High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors.


:Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors.


J Virol


Journal of virology


Rinaldo C,Huang XL,Fan ZF,Ding M,Beltz L,Logar A,Panicali D,Mazzara G,Liebmann J,Cottrill M




Has Abstract,Author List Incomplete


1995-09-01 00:00:00












  • Isolation of the novel agent from human stool samples that is associated with sporadic non-A, non-B hepatitis.

    abstract::The agent(s) responsible for sporadic non-A, non-B hepatitis in humans was serially transmitted in rhesus monkeys by intravenous inoculation of the stool extract from a patient. A novel agent called HFV (hepatitis French [origin] virus) was present as 27- to 37-nm particles in the infectious stool extract. Hepatopathi...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Deka N,Sharma MD,Mukerjee R

    更新日期:1994-12-01 00:00:00

  • Generation of a complete single-gene knockout bacterial artificial chromosome library of cowpox virus and identification of its essential genes.

    abstract::Cowpox virus (CPXV) belongs to the genus Orthopoxvirus in the Poxviridae family. It infects a broad range of vertebrates and can cause zoonotic infections. CPXV has the largest genome among the orthopoxviruses and is therefore considered to have the most complete set of genes of all members of the genus. Since CPXV ha...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Xu Z,Zikos D,Osterrieder N,Tischer BK

    更新日期:2014-01-01 00:00:00

  • Bovine herpesvirus 1 tegument protein VP22 interacts with histones, and the carboxyl terminus of VP22 is required for nuclear localization.

    abstract::The bovine herpesvirus 1 (BHV-1) UL49 gene encodes a viral tegument protein termed VP22. UL49 homologs are conserved among alphaherpesviruses. Interestingly, the BHV-1 VP22 deletion mutant virus is asymptomatic and avirulent in infected cattle but produces only a slight reduction in titer in vitro. Attenuation of the ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ren X,Harms JS,Splitter GA

    更新日期:2001-09-01 00:00:00

  • Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures.

    abstract::Herpes simplex virus DNA replication proteins localize in characteristic patterns corresponding to viral DNA replication structures in the infected cell nucleus. The intranuclear spatial organization of the HSV DNA replication structures and the factors regulating their nuclear location remain to be defined. We have u...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: de Bruyn Kops A,Knipe DM

    更新日期:1994-06-01 00:00:00

  • Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses.

    abstract::The recent advent of genome sequences as the only source available to classify many newly discovered viruses challenges the development of virus taxonomy by expert virologists who traditionally rely on extensive virus characterization. In this proof-of-principle study, we address this issue by presenting a computation...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Lauber C,Gorbalenya AE

    更新日期:2012-04-01 00:00:00

  • Upstream DNA sequences determine different autoregulatory responses of the adenovirus types 5 and 3 E1A promoters.

    abstract::Adenovirus types 5 and 3 (Ad5 and Ad3), two human adenovirus serotypes of evolutionarily divergent subgroups, show very different levels of E1A gene expression early after infection of permissive cells. Since adenovirus E1A gene expression is known to be transcriptionally autoregulated, we have investigated the differ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Jones SN,Tibbetts C

    更新日期:1989-04-01 00:00:00

  • VPg of tobacco etch potyvirus is a host genotype-specific determinant for long-distance movement.

    abstract::The V20 cultivar of Nicotiana tabacum was shown previously to exhibit a strain-specific restriction of long-distance movement of tobacco etch potyvirus (TEV). In V20, both TEV-HAT and TEV-Oxnard strains are capable of genome amplification and cell-to-cell movement, but only TEV-Oxnard is capable of systemic infection ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Schaad MC,Lellis AD,Carrington JC

    更新日期:1997-11-01 00:00:00

  • NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs.

    abstract::The genome of lymphocytic choriomeningitis virus (LCMV) consists of two negative-sense single-stranded RNA segments, designated L and S. Both segments contain two viral genes in an ambisense coding strategy, with the genes being separated by an intergenic region (IGR). We have developed a reverse genetic system that a...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Lee KJ,Novella IS,Teng MN,Oldstone MB,de La Torre JC

    更新日期:2000-04-01 00:00:00

  • Variable transforming activity of nonglucosylated and fragmented T4 DNA.

    abstract::Nonglucosylated and fragmented T4 DNA shows a gene-specific variation in transformation efficiency. ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: McNicol LA

    更新日期:1973-08-01 00:00:00

  • Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus.

    abstract::Rhesus monkey rhadinovirus (RRV) is a gammaherpesvirus that is closely related to human Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). RRV is the closest relative to KSHV that has a fully sequenced genome and serves as an in vitro and an in vivo model system for KSHV. The latency-associated nuclear antigen (LAN...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Wen KW,Dittmer DP,Damania B

