes, plays a key role in cell immortalization. Tax activity is mediated by interaction with cellular transcription factors including members of the CREB/ATF family, the N...

journal_title：Journal of virology

authors： Mulloy JC,Kislyakova T,Cereseto A,Casareto L,LoMonico A,Fullen J,Lorenzi MV,Cara A,Nicot C,Giam C,Franchini G

更新日期：1998-11-01 00:00:00

abstract：:The two canine adenoviruses, infectious canine hepatitis (ICH) virus and infectious canine laryngotracheitis (ICL) virus (also designated as Toronto A26/61 virus), were studied with respect to their morphology and the biological properties of their soluble components. The two viruses were found to be composed of solub...

journal_title：Journal of virology

authors： Marusyk RG,Norrby E,Lundqvist U

更新日期：1970-04-01 00:00:00

abstract：:The P4 promoter of the parvovirus minute virus of mice contains a single degenerate GC box sequence which binds the transcription factor Sp1 with high affinity. The two promoters of murine Sp1 were affinity purified, and their interactions with the P4 promoter were examined. Several unusual features were observed. Met...

journal_title：Journal of virology

authors： Pitluk ZW,Ward DC

更新日期：1991-12-01 00:00:00

abstract：:The neutralizing activities of polyclonal antibodies and monoclonal antibodies (MAbs) obtained by immunization of mice with L1 virus-like particles (VLPs) were investigated by using pseudovirion infectivity assays for human papillomavirus type 16 (HPV-16), HPV-31, HPV-33, HPV-45, HPV-58, and HPV-59 to obtain a better ...

journal_title：Journal of virology

authors： Combita AL,Touzé A,Bousarghin L,Christensen ND,Coursaget P

更新日期：2002-07-01 00:00:00

abstract：:A recombinant adenovirus was constructed by inserting the human immunodeficiency virus type 1 (HIV-1) envelope gene downstream from the early region 3 (E3) promoter of adenovirus type 5 (Ad5), replacing the coding sequences of E3. The recombinant virus replicated as efficiently as the parent virus in all cell lines te...

journal_title：Journal of virology

authors： Dewar RL,Natarajan V,Vasudevachari MB,Salzman NP

更新日期：1989-01-01 00:00:00

abstract：:A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 vir...

journal_title：Journal of virology

authors： Hellman A,Peebles PT,Strickland JE,Fowler AK,Kalter SS,Oroszlan KS,Gilden RV

更新日期：1974-07-01 00:00:00

abstract：:Striking morphologic similarities between Machupo, Tacaribe, and lymphocytic choriomeningitis viruses were found by thin-section electron microscopy. It is proposed that these viruses be brought together into a single taxonomic group. ...

journal_title：Journal of virology

authors： Murphy FA,Webb PA,Johnson KM,Whitfield SG

更新日期：1969-10-01 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus (HeV) are emerging zoonotic viruses and the causative agents of severe respiratory disease and encephalitis in humans. Little is known about the mechanisms that govern the development of respiratory and neurological disease. Using a hamster model of lethal NiV and HeV infection, we d...

journal_title：Journal of virology

authors： Rockx B,Brining D,Kramer J,Callison J,Ebihara H,Mansfield K,Feldmann H

更新日期：2011-08-01 00:00:00

abstract：:Specific cleavage of BK virus (MM) DNA with restriction endonuclease MboI gives rise to 10 fragments. Two techniques were used to determine the location of these fragments on the viral genome with respect to the three known sites for HindIII cleavage. In the first method, reciprocal digestion, individual MboI fragment...

journal_title：Journal of virology

authors： Yang RC,Wu R

更新日期：1978-09-01 00:00:00

abstract：:Type C RNA virus(es) was readily released from primary lymphosarcoma cell cultures of WH/J rabbits after induction with halogenated pyrimidines. The virus contained an RNA-directed DNA polymerase and the p30 structural protein. The rabbit virus RNA-directed DNA polymerase and p30 protein shared antigenic homologies wi...

journal_title：Journal of virology

authors： Bedigian HG,Fox RR,Meier H

更新日期：1978-08-01 00:00:00

abstract：UNLABELLED:Equine influenza viruses (EIV) are responsible for rapidly spreading outbreaks of respiratory disease in horses. Although natural infections of humans with EIV have not been reported, experimental inoculation of humans with these viruses can lead to a productive infection and elicit a neutralizing antibody r...

