Hepatitis delta antigens enhance the ribozyme activities of hepatitis delta virus RNA in vivo.

abstract：:We have analyzed the production of tumor necrosis factor alpha (TNF-alpha) induced by in vitro infection with African swine fever (ASF) virus (ASFV) and the systemic and local release of this inflammatory cytokine upon in vivo infection. An early increase in TNF-alpha mRNA expression was detected in ASFV-infected alve...

journal_title：Journal of virology

authors： Gómez del Moral M,Ortuño E,Fernández-Zapatero P,Alonso F,Alonso C,Ezquerra A,Domínguez J

更新日期：1999-03-01 00:00:00

abstract：:Expression of the selectable drug resistance gene in retroviral vectors used for gene therapy can lead to a decreased expression of the gene of interest and may induce a host immune response, resulting in a decreased efficiency of gene therapy. In this study, we demonstrate that high-frequency deletion of direct repea...

journal_title：Journal of virology

authors： Delviks KA,Pathak VK

更新日期：1999-10-01 00:00:00

abstract：:Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ass...

journal_title：Journal of virology

authors： Brass V,Pal Z,Sapay N,Deléage G,Blum HE,Penin F,Moradpour D

更新日期：2007-03-01 00:00:00

abstract：:Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) cells are predominantly infected with latent Kaposi's sarcoma-associated herpesvirus (KSHV), presenting a barrier to the destruction of tumor cells. Latent KSHV can be reactivated to undergo lytic replication. Here we report that in PEL cells, oxidative stress ...

journal_title：Journal of virology

authors： Li X,Feng J,Sun R

更新日期：2011-01-01 00:00:00

abstract：:Betanodaviruses, the causal agents of viral nervous necrosis in marine fish, have bipartite positive-sense RNAs as genomes. The larger genomic segment, RNA1 (3.1 kb), encodes an RNA-dependent RNA polymerase, and the smaller genomic segment, RNA2 (1.4 kb), codes for the coat protein. Betanodaviruses have marked host sp...

journal_title：Journal of virology

authors： Iwamoto T,Okinaka Y,Mise K,Mori K,Arimoto M,Okuno T,Nakai T

更新日期：2004-02-01 00:00:00

abstract：:The human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) controls viral gene transcription in a cell-type-specific manner. The HPV-18 URR is active in HeLa cells but inactive in HepG2 cells. The activating activity of YY1 in HeLa cells is dependent on its functional interactions with the switch regio...

journal_title：Journal of virology

authors： Bauknecht T,See RH,Shi Y

更新日期：1996-11-01 00:00:00

abstract：:Reassortant viruses which possessed the hemagglutinin and neuraminidase genes of wild-type human influenza A viruses and the remaining six RNA segments (internal genes) of the avian A/Pintail/Alberta/119/79 (H4N6) virus were previously found to be attenuated in humans. To study the genetic basis of this attenuation, w...

journal_title：Journal of virology

authors： Snyder MH,Buckler-White AJ,London WT,Tierney EL,Murphy BR

更新日期：1987-09-01 00:00:00

abstract：:The p24 protein, one of the three proteins implicated in local movement of potato virus X (PVX), was expressed in transgenic tobacco plants (Nicotiana tabacum Xanthi D8 NN). Plants with the highest level of p24 accumulation exhibited a stunted and slightly chlorotic phenotype. These transgenic plants facilitate the ce...

journal_title：Journal of virology

authors： Ares X,Calamante G,Cabral S,Lodge J,Hemenway P,Beachy RN,Mentaberry A

更新日期：1998-01-01 00:00:00

abstract：:Disulfide bonds reportedly stabilize the capsids of several viruses, including papillomavirus, polyomavirus, and simian virus 40, and have been detected in herpes simplex virus (HSV) capsids. In this study, we show that in mature HSV-1 virions, capsid proteins VP5, VP23, VP19C, UL17, and UL25 participate in covalent c...

journal_title：Journal of virology

authors： Szczepaniak R,Nellissery J,Jadwin JA,Makhov AM,Kosinski A,Conway JF,Weller SK

