Abstract:
:Recently we reported that in vitro RNA transcripts complementary to the genome of hepatitis delta virus (HDV) contain a unique site at which self-cleavage can occur. Subsequent studies showed that a similar self-cleavage site was present on in vitro RNA transcripts of genomic HDV RNA. The same self-cleavage reactions were also found to occur on HDV RNAs from the livers of infected chimpanzees. Using the in vitro RNA it was also possible to determine that the minimum length of contiguous sequence needed for self-cleavage of genomic RNA was 30 bases 5' and 74 bases 3' of the cleavage site. This sequence was not compatible with the "hammerhead" structure hypothesized to be important in the self-cleavage reactions of other RNAs.
journal_name
J Viroljournal_title
Journal of virologyauthors
Kuo MY,Sharmeen L,Dinter-Gottlieb G,Taylor Jdoi
10.1128/JVI.62.12.4439-4444.1988subject
Has Abstractpub_date
1988-12-01 00:00:00pages
4439-44issue
12eissn
0022-538Xissn
1098-5514journal_volume
62pub_type
杂志文章abstract::The entry of enveloped viruses into cells is normally mediated by fusion between viral and cellular membranes, in which the fusion peptide plays a crucial role. The fusion peptides of group II nucleopolyhedrovirus (NPV) F proteins are quite conserved, with a hydrophobic region located at the N terminal of the F(1) fra...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00368-08
更新日期:2008-08-01 00:00:00
abstract::Tankyrase (TNKS) is a telomere-associated poly-ADP ribose polymerase (PARP) that has been implicated along with several telomere repeat binding factors in the regulation of Epstein-Barr virus origin of plasmid replication (OriP). We now show that TNKS1 can bind to the family of repeats (FR) and dyad symmetry regions o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.8.4640-4650.2005
更新日期:2005-04-01 00:00:00
abstract::Human immunodeficiency virus type 2 (HIV-2), like other lentiviruses, is capable of infecting nondividing T cells and macrophages. The present work shows that in HIV-2-infected cells, Vpx is necessary for efficient nuclear import of the preintegration complex. In agreement with this finding, the subcellular localizati...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.13.6162-6167.2000
更新日期:2000-07-01 00:00:00
abstract::The genome of the human immunodeficiency virus type 1 (HIV-1) is highly heterogeneous. Some of this genomic variability is reflected in the biologic and serologic differences observed among various strains of HIV-1. To map the viral determinants that correlate with pathogenicity of the virus, recombinant viruses were ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.9.4390-4398.1990
更新日期:1990-09-01 00:00:00
abstract::To examine the pathway of the coreceptor switching of CCR5-using (R5) virus to CXCR4-using (X4) virus in simian-human immunodeficiency virus SHIV(SF162P3N)-infected rhesus macaque BR24, analysis was performed on variants present at 20 weeks postinfection, the time when the signature gp120 V3 loop sequence of the X4 sw...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00570-08
更新日期:2008-07-01 00:00:00
abstract::Following subcutaneous inoculation of newborn Wistar-Furth rats with human adenovirus type 9 (Ad9), 16 of 16 female and 0 of 11 male rats developed mammary tumors. Tumor-positive animals usually developed tumors in multiple glands. Histopathological analyses indicated that three general categories of tumor could be id...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.6.3192-3202.1991
更新日期:1991-06-01 00:00:00
abstract::We have previously shown that the nonconserved carboxy-terminal exon of the adenovirus type 2 E1A-289R protein contains two interchangeable sequence elements, auxiliary region (AR) 1 and AR2, that are required for efficient CR3-mediated transcriptional activation of the viral E4 promoter (M. Bondesson, C. Svensson, S....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.7.5978-5983.1998
更新日期:1998-07-01 00:00:00
abstract::The parameters governing the activity of the cloned T4 gene 23, which codes for the major T4 head protein, were analyzed. Suppressor-negative bacteria carrying wild-type T4 gene 23 cloned into plasmid pCR1 or pBR322 were infected with T4 gene 23 amber phage also carrying mutations in the following genes: (i) denA and ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.39.1.46-59.1981
更新日期:1981-07-01 00:00:00
abstract::Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young children worldwide. These nonenveloped viruses enter cells using different types of endocytosis and, depending on the virus strain, travel to different endosomal compartments before exiting to the cytosolic space. In this Gem,...
journal_title:Journal of virology
pub_type: 杂志文章,评审
doi:10.1128/JVI.01787-14
更新日期:2015-01-15 00:00:00
abstract:UNLABELLED:The four serotypes of dengue virus (DENV) cause the most important and rapidly emerging arboviral diseases in humans. The recent phase 2b and 3 studies of a tetravalent dengue vaccine reported a moderate efficacy despite the presence of neutralizing antibodies, highlighting the need for a better understandin...
