Immunological surveillance against DNA-virus-transformed cells: correlations between natural killer cell cytolytic competence and tumor susceptibility of athymic rodents.

abstract：UNLABELLED:The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of cytomegalovirus genomes is largely performed using infectious bacterial artificial chromosomes (BACs), which necessitates the maintenance of the viral genome in...

journal_title：Journal of virology

authors： Bierle CJ,Anderholm KM,Wang JB,McVoy MA,Schleiss MR

更新日期：2016-07-11 00:00:00

abstract：:Bluetongue virus (BTV), an insect-vectored emerging pathogen of both wild ruminants and livestock, has had a severe economic impact in agriculture in many parts of the world. The investigation of BTV replication and pathogenesis has been hampered by the lack of a reverse genetics system. Recovery of infectious BTV is ...

journal_title：Journal of virology

authors： Boyce M,Celma CC,Roy P

更新日期：2008-09-01 00:00:00

abstract：:Due to increasing concerns about human infection by various H7 influenza viruses, including recent H7N9 viruses, we evaluated the genetic relationships and cross-protective efficacies of three different Eurasian H7 avian influenza viruses. Phylogenic and molecular analyses revealed that recent Eurasian H7 viruses can ...

journal_title：Journal of virology

authors： Kwon HI,Kim YI,Park SJ,Song MS,Kim EH,Kim SM,Si YJ,Lee IW,Song BM,Lee YJ,Yun SJ,Kim WJ,Choi YK

更新日期：2017-05-12 00:00:00

abstract：:Rotavirus is the leading global cause of diarrheal mortality for unvaccinated children under 5 years of age. The outer capsid of rotavirus virions consists of VP7 and VP4 proteins, which determine viral G and P types, respectively, and are primary targets of neutralizing antibodies. Successful vaccination depends upon...

journal_title：Journal of virology

authors： Ogden KM,Tan Y,Akopov A,Stewart LS,McHenry R,Fonnesbeck CJ,Piya B,Carter MH,Fedorova NB,Halpin RA,Shilts MH,Edwards KM,Payne DC,Esona MD,Mijatovic-Rustempasic S,Chappell JD,Patton JT,Halasa NB,Das SR

更新日期：2018-12-10 00:00:00

abstract：:The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...

journal_title：Journal of virology

authors： Naeve CW,Summers DF

更新日期：1980-06-01 00:00:00

abstract：:The long terminal repeat U3 sequences were determined for multiple feline leukemia virus proviruses isolated from naturally occurring T-cell tumors. Heterogeneity was evident, even among proviruses cloned from individual tumors. Proviruses with one, two, or three repeats of the long terminal repeat enhancer sequences ...

journal_title：Journal of virology

authors： Fulton R,Plumb M,Shield L,Neil JC

更新日期：1990-04-01 00:00:00

abstract：:Vilyuisk human encephalitis virus (VHEV) is a picornavirus related to Theiler's murine encephalomyelitis virus (TMEV). VHEV was isolated from human material passaged in mice. Whether this VHEV is of human or mouse origin is therefore unclear. We took advantage of the species-specific activity of the nonstructural L* p...

journal_title：Journal of virology

authors： Drappier M,Opperdoes FR,Michiels T

更新日期：2017-06-26 00:00:00

abstract：:The glycoprotein E(rns) of pestiviruses is a virion-associated and -secreted RNase that is involved in virulence. The requirements at the cleavage site in heteropolymeric RNA substrates were studied for E(rns). Limited digestion of heteropolymeric RNA substrates indicated a cleavage 5' of uridine residues irrespective...

journal_title：Journal of virology

authors： Hausmann Y,Roman-Sosa G,Thiel HJ,Rümenapf T

更新日期：2004-05-01 00:00:00

abstract：:Immunization of mice with DNA encoding the influenza virus hemagglutinin (HA) affords complete protection against lethal influenza virus infection and the means to investigate the mechanisms of B-cell responsiveness to virus challenge. Using a single-cell enzyme-linked immunospot assay, we sought to determine the loca...

journal_title：Journal of virology

authors： Justewicz DM,Morin MJ,Robinson HL,Webster RG

更新日期：1995-12-01 00:00:00

abstract：:Mitogenic activities of simian virus 40 large T and small t antigens were studied in serum-deprived human diploid fibroblasts. Wild-type large T and small t cooperated in stimulating DNA synthesis and in inducing hyperphosphorylation of the Rb gene product (pRb). In contrast, a T antigen mutant defective for pRb bindi...

