The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.

Abstract:

:The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x(L) transcript versus the Bcl-x(S) transcript in Neuro-2A cells. Bcl-x(L) encodes an antiapoptotic protein, whereas Bcl-x(S) encodes a proapoptotic protein. Promoting the accumulation of Bcl-x(L) in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

journal_name

J Virol

journal_title

Journal of virology

authors

Peng W,Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

doi

10.1128/jvi.77.19.10714-10718.2003

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

10714-8

issue

19

eissn

0022-538X

issn

1098-5514

journal_volume

77

pub_type

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