Abstract:
:The isolation of a temperature phage specific for the photosynthetic bacterium Rhodopseudomonas spheroides is reported. This phage, Rphi-1, establishes a state of lysogeny and can be induced from the prophage state by exposure to mitomycin C or UV irradiation. Mutants of Rphi-1 which grow on a standard laboratory strain (2.4.1) of Rhodopseudomonas spheroides were isolated. Although the original Rphi-1 isolated was chloroform sensitive, the mutant which plates on strain 2.4.1 is chloroform resistant. Rphi-1 does not grow on closely related bacteria, such as Rhodopseudomonas palustris or Rhodopseudomonas capsulata. Rphi-1 mutants forms plaques with the same efficiency whether the plates are incubated under aerobic conditions in the dark or under anaerobic conditions in the light (phototropic conditions).
journal_name
J Viroljournal_title
Journal of virologyauthors
Mural RJ,Friedman DIdoi
10.1128/JVI.14.5.1288-1292.1974subject
Has Abstractpub_date
1974-11-01 00:00:00pages
1288-92issue
5eissn
0022-538Xissn
1098-5514journal_volume
14pub_type
杂志文章abstract::The RNA genome of human immunodeficiency virus type 1 (HIV-1) is converted into DNA after infection in order to integrate into the host cell DNA. However, a large number of these reverse-transcribed genomes remain unintegrated in the nucleus of infected cells. Currently, there are no data available about the intranucl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.16.7683-7691.2001
更新日期:2001-08-01 00:00:00
abstract::In response to viral infection, reactive oxygen species (ROS) mediate innate immune signaling or generate danger signals to activate immune cells. The mechanisms of virally induced ROS are poorly defined, however. We demonstrate that ROS are produced within minutes of adenovirus type 5 (Ad5) infection of macrophages a...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00675-11
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.1.49-56.2000
更新日期:2000-01-01 00:00:00
abstract::To assess the heterogeneity of cytotoxic T lymphocytes (CTLs) directed against viral epitopes, we studied six class I major histocompatibility complex-restricted (H-2Db) CTL clones that recognize the same 9-amino-acid immunodominant epitope, amino acids 278 to 286 from envelope glycoprotein 2 (GP2) of lymphocytic chor...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.5.1845-1851.1989
更新日期:1989-05-01 00:00:00
abstract::Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. In other picornaviruses, homodimerization of 3A has been shown to be relevant for its biological activity. In this work, FMDV 3A homodimerization was evidenced by an in situ protein fluor...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00580-12
更新日期:2012-10-01 00:00:00
abstract::Sindbis virus (SINV) is an alphavirus that causes infection of neurons and encephalomyelitis in adult immunocompetent mice. Recovery can occur without apparent neurological damage. To better define the factors facilitating noncytolytic clearance of SINV in different regions of the central nervous system (CNS) and the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01152-06
更新日期:2007-06-01 00:00:00
abstract::In order to study primate lentivirus evolution in the Colobinae subfamily, in which only one simian immunodeficiency virus (SIV) has been described to date, we screened additional species from the three different genera of African colobus monkeys for SIV infection. Blood was obtained from 13 West African colobids, and...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.1.744-748.2003
更新日期:2003-01-01 00:00:00
abstract::The sequence relations between Kirsten murine sarcoma virus (Ki-SV), Harvey murine sarcoma virus (Ha-SV), and a rat endogenous 30S RNA were studied by electron microscope heteroduplex analysis. The sequence relationships between the sarcoma viruses and their respective parental murine leukemia viruses (Kirsten and Mol...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.31.3.752-760.1979
更新日期:1979-09-01 00:00:00
abstract::Rickard's strain of feline leukemia virus (FeLV) contains two large glycoproteins and five smaller polypeptides of molecular weights 100,000 (gp >/= 100), 70,000 (gp70), 30,000 (p30), 21,000 (p21), 15,000 (p15), 11,200 (p11), and 10,000 (p10) when chromatographed on 6% agarose in the presence of 6 M guanidine hydrochl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.14.2.349-365.1974
更新日期:1974-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00622-13
更新日期:2013-08-01 00:00:00
abstract::Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.12.3665-3671.1987
更新日期:1987-12-01 00:00:00
abstract:UNLABELLED:While numerous viral microRNAs (miRNAs) expressed by DNA viruses, especially herpesvirus family members, have been reported, there have been very few reports of miRNAs derived from RNA viruses. Here we describe three miRNAs expressed by bovine foamy virus (BFV), a member of the spumavirus subfamily of retrov...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03587-13
更新日期:2014-05-01 00:00:00
abstract::To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. Here we apply MVA to human immunodeficiency virus type 1 (HIV-1) vaccine development by incorporating the envelope protein gp160 of HIV-1 pr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.10.8264-8272.1998
更新日期:1998-10-01 00:00:00
abstract::The 3C region of human rhinovirus 14 was expressed in Escherichia coli. The microbially synthesized protease was functional, since the expressed precursor underwent autoproteolytic processing to generate mature molecules of the expected molecular weight and antigenicity. Mutation of the putative active-site Cys-146 re...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.12.5037-5045.1989
更新日期:1989-12-01 00:00:00
