Abstract:
:Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
journal_name
J Viroljournal_title
Journal of virologyauthors
Van Poucke S,Doedt J,Baumann J,Qiu Y,Matrosovich T,Klenk HD,Van Reeth K,Matrosovich Mdoi
10.1128/JVI.01292-15subject
Has Abstractpub_date
2015-12-01 00:00:00pages
12211-6issue
23eissn
0022-538Xissn
1098-5514pii
JVI.01292-15journal_volume
89pub_type
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