Abstract:
:Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.
journal_name
J Viroljournal_title
Journal of virologyauthors
Norbeck O,Isa A,Pöhlmann C,Broliden K,Kasprowicz V,Bowness P,Klenerman P,Tolfvenstam Tdoi
10.1128/JVI.79.18.12117-12121.2005subject
Has Abstractpub_date
2005-09-01 00:00:00pages
12117-21issue
18eissn
0022-538Xissn
1098-5514pii
79/18/12117journal_volume
79pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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