Cas-Br-E murine leukemia virus: sequencing of the paralytogenic region of its genome and derivation of specific probes to study its origin and the structure of its recombinant genomes in leukemic tissues.

abstract：:The effectiveness and potential immunosuppressive effects of anti-inflammatory glucocorticoids in the lungs of severe acute respiratory syndrome (SARS) patients are undefined. We treated porcine respiratory coronavirus (PRCV)-infected conventional pigs with the corticosteroid dexamethasone (DEX) as a model for SARS. I...

journal_title：Journal of virology

authors： Zhang X,Alekseev K,Jung K,Vlasova A,Hadya N,Saif LJ

更新日期：2008-05-01 00:00:00

abstract：:The gastrointestinal tract is constantly exposed to a variety of potentially invasive bacteria and viruses. The first line of defense of the host against these pathogens is the intestinal mucosal surface, which consists of epithelial cells, intraepithelial lymphocytes (IELs), mucus, and secretory immunoglobulins. Litt...

journal_title：Journal of virology

authors： Offit PA,Dudzik KI

更新日期：1989-08-01 00:00:00

abstract：:The major capsid protein of polyomavirus, VP1, was separated into at least four subspecies by isoelectric focusing. One of these subspecies was selectively extracted from purified virions by mild treatment with sodium dodecyl sulfate, leaving a 140S particle enriched in the other three forms. The two most acidic subsp...

journal_title：Journal of virology

authors： Garcea RL,Ballmer-Hofer K,Benjamin TL

更新日期：1985-05-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a ubiquitously distributed pathogen that causes severe disease in immunosuppressed patients and newborn infants infected in utero. The viral envelope glycoprotein B (gB) is an attractive molecule for active vaccination and passive immunoprophylaxis and therapy. Using human monoclonal an...

journal_title：Journal of virology

authors： Spindler N,Rücker P,Pötzsch S,Diestel U,Sticht H,Martin-Parras L,Winkler TH,Mach M

更新日期：2013-08-01 00:00:00

abstract：:A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans. The gene is transcribed abundantly early in infection and is found immediately outside the inv...

journal_title：Journal of virology

authors： Lyttle DJ,Fraser KM,Fleming SB,Mercer AA,Robinson AJ

更新日期：1994-01-01 00:00:00

abstract：:The classical swine fever virus (CSFV) live attenuated vaccine C-strain is adaptive to rabbits and attenuated in pigs, in contrast with the highly virulent CSFV Shimen strain. Previously, we demonstrated that P108 and T109 on the E2 glycoprotein (E2P108-T109) in domain I (E2DomainI) rather than R132, S133, and D191 in...

journal_title：Journal of virology

authors： Xie L,Han Y,Ma Y,Yuan M,Li W,Li LF,Li M,Sun Y,Luo Y,Li S,Hu S,Li Y,Qiu HJ

更新日期：2020-08-17 00:00:00

abstract：:cis-Acting elements in the viral genome RNA (vRNA) are essential for the translation, replication, and/or encapsidation of RNA viruses. In this study, a novel conserved cis-acting element was identified in the capsid-coding region of mosquito-borne flavivirus. The downstream of 5' cyclization sequence (5'CS) pseudokno...

journal_title：Journal of virology

authors： Liu ZY,Li XF,Jiang T,Deng YQ,Zhao H,Wang HJ,Ye Q,Zhu SY,Qiu Y,Zhou X,Qin ED,Qin CF

更新日期：2013-06-01 00:00:00

abstract：:The Vpr accessory gene product of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus is believed to play a role in permitting entry of the viral core into the nucleus of nondividing cells. A second role for Vpr was recently suggested by Rogel et al. (M. E. Rogel, L. I. Wu, and M. Emerman, J. ...

journal_title：Journal of virology

authors： He J,Choe S,Walker R,Di Marzio P,Morgan DO,Landau NR

更新日期：1995-11-01 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit th...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Collins PL

更新日期：2005-05-01 00:00:00

abstract：:In eukaryotic cells, cell growth and division occur in a stepwise, orderly fashion described by a process known as the cell cycle. The relationship between positive-strand RNA viruses and the cell cycle and the concomitant effects on virus replication are not clearly understood. We have shown that infection of asynchr...

journal_title：Journal of virology

authors： Dove B,Brooks G,Bicknell K,Wurm T,Hiscox JA

更新日期：2006-04-01 00:00:00

abstract：:Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy...