journal_title：Journal of virology

authors： Baz M,Paskel M,Matsuoka Y,Zengel J,Cheng X,Treanor JJ,Jin H,Subbarao K

更新日期：2015-02-01 00:00:00

abstract：:Pestiviruses prevent alpha/beta interferon (IFN-alpha/beta) production by promoting proteasomal degradation of interferon regulatory factor 3 (IRF3) by means of the viral N(pro) nonstructural protein. N(pro) is also an autoprotease, and its amino-terminal coding sequence is involved in translation initiation. We previ...

journal_title：Journal of virology

authors： Ruggli N,Summerfield A,Fiebach AR,Guzylack-Piriou L,Bauhofer O,Lamm CG,Waltersperger S,Matsuno K,Liu L,Gerber M,Choi KH,Hofmann MA,Sakoda Y,Tratschin JD

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both spliced and unspliced RNA transcripts, and RNA export mechanisms of gammaretroviruses are poorly characterized. Here, we report the involvement of the...

journal_title：Journal of virology

authors： Sakuma T,Davila JI,Malcolm JA,Kocher JP,Tonne JM,Ikeda Y

更新日期：2014-04-01 00:00:00

abstract：:The genome of infectious hematopoietic necrosis virus (IHNV), a salmonid novirhabdovirus, has been engineered to modify the gene order and to evaluate the impact on a possible attenuation of the virus in vitro and in vivo By reverse genetics, eight recombinant IHNVs (rIHNVs), termed NxGy according to the respective po...

journal_title：Journal of virology

authors： Rouxel RN,Tafalla C,Mérour E,Leal E,Biacchesi S,Brémont M

更新日期：2016-11-14 00:00:00

abstract：:Human immunodeficiency virus type 1 Tat exerts prominent angiogenic effects which may lead to a variety of vasculopathic conditions in AIDS patients. Because endothelial cells undergo prominent cytoskeletal rearrangement during angiogenesis, we investigated the specific effects of Tat on the endothelial cell actin cyt...

journal_title：Journal of virology

authors： Wu RF,Gu Y,Xu YC,Mitola S,Bussolino F,Terada LS

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and type I interferon (IFN-I)-inducible myxov...

journal_title：Journal of virology

authors： Singh R,Patel V,Mureithi MW,Naranbhai V,Ramsuran D,Tulsi S,Hiramen K,Werner L,Mlisana K,Altfeld M,Luban J,Kasprowicz V,Dheda K,Abdool Karim SS,Ndung'u T

更新日期：2014-04-01 00:00:00

abstract：:Cell-based hepatitis C virus (HCV) replicon systems have provided a means for understanding HCV replication mechanisms and for testing new antiviral agents. We describe here a mathematical model of HCV replication that assumes that the translation of the HCV polyprotein occurs in the cytoplasm, that HCV RNA synthesis ...

journal_title：Journal of virology

authors： Dahari H,Ribeiro RM,Rice CM,Perelson AS

更新日期：2007-01-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of reactivation from laten...

journal_title：Journal of virology

authors： Harrison KS,Zhu L,Thunuguntla P,Jones C

更新日期：2019-06-14 00:00:00

abstract：:To replicate its segmented, double-stranded RNA (dsRNA) genome, the rotavirus RNA-dependent RNA polymerase, VP1, must recognize viral plus-strand RNAs (+RNAs) and guide them into the catalytic center. VP1 binds to the conserved 3' end of rotavirus +RNAs via both sequence-dependent and sequence-independent contacts. Se...

journal_title：Journal of virology

authors： Ogden KM,Ramanathan HN,Patton JT

更新日期：2011-03-01 00:00:00

abstract：:The Group B Staphylococcus phage P11-M15 is shown to be 51% protein and 49% deoxyribonucleic acid (DNA). The intact virion has a molecular weight of 66.7 x 10(6) daltons. The purified viral DNA has a molecular weight of 32.7 x 10(6) daltons. The intact virion is shown to be composed of a polyhedral head which is attac...