journal_title：Journal of virology

authors： Ogryzko VV,Hirai TH,Shih CE,Howard BH

更新日期：1994-06-01 00:00:00

abstract：:Processing of the hepatitis C virus polyprotein is accomplished by a series of cotranslational and posttranslational cleavages mediated by host cell signalases and two virally encoded proteinases. Of these the NS3 proteinase is essential for processing at the NS3/4A, NS4A/4B, NS4B/5A, and NS5A/5B junctions. Processing...

journal_title：Journal of virology

authors： Bartenschlager R,Ahlborn-Laake L,Yasargil K,Mous J,Jacobsen H

更新日期：1995-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen 3B (EBNA-3B) is considered nonessential for EBV-mediated B-cell growth transformation in vitro based on three virus isolates with EBNA-3B mutations. Two of these isolates could potentially express truncated EBNA-3B products, and, similarly, we now show that the third isolat...

journal_title：Journal of virology

authors： Chen A,Divisconte M,Jiang X,Quink C,Wang F

更新日期：2005-04-01 00:00:00

abstract：:Five regions of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) have been shown to be important in the transcriptional regulation of HIV in HeLa cells. These include the negative regulatory, enhancer, SP1, TATA, and TAR regions. Previous studies in which purified SP1 was used showed that the...

journal_title：Journal of virology

authors： Harrich D,Garcia J,Wu F,Mitsuyasu R,Gonazalez J,Gaynor R

更新日期：1989-06-01 00:00:00

abstract：:The DNA region encoding the complete herpes simplex virus type 1 (HSV-1) glycoprotein K (gK) was inserted into a baculovirus transfer vector, and recombinant viruses expressing gK were isolated. Four gK-related recombinant baculovirus-expressed peptides of 29, 35, 38, and 40 kDa were detected with polyclonal antibody ...

journal_title：Journal of virology

authors： Ghiasi H,Slanina S,Nesburn AB,Wechsler SL

更新日期：1994-04-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope glycoprotein (Env) is a trimer of gp120-gp41 heterodimers and is essential for viral entry. The gp41 subunit in native, prefusion trimeric Env exists in a metastable conformation and attains a stable six-helix bundle (6-HB) conformation comprised of a trimer of N-heptad repeat (NHR) and C-...

journal_title：Journal of virology

authors： Kesavardhana S,Varadarajan R

更新日期：2014-09-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) glycoprotein plays a critical role in parainfluenza virus replication. We recently found that in addition to the catalytic binding site, HN of human parainfluenza virus type 1 (hPIV-1) may have a second receptor-binding site covered by an N-linked glycan at residue 173, which is ne...

journal_title：Journal of virology

authors： Mishin VP,Watanabe M,Taylor G,Devincenzo J,Bose M,Portner A,Alymova IV

更新日期：2010-03-01 00:00:00

abstract：:The entire varicella-zoster virus (VZV) genome appears to be present in latently infected human ganglia, but the extent of virus DNA transcription is unknown. Conventional methods to study virus gene transcripts by Northern (RNA) blotting are not feasible, since ganglia are small and VZV DNA is not abundant. To circum...

journal_title：Journal of virology

authors： Cohrs RJ,Srock K,Barbour MB,Owens G,Mahalingam R,Devlin ME,Wellish M,Gilden DH

更新日期：1994-12-01 00:00:00

abstract：:Nuclear domains called ND10 (nuclear domain 10) are discrete nuclear protein aggregations characterized by a set of interferon-upregulated proteins including Sp100 and PML, where papova-, adeno-, and herpesviruses begin their transcription and DNA replication. Both the alpha- and betaherpesvirus subfamilies disrupt ND...

journal_title：Journal of virology

authors： Bell P,Lieberman PM,Maul GG

更新日期：2000-12-01 00:00:00

abstract：UNLABELLED:Venezuelan equine encephalitis virus (VEEV) is an important human and animal pathogen, for which no safe and efficient vaccines or therapeutic means have been developed. Viral particle assembly and budding processes represent potential targets for therapeutic intervention. However, our understanding of the m...

journal_title：Journal of virology

authors： Reynaud JM,Lulla V,Kim DY,Frolova EI,Frolov I

更新日期：2015-12-09 00:00:00

abstract：:The expression of interleukin-2 (IL-2) has been implicated in the modulation of the outcome of ocular infection with herpes simplex virus type 1 (HSV-1); however, its effects remain controversial. To clarify the role of IL-2, we constructed a recombinant HSV-1 (HSV-IL-2) that expresses two copies of the murine IL-2 ge...