journal_title:Journal of virology
pub_type: 杂志文章,随机对照试验
doi:10.1128/JVI.00273-15
更新日期:2015-07-01 00:00:00
abstract::Animals that naturally acquire the prion diseases have a well-developed olfactory sense that they utilize for a variety of basic behaviors. To assess the potential for the nasal cavity to serve as a point of entry for prion diseases, a small amount of prion-infected brain homogenate was placed inferior to the nostrils...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02649-06
更新日期:2007-05-01 00:00:00
abstract::The region of the UL component of the herpes simplex virus type 1 genome between nucleotides 17,793 and 25,150 includes three open reading frames that code for the protein products of the UL8, UL9, and UL10 genes (D.J. McGeogh, M.A. Dalrymple, A.J. Davison, A. Dolan, M.C. Frame, D. McNab, L.J. Perry, J.E. Scott, and P...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.7.4251-4261.1994
更新日期:1994-07-01 00:00:00
abstract::GP64, the major envelope glycoprotein of the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) budded virion, is important for host cell receptor binding and mediates low-pH-triggered membrane fusion during entry by endocytosis. In the current study, we examined the functional role of the AcMNPV GP64 tr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02104-07
更新日期:2008-04-01 00:00:00
abstract::Immune precipitation with monospecific antiserum was employed to study the intracellular synthesis of viral glycoproteins gp85 and gp37. Labeled gp85 and gp37 were detected from lysates of cells transformed with Rous sacroma virus, strain B77, after long-term labeling with radioactive glucosamine or phenylalanine. Imm...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.22.3.598-607.1977
更新日期:1977-06-01 00:00:00
abstract::Breast cancer is the second leading cause of cancer-related deaths in women in the United States. Triple-negative breast cancer constitutes a subset of breast cancer that is associated with higher rates of relapse, decreased survival, and limited therapeutic options for patients afflicted with this type of breast canc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01411-19
更新日期:2019-11-13 00:00:00
abstract:UNLABELLED:The HIV-1 virion infectivity factor (Vif) targets the cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) for degradation via the host ubiquitin-proteasome pathway. Vif recruits a cellular E3 ubiquitin ligase to polyubiquitinate A3G/F. The activity of Vif critically depends on the cellular core bi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03824-13
更新日期:2014-03-01 00:00:00
abstract::The bacteriophage PRD1 is a lipid-bearing phage that infects a wide variety of gram-negative bacteria, including Escherichia coli and Salmonella typhimurium when they contain the appropriate plasmid. It contains a linear duplex DNA molecule that is covalently bound by its 5' ends to a terminal protein. We report here ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.2.594-596.1987
更新日期:1987-02-01 00:00:00
abstract::Chemokines induce the directional migration of targeted populations of leukocytes during periods of inflammation. Moreover, these molecules also regulate T-cell activation and differentiation following antigenic stimulation. In the present study, the contributions of the CC chemokine ligand 3 (CCL3) to the differentia...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.7.4004-4014.2003
更新日期:2003-04-01 00:00:00
abstract::Ebola viruses (EboV) are enveloped RNA viruses infecting cells by a pH-dependent process mediated by viral glycoproteins (GP) involving endocytosis of virions and their routing into acidic endosomes. As with well-characterized pH-dependent viral entry proteins, in particular influenza virus hemagglutinin, it is though...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.6.2815-2822.2006
更新日期:2006-03-01 00:00:00
abstract:UNLABELLED:The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we surveyed the interactome of ORF45 using a panel of monoc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02925-14
更新日期:2015-05-01 00:00:00
abstract::Wild-type simian virus 40 A protein (large T antigen) bound to three tandem regions of simian virus 40 DNA. The binding regions were defined by the ability of A protein to protect simian virus 40 DNA from digestion with limited (footprint assay) or excess (fragment assay) amounts of DNase I. At low concentrations, pro...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.44.2.458-466.1982
更新日期:1982-11-01 00:00:00
abstract::A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between ex...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.12.10301-10304.1998
更新日期:1998-12-01 00:00:00
abstract::The Vpr accessory gene product of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus is believed to play a role in permitting entry of the viral core into the nucleus of nondividing cells. A second role for Vpr was recently suggested by Rogel et al. (M. E. Rogel, L. I. Wu, and M. Emerman, J. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.11.6705-6711.1995
更新日期:1995-11-01 00:00:00
abstract::Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.2.757-765.1992
更新日期:1992-02-01 00:00:00
abstract:UNLABELLED:Children with acute respiratory syncytial virus (RSV) infection often develop sequelae of persistent airway inflammation and wheezing. Pulmonary C fibers (PCFs) are involved in the generation of airway inflammation and resistance; however, their role in persistent airway diseases after RSV is unexplored. Her...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02534-15
更新日期:2015-12-16 00:00:00
abstract::HIV protease is known to cause cell death, which is dependent upon cleavage of procaspase 8. HIV protease cleavage of procaspase 8 generates Casp8p41, which directly binds Bak with nanomolar affinity, causing Bak activation and consequent cell death. Casp8p41 can also bind Bcl2 with nanomolar affinity, in which case c...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00037-18
更新日期:2018-06-13 00:00:00
abstract:UNLABELLED:A hallmark of Ebola virus (EBOV) infection is the formation of viral inclusions in the cytoplasm of infected cells. These viral inclusions contain the EBOV nucleocapsids and are sites of viral replication and nucleocapsid maturation. Although there is growing evidence that viral inclusions create a protected...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00459-16
更新日期:2016-07-27 00:00:00
abstract::The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.12.8151-8154.1995
更新日期:1995-12-01 00:00:00
abstract::The effects of human papillomavirus type 18 (HPV-18) E6 and E7 proteins on global patterns of host gene expression in primary human keratinocytes grown in organotypic raft culture system were assessed. Primary human keratinocytes were infected with retroviruses that express the wild-type HPV-18 E6 and E7 genes from th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.17.9041-9050.2004
更新日期:2004-09-01 00:00:00
abstract::Endogenous retroviruses, records of past retroviral infections, are ubiquitous in vertebrate genomes. On occasion, vertebrate hosts have co-opted retroviral genes for their own biological functions. Here, we perform a phylogenomic survey of retroviral gag gene homologs within vertebrate genomes and identify two ancien...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00542-19
更新日期:2019-06-28 00:00:00