Abstract:
:Foamy viruses (FVs) are the least known retroviruses commonly found in primates, cats, horses, and cattle. Although FVs are considered apathogenic, simian and feline FVs have been shown to be associated with some transient health abnormalities in animal models. Currently, data regarding the course of infection with bovine FV (BFV) are not available. In this study, we conducted experimental infections of natural (cattle) and heterologous (sheep) hosts with the BFV(100) isolate and monitored infection patterns in both hosts during the early phase postinoculation as well as after long-term infection. Four calves and six sheep inoculated with BFV(100) showed no signs of pathology but developed persistent infection, as confirmed by virus rescue, consistent detection of BFV-specific antibodies, and presence of viral DNA. In both hosts, antibodies against BFV Gag and Bet appeared early after infection and persisted at high and stable levels while seroreactivity toward Env was consistently detectable only in BFV-infected sheep. Interestingly, the BFV proviral DNA load was highest in lung, spleen, and liver and moderate in leukocytes, while salivary glands contained either low or undetectable DNA loads in calves or sheep, respectively. Additionally, comparison of partial BFV sequences from inoculum and infected animals demonstrated very limited changes after long-term infection in the heterologous host, clearly less than those found in BFV field isolates. The persistence of BFV infection in both hosts suggests full replication competence of the BFV(100) isolate with no requirement of genetic adaptation for productive replication in the authentic and even in a heterologous host.
journal_name
J Viroljournal_title
Journal of virologyauthors
Materniak M,Hechler T,Löchelt M,Kuzmak Jdoi
10.1128/JVI.02447-12subject
Has Abstractpub_date
2013-03-01 00:00:00pages
3516-25issue
6eissn
0022-538Xissn
1098-5514pii
JVI.02447-12journal_volume
87pub_type
杂志文章abstract:UNLABELLED:Development of a vaccine to prevent congenital cytomegalovirus infection is a major public health priority. Live vaccines attenuated through mutations targeting viral mechanisms responsible for evasion of host defense may be both safe and efficacious. Safety and vaccine efficacy were evaluated using a guinea...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01419-15
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.14.6893-6899.2002
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.3.3.290-296.1969
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pub_type: 杂志文章
doi:10.1128/JVI.01672-12
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.21.10112-10121.2000
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.11.7006-7014.1995
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pub_type: 杂志文章
doi:10.1128/JVI.71.1.800-806.1997
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01522-06
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01202-07
更新日期:2008-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.2.1054-1060.2001
更新日期:2001-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.10.6733-6740.1996
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.8.4494-4497.1991
更新日期:1991-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.2.1125-1132.2005
更新日期:2005-01-01 00:00:00
abstract::The emergence and subsequent swift and global spread of the swine-origin influenza virus A(H1N1) in 2009 once again emphasizes the strong need for effective vaccines that can be developed rapidly and applied safely. With this aim, we produced soluble, multimeric forms of the 2009 A(H1N1) HA (sHA(3)) and NA (sNA(4)) su...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
abstract::Here we report the complete genome sequence of a dengue virus serotype 2 (DENV-2) strain, GZ40, isolated in Guangdong, China, in 2010. A phylogenetic analysis classified GZ40 into the Cosmopolitan genotype, while previous Chinese DENV-2 isolates belong to the Asian I genotype. The reemergence of the Cosmopolitan genot...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02562-12
更新日期:2012-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.8.5642-5645.1996
更新日期:1996-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.6.2840-2846.2000
更新日期:2000-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.7.5981-5993.1999
更新日期:1999-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.8.6637-6645.1998
更新日期:1998-08-01 00:00:00