更新日期：2011-09-01 00:00:00

abstract：:The roles of the capsid protein (CP) and the CP coding sequence of tobacco etch potyvirus (TEV) in genome amplification were analyzed. A series of frameshift-stop codon mutations that interrupted translation of the CP coding sequence at various positions were introduced into the TEV genome. A series of 3' deletion mut...

journal_title：Journal of virology

authors： Mahajan S,Dolja VV,Carrington JC

更新日期：1996-07-01 00:00:00

abstract：:Transfection has been found and characterized in pneumococcus. For replicating omega3 phage DNA extracted from infected cells, transfection was relatively efficient and rose linearly with DNA concentration and quadratically with time, according to T(T - 3.5) min(2). For mature DNA extracted from phage particles, trans...

journal_title：Journal of virology

authors： Porter RD,Guild WR

更新日期：1978-01-01 00:00:00

abstract：:The Sindbis virus minimal subgenomic mRNA promoter (spanning positions -19 to +5 relative to the subgenomic mRNA start site) is approximately three- to sixfold less active than the fully active -98 to +14 promoter region. We identified two elements flanking the -19 to +5 region which increase its transcription to leve...

journal_title：Journal of virology

authors： Wielgosz MM,Raju R,Huang HV

更新日期：2001-04-01 00:00:00

abstract：:Hemorrhagic enteritis virus (HEV), a type II avian adenovirus, causes intestinal hemorrhages and immunosuppression in turkeys. In this study, we exposed turkeys to virulent HEV and examined fractionated spleen cells for the presence of viral DNA by in situ hybridization and amplification of DNA extracted from virus-in...

journal_title：Journal of virology

authors： Suresh M,Sharma JM

更新日期：1996-01-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, inf...

journal_title：Journal of virology

authors： Shen R,Raska M,Bimczok D,Novak J,Smith PD

更新日期：2014-12-01 00:00:00

abstract：:Experimental reverse genetic replacement of Epstein-Barr virus nuclear antigen 3A (EBNA3A) with a conditional mutant EBNA3A revealed that EBNA3A is critical for continued lymphoblastoid cell (LCL) growth. Wild-type (wt) EBNA3A expressed in the LCLs specifically sustained growth under nonpermissive conditions, whereas ...

journal_title：Journal of virology

authors： Maruo S,Johannsen E,Illanes D,Cooper A,Zhao B,Kieff E

更新日期：2005-08-01 00:00:00

abstract：:Streptomyces coelicolor is a model system for the study of Streptomyces, a genus of bacteria responsible for the production of many clinically important antibiotics. Here we report the genome sequence of ΦCAM, a new S. coelicolor generalized transducing bacteriophage, isolated from a soil sample originating from Linco...

journal_title：Journal of virology

authors： Monson R,Salmond GP

更新日期：2012-12-01 00:00:00

abstract：:Virus-specific cytotoxic T lymphocytes (CTL) exert intense selection pressure on replicating simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) in infected individuals. The immunodominant Mamu-A(*)01-restricted Gag p11C, C-M epitope is highly conserved among all sequenced isolates of S...

journal_title：Journal of virology

authors： Peyerl FW,Barouch DH,Yeh WW,Bazick HS,Kunstman J,Kunstman KJ,Wolinsky SM,Letvin NL

更新日期：2003-12-01 00:00:00

abstract：:Yaba tumor poxvirus deoxyribonucleic acid (DNA) has a density of 1.6905 in CsCl and its T(m) value in 0.015 m citrate in saline is 82.3. The guanine plus cytosine content estimated from these properties was taken to be 32.5 +/- 0.5%, a value 2 to 3% less than for DNA from other poxviruses reported to date. ...

journal_title：Journal of virology

authors： Yohn DS,Gallagher JF

更新日期：1969-02-01 00:00:00

abstract：UNLABELLED:JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers results...

journal_title：Journal of virology

authors： Nelson CD,Ströh LJ,Gee GV,O'Hara BA,Stehle T,Atwood WJ

更新日期：2015-04-01 00:00:00

abstract：:Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Sa...

