Characterization of endogenous avian leukosis viruses in chicken embryonic fibroblast substrates used in production of measles and mumps vaccines.

abstract：:Retroviral vectors offer major advantages for gene transfer studies but have not been useful for producing proteins in large quantities. This deficiency has resulted in part from interference to superinfection, which limits the numbers of active proviruses in cells. Recently, we found that these vectors amplify when t...

journal_title：Journal of virology

authors： Kozak SL,Kabat D

更新日期：1990-07-01 00:00:00

abstract：:The mechanism of regulation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unknown. Previously, we developed a direct assay capable of detecting the ribozyme activity of HDV dimer or trimer RNAs in vivo (K.-S. Jeng, A. Daniel, and M. M. C. Lai, J. Virol, 70:2403-2410, 1996). In this ...

journal_title：Journal of virology

authors： Jeng KS,Su PY,Lai MM

更新日期：1996-07-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) enhances the growth of T lymphocytes, allowing the generation of T-lymphocyte cell lines. This report describes a limiting-dilution assay system which uses low input numbers of HTLV-1-producing cells for generation of T-lymphocyte cultures. The HTLV-1 transformants gener...

journal_title：Journal of virology

authors： Persaud D,Muñoz JL,Tarsis SL,Parks ES,Parks WP

更新日期：1995-10-01 00:00:00

abstract：:Prior to the introduction of live-attenuated vaccines, mumps virus (MuV) was the leading cause of virus-induced meningitis. Although vaccination has been effective at controlling the disease, the use of insufficiently attenuated strains has been associated with high rates of aseptic meningitis in vaccinees. The molecu...

journal_title：Journal of virology

authors： Lemon K,Rima BK,McQuaid S,Allen IV,Duprex WP

更新日期：2007-08-01 00:00:00

abstract：:The ecotropic Cas-Br-E murine leukemia virus (MuLV) and its molecularly cloned derivative pBR-NE-8 MuLV are capable of inducing hind-limb paralysis and leukemia after inoculation into susceptible mice. T1 oligonucleotide fingerprinting, molecular hybridization, and restriction enzyme analysis previously showed that th...

journal_title：Journal of virology

authors： Rassart E,Nelbach L,Jolicoeur P

更新日期：1986-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) pathogenesis is dependent on the hematogenous spread of the virus to host tissue. While data suggest that infected monocytes are required for viral dissemination from the blood to the host organs, infected endothelial cells are also thought to contribute to this key step in viral pathogene...

journal_title：Journal of virology

authors： Bentz GL,Jarquin-Pardo M,Chan G,Smith MS,Sinzger C,Yurochko AD

更新日期：2006-12-01 00:00:00

abstract：:Herpes simplex virus VP22 is a major tegument protein of unknown function. Very recently, we reported that the predominant effect of deleting the VP22 gene was on the expression, localization, and virion incorporation of ICP0. In addition, the Delta22 virus replicated poorly in epithelial MDBK cells. We have also prev...

journal_title：Journal of virology

authors： Potel C,Elliott G

更新日期：2005-11-01 00:00:00

abstract：:The discovery that hepatitis B virus (HBV) integrates into host chromosomes raises the question of whether such viral DNA integration correlates directly with the activation of specific oncogenes or the inactivation of anti-oncogenes. To obtain insight into this problem, we randomly collected HBV integrant samples fro...

journal_title：Journal of virology

authors： Tokino T,Matsubara K

更新日期：1991-12-01 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are being considered for in vivo applications of gene therapy in the treatment of a variety of disorders. This study evaluates the biology of second-generation vectors based on the novel serotypes AAV7 and AAV8 and containing self-complementary genomes in the nonhuman primate liver...

journal_title：Journal of virology

authors： Gao GP,Lu Y,Sun X,Johnston J,Calcedo R,Grant R,Wilson JM

更新日期：2006-06-01 00:00:00

abstract：:The genome of the human immunodeficiency virus type 1 (HIV-1) is highly heterogeneous. Some of this genomic variability is reflected in the biologic and serologic differences observed among various strains of HIV-1. To map the viral determinants that correlate with pathogenicity of the virus, recombinant viruses were ...

journal_title：Journal of virology

authors： Cheng-Mayer C,Quiroga M,Tung JW,Dina D,Levy JA

更新日期：1990-09-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway that mediates the synthesis of prostaglandins from arachidonic acid. The eicosanoids function as critical regulators of a number of cellular processes, including the acute and chronic inflammatory response, hemostasis, and the innate imm...

