Sequence relationships between adenovirus 2 early RNA and viral RNA size classes synthesized at 18 hours after infection.

abstract：:Hepatitis C Virus (HCV) NS4B protein induces a specialized membrane structure which may serve as the replication platform for HCV RNA replication. In the present study, we demonstrated that NS4B has lipid modifications (palmitoylation) on two cysteine residues (cysteines 257 and 261) at the C-terminal end. Site-specif...

journal_title：Journal of virology

authors： Yu GY,Lee KJ,Gao L,Lai MM

更新日期：2006-06-01 00:00:00

abstract：:Recently it has been shown that kaposica, an immune evasion protein of Kaposi's sarcoma-associated herpesvirus, inactivates complement by acting on C3-convertases by accelerating their decay as well as by acting as a cofactor in factor I-mediated inactivation of their subunits C3b and C4b. Here, we have mapped the fun...

journal_title：Journal of virology

authors： Mullick J,Singh AK,Panse Y,Yadav V,Bernet J,Sahu A

更新日期：2005-05-01 00:00:00

abstract：:Residual hepatitis B virus (HBV) DNA can be detected in serum and liver after apparent recovery from transient infection. However, it is not known if this residual HBV DNA represents ongoing viral replication and antigen expression. In the current study, ducks inoculated with duck hepatitis B virus (DHBV) were monitor...

journal_title：Journal of virology

authors： Le Mire MF,Miller DS,Foster WK,Burrell CJ,Jilbert AR

更新日期：2005-10-01 00:00:00

abstract：:Hemagglutinin from influenza A/PR8 virus was purified after treatment of the virus with sodium deoxycholate followed by extraction with tri-n-butyl phosphate. This fully disrupted the virus while preserving hemagglutinating activity. The hemagglutinin was obtained in the form of small aggregates that could be separate...

journal_title：Journal of virology

authors： Collins JK,Knight CA

更新日期：1978-05-01 00:00:00

abstract：:The cell culture lines HTG2 and HTG3 were established from a transplantable hamster tumor induced by a murine sarcoma virus (strain Gz-MSV) after 17 and 60 in vivo passages, respectively. The viruses released by these two cell lines markedly differ in morphology, antigenic composition, infectivity, transforming abilit...

journal_title：Journal of virology

authors： Gazdar AF,Russell E,Sarma PS,Sarin PS,Hall W,Chopra HC

更新日期：1973-10-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates very efficiently into a specific site (AAVS1) of human chromosome 19. Two elements of the AAV genome are sufficient: the inverted terminal repeats (ITRs) and the Rep78 or Rep68 protein. The incorporation of the AAV integration machinery in nonviral delivery systems is of great i...

journal_title：Journal of virology

authors： Lamartina S,Roscilli G,Rinaudo D,Delmastro P,Toniatti C

更新日期：1998-09-01 00:00:00

abstract：:Adenovirus type 2 (Ad2)-transformed hamster and rat cells are susceptible to lysis by natural killer (NK) cells from the host of origin and are nontumorigenic in immunocompetent hamsters and rats, respectively. These NK-cell-susceptible, virus-transformed cells are, however, highly tumorigenic in athymic (nude) mice--...

journal_title：Journal of virology

authors： Cook JL,Lewis AM Jr

更新日期：1987-07-01 00:00:00

abstract：:Hepatitis delta virus (HDV) is a defective RNA virus which is dependent on hepatitis B virus for essential helper functions. Only a single highly basic phosphoprotein, HDV antigen (HDAg), is expressed by the HDV genome during infection in humans. Antibody directed to HDAg is important in the diagnosis of HDV infection...

journal_title：Journal of virology

authors： Wang JG,Jansen RW,Brown EA,Lemon SM

更新日期：1990-03-01 00:00:00

abstract：UNLABELLED:Recent experiments suggest that some glycoprotein (GP)-specific monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (EBOV). There is a need for isolation of MAbs capable of neutralizing multiple filoviruses. Antibody neutralization assays for filoviruses frequently...

journal_title：Journal of virology

authors： Ilinykh PA,Shen X,Flyak AI,Kuzmina N,Ksiazek TG,Crowe JE Jr,Bukreyev A

更新日期：2016-03-28 00:00:00

abstract：:Hantaviruses are rodent-borne agents that cause hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome in humans. The nucleocapsid protein (N) is relatively conserved among hantaviruses and highly immunogenic in both laboratory animals and humans, and it has been shown to induce efficient protective im...

