Genome sequence of a new Streptomyces coelicolor generalized transducing bacteriophage, ΦCAM.

abstract：:Highly active antiretroviral therapy (HAART) enables long-term suppression of plasma HIV-1 loads in infected persons, but low-level virus persists and rebounds following cessation of therapy. During HAART, this virus resides in latently infected cells, such as resting CD4(+) T cells, and in other cell types that may s...

journal_title：Journal of virology

authors： North TW,Higgins J,Deere JD,Hayes TL,Villalobos A,Adamson L,Shacklett BL,Schinazi RF,Luciw PA

更新日期：2010-03-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Vpr protein is both packaged into virions and efficiently localized to the nucleus. In this report, we show that a significant fraction of Vpr also accumulates in the cytoplasm of virus-producing cells. Although Vpr shuttles between the nucleus and the cytoplasm, studies with an...

journal_title：Journal of virology

authors： Jenkins Y,Sanchez PV,Meyer BE,Malim MH

更新日期：2001-09-01 00:00:00

abstract：:Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) binds complement component C3b and protects virus from complement-mediated neutralization. Differences in complement interacting domains exist between gC of HSV-1 (gC1) and HSV-2 (gC2), since the amino terminus of gC1 blocks complement C5 fr...

journal_title：Journal of virology

authors： Hook LM,Lubinski JM,Jiang M,Pangburn MK,Friedman HM

更新日期：2006-04-01 00:00:00

abstract：:Oncornavirus 60 to 70S ribonucleic acids (RNA), such as those from avian myeloblastosis virus, Schmidt-Ruppin virus, or mouse sarcoma-mouse leukemia viruses, isolated by conventional techniques, contain 4S transferlike RNA molecules that are released upon dissociation of the 60 to 70S RNA with heat. The 4S RNA represe...

journal_title：Journal of virology

authors： Erikson E,Erikson RL

更新日期：1971-08-01 00:00:00

abstract：:Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics, representing a serious public health concern. It has been described that one mechanism used by some IAV strains to escape the host innate immune responses and modulate virus pathogenicity involves the ability of the PA-X and NS1 proteins to ...

journal_title：Journal of virology

authors： Nogales A,Rodriguez L,DeDiego ML,Topham DJ,Martínez-Sobrido L

更新日期：2017-08-10 00:00:00

abstract：:The efficiency and specificity of gene transfer with human adenovirus (hAd)-derived gene transfer vectors would be improved if the native viral tropism could be modified. Here, we demonstrate that the minor capsid protein IX (pIX), which is present in 240 copies in the Ad capsid, can be exploited as an anchor for hete...

journal_title：Journal of virology

authors： Vellinga J,Rabelink MJ,Cramer SJ,van den Wollenberg DJ,Van der Meulen H,Leppard KN,Fallaux FJ,Hoeben RC

更新日期：2004-04-01 00:00:00

abstract：:During infection, adenovirus-associated virus (AAV) undergoes microtubule-dependent retrograde transport as part of a program of vectorial transport of viral genome to the nucleus. A microtubule binding assay was used to evaluate the hypothesis that cytoplasmic dynein mediates AAV interaction with microtubules. Bindin...

journal_title：Journal of virology

authors： Kelkar S,De BP,Gao G,Wilson JM,Crystal RG,Leopold PL

更新日期：2006-08-01 00:00:00

abstract：:Certain murine leukemia viruses (MLVs) can induce progressive noninflammatory spongiform neurodegeneration similar to that caused by prions. The primary MLV determinants responsible have been mapped to within the env gene; however, it has remained unclear how env mediates disease, whether non-Env viral components are ...

journal_title：Journal of virology

authors： Li Y,Cardona SM,Traister RS,Lynch WP

更新日期：2011-03-01 00:00:00

abstract：:Equine rhinitis A virus (ERAV) has recently been classified as an aphthovirus, a genus otherwise comprised of the different serotypes of Foot-and-mouth disease virus (FMDV). FMDV initiates translation via a type II internal ribosomal entry site (IRES) and utilizes two in-frame AUG codons to produce the leader proteina...