journal_title：Journal of virology

authors： Chang J,Naif HM,Li S,Sullivan JS,Randle CM,Cunningham AL

更新日期：1996-11-01 00:00:00

abstract：:Cylindrical projections surrounding the fivefold-symmetry axes in minute virus of mice (MVM) harbor central pores that penetrate through the virion shell. In newly released DNA-containing particles, these pores contain residues 28 to 38 belonging to a single copy of VP2, disposed so that its extreme N-terminal domain ...

journal_title：Journal of virology

authors： Farr GA,Cotmore SF,Tattersall P

更新日期：2006-01-01 00:00:00

abstract：:Synthesis of the proteins of rabies virus was studied in hamster cells infected with UV-irradiated virus. The UV target size of genes L, N, M1, and M2 was measured during primary transcription. Except for N, the target size of the remaining genes was considerably larger than that of their physical sizes. The data fit ...

journal_title：Journal of virology

authors： Flamand A,Delagneau JF

更新日期：1978-11-01 00:00:00

abstract：:The nucleic acids of influenza A, B, and C viruses were compared. Susceptibility to nucleases demonstrates that influenza C virus, just as influenza A and B viruses, possesses single-stranded RNA as its genome. The base compositions of the RNAs of influenza A, B, and influenza C virus are almost identical and comparat...

journal_title：Journal of virology

authors： Ritchey MB,Palese P,Kilbourne ED

更新日期：1976-05-01 00:00:00

abstract：:The swine-specific coronavirus transmissible gastroenteritis virus (TGEV) uses pig aminopeptidase-N (pAPN) as a cellular receptor. We showed that the human aminopeptidase-N (hAPN) cannot substitute for pAPN in this respect, although the two enzymes have 80% amino acid sequence identity. In order to map the TGEV bindin...

journal_title：Journal of virology

authors： Delmas B,Gelfi J,Kut E,Sjöström H,Noren O,Laude H

更新日期：1994-08-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) glycoprotein plays a critical role in parainfluenza virus replication. We recently found that in addition to the catalytic binding site, HN of human parainfluenza virus type 1 (hPIV-1) may have a second receptor-binding site covered by an N-linked glycan at residue 173, which is ne...

journal_title：Journal of virology

authors： Mishin VP,Watanabe M,Taylor G,Devincenzo J,Bose M,Portner A,Alymova IV

更新日期：2010-03-01 00:00:00

abstract：:Based on sequence divergence in the transformation-relevant region, herpesvirus saimiri strains are classified into three subgroups. Only members of subgroup C transform human T lymphocytes to continuous interleukin-2-dependent growth in culture. In this study, human cord blood T cells were immortalized by using diffe...

journal_title：Journal of virology

authors： Fickenscher H,Bökel C,Knappe A,Biesinger B,Meinl E,Fleischer B,Fleckenstein B,Bröker BM

更新日期：1997-03-01 00:00:00

abstract：:More than 200 open reading frames (ORFs) from the human cytomegalovirus genome have been reported as potentially coding for proteins. We have used two pattern-based in silico approaches to analyze this set of putative viral genes. With the help of an objective annotation method that is based on the Bio-Dictionary, a c...

journal_title：Journal of virology

authors： Rigoutsos I,Novotny J,Huynh T,Chin-Bow ST,Parida L,Platt D,Coleman D,Shenk T

更新日期：2003-04-01 00:00:00

abstract：:The protein kinase inhibitor H7 blocks influenza virus replication, inhibits production of the matrix protein (M1), and leads to a retention of the viral ribonucleoproteins (vRNPs) in the nucleus at late times of infection (K. Martin and A. Helenius, Cell 67:117-130, 1991). We show here that production of assembled vR...

journal_title：Journal of virology

authors： Bui M,Wills EG,Helenius A,Whittaker GR

更新日期：2000-02-01 00:00:00

abstract：:Glycoprotein B (gB) is the most highly conserved of the envelope glycoproteins of human herpesviruses. The gB protein of human cytomegalovirus (CMV) serves multiple roles in the life cycle of the virus. To investigate structural properties of gB that give rise to its function, we sought to determine the disulfide bond...