journal_title：Journal of virology

authors： de Carvalho Nicacio C,Gonzalez Della Valle M,Padula P,Björling E,Plyusnin A,Lundkvist A

更新日期：2002-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex virus (HSV) have been incurable to date because effective antiviral therapies target only replicating viruses and do not eradicate latently integrated or nonreplicating episomal viral genomes. Endonucleases that can target and cle...

journal_title：Journal of virology

authors： Schiffer JT,Aubert M,Weber ND,Mintzer E,Stone D,Jerome KR

更新日期：2012-09-01 00:00:00

abstract：:The primary pathophysiologic finding of the viral disease known as Korean hemorrhagic fever, the etiological agent of which is Hantaan virus (HTV), is vascular instability. To investigate whether HTV was able to infect cells derived from human vascular tissue and alter their behavior, we infected in vitro primary adul...

journal_title：Journal of virology

authors： Pensiero MN,Sharefkin JB,Dieffenbach CW,Hay J

更新日期：1992-10-01 00:00:00

abstract：:Preclinical studies have shown that gene transfer following readministration of viral vectors is often inefficient due to the presence of neutralizing antibodies. Vectors derived from ubiquitous human adenoviruses may have limited clinical use because preexisting humoral and cellular immunity is found in 90% of the po...

journal_title：Journal of virology

authors： Kremer EJ,Boutin S,Chillon M,Danos O

更新日期：2000-01-01 00:00:00

abstract：:PM2 DNA was prepared with different superhelical densities (sigma) in order to examine the relationship betweenn supercoiling and the occurrence of a region(s) of unpaired bases in this DNA. A previous study showed that CH3HgOH reacts with native superhelical PM2 DNA more rapidly than the nicked form II. This evaluati...

journal_title：Journal of virology

authors： Woodworth-Gutai M,Lebowitz J

更新日期：1976-04-01 00:00:00

abstract：:L2 cells infected with vesicular stomatitis virus under single-cycle conditions have been studied by scanning electron microscopy after preparation by the critical point drying technique. Three dimensional images of intact cells show bullet-shaped vesicular stomatitis virus virions budding singly and in radiating clus...

journal_title：Journal of virology

authors： Holmes KV

更新日期：1975-02-01 00:00:00

abstract：:The relationship between NS protein phosphorylation and RNA polymerase activities was determined in nucleocapsids purified from vesicular stomatitis virus grown in BHK cells. Phosphate incorporation into endogenous NS protein under transcription conditions reached a maximum value of 0.06 mol/mol of NS within 20 to 30 ...

journal_title：Journal of virology

authors： Massey DM,Deans N,Lenard J

更新日期：1990-07-01 00:00:00

abstract：:Hepatitis B viruses (HBVs) replicate by reverse transcription of an RNA intermediate. Packaging of this RNA pregenome into nucleocapsids and replication initiation depend crucially on the interaction of the reverse transcriptase, P protein, with the cis-acting, 5' end-proximal encapsidation signal epsilon. The overall...

journal_title：Journal of virology

authors： Beck J,Nassal M

更新日期：1997-07-01 00:00:00

abstract：:During cell entry, native poliovirus (160S) converts to a cell-entry intermediate (135S) particle, resulting in the externalization of capsid proteins VP4 and the amino terminus of VP1 (residues 1 to 53). Externalization of these entities is followed by release of the RNA genome (uncoating), leaving an empty (80S) par...

journal_title：Journal of virology

authors： Lin J,Cheng N,Chow M,Filman DJ,Steven AC,Hogle JM,Belnap DM

更新日期：2011-10-01 00:00:00

abstract：:Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated the immunogenicity and relative efficacy of systemic immunization with two human ALVAC-HIV-1 recombinant vaccines express...

journal_title：Journal of virology

authors： Pal R,Venzon D,Santra S,Kalyanaraman VS,Montefiori DC,Hocker L,Hudacik L,Rose N,Nacsa J,Edghill-Smith Y,Moniuszko M,Hel Z,Belyakov IM,Berzofsky JA,Parks RW,Markham PD,Letvin NL,Tartaglia J,Franchini G

更新日期：2006-04-01 00:00:00

abstract：:Cytotoxic T-lymphocyte (CTL) responses are crucial for the control of immunodeficiency virus replication. Possible involvement of a dominant single epitope-specific CTL in control of viral replication has recently been indicated in preclinical AIDS vaccine trials, but it has remained unclear if multiple epitope-specif...

journal_title：Journal of virology

authors： Kawada M,Igarashi H,Takeda A,Tsukamoto T,Yamamoto H,Dohki S,Takiguchi M,Matano T