abstract::CaM kinase-Gr is a multifunctional Ca2+/calmodulin-dependent protein kinase which is enriched in neurons and T lymphocytes. The kinase is absent from primary human B lymphocytes but is expressed in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cell lines, suggesting that expression of the kinase can be upregul...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.3.1697-1705.1994
更新日期:1994-03-01 00:00:00
abstract::Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine triphosphate (3TCTP) were 35-fold higher than the equivalent values for wild-type RT but only about twice as high as the equiva...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.8.5642-5645.1996
更新日期:1996-08-01 00:00:00
abstract:UNLABELLED:The live attenuated measles virus vaccine is highly immunostimulatory. Identification and characterization of its components that activate the innate immune response might provide new strategies and agents for the rational design and development of chemically defined adjuvants. In this study, we report on th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02161-15
更新日期:2015-11-25 00:00:00
abstract::Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01433-13
更新日期:2013-10-01 00:00:00
abstract:UNLABELLED:Due to a scarcity of immunocompetent animal models for viral hepatitis, little is known about the early innate immune responses in the liver. In various hepatotoxic models, both pro- and anti-inflammatory activities of recruited monocytes have been described. In this study, we compared the effect of liver in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03733-14
更新日期:2015-05-01 00:00:00
abstract::Heterosubtypic immunity (HSI) is defined as cross-protection to infection with an influenza A virus serotype other than the one used for primary infection. Although HSI has been thought to be mediated by serotype cross-reactive cytotoxic T lymphocytes (CTL) that recognize conserved epitopes of structural proteins, rec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00751-07
更新日期:2007-09-01 00:00:00
abstract::HIV-1 Nef promotes virus spread and disease progression by altering host cell transport and signaling processes through interaction with multiple host cell proteins. The N-terminal region in HIV-1 Nef encompassing residues 12 to 39 has been implicated in many Nef activities, including disruption of CD4 T lymphocyte po...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01398-19
更新日期:2019-12-12 00:00:00
abstract::The pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza virus infections. Here, we investigated ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01284-16
更新日期:2016-11-14 00:00:00
abstract::How chemokines shape the immune response to viral infection of the central nervous system (CNS) has largely been considered within the context of recruitment and activation of antigen-specific lymphocytes. However, chemokines are expressed early following viral infection, suggesting an important role in coordinating i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.2.585-594.2004
更新日期:2004-01-01 00:00:00
abstract::Group I host range (hr) mutants of adenovirus type 5 are unable to transform rat embryo or rat embryo brain cells but induce an abnormal transformation of baby rat kidney cells. We established several transformed rat kidney cell lines and characterized them with respect to the transformed phenotype and the structure o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.41.2.674-685.1982
更新日期:1982-02-01 00:00:00
abstract::Current adeno-associated virus (AAV) gene therapy vectors package a transgene flanked by the terminal repeats (TRs) of AAV type 2 (AAV2). Although these vectors are replication deficient, wild-type (wt) AAV2 prevalent in the human population could lead to replication and packaging of a type 2 TR (TR2)-flanked transgen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02466-08
更新日期:2009-04-01 00:00:00
abstract::Human cytomegalovirus encodes four unique short (US) region proteins, each of which is independently sufficient for causing the down-regulation of major histocompatibility complex (MHC) class I molecules on the cell surface. This down-regulation enables infected cells to evade recognition by cytotoxic T lymphocytes (C...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02397-05
更新日期:2006-06-01 00:00:00
abstract::Rhesus monkey rhadinovirus (RRV) is a gammaherpesvirus that is closely related to human Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). RRV is the closest relative to KSHV that has a fully sequenced genome and serves as an in vitro and an in vivo model system for KSHV. The latency-associated nuclear antigen (LAN...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00704-09
更新日期:2009-10-01 00:00:00
abstract::The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that expression of the coinhibitory molecule PD-1 predicts CD8+ antiviral T-cell exhaustion and may contribute to inadequate pat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02021-06
更新日期:2007-03-01 00:00:00
abstract::Human immunodeficiency virus infection in humans and simian immunodeficiency virus (SIV) infection in rhesus macaques (RM) leads to a generalized loss of immune responses involving perturbations in T-cell receptor (TCR) signaling. In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.23.11298-11306.2001
更新日期:2001-12-01 00:00:00
abstract::V3-glycan-targeting broadly neutralizing antibodies (bNAbs) are a focus of HIV-1 vaccine development. Understanding the viral dynamics that stimulate the development of these antibodies can provide insights for immunogen design. We used a deep-sequencing approach, together with neutralization phenotyping, to investiga...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00828-17
更新日期:2017-08-24 00:00:00