journal_title：Journal of virology

authors： Gori-Savellini G,Valentini M,Cusi MG

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:The RNA genome of respiratory syncytial virus (RSV) is constitutively encapsidated by the viral nucleoprotein N, thus forming a helical nucleocapsid. Polymerization of N along the genomic and antigenomic RNAs is concomitant to replication and requires the preservation of an unassembled monomeric nucleoprotei...

journal_title：Journal of virology

authors： Galloux M,Gabiane G,Sourimant J,Richard CA,England P,Moudjou M,Aumont-Nicaise M,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2015-04-01 00:00:00

abstract：:Actinophage MSP2 is infectious for Streptomyces venezuelae S13. Based upon electron microscopy of coliphage T4 mixed with MSP2, MSP2 had a head about 48 +/- 2 nm wide and 87 +/- 5 nm long. DNA from polyoma virus and from coliphages T4 and T7 served as reference markers in estimating the molecular weight of MSP2 DNA fr...

journal_title：Journal of virology

authors： Lancaster WD,Jones LA

更新日期：1975-09-01 00:00:00

abstract：:LA3382 is a temperature-sensitive replication-defective mutant of Rous sarcoma virus that contains four active mutations. In this study we performed experiments to determine the biochemical defect that blocks the synthesis of infections virus late in the replication cycle. At the nonpermissive temperature (41 degrees ...

journal_title：Journal of virology

authors： Hardwick JM,Hunter E

更新日期：1981-12-01 00:00:00

abstract：:Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells. ...

journal_title：Journal of virology

authors： Flomenberg PR,Chen M,Horwitz MS

更新日期：1987-12-01 00:00:00

abstract：:Poliovirus (PV) is easily transferred to humans orally; however, no rodent model for oral infections has been developed because of the alimentary tract's low sensitivity to the virus. Here we showed that PV is inactivated by the low pH of the gastric contents in mice. The addition of 3% NaHCO3 to the viral inoculum in...

journal_title：Journal of virology

authors： Ohka S,Igarashi H,Nagata N,Sakai M,Koike S,Nochi T,Kiyono H,Nomoto A

更新日期：2007-08-01 00:00:00

abstract：:The flavivirus dengue virus (DV) infects cells through a low-pH-triggered membrane fusion reaction mediated by the viral envelope protein E. E is an elongated transmembrane protein with three domains and is organized as a homodimer on the mature virus particle. During fusion, the E protein homodimer dissociates, inser...

journal_title：Journal of virology

authors： Liao M,Sánchez-San Martín C,Zheng A,Kielian M

更新日期：2010-06-01 00:00:00

abstract：:Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into...

journal_title：Journal of virology

authors： Bonham L,Wolgamot G,Miller AD

更新日期：1997-06-01 00:00:00

abstract：:Hepatitis C Virus (HCV) NS4B protein induces a specialized membrane structure which may serve as the replication platform for HCV RNA replication. In the present study, we demonstrated that NS4B has lipid modifications (palmitoylation) on two cysteine residues (cysteines 257 and 261) at the C-terminal end. Site-specif...

journal_title：Journal of virology

authors： Yu GY,Lee KJ,Gao L,Lai MM

更新日期：2006-06-01 00:00:00

abstract：:A characterization of the antigenic determinants (epitopes) of the glycoprotein (G) of infectious hematopoietic necrosis virus was made by expressing different regions of the G gene in Escherichia coli. A cDNA copy of the G gene was divided into four fragments by TaqI digestion, and the fragments were subcloned into p...

journal_title：Journal of virology

authors： Xu L,Mourich DV,Engelking HM,Ristow S,Arnzen J,Leong JC

更新日期：1991-03-01 00:00:00

abstract：UNLABELLED:Avian metapneumovirus (aMPV), also known as avian pneumovirus or turkey rhinotracheitis virus, is the causative agent of turkey rhinotracheitis and is associated with swollen head syndrome in chickens. Since its discovery in the 1970s, aMPV has been recognized as an economically important pathogen in the pou...

journal_title：Journal of virology

authors： Sun J,Wei Y,Rauf A,Zhang Y,Ma Y,Zhang X,Shilo K,Yu Q,Saif YM,Lu X,Yu L,Li J

更新日期：2014-11-01 00:00:00