更新日期：2006-02-01 00:00:00

abstract：:Disulfide bonds reportedly stabilize the capsids of several viruses, including papillomavirus, polyomavirus, and simian virus 40, and have been detected in herpes simplex virus (HSV) capsids. In this study, we show that in mature HSV-1 virions, capsid proteins VP5, VP23, VP19C, UL17, and UL25 participate in covalent c...

journal_title：Journal of virology

authors： Szczepaniak R,Nellissery J,Jadwin JA,Makhov AM,Kosinski A,Conway JF,Weller SK

更新日期：2011-09-01 00:00:00

abstract：:Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either r...

journal_title：Journal of virology

authors： Netterwald JR,Jones TR,Britt WJ,Yang SJ,McCrone IP,Zhu H

更新日期：2004-06-01 00:00:00

abstract：:Myxomatosis is a recurrent problem on rabbit farms throughout Europe despite the success of vaccines. To identify gene variations of field and vaccine strains that may be responsible for changes in virulence, immunomodulation, and immunoprotection, the genomes of 6 myxoma virus (MYXV) strains were sequenced: German fi...

journal_title：Journal of virology

authors： Braun C,Thürmer A,Daniel R,Schultz AK,Bulla I,Schirrmeier H,Mayer D,Neubert A,Czerny CP

更新日期：2017-01-31 00:00:00

abstract：:Newcastle disease virus (NDV) edits its P-gene mRNA by inserting a nontemplated G residue(s) at a conserved editing site (3'-UUUUUCCC-template strand). In the wild-type virus, three amino-coterminal P-gene-derived proteins, P, V, and W, are produced at frequencies of approximately 68, 29, and 2%, respectively. By appl...

journal_title：Journal of virology

authors： Mebatsion T,Verstegen S,De Vaan LT,Römer-Oberdörfer A,Schrier CC

更新日期：2001-01-01 00:00:00

abstract：:Higher-order RNA structures in the 3' untranslated region (3'UTR) of enteroviruses are thought to play a pivotal role in viral negative-strand RNA synthesis. The structure of the 3'UTR was predicted by thermodynamic calculations using the STAR (structural analysis of RNA) computer program and experimentally verified u...

journal_title：Journal of virology

authors： Melchers WJ,Hoenderop JG,Bruins Slot HJ,Pleij CW,Pilipenko EV,Agol VI,Galama JM

更新日期：1997-01-01 00:00:00

abstract：:The activity of uracil-DNA glycosylase in Escherichia coli decreases dramatically to less than 10% of its original level after infection of the cells by phage T5. Phage-induced protein synthesis is required for this inhibition to occur, and the inhibition is induced by a mutant capable of injecting only the first 8% o...

journal_title：Journal of virology

authors： Warner HR,Johnson LK,Snustad DP

更新日期：1980-01-01 00:00:00

abstract：:Reovirus infection of the murine spinal cord (SC) was used as a model system to investigate innate immune responses during viral myelitis, including the activation of glia (microglia and astrocytes) and interferon (IFN) signaling and increased expression of inflammatory mediators. Reovirus myelitis was associated with...

journal_title：Journal of virology

authors： Schittone SA,Dionne KR,Tyler KL,Clarke P

更新日期：2012-08-01 00:00:00

abstract：:The pathway of envelopment and egress of the varicella-zoster virus (VZV) and the primary site of viral production within the epidermal layer of the skin are not fully understood. There are several hypotheses to explain how the virus may receive an envelope as it travels to the surface of the monolayer. In this study,...

journal_title：Journal of virology

authors： Harson R,Grose C

更新日期：1995-08-01 00:00:00

abstract：:Molluscs, comprising one of the most successful phyla, lack clear evidence of adaptive immunity and yet thrive in the oceans, which are rich in viruses. There are thought to be nearly 120,000 species of Mollusca, most living in marine habitats. Despite the extraordinary abundance of viruses in oceans, molluscs often h...

journal_title：Journal of virology

authors： Dang VT,Benkendorff K,Green T,Speck P

更新日期：2015-08-01 00:00:00

abstract：:Alfalfa mosaic virus (AMV) and ilarvirus RNAs are infectious only in the presence of the viral coat protein; therefore, an understanding of coat protein's function is important for defining viral replication mechanisms. Based on in vitro replication experiments, the conformational switch model states that AMV coat pro...

journal_title：Journal of virology

authors： Guogas LM,Laforest SM,Gehrke L

更新日期：2005-05-01 00:00:00