journal_title：Journal of virology

authors： Ghiasi H,Osorio Y,Perng GC,Nesburn AB,Wechsler SL

更新日期：2002-09-01 00:00:00

abstract：:Foamy viruses (FVs) are the least known retroviruses commonly found in primates, cats, horses, and cattle. Although FVs are considered apathogenic, simian and feline FVs have been shown to be associated with some transient health abnormalities in animal models. Currently, data regarding the course of infection with bo...

journal_title：Journal of virology

authors： Materniak M,Hechler T,Löchelt M,Kuzmak J

更新日期：2013-03-01 00:00:00

abstract：:The minor glycoproteins from hepatitis B surface antigen, GP33 and GP36, contain at their carboxy-terminal part the sequence of the major protein P24. They have 55 additional amino acids at the amino-terminal part which are coded by the pre-S region of the viral DNA. ...

journal_title：Journal of virology

authors： Stibbe W,Gerlich WH

更新日期：1983-05-01 00:00:00

abstract：:V2/V3 conformational epitope antibodies that broadly neutralize HIV-1 (PG9 and PG16) have been recently described. Since an elicitation of previously known broadly neutralizing antibodies has proven elusive, the induction of antibodies with such specificity is an important goal for HIV-1 vaccine development. A critica...

journal_title：Journal of virology

authors： Bonsignori M,Hwang KK,Chen X,Tsao CY,Morris L,Gray E,Marshall DJ,Crump JA,Kapiga SH,Sam NE,Sinangil F,Pancera M,Yongping Y,Zhang B,Zhu J,Kwong PD,O'Dell S,Mascola JR,Wu L,Nabel GJ,Phogat S,Seaman MS,Whitesides

更新日期：2011-10-01 00:00:00

abstract：:Retroviral integration has recently been shown to be nonrandom, favoring transcriptionally active regions of chromatin. However, the mechanism for integration site selection by retroviruses is not clear. We show here the occurrence of Alu-like motifs in the sequences flanking the reported viral integration sites that ...

journal_title：Journal of virology

authors： Kumar PP,Mehta S,Purbey PK,Notani D,Jayani RS,Purohit HJ,Raje DV,Ravi DS,Bhonde RR,Mitra D,Galande S

更新日期：2007-06-01 00:00:00

abstract：:The simian virus 40 large T antigen is a promiscuous transcriptional activator of many viral and cellular promoters. We show that the promoter structure necessary for T antigen-mediated transcriptional activation is very simple. A TATA or initiator element is required, in addition to an upstream factor-binding site, w...

journal_title：Journal of virology

authors： Gilinger G,Alwine JC

更新日期：1993-11-01 00:00:00

abstract：:Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with...

journal_title：Journal of virology

authors： Djavani MM,Crasta OR,Zapata JC,Fei Z,Folkerts O,Sobral B,Swindells M,Bryant J,Davis H,Pauza CD,Lukashevich IS,Hammamieh R,Jett M,Salvato MS

更新日期：2007-08-01 00:00:00

abstract：:The core gene of hepatitis B virus contains two in-phase AUG codons which may both be used in the viral life cycle. By in vitro translation of transcripts produced in vitro, we investigated the corresponding core gene products and their counterparts in vivo. Depending on the location of the 5' end of the transcripts, ...

journal_title：Journal of virology

authors： Weimer T,Salfeld J,Will H

更新日期：1987-10-01 00:00:00

abstract：:Signal peptidase cleavage at the C-prM junction in the flavivirus structural polyprotein is inefficient in the absence of the cytoplasmic viral protease, which catalyzes cleavage at the COOH terminus of the C protein. The signal peptidase cleavage occurs efficiently in circumstances where the C protein is deleted or i...

journal_title：Journal of virology

authors： Stocks CE,Lobigs M

更新日期：1998-03-01 00:00:00

abstract：:We constructed a matched set of plasmids to investigate the interactions of essential core sequences of the simian virus 40 replication origin with flanking regulatory sequences. Deletions of either T-antigen-binding region I or the 21-base-pair repeated promoter elements reduced replication to 50 to 70% of wild-type ...

journal_title：Journal of virology

authors： DeLucia AL,Deb S,Partin K,Tegtmeyer P

更新日期：1986-01-01 00:00:00

abstract：:ICP0 is a nuclear phosphoprotein involved in the activation of herpes simplex virus type 1 (HSV-1) gene expression during lytic infection and reactivation from viral latency. Although available evidence suggests that ICP0 acts at the level of transcription, definitive studies specifically addressing this issue have no...

journal_title：Journal of virology

authors： Jordan R,Schaffer PA

更新日期：1997-09-01 00:00:00