Respiratory syncytial virus infection in C57BL/6 mice: clearance of virus from the lungs with virus-specific cytotoxic T cells.

abstract：:When herpes simplex virus was inoculated into the flank of a BALB/c mouse by scarification, the local replication of virus was followed by the establishment of an acute ganglionic infection. The subsequent centrifugal spread of this virus along nerves to the skin of the whole dermatome led to the development of a band...

journal_title：Journal of virology

authors： Simmons A,Nash AA

更新日期：1985-03-01 00:00:00

abstract：:The RNA polymerase in the nucleocapsid of Pseudomonas phaseolicola bacteriophage phi 6 transcribed large, medium, and small single-stranded RNA from the viral double-stranded RNA genome by a semiconservative (displacement) mechanism. Approximately 23%, 63%, and 65% of the nucleocapsid particles in the assay mixture sy...

journal_title：Journal of virology

authors： Van Etten JL,Burbank DE,Cuppels DA,Lane LC,Vidaver AK

更新日期：1980-02-01 00:00:00

abstract：:Muscle is an attractive target for gene delivery because of its mass and because vectors can be delivered in a noninvasive fashion. Adeno-associated virus (AAV) has been shown to be effective for muscle-targeted gene transfer. Recent progress in characterization of AAV serotype 1 (AAV1) and AAV6 demonstrated that thes...

journal_title：Journal of virology

authors： Hauck B,Xiao W

更新日期：2003-02-01 00:00:00

abstract：:The transcription map of the Aedes albopictus densovirus (AalDNV) brevidensovirus was identified by Northern blotting, rapid amplification of cDNA ends (RACE) analysis, and RNase protection assays. AalDNV produced mRNAs of 3,359 (NS1), 3,345 (NS2), and 1,246 (VP) nucleotides. The two overlapping P7/7.4 NS promoters em...

journal_title：Journal of virology

authors： Pham HT,Jousset FX,Perreault J,Shike H,Szelei J,Bergoin M,Tijssen P

更新日期：2013-09-01 00:00:00

abstract：:A marked virus-inhibiting potency is obtained in the serum after intraperitoneal injection of polyacrylic acid (PAA) and polymethacrylic acid (PMAA) in mice. Much higher antiviral levels were reached than for other related polymers including dextran sulfate, heparin, polyvinyl sulfate, pyran copolymer, polystyrene sul...

journal_title：Journal of virology

authors： De Somer P,De Clercq E,Billiau A,Schonne E,Claesen M

更新日期：1968-09-01 00:00:00

abstract：:Secondary cultures of chicken embryo fibroblasts were infected with the Schmidt Ruppin strain of Rous sarcoma virus (RSV). Five days after infection, the medium was replaced at 2-h intervals with phosphate-free Eagle medium containing 50 muCi of [32P]orthophosphate per ml. Virus was collected by centrifugation, and th...

journal_title：Journal of virology

authors： Jacobson AB,Bromley PA

更新日期：1975-01-01 00:00:00

abstract：:Attempts to elicit broadly neutralizing antibody responses by human immunodeficiency virus type 1 (HIV-1) vaccine antigens have been met with limited success. To better understand the requirements for cross-neutralization of HIV-1, we have characterized the neutralizing antibody specificities present in the sera of th...

journal_title：Journal of virology

authors： Dhillon AK,Donners H,Pantophlet R,Johnson WE,Decker JM,Shaw GM,Lee FH,Richman DD,Doms RW,Vanham G,Burton DR

更新日期：2007-06-01 00:00:00

abstract：:Chinese hamster X mouse somatic cell hybrids were analyzed by Southern blot hybridization with a probe specific for the cellular c-fms proto-oncogene. Results demonstrate that Fms, the genetic locus containing this sequence, maps to mouse chromosome 18. Mouse Fms is thus not linked to the same set of genes involved in...

journal_title：Journal of virology

authors： Hoggan MD,Halden NF,Buckler CE,Kozak CA

更新日期：1988-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded molecules have been detected in the tumor tissues of several cancers, including nasopharyngeal carcinoma (NPC), suggesting that EBV plays an important role in tumorigenesis. However, the nature of EBV with respect to genome width in vivo and whether EBV undergoes clonal expansion in th...

journal_title：Journal of virology

authors： Liu P,Fang X,Feng Z,Guo YM,Peng RJ,Liu T,Huang Z,Feng Y,Sun X,Xiong Z,Guo X,Pang SS,Wang B,Lv X,Feng FT,Li DJ,Chen LZ,Feng QS,Huang WL,Zeng MS,Bei JX,Zhang Y,Zeng YX

更新日期：2011-11-01 00:00:00

abstract：:In order to clarify antigenic variations among various isolates of human herpesvirus 6 (HHV-6) and cross-reactivity among HHV-6, HHV-7, and human cytomegalovirus (HCMV) in the T-cell immune response, the antigenic specificity of the proliferative response mediated by 232 CD4+ human T-cell clones directed against HHV-6...