journal_title：Journal of virology

authors： Lopper M,Compton T

更新日期：2002-06-01 00:00:00

abstract：:N6-adenosine methylation (m6A) is the most common posttranscriptional RNA modification in mammalian cells. We found that most transcripts encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome undergo m6A modification. The levels of m6A-modified mRNAs increased substantially upon stimulation for lytic re...

journal_title：Journal of virology

authors： Ye F,Chen ER,Nilsen TW

更新日期：2017-07-27 00:00:00

abstract：:A rapid assay for retroviral reverse transcriptase activity released into the culture medium by infected cells was developed. With the assay, 4,000 clonally infected cell lines could be tested in a few hours. We have adapted the assay for use as a screen for the detection of spontaneous viral mutants. Mutants of Molon...

journal_title：Journal of virology

authors： Goff S,Traktman P,Baltimore D

更新日期：1981-04-01 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain. In Africa, epidemic emergence of CHIKV involves the transition from an enzootic, sylvatic cycle involving arboreal mosquito vectors and nonhu...

journal_title：Journal of virology

authors： Volk SM,Chen R,Tsetsarkin KA,Adams AP,Garcia TI,Sall AA,Nasar F,Schuh AJ,Holmes EC,Higgs S,Maharaj PD,Brault AC,Weaver SC

更新日期：2010-07-01 00:00:00

abstract：:Recombinant viruses were constructed to have an Escherichia coli replicon containing a mutagenesis marker, the supF gene, integrated within the thymidine kinase locus (tk) of herpes simplex virus type 1. These viruses expressed either wild-type or mutant DNA polymerase (Pol) and were tested in a mutagenesis assay for ...

journal_title：Journal of virology

authors： Hwang YT,Liu BY,Hwang CB

更新日期：2002-04-01 00:00:00

abstract：UNLABELLED:Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) cause large-scale epidemics of severe musculoskeletal disease and have been progressively expanding their global distribution. Since its introduction in July 2014, CHIKV now circulates in the United States. The hallmark o...

journal_title：Journal of virology

authors： Herrero LJ,Foo SS,Sheng KC,Chen W,Forwood MR,Bucala R,Mahalingam S

更新日期：2015-08-01 00:00:00

abstract：:Inhibition of hepatitis B virus (HBV) replication and viral clearance from an infected host requires both the innate and adaptive immune responses. Expression of interferon (IFN)-inducible proteasome catalytic and regulatory subunits correlates with the IFN-alpha/beta- and IFN-gamma-mediated noncytopathic inhibition o...

journal_title：Journal of virology

authors： Robek MD,Garcia ML,Boyd BS,Chisari FV

更新日期：2007-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV), a member of human gammaherpesvirus, infects mainly B cells. EBV has two alternative life cycles, latent and lytic, and is reactivated occasionally from the latent stage to the lytic cycle. To combat EBV-associated disorders, understanding the molecular mechanisms of the EBV lytic replication ...

journal_title：Journal of virology

authors： Masud HMAA,Watanabe T,Yoshida M,Sato Y,Goshima F,Kimura H,Murata T

更新日期：2017-11-14 00:00:00

abstract：:Since dendritic cells may play a key role in defense against influenza virus infection, we examined the effects of recombinant hemagglutinin (HA) proteins derived from mouse-adapted H1N1 (A/WSN/1933), swine-origin 2009 pandemic H1N1 (A/Texas/05/2009), and highly pathogenic avian influenza H5N1 (A/Thailand/KAN-1/2004) ...

journal_title：Journal of virology

authors： Liu WC,Lin SC,Yu YL,Chu CL,Wu SC

更新日期：2010-11-01 00:00:00

abstract：:Synthetic peptides of increasing length and corresponding in sequence to the C-terminal end of the HA1 molecule of influenza virus were constructed and examined for their immunogenic and antigenic properties. Peptides containing at least the four C-terminal amino acids, when coupled to keyhole limpet hemocyanin, were ...

journal_title：Journal of virology

authors： Tang XL,Tregear GW,White DO,Jackson DC

更新日期：1988-12-01 00:00:00

abstract：:The envelope of human parainfluenza virus type 3 (HPF3) contains two viral glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion protein (F). HN, which is responsible for receptor attachment and for promoting F-mediated fusion, also possesses neuraminidase (receptor-destroying) activity. We reported previ...

journal_title：Journal of virology

authors： Porotto M,Greengard O,Poltoratskaia N,Horga MA,Moscona A

更新日期：2001-08-01 00:00:00