    更新日期:2009-10-01 00:00:00

  • Monoclonal antibody analysis of simian virus 40 small t-antigen expression in infected and transformed cells.

    abstract::The monoclonal antibody PAb280 binds to small t antigen but not to large T antigen. Its binding site within the unique region of small t antigen was localized by studying its reaction with simian virus 40 mutants, other papovaviruses, and bacterial expression vectors coding for fragments of small t antigen. The antibo...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Montano X,Lane DP

    更新日期:1989-07-01 00:00:00

  • Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo.

    abstract::In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4+ T cell activation and vir...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Raposo RA,Abdel-Mohsen M,Deng X,Hecht FM,Pilcher CD,Pillai SK,Nixon DF

    更新日期:2014-10-01 00:00:00

  • Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection.

    abstract::Poliovirus (PV) modifies membrane-trafficking machinery in host cells for its viral RNA replication. To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), including PV, involved in membrane traffic. In this study, we performed small interfering RNA (siRNA) scr...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Arita M,Wakita T,Shimizu H

    更新日期:2012-05-01 00:00:00

  • Properties of feline leukemia virus. I. Chromatographic separation and analysis of the polypeptides.

    abstract::Rickard's strain of feline leukemia virus (FeLV) contains two large glycoproteins and five smaller polypeptides of molecular weights 100,000 (gp >/= 100), 70,000 (gp70), 30,000 (p30), 21,000 (p21), 15,000 (p15), 11,200 (p11), and 10,000 (p10) when chromatographed on 6% agarose in the presence of 6 M guanidine hydrochl...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Graves DC,Velicer LF

    更新日期:1974-08-01 00:00:00

  • In Vivo Dynamics of Reporter Flaviviridae Viruses.

    abstract::Recombinant viruses possessing reporter proteins have been generated for virus research. In the case of the family Flaviviridae, we recently generated recombinant viruses, including the hepatitis C virus of the genus Hepacivirus, Japanese encephalitis virus (JEV) of the genus Flavivirus, and bovine viral diarrhea viru...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Tamura T,Igarashi M,Enkhbold B,Suzuki T,Okamatsu M,Ono C,Mori H,Izumi T,Sato A,Fauzyah Y,Okamoto T,Sakoda Y,Fukuhara T,Matsuura Y

    更新日期:2019-10-29 00:00:00

  • Release of human immunodeficiency virus by THP-1 cells and human macrophages is regulated by cellular adherence and activation.

    abstract::Macrophage adherence, an important regulatory signal, has the potential to affect human immunodeficiency virus (HIV) production either directly or by priming monocytes to respond to other activating signals. We have investigated the role of adherence as an activator of HIV-1 transcription and release. The effects of a...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Shattock RJ,Friedland JS,Griffin GE

    更新日期:1993-06-01 00:00:00

  • Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition.

    abstract:UNLABELLED:Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human pathogens. Both viruses can recognize, via the surface envelope glycoprotein D (gD), human nectin-1 as a functional receptor. Previous studies have successfully elucidated the molecular basis of the binding between HSV-1 gD and necti...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Lu G,Zhang N,Qi J,Li Y,Chen Z,Zheng C,Gao GF,Yan J

    更新日期:2014-12-01 00:00:00

  • Thermostability of the Foot-and-Mouth Disease Virus Capsid Is Modulated by Lethal and Viability-Restoring Compensatory Amino Acid Substitutions.

    abstract::Infection by viruses depends on a balance between capsid stability and dynamics. This study investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability and between thermostability and infectivity. In the FMDV ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: López-Argüello S,Rincón V,Rodríguez-Huete A,Martínez-Salas E,Belsham GJ,Valbuena A,Mateu MG

    更新日期:2019-05-01 00:00:00

  • Chromosome integration domain for bovine leukemia provirus in tumors.

    abstract::The 3'-end host-virus junction fragments from two bovine leukemia virus (BLV)-induced lymphoid tumors (tumors 15-4 and 1351), each containing a single provirus, were used as probes to detect large restriction fragments flanking these proviruses. The DNAs from 28 other independent BLV-induced tumors were checked by Sou...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kettmann R,Deschamps J,Couez D,Claustriaux JJ,Palm R,Burny A

    更新日期:1983-07-01 00:00:00

  • African swine fever virus multigene family 360 and 530 genes affect host interferon response.