journal_title：Journal of virology

authors： Yasukawa M,Yakushijin Y,Furukawa M,Fujita S

更新日期：1993-10-01 00:00:00

abstract：:The helicase-like 1a and polymerase-like 2a proteins of brome mosaic virus (BMV) are required for viral RNA replication in vivo, are present in membrane-bound viral RNA polymerase extracts, and share conservation with the many other members of the alphavirus-like superfamily. To better understand BMV RNA replication a...

journal_title：Journal of virology

authors： Restrepo-Hartwig MA,Ahlquist P

更新日期：1996-12-01 00:00:00

abstract：:The mechanisms of cell death in CD4+ T cells mediated by human herpesvirus 6 (HHV-6) were investigated. The frequency of cell death in the human CD4+ T-cell line JJHAN, which had been inoculated with HHV-6 variant A or B, appeared to be augmented by tumor necrosis factor alpha (TNF-alpha). Agarose gel electrophoresis ...

journal_title：Journal of virology

authors： Inoue Y,Yasukawa M,Fujita S

更新日期：1997-05-01 00:00:00

abstract：:We have used Northern blot hybridization to study the accumulation of specific cellular mRNAs in Vero cells infected with herpes simplex virus (HSV) type 1 or type 2. HSV-1 infection decreased the cytoplasmic levels of beta- and gamma-actin, beta-tubulin, and histone H3 and H4 mRNAs, though not all at the same rate. H...

journal_title：Journal of virology

authors： Schek N,Bachenheimer SL

更新日期：1985-09-01 00:00:00

abstract：:PCR amplification of baboon endogenous virus (BaEV) long terminal repeat, reverse transcriptase gene, and env fragments from 24 different species of African monkeys indicates that BaEV is less widespread than was formerly thought. Instead of being present in every species of African primates, BaEV can be found only in...

journal_title：Journal of virology

authors： van der Kuyl AC,Dekker JT,Goudsmit J

更新日期：1995-12-01 00:00:00

abstract：:T-even bacteriophages were grown and purified in bulk quantities. The protein coats were disrupted into their component substructures by treatment with 67% dimethyl sulfoxide (DMSO). Tail fibers and tubes were purified on glycerol-CsCl-D(2)O gradients and examined with respect to sedimentation properties, subunit mole...

journal_title：Journal of virology

authors： Cummings DJ,Kusy AR,Chapman VA,DeLong SS,Stone KR

更新日期：1970-10-01 00:00:00

abstract：:Translation of aphthovirus RNA is initiated at an internal ribosome entry site (IRES) element, preceding the first functional AUG initiation codon. The effect of mutations at the base of domain 3 of the aphthovirus IRES on translation activity has been analyzed by site-directed mutagenesis and expression of bicistroni...

journal_title：Journal of virology

authors： Martínez-Salas E,Regalado MP,Domingo E

更新日期：1996-02-01 00:00:00

abstract：:Turkeys inoculated with spleen extracts from lymphoproliferative disease (LPD)-affected birds developed viremia, followed by typical LPD lesions. Electron microscopy and biochemical characterization established that the virus present in the blood of infected turkeys is a type C retrovirus. The viral particles possess ...

journal_title：Journal of virology

authors： Yaniv A,Gazit A,Ianconescu M,Perk K,Aizenberg B,Zimber A

更新日期：1979-04-01 00:00:00

abstract：:DNA of the avian hepadnavirus, duck hepatitis B virus, was found to be integrated at low abundance into the cellular DNA extracted from the livers of infected ducklings. The frequency of integration was estimated to be at least one viral genome per 10(3) to 10(4) cells by 6 days postinfection. The structures of virus-...

journal_title：Journal of virology

authors： Yang W,Summers J

更新日期：1999-12-01 00:00:00

abstract：:Growth of phage phi105 and its deoxyribonucleic acid (DNA) was studied in radiation-sensitive mutants of Bacillus subtilis. The recA gene is required for optimal prophage induction with mitomycin C and for infectivity of prophage DNA. rec B gene is required for marker rescue from mature DNA. The importance of bacteria...

journal_title：Journal of virology

authors： Rutberg B,Rutberg L

更新日期：1971-12-01 00:00:00

abstract：:Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated the immunogenicity and relative efficacy of systemic immunization with two human ALVAC-HIV-1 recombinant vaccines express...

journal_title：Journal of virology

authors： Pal R,Venzon D,Santra S,Kalyanaraman VS,Montefiori DC,Hocker L,Hudacik L,Rose N,Nacsa J,Edghill-Smith Y,Moniuszko M,Hel Z,Belyakov IM,Berzofsky JA,Parks RW,Markham PD,Letvin NL,Tartaglia J,Franchini G

