Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels.

abstract：:The ribonucleic acid (RNA) of murine leukemia virus (MLV) Rauscher strain was observed by the aid of electron microscopy with the use of the protein monolayer technique. RNA was observed directly after release from virus particles or after isolation by sedimentation in sucrose density gradients. Molecules were found i...

journal_title：Journal of virology

authors： Kakefuda T,Bader JP

更新日期：1969-10-01 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (pRb) can associate with the transforming proteins of several DNA tumor viruses, including the large T antigen encoded by polyomavirus (Py T Ag). Although pRb function is critical for regulating progression from G1 to S phase, a role for pRb in S phase has not been demonstra...

journal_title：Journal of virology

authors： Reynisdóttir I,Bhattacharyya S,Zhang D,Prives C

更新日期：1999-04-01 00:00:00

abstract：:In intact Madin-Darby canine kidney (MDCK) cell monolayers, vesicular stomatitis virus (VSV) matures only at basolateral membranes beneath tight junctions, whereas influenza virus buds from apical cell surfaces. Early in the growth cycle, the viral glycoproteins are restricted to the membrane domain from which each vi...

journal_title：Journal of virology

authors： Roth MG,Compans RW

更新日期：1981-12-01 00:00:00

abstract：:Multispecific CD8(+) T-cell responses are thought to be important for the control of acute hepatitis C virus (HCV) infection, but to date little information is actually available on the breadth of responses at early time points. Additionally, the influence of early therapy on these responses and their relationships to...

journal_title：Journal of virology

authors： Lauer GM,Lucas M,Timm J,Ouchi K,Kim AY,Day CL,Schulze Zur Wiesch J,Paranhos-Baccala G,Sheridan I,Casson DR,Reiser M,Gandhi RT,Li B,Allen TM,Chung RT,Klenerman P,Walker BD

更新日期：2005-10-01 00:00:00

abstract：:The genome of the Neodiprion sertifer nucleopolyhedrovirus (NeseNPV), which infects the European pine sawfly, N. sertifer (Hymenoptera: Diprionidae), was sequenced and analyzed. The genome was 86,462 bp in size. The C+G content of 34% was lower than that of the majority of baculoviruses. A total of 90 methionine-initi...

journal_title：Journal of virology

authors： Garcia-Maruniak A,Maruniak JE,Zanotto PM,Doumbouya AE,Liu JC,Merritt TM,Lanoie JS

更新日期：2004-07-01 00:00:00

abstract：:Three tegument proteins of human cytomegalovirus (HCMV), ppUL82 (pp71), pUL69, and ppUL83 (pp65), were examined for the ability to stimulate the production of infectious virus from human diploid fibroblasts transfected with viral DNA. Although viral DNA alone had a low intrinsic infectivity of 3 to 8 plaques/microg of...

journal_title：Journal of virology

authors： Baldick CJ Jr,Marchini A,Patterson CE,Shenk T

更新日期：1997-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is the first human virus found to encode many microRNAs. It is etiologically linked to nasopharyngeal carcinoma and EBV-associated gastric carcinoma. During the latent infection period, there are only a few EBV proteins expressed, whereas EBV microRNAs, such as the BamHI-A region rightward tra...

journal_title：Journal of virology

authors： Zheng X,Wang J,Wei L,Peng Q,Gao Y,Fu Y,Lu Y,Qin Z,Zhang X,Lu J,Ou C,Li Z,Zhang X,Liu P,Xiong W,Li G,Yan Q,Ma J

更新日期：2018-11-12 00:00:00

abstract：:Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-ce...

journal_title：Journal of virology

authors： Norbeck O,Isa A,Pöhlmann C,Broliden K,Kasprowicz V,Bowness P,Klenerman P,Tolfvenstam T

更新日期：2005-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) clade C causes >50% of all HIV infections worldwide, and an estimated 90% of all transmissions occur mucosally with R5 strains. A pathogenic R5 simian-human immunodeficiency virus (SHIV) encoding HIV clade C env is highly desirable to evaluate candidate AIDS vaccines in nonh...

journal_title：Journal of virology

authors： Song RJ,Chenine AL,Rasmussen RA,Ruprecht CR,Mirshahidi S,Grisson RD,Xu W,Whitney JB,Goins LM,Ong H,Li PL,Shai-Kobiler E,Wang T,McCann CM,Zhang H,Wood C,Kankasa C,Secor WE,McClure HM,Strobert E,Else JG,Ruprecht R

