Abstract:
:How chemokines shape the immune response to viral infection of the central nervous system (CNS) has largely been considered within the context of recruitment and activation of antigen-specific lymphocytes. However, chemokines are expressed early following viral infection, suggesting an important role in coordinating innate immune responses. Herein, we evaluated the contributions of CXC chemokine ligand 10 (CXCL10) in promoting innate defense mechanisms following coronavirus infection of the CNS. Intracerebral infection of RAG1(-/-) mice with a recombinant CXCL10-expressing murine coronavirus (mouse hepatitis virus) resulted in protection from disease and increased survival that correlated with a significant increase in recruitment and activation of natural killer (NK) cells within the CNS. Accumulation of NK cells resulted in a reduction in viral titers that was dependent on gamma interferon secretion. These results indicate that CXCL10 expression plays a pivotal role in defense following coronavirus infection of the CNS by enhancing innate immune responses.
journal_name
J Viroljournal_title
Journal of virologyauthors
Trifilo MJ,Montalto-Morrison C,Stiles LN,Hurst KR,Hardison JL,Manning JE,Masters PS,Lane TEdoi
10.1128/jvi.78.2.585-594.2004subject
Has Abstractpub_date
2004-01-01 00:00:00pages
585-94issue
2eissn
0022-538Xissn
1098-5514journal_volume
78pub_type
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