更新日期：2006-04-01 00:00:00

abstract：:A number of eucaryotic viruses have devised strategies to minimize the deleterious effects on protein synthesis caused by activation of the interferon-induced, double-stranded-RNA-activated protein kinase, P68. In a recent report, we described the down regulation of the P68 protein kinase in cells infected by human im...

journal_title：Journal of virology

authors： Roy S,Agy M,Hovanessian AG,Sonenberg N,Katze MG

更新日期：1991-02-01 00:00:00

abstract：:F111 rat cells transformed by simian virus 40 mutant tsA1499 are cold sensitive for the expression of transformation. Yet, unlike F111 cells transformed by tsA58, they do not lose the ability to stabilize the transformation-associated host cell protein p53 at the temperature at which transformation is extinguished. ...

journal_title：Journal of virology

authors： Bouck N,Fikes J,Rundell MK

更新日期：1984-03-01 00:00:00

abstract：:Noroviruses are the causative agents of the majority of viral gastroenteritis outbreaks in humans. During the past 15 years, noroviruses of genotype GGII.4 have caused four epidemic seasons of viral gastroenteritis, during which four novel variants (termed epidemic variants) emerged and displaced the resident viruses....

journal_title：Journal of virology

authors： Siebenga JJ,Vennema H,Renckens B,de Bruin E,van der Veer B,Siezen RJ,Koopmans M

更新日期：2007-09-01 00:00:00

abstract：:Human CD317 (BST-2/tetherin) is an intrinsic immunity factor that blocks the release of retroviruses, filoviruses, herpesviruses, and arenaviruses. It is unclear whether CD317 expressed endogenously in rodent cells has the capacity to interfere with the replication of the retroviral rodent pathogen murine leukemia vir...

journal_title：Journal of virology

authors： Goffinet C,Schmidt S,Kern C,Oberbremer L,Keppler OT

更新日期：2010-11-01 00:00:00

abstract：UNLABELLED:Pandemic influenza is a major public health concern, but conventional strain-matched vaccines are unavailable early in a pandemic. Candidate "universal" vaccines targeting the viral antigens nucleoprotein (NP) and matrix 2 (M2), which are conserved among all influenza A virus strains and subtypes, could be m...

journal_title：Journal of virology

authors： Price GE,Lo CY,Misplon JA,Epstein SL

更新日期：2014-06-01 00:00:00

abstract：:The rat-derived Harvey murine sarcoma virus (Ha-MuSV) contains a transduced ras oncogene activated by two missense mutations and flanked by rat retroviruslike VL30 sequences. Ha-MuSV induces focal transformation of mouse NIH 3T3 cells in vitro and tumors (fibrosarcomas and splenic erythroleukemias) in newborn mice. We...

journal_title：Journal of virology

authors： Velu TJ,Vass WC,Lowy DR,Tambourin PE

更新日期：1989-03-01 00:00:00

abstract：:Cytotoxic T lymphocyte (CTL) activity was assessed in mice immunized with DNA plasmids containing the human immunodeficiency virus type 1 (HIV-1) gp120 envelope (pTMIgp120) or p55gag (pTMIgag) gene regulated by the bacteriophage T7 promoter. Immunization with either plasmid resulted in CTL activity against class I maj...

journal_title：Journal of virology

authors： Selby MJ,Doe B,Walker CM

更新日期：1997-10-01 00:00:00

abstract：:We previously identified two novel endogenous murine leukemia virus proviruses, PreXMRV-1 and PreXMRV-2, and showed that they most likely recombined during xenograft passaging of a human prostate tumor in mice to generate xenotropic murine leukemia virus-related virus (XMRV). To determine the recombination potential o...

journal_title：Journal of virology

authors： Delviks-Frankenberry K,Paprotka T,Cingöz O,Wildt S,Hu WS,Coffin JM,Pathak VK

更新日期：2013-11-01 00:00:00

abstract：:Hemorrhagic enteritis virus (HEV), a type II avian adenovirus, causes intestinal hemorrhages and immunosuppression in turkeys. In this study, we exposed turkeys to virulent HEV and examined fractionated spleen cells for the presence of viral DNA by in situ hybridization and amplification of DNA extracted from virus-in...

journal_title：Journal of virology

authors： Suresh M,Sharma JM

更新日期：1996-01-01 00:00:00

abstract：:The ectopic overexpression of Bcl-2 restricts both influenza A virus-induced apoptosis and influenza A virus replication in MDCK cells, thus suggesting a role for Bcl-2 family members during infection. Here we report that influenza A virus cannot establish an apoptotic response without functional Bax, a downstream tar...

journal_title：Journal of virology

authors： McLean JE,Datan E,Matassov D,Zakeri ZF

更新日期：2009-08-01 00:00:00