更新日期：2006-09-01 00:00:00

abstract：:The adenovirus type 2 L1 region, which is located at 30.7 to 39.2 map units on the viral genome, is transcribed from the major late promoter during both early and late stages of virus replication, and a 52,000-Mr (52K) protein-55K protein doublet has been translated in vitro on L1-specific RNA. To investigate the bios...

journal_title：Journal of virology

authors： Lucher LA,Symington JS,Green M

更新日期：1986-03-01 00:00:00

abstract：:Temperature-sensitive COS cells, clone E540, have been stably transformed at a restrictive temperature with plasmid pVA1, which contains the adenovirus type 5 virus-associated (VA) genes in addition to the Neor marker. Transformed cell clones, named EVA cells, contained adenovirus DNA in an integrated form while grown...

journal_title：Journal of virology

authors： Martínez C,de la Luna S,Peláez F,Lopez-Turiso A,Valcárcel J,de Haro C,Ortín J

更新日期：1989-12-01 00:00:00

abstract：:Recent evidence suggests that the type II feline coronavirus (FCoV) strains 79-1146 and 79-1683 have arisen from a homologous RNA recombination event between FCoV type I and canine coronavirus (CCV). In both cases, the template switch apparently took place between the S and M genes, giving rise to recombinant viruses ...

journal_title：Journal of virology

authors： Herrewegh AA,Smeenk I,Horzinek MC,Rottier PJ,de Groot RJ

更新日期：1998-05-01 00:00:00

abstract：:Previous findings of low levels of reverse transcriptase (RT) activity in chick cell-derived measles and mumps vaccines showed this activity to be associated with virus particles containing RNA of both subgroup E endogenous avian leukosis viruses (ALV-E) and endogenous avian viruses (EAV). These particles originate fr...

journal_title：Journal of virology

authors： Johnson JA,Heneine W

更新日期：2001-04-01 00:00:00

abstract：:The baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) initiates apoptosis in diverse insects through events triggered by virus DNA (vDNA) replication. To define the proapoptotic pathway and its role in antivirus defense, we investigated the link between the host's DNA damage response (DDR) a...

journal_title：Journal of virology

authors： Mitchell JK,Friesen PD

更新日期：2012-12-01 00:00:00

abstract：:The activity of human immunodeficiency virus Rev as a regulator of viral mRNA expression is tightly linked to its ability to shuttle between the nucleus and cytoplasm; these properties are conferred by a leucine-rich nuclear export signal (NES) and by an arginine-rich nuclear localization signal/RNA binding domain (NL...

journal_title：Journal of virology

authors： D'Agostino DM,Ferro T,Zotti L,Meggio F,Pinna LA,Chieco-Bianchi L,Ciminale V

更新日期：2000-12-01 00:00:00

abstract：:The entire varicella-zoster virus (VZV) genome appears to be present in latently infected human ganglia, but the extent of virus DNA transcription is unknown. Conventional methods to study virus gene transcripts by Northern (RNA) blotting are not feasible, since ganglia are small and VZV DNA is not abundant. To circum...

journal_title：Journal of virology

authors： Cohrs RJ,Srock K,Barbour MB,Owens G,Mahalingam R,Devlin ME,Wellish M,Gilden DH

更新日期：1994-12-01 00:00:00

abstract：:All known DNA tumor viruses are known to target and inactivate two main cell cycle regulatory proteins, retinoblastoma protein (pRb) and p53. Inactivation of pRb promotes host cell cycle progression into S phase, and inactivation of p53 promotes cell immortalization. The DNA tumor virus Kaposi's sarcoma associated her...

journal_title：Journal of virology

authors： Borah S,Verma SC,Robertson ES

更新日期：2004-10-01 00:00:00

abstract：:Based on previous structural and functional studies, a potential receptor-binding site composed of residues that form a pocket at one end of the two long antiparallel helices in the receptor-binding domain of Friend 57 murine leukemia virus envelope protein (RBD) has been proposed. To test this hypothesis, directed su...

journal_title：Journal of virology

authors： Davey RA,Zuo Y,Cunningham JM

更新日期：1999-05-01 00:00:00

abstract：:High-risk human papillomavirus type 16 (HPV16) is the primary causative agent of cervical cancer and therefore is responsible for significant morbidity and mortality worldwide. Cellular transformation is mediated directly by the expression of viral oncogenes, the least characterized of which, E5, subverts cellular pro...