journal_title：Journal of virology

authors： Rue CA,Jarvis MA,Knoche AJ,Meyers HL,DeFilippis VR,Hansen SG,Wagner M,Früh K,Anders DG,Wong SW,Barry PA,Nelson JA

更新日期：2004-11-01 00:00:00

abstract：:The integrase protein of human immunodeficiency virus type 1 removes two nucleotides from the 3' ends of reverse-transcribed human immunodeficiency virus type 1 DNA (3' processing) and covalently inserts the processed ends into a target DNA (DNA strand transfer). Mutant integrase proteins that lack the amino-and/or ca...

journal_title：Journal of virology

authors： Engelman A,Hickman AB,Craigie R

更新日期：1994-09-01 00:00:00

abstract：:Dengue virus (DENV) infection causes serious clinical symptoms, including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular permeability change is the main feature of the diseases, and the abnormal expression of proinflammatory cytokines is the important cause of vascular permeability change. Ho...

journal_title：Journal of virology

authors： Pan P,Zhang Q,Liu W,Wang W,Lao Z,Zhang W,Shen M,Wan P,Xiao F,Liu F,Zhang W,Tan Q,Liu X,Wu K,Liu Y,Li G,Wu J

更新日期：2019-10-15 00:00:00

abstract：:Recent studies have established the presence of human T-cell lymphoma/leukemia virus type I (HTLV-I) in Melanesia. An HTLV-I strain, PNG-1, has now been isolated from a healthy member of the Hagahai, a remote, recently contacted group in Papua New Guinea. To further characterize PNG-1, we employed polymerase chain rea...

journal_title：Journal of virology

authors： Sherman MP,Saksena NK,Dube DK,Yanagihara R,Poiesz BJ

更新日期：1992-04-01 00:00:00

abstract：UNLABELLED:Identification and characterization of CD8(+) T cells effectively controlling HIV-1 variants are necessary for the development of AIDS vaccines and for studies of AIDS pathogenesis, although such CD8(+) T cells have been only partially identified. In this study, we sought to identify CD8(+) T cells controlli...

journal_title：Journal of virology

authors： Murakoshi H,Akahoshi T,Koyanagi M,Chikata T,Naruto T,Maruyama R,Tamura Y,Ishizuka N,Gatanaga H,Oka S,Takiguchi M

更新日期：2015-05-01 00:00:00

abstract：:The inhibition of multilineage hematopoiesis which occurs in the severe combined immunodeficiency mouse with transplanted human fetal thymus and liver tissues (SCID-hu Thy/Liv) due to human immunodeficiency virus type 1 (HIV-1) infection is also accompanied by a severe loss of c-Mpl expression on these progenitor cell...

journal_title：Journal of virology

authors： Koka PS,Kitchen CM,Reddy ST

更新日期：2004-10-01 00:00:00

abstract：:Competitive quantitative PCR and reverse transcriptase-PCR were used to quantitate DNA and RNA from an attenuated ribonucleotide reductase-deleted herpes simplex virus type 1 (HSV-1) mutant in the rat trigeminal ganglion after peripheral inoculation following corneal scarification. Amplification of ganglionic DNA with...

journal_title：Journal of virology

authors： Ramakrishnan R,Levine M,Fink DJ

更新日期：1994-11-01 00:00:00

abstract：:A DNA vaccine plasmid containing the Japanese encephalitis (JE) virus premembrane (prM) and envelope (E) genes (designated pcDNA3JEME) was evaluated for immunogenicity and protective efficacy in mice. Two immunizations of 4-week-old female ICR mice with pcDNA3JEME by intramuscular or intradermal injections at a dose o...

journal_title：Journal of virology

authors： Konishi E,Yamaoka M,Khin-Sane-Win,Kurane I,Mason PW

更新日期：1998-06-01 00:00:00

abstract：:A double-isotopic label difference analysis of polyacrylamide gels has been used to distinguish between cellular and viral protein accumulation in infected cells and to quantify the kinetics of accumulation of viral polypeptides. This technique, coupled with the determination of total radioactive amino acid incorporat...