journal_title：Journal of virology

authors： Brown DT,Brown NC,Burlingham BT

更新日期：1972-04-01 00:00:00

abstract：UNLABELLED:An understanding of the antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines, but it has not been possible to examine these cells directly because HA binds to sialic acid (SA) on most cell types. Here, we use structure-based...

journal_title：Journal of virology

authors： Whittle JR,Wheatley AK,Wu L,Lingwood D,Kanekiyo M,Ma SS,Narpala SR,Yassine HM,Frank GM,Yewdell JW,Ledgerwood JE,Wei CJ,McDermott AB,Graham BS,Koup RA,Nabel GJ

更新日期：2014-04-01 00:00:00

abstract：:We have previously designed in vitro model systems to characterize the herpes simplex virus type 1 (HSV-1) genome during in vitro virus latency. Latency was established by treatment of infected human embryo lung fibroblast (HEL-F) cells or rat fetal neurons with (E)-5-(2-bromovinyl)-2'-deoxyuridine and human leukocyte...

journal_title：Journal of virology

authors： Wigdahl B,Scheck AC,Ziegler RJ,De Clercq E,Rapp F

更新日期：1984-01-01 00:00:00

abstract：:The evolution of human immunodeficiency virus (HIV) type 1 nef quasispecies in a patient clonally infected with a contaminated batch of blood clotting factor IX was monitored. nef sequences were derived at 11, 25, and 41 months postinfection from infected peripheral blood mononuclear cells after molecular cloning of P...

journal_title：Journal of virology

authors： Plikat U,Nieselt-Struwe K,Meyerhans A

更新日期：1997-06-01 00:00:00

abstract：UNLABELLED:The emergence of Middle East respiratory syndrome-coronavirus (MERS-CoV) in the Middle East since 2012 has caused more than 900 human infections with ∼40% mortality to date. Animal models are needed for studying pathogenesis and for development of preventive and therapeutic agents against MERS-CoV infection....

journal_title：Journal of virology

authors： Agrawal AS,Garron T,Tao X,Peng BH,Wakamiya M,Chan TS,Couch RB,Tseng CT

更新日期：2015-04-01 00:00:00

abstract：:A number of full-length cDNA clones of Kunjin virus (KUN) were previously prepared; it was shown that two of them, pAKUN and FLSDX, differed in specific infectivities of corresponding in vitro transcribed RNAs by approximately 100,000-fold (A. A. Khromykh et al., J. Virol. 72:7270-7279, 1998). In this study, we analyz...

journal_title：Journal of virology

authors： Liu WJ,Chen HB,Khromykh AA

更新日期：2003-07-01 00:00:00

abstract：:The three primary capsid proteins (A, B, and C) of adeno-associated viruses have been shown previously to contain overlapping amino acid sequences (R. McPherson and J. Rose, J. Virol. 46:523-529, 1983). In the present study we demonstrate definitively that these proteins are encoded in the right half of the adeno-asso...

journal_title：Journal of virology

authors： Janik JE,Huston MM,Rose JA

更新日期：1984-11-01 00:00:00

abstract：:In some type C retroviruses, translation of the pol gene appears to require translational suppression of the proximal gag amber codon. To identify the region of the viral nucleic acid responsible for synthesis of the pol gene products, a 300-base-pair DNA fragment containing the stop codon from a type C murine virus (...

journal_title：Journal of virology

authors： Panganiban AT

更新日期：1988-10-01 00:00:00

abstract：:Since its detection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hosts, and bovines have been identified as its natural reservoir. However, it remains unclear how IDVs emerge, evolve, spread, and maintain in bovine populations. Through multiple years of virological and serological ...

journal_title：Journal of virology

authors： Wan XF,Ferguson L,Oliva J,Rubrum A,Eckard L,Zhang X,Woolums AR,Lion A,Meyer G,Murakami S,Ma W,Horimoto T,Webby R,Ducatez MF,Epperson W

更新日期：2020-08-31 00:00:00

abstract：:Recognition of virus infections by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation associated gene 5 (MDA5), activates signaling pathways, leading to the induction of inflammatory cytokines that limit viral replication. To d...

journal_title：Journal of virology

authors： Guo H,Jiang D,Ma D,Chang J,Dougherty AM,Cuconati A,Block TM,Guo JT

更新日期：2009-01-01 00:00:00