journal_title：Journal of virology

authors： Wetherill LF,Holmes KK,Verow M,Müller M,Howell G,Harris M,Fishwick C,Stonehouse N,Foster R,Blair GE,Griffin S,Macdonald A

更新日期：2012-05-01 00:00:00

abstract：:The major envelope glycoprotein of bovine leukemia virus was isolated by lectin-bound Sepharose and DEAE-cellulose column chromatography. This protein was shown to have a molecular weight of about 41,000 and to lack detectable immunological cross-reactivity with glycoproteins of other oncornaviruses. Sera obtained fro...

journal_title：Journal of virology

authors： Devare SG,Stephenson JR

更新日期：1977-08-01 00:00:00

abstract：:The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized dur...

journal_title：Journal of virology

authors： Feng YX,Moore SP,Garfinkel DJ,Rein A

更新日期：2000-11-01 00:00:00

abstract：:The amount and distribution of viral DNA were established in a horse acutely infected with the Wyoming strain of equine infectious anemia virus (EIAV). The highest concentration of viral DNA were found in the liver, lymph nodes, bone marrow, and spleen. The kidney, choroid plexus, and peripheral blood leukocytes also ...

journal_title：Journal of virology

authors： Rice NR,Lequarre AS,Casey JW,Lahn S,Stephens RM,Edwards J

更新日期：1989-12-01 00:00:00

abstract：:The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypepti...

journal_title：Journal of virology

authors： Pal BK,McAllister RM,Gardner MB,Roy-Burman P

更新日期：1975-07-01 00:00:00

abstract：:Viruses actively interact with host metabolism because viral replication relies on host cells to provide nutrients and energy. Vaccinia virus (VACV; the prototype poxvirus) prefers glutamine to glucose for efficient replication to the extent that VACV replication is hindered in glutamine-free medium. Remarkably, our d...

journal_title：Journal of virology

authors： Pant A,Cao S,Yang Z

更新日期：2019-06-14 00:00:00

abstract：:HB-3, a temperate bacteriophage of Streptococcus pneumoniae, synthesizes its own murein hydrolase activity when multiplying on cultures of pneumococcus. The enzyme (HBL) was purified and biochemically characterized as an N-acetylmuramoyl-L-alanine amidase of 36,000 daltons, and a 2.1-kilobase DraI fragment containing ...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1990-01-01 00:00:00

abstract：:The recent finding that the E1 glycoproteins of murine coronaviruses contain only O-linked oligosaccharides suggested that this unusual modification might be a distinguishing feature of coronaviruses and might play an essential role in the life cycle of this family of viruses. To examine these possibilities, we analyz...

journal_title：Journal of virology

authors： Stern DF,Sefton BM

更新日期：1982-12-01 00:00:00

abstract：:Human metapneumovirus (HMPV) has recently been identified as a significant cause of serious respiratory tract disease in humans. In particular, the emerging information on the contribution of HMPV to pediatric respiratory tract disease suggests that it will be important to develop a vaccine against this virus for use ...

journal_title：Journal of virology

authors： Biacchesi S,Skiadopoulos MH,Yang L,Lamirande EW,Tran KC,Murphy BR,Collins PL,Buchholz UJ

更新日期：2004-12-01 00:00:00

abstract：:Autoradiographic analyses of deoxyribonucleic acid (DNA) synthesis in randomly growing KB cell cultures infected with equine abortion virus (EAV) suggested that viral DNA synthesis was initiated only at times that coincided with the entry of noninfected control cells into the S phase of the cell cycle. Synchronized cu...

journal_title：Journal of virology

authors： Lawrence WC

更新日期：1971-06-01 00:00:00

abstract：:Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (p...

journal_title：Journal of virology

authors： Van Poucke S,Doedt J,Baumann J,Qiu Y,Matrosovich T,Klenk HD,Van Reeth K,Matrosovich M

更新日期：2015-12-01 00:00:00

abstract：:Host cell-mediated proteolytic cleavage of the human immunodeficiency virus type 1 (HIV-1) gp160 precursor glycoprotein into gp120 and gp41 subunits is required to generate fusion-competent envelope glycoprotein (Env) spikes. The gp120-directed broadly neutralizing monoclonal antibodies (bNabs) isolated from HIV-infec...

journal_title：Journal of virology

authors： Chakrabarti BK,Feng Y,Sharma SK,McKee K,Karlsson Hedestam GB,Labranche CC,Montefiori DC,Mascola JR,Wyatt RT

更新日期：2013-12-01 00:00:00