journal_title：Journal of virology

authors： Hightower LE,Bratt MA

更新日期：1974-04-01 00:00:00

abstract：:The use of different viral promoters for the expression of the EBNA1 gene product appears to be a critical step in the regulation of Epstein-Barr virus latent gene expression and may reflect the extent of differentiation of B-cell hosts. Low-passage Burkitt lymphoma cell lines resemble immature B cells in that they ex...

journal_title：Journal of virology

authors： Taylor KA,Wetzel S,Lyles DS,Pollok BA

更新日期：1994-10-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of different sizes and are in frame. The herpesvirus shell assembles arou...

journal_title：Journal of virology

authors： Robertson BJ,McCann PJ 3rd,Matusick-Kumar L,Preston VG,Gao M

更新日期：1997-02-01 00:00:00

abstract：:An immunochemical analysis of the hemagglutinin (VP4) of the simian rotavirus SA11 was performed to better understand the structure and function of this molecule. Following immunization of mice with double-shelled virus particles and VP4-enriched fractions from CsCl gradients, a battery of anti-SA11 hybridomas was gen...

journal_title：Journal of virology

authors： Burns JW,Greenberg HB,Shaw RD,Estes MK

更新日期：1988-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV) undergoes latent and lytic replication cycles, and its reactivation from latency to lytic replication is initiated by expression of the two viral immediate-early transactivators, Zta and Rta. In vitro, reactivation of EBV can be induced by anti-immunoglobulin, tetradecanoyl phorbol acetate, an...

journal_title：Journal of virology

authors： Tsai PF,Lin SJ,Weng PL,Tsai SC,Lin JH,Chou YC,Tsai CH

更新日期：2011-03-01 00:00:00

abstract：:Infection of normal rat fibroblasts (FR 3T3) with the early tsa mutant of polyoma virus may lead to either the A or the N phenotype, tsa-A transformants, originally derived by agar selection, are not temperature dependent for maintenance of the transformed phenotype, whereas tsa-N transormants revert at high temperatu...

journal_title：Journal of virology

authors： Rassoulzadegan M,Seif R,Cuzin F

更新日期：1978-11-01 00:00:00

abstract：:AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine cytomegalovirus (MCMV) retinitis with retrovirus-induced murine AIDS (MAIDS) that mimics the progres...

journal_title：Journal of virology

authors： Chien H,Alston CI,Dix RD

更新日期：2018-08-29 00:00:00

abstract：:Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Sa...

journal_title：Journal of virology

authors： Gori-Savellini G,Valentini M,Cusi MG

更新日期：2013-06-01 00:00:00

abstract：:With the rationale that the neuropathological similarities between scrapie and Alzheimer's disease reflect convergent pathological mechanisms involving altered gene expression, we set out to identify molecular events involved in both processes, using scrapie as a model to study the time course of these changes. We dif...

journal_title：Journal of virology

authors： Diedrich JF,Minnigan H,Carp RI,Whitaker JN,Race R,Frey W 2nd,Haase AT

更新日期：1991-09-01 00:00:00

abstract：:The replication and transcription of double-stranded RNA (dsRNA) viruses occur within a polymerase complex particle in which the viral genome is enclosed throughout the entire life cycle of the virus. A single protein subunit in the polymerase complex is responsible for the template-dependent RNA polymerization activi...

journal_title：Journal of virology

authors： Poranen MM,Koivunen MR,Bamford DH

更新日期：2008-09-01 00:00:00

abstract：:Chimeric bovine respiratory syncytial viruses (BRSV) expressing glycoproteins of bovine parainfluenza virus type 3 (BPIV-3) instead of BRSV glycoproteins were generated from cDNA. In the BRSV antigenome cDNA, the open reading frames of the major BRSV glycoproteins, attachment protein G and fusion protein F, were repla...

journal_title：Journal of virology

authors： Stope MB,Karger A,Schmidt U,Buchholz UJ

更新日期：2001-10-01 00:00:00

abstract：:Avian influenza virus (AIV) surveillance in Antarctica during 2013 revealed the prevalence of evolutionarily distinct influenza viruses of the H11N2 subtype in Adélie penguins. Here we present results from the continued surveillance of AIV on the Antarctic Peninsula during 2014 and 2015. In addition to the continued d...

journal_title：Journal of virology

authors： Hurt AC,Su YCF,Aban M,Peck H,Lau H,Baas C,Deng YM,Spirason N,Ellström P,Hernandez J,Olsen B,Barr IG,Vijaykrishna D,Gonzalez-Acuna D

更新日期：2016-10-14 00:00:00