journal_title：Journal of virology

authors： Hinton TM,Li F,Crabb BS

更新日期：2000-12-01 00:00:00

abstract：:The mechanism whereby picornaviruses inhibit host protein synthesis while their own synthetic processes proceed unabated has remained elusive. One of our approaches to this problem was to study the ability of cell-free extracts derived from uninfected and mengovirus-infected Ehrlich ascites tumor cells to translate vi...

journal_title：Journal of virology

authors： Abreu SL,Lucas-Lenard J

更新日期：1976-04-01 00:00:00

abstract：:The mutational alterations in polyoma virus mutants ts-a and ts-25E which cause their large T-antigens to be thermolabile have been identified. In ts-a, a G leads to A transition at nucleotide 2193 causes the replacement of Ala (GCT) by Thr (ACT). In ts-25E, a G leads to T transversion at nucleotide 2883 causes the re...

journal_title：Journal of virology

authors： Thomas T,Vollmer P,Folk WR

更新日期：1981-03-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) tegument protein pp71, encoded by gene UL82, stimulates viral immediate-early (IE) transcription. pp71 interacts with the cellular protein hDaxx at nuclear domain 10 (ND10) sites, resulting in the reversal of hDaxx-mediated repression of viral transcription. We demonstrate that pp71 di...

journal_title：Journal of virology

authors： Lukashchuk V,McFarlane S,Everett RD,Preston CM

更新日期：2008-12-01 00:00:00

abstract：:The structural gene for diphtherial toxin is present in corynebacteriophage beta. Previous studies located several point mutations within the tox locus and determined the orientation of transcription of the toxin structural gene. The production of maximal quantities of toxin by Corynebacterium diphtheriae C7(beta) occ...

journal_title：Journal of virology

authors： Welkos SL,Holmes RK

更新日期：1981-03-01 00:00:00

abstract：:HIV-1 circulates within an infected host as a genetically heterogeneous viral population. Viral intrahost diversity is shaped by substitutional evolution and recombination. Although many studies have speculated that recombination could have a significant impact on viral phenotype, this has never been definitively demo...

journal_title：Journal of virology

authors： Brown RJ,Peters PJ,Caron C,Gonzalez-Perez MP,Stones L,Ankghuambom C,Pondei K,McClure CP,Alemnji G,Taylor S,Sharp PM,Clapham PR,Ball JK

更新日期：2011-06-01 00:00:00

abstract：:The p21 proteins of ras oncogenes are synthesized as precursors in the cytosol. After processing, which involves acylation, the products are associated with the plasma membrane in eucaryotic cells. The p21 overproduced in Escherichia coli, however, is not processed by acylation. A synthetic tetrapeptide of the p21 C t...

journal_title：Journal of virology

authors： Chen ZQ,Ulsh LS,DuBois G,Shih TY

更新日期：1985-11-01 00:00:00

abstract：:A substantial number of viruses have been demonstrated to subvert autophagy to promote their own replication. Recent publications have reported the proviral effect of autophagy induction on hepatitis B virus (HBV) replication. Hepatitis delta virus (HDV) is a defective virus and an occasional obligate satellite of HBV...

journal_title：Journal of virology

authors： Khabir M,Aliche AZ,Sureau C,Blanchet M,Labonté P

更新日期：2020-01-31 00:00:00

abstract：:We previously demonstrated that human cytomegalovirus (HCMV) infection induced the activation of the cellular transcription factor NF-kappaB. Here, we investigate the mechanism for the HCMV-induced NF-kappaB activation and the role that the induced NF-kappaB plays in transactivation of the major immediate-early promot...

journal_title：Journal of virology

authors： DeMeritt IB,Milford LE,Yurochko AD

更新日期：2004-05-01 00:00:00

abstract：UNLABELLED:Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients, underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular microRNAs (miRNAs) in cells that promote latency to regulate exp...

journal_title：Journal of virology

authors： O'Connor CM,Vanicek J,Murphy EA

更新日期：2014-05-01 00:00:00

abstract：:The smallpox vaccine is the prototypic vaccine, yet the viral targets critical for vaccine-mediated protection remain unclear in humans. We have produced protein microarrays of a near-complete vaccinia proteome and used them to determine the major antigen specificities of the human humoral immune response to the small...

journal_title：Journal of virology

authors： Davies DH,McCausland MM,Valdez C,Huynh D,Hernandez JE,Mu Y,Hirst S,Villarreal L,Felgner PL,Crotty S