    abstract::African swine fever virus (ASFV) multigene family 360 and 530 (MGF360/530) genes affect viral growth in macrophage cell cultures and virulence in pigs (L. Zsak, Z. Lu, T. G. Burrage, J. G. Neilan, G. F. Kutish, D. M. Moore, and D. L. Rock, J. Virol. 75:3066-3076, 2001). The mechanism by which these novel genes affect ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Afonso CL,Piccone ME,Zaffuto KM,Neilan J,Kutish GF,Lu Z,Balinsky CA,Gibb TR,Bean TJ,Zsak L,Rock DL

    更新日期:2004-02-01 00:00:00

  • Pathogenesis of Influenza D Virus in Cattle.

    abstract:UNLABELLED:Cattle have been proposed as the natural reservoir of a novel member of the virus family Orthomyxoviridae, which has been tentatively classified as influenza D virus (IDV). Although isolated from sick animals, it is unclear whether IDV causes any clinical disease in cattle. To address this aspect of Koch's p...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ferguson L,Olivier AK,Genova S,Epperson WB,Smith DR,Schneider L,Barton K,McCuan K,Webby RJ,Wan XF

    更新日期:2016-05-27 00:00:00

  • The major core protein P4a (A10L gene) of vaccinia virus is essential for correct assembly of viral DNA into the nucleoprotein complex to form immature viral particles.

    abstract::The vaccinia virus (VV) A10L gene codes for a major core protein, P4a. This polypeptide is synthesized at late times during viral infection and is proteolytically cleaved during virion assembly. To investigate the role of P4a in the virus life cycle and morphogenesis, we have generated an inducer-dependent conditional...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Heljasvaara R,Rodríguez D,Risco C,Carrascosa JL,Esteban M,Rodríguez JR

    更新日期:2001-07-01 00:00:00

  • A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting.

    abstract::Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leading to the destruction of cellular signal transducer and activator of transcription (STAT) proteins. While many V proteins target the interferon-activated STA...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Puri M,Lemon K,Duprex WP,Rima BK,Horvath CM

    更新日期:2009-07-01 00:00:00

  • A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly.

    abstract::Mutations introduced into the capsid gene of duck hepatitis B virus (DHBV) were tested for their effects on viral DNA synthesis and assembly of enveloped viruses. Four classes of mutant phenotypes were observed among a series of deletions of covering the 3' end of the capsid open reading frame. Class I mutant capsids ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Yu M,Summers J

    更新日期:1991-05-01 00:00:00

  • Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.

    abstract::Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A to PPP2R5E). While APOBEC3 antagonism is the canonical function of HIV-1 Vif, this viral accessory protein is also known to trigger G2/...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Salamango DJ,McCann JL,Demir Ö,Becker JT,Wang J,Lingappa JR,Temiz NA,Brown WL,Amaro RE,Harris RS

    更新日期:2020-10-14 00:00:00

  • Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells.

    abstract::The severe acute respiratory syndrome coronavirus (SARS-CoV) nsp1 protein has unique biological functions that have not been described in the viral proteins of any RNA viruses; expressed SARS-CoV nsp1 protein has been found to suppress host gene expression by promoting host mRNA degradation and inhibiting translation....

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Narayanan K,Huang C,Lokugamage K,Kamitani W,Ikegami T,Tseng CT,Makino S

    更新日期:2008-05-01 00:00:00

  • Baculovirus gene ME53, which contains a putative zinc finger motif, is one of the major early-transcribed genes.

    abstract::We have been investigating the first viral genes to be transcribed in Spodoptera frugiperda cells after the infection with Autographa california nuclear polyhedrosis virus in order to identify regulatory proteins required for the activation of early and/or late gene transcription. By screening a cDNA library from poly...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Knebel-Mörsdorf D,Kremer A,Jahnel F

    更新日期:1993-02-01 00:00:00

  • Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry.

    abstract::Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional p...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ghez D,Lepelletier Y,Lambert S,Fourneau JM,Blot V,Janvier S,Arnulf B,van Endert PM,Heveker N,Pique C,Hermine O

    更新日期:2006-07-01 00:00:00

  • Pseudorabies virus glycoprotein gIII is required for efficient virus growth in tissue culture.

    abstract::Glycoprotein gIII of pseudorabies virus is a major antigen found in the envelopes of virus particles as well as in and on the surfaces of infected cells. It is not an essential gene product for virus growth in tissue culture. In this report, we provide evidence that, although it is not essential, the gIII protein is r...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Whealy ME,Robbins AK,Enquist LW

    更新日期:1988-07-01 00:00:00

  • Monomeric APOBEC3G is catalytically active and has antiviral activity.

    abstract::APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the propensity to form homo-multimers. In the current study, we investigated the functional determinants for multimerization o...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Opi S,Takeuchi H,Kao S,Khan MA,Miyagi E,Goila-Gaur R,Iwatani Y,Levin JG,Strebel K

    更新日期:2006-05-01 00:00:00