更新日期：2005-09-01 00:00:00

abstract：:Accumulation of the interferon-stimulated gene 15 (ISG15) protein product, which is reversibly conjugated to numerous polypeptide targets, impacts the proteome and physiology of uninfected and infected cells. While many viruses, including human cytomegalovirus (HCMV), blunt host antiviral defenses by limiting ISG expr...

journal_title：Journal of virology

authors： Bianco C,Mohr I

更新日期：2017-04-13 00:00:00

abstract：:The baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) initiates apoptosis in diverse insects through events triggered by virus DNA (vDNA) replication. To define the proapoptotic pathway and its role in antivirus defense, we investigated the link between the host's DNA damage response (DDR) a...

journal_title：Journal of virology

authors： Mitchell JK,Friesen PD

更新日期：2012-12-01 00:00:00

abstract：:The genetic evolution of human immunodeficiency virus type 1 (HIV-1) in the brain is distinct from that in lymphoid tissues, indicating tissue-specific compartmentalization of the virus. Few primary HIV-1 envelope glycoproteins (Envs) from uncultured brain tissues have been biologically well characterized. In this stu...

journal_title：Journal of virology

authors： Ohagen A,Devitt A,Kunstman KJ,Gorry PR,Rose PP,Korber B,Taylor J,Levy R,Murphy RL,Wolinsky SM,Gabuzda D

更新日期：2003-11-01 00:00:00

abstract：:The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3' noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne fl...

journal_title：Journal of virology

authors： Men R,Bray M,Clark D,Chanock RM,Lai CJ

更新日期：1996-06-01 00:00:00

abstract：:Infection with human papillomavirus (HPV) is a critical factor in the pathogenesis of most cervical cancers and some aerodigestive cancers. The HPV E6 oncoprotein from high-risk HPV types contributes to the immortalization and transformation of cells by multiple mechanisms, including degradation of p53, transcriptiona...

journal_title：Journal of virology

authors： James MA,Lee JH,Klingelhutz AJ

更新日期：2006-06-01 00:00:00

abstract：:We studied the effect of booster injections and the long-term immune response after injections of an anti-human immunodeficiency virus type 1 (HIV-1) lipopeptide vaccine. This vaccine was injected alone or with QS21 adjuvant to 28 HIV-uninfected volunteers. One month later, after a fourth injection of the vaccine, B- ...

journal_title：Journal of virology

authors： Gahéry-Ségard H,Pialoux G,Figueiredo S,Igéa C,Surenaud M,Gaston J,Gras-Masse H,Lévy JP,Guillet JG

更新日期：2003-10-01 00:00:00

abstract：:The effect DNA repair might have on the integration of exogenous proviral DNA into host cell DNA was investigated by comparing the efficiency of proviral DNA integration in normal chicken embryonic fibroblasts and in chicken embryonic fibroblasts treated with UV or 4-nitroquinoline-1-oxide. The cells were treated with...

journal_title：Journal of virology

authors： Tsuruo T,Baluda MA

更新日期：1977-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：UNLABELLED:JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers results...

journal_title：Journal of virology

authors： Nelson CD,Ströh LJ,Gee GV,O'Hara BA,Stehle T,Atwood WJ

更新日期：2015-04-01 00:00:00

abstract：:The influenza A virus nucleoprotein (NP) is a single-stranded RNA-binding protein that encapsidates the virus genome and has essential functions in viral-RNA synthesis. Here, we report the characterization of a temperature-sensitive (ts) NP mutant (US3) originally generated in fowl plague virus (A/chicken/Rostock/34)....

journal_title：Journal of virology

authors： Noton SL,Simpson-Holley M,Medcalf E,Wise HM,Hutchinson EC,McCauley JW,Digard P

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:While a clear understanding of the events leading to successful establishment of host-specific viral populations and productive infection in the central nervous system (CNS) has not yet been reached, the simian immunodeficiency virus (SIV)-infected rhesus macaque provides a powerful model for the study of hu...

journal_title：Journal of virology

authors： Lamers SL,Nolan DJ,Rife BD,Fogel GB,McGrath MS,Burdo TH,Autissier P,Williams KC,Goodenow MM,Salemi M

更新日期：2015-08-01 00:00:00