Abstract:
:Chinese hamster X mouse somatic cell hybrids were analyzed by Southern blot hybridization with a probe specific for the cellular c-fms proto-oncogene. Results demonstrate that Fms, the genetic locus containing this sequence, maps to mouse chromosome 18. Mouse Fms is thus not linked to the same set of genes involved in growth regulation that human FMS is linked to.
journal_name
J Viroljournal_title
Journal of virologyauthors
Hoggan MD,Halden NF,Buckler CE,Kozak CAdoi
10.1128/JVI.62.3.1055-1056.1988subject
Has Abstractpub_date
1988-03-01 00:00:00pages
1055-6issue
3eissn
0022-538Xissn
1098-5514journal_volume
62pub_type
杂志文章abstract::The cellular site of herpesvirus tegument assembly has yet to be defined. We have previously used a recombinant herpes simplex virus type 1 expressing a green fluorescent protein (GFP)-tagged tegument protein, namely VP22, to show that VP22 is localized exclusively to the cytoplasm during infection. Here we have const...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.6.2575-2583.2001
更新日期:2001-03-01 00:00:00
abstract::Although adeno-associated virus type 2 (AAV) has gained attention as a potentially useful vector for human gene therapy, the transduction efficiencies of AAV vectors vary greatly in different cells and tissues in vitro and in vivo. We have documented that a cellular tyrosine phosphoprotein, designated the single-stran...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.19.8968-8976.2001
更新日期:2001-10-01 00:00:00
abstract::Adeno-associated virus (AAV) codes for four related nonstructural Rep proteins. AAV both replicates and assembles in the nucleus and requires coinfection with a helper virus, either adenovirus (Ad) or herpesvirus, for a productive infection. Like other more complex DNA viruses, it is believed that AAV interacts or mod...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01939-08
更新日期:2009-01-01 00:00:00
abstract::Simian virus 40 tumor (T) antigen, an established viral oncoprotein, causes alterations in cell growth control through interacting with, and altering the function of, cellular proteins. To examine the effects of T antigen on cell growth control, and to identify the cellular proteins with which it may functionally inte...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.2.756-763.1995
更新日期:1995-02-01 00:00:00
abstract::Nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) possesses an RNA-dependent RNA polymerase activity responsible for viral genome RNA replication. Despite several reports on the characterization of this essential viral enzyme, little is known about the reaction pathway of NS5B-catalyzed nucleotide incorporati...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.19.9134-9143.2000
更新日期:2000-10-01 00:00:00
abstract:UNLABELLED:Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human pathogens. Both viruses can recognize, via the surface envelope glycoprotein D (gD), human nectin-1 as a functional receptor. Previous studies have successfully elucidated the molecular basis of the binding between HSV-1 gD and necti...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01906-14
更新日期:2014-12-01 00:00:00
abstract::Deoxyribonucleic acid (DNA) synthesis was studied in poxvirus-infected cells by measuring (14)C-thymidine incorporation into viral and host cell DNA. A complete separation of the two species of DNA was achieved by combining the previously used "Dounce method" with a separation method based on different reannealing pro...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.2.5.401-408.1968
更新日期:1968-05-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) is a novel gammaherpesvirus strongly implicated in the pathogenesis of Kaposi's sarcoma. Although virions can be produced in high yield from latently infected B-cell lines treated with phorbol esters, little is known about the infectivity...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.6.5182-5188.1998
更新日期:1998-06-01 00:00:00
abstract::Certain chicken cells that do not spontaneously release virus particles have been shown to produce a subgroup E avian RNA tumor virus, Rous-associated virus 60 (RAV-60), after infection with viruses of other subgroups. The nucleic acids of RAV-60 were analyzed for sequence homologies with the viral nucleic acids conta...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.15.6.1367-1377.1975
更新日期:1975-06-01 00:00:00
abstract::The S1 gene nucleotide sequences of 10 type 3 (T3) reovirus strains were determined and compared with the T3 prototype Dearing strain in order to study sequence diversity in strains of a single reovirus serotype and to learn more about structure-function relationships of the two S1 translation products, sigma 1 and si...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.10.4842-4850.1990
更新日期:1990-10-01 00:00:00
abstract::Intranuclear and intracytoplasmic inclusions in monkey kidney cells infected with African horsesickness virus were studied with the aid of electron microscopy. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.4.1.109-112.1969
更新日期:1969-07-01 00:00:00
abstract::Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta). However, recombinant HRSV lacking the NS1 and NS2 genes (Delta NS1/2) induced high levels of IFN-alpha and -beta in human pulmonary epithelial cells (A549) as well as in macrophages derived from primary hum...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.8.4363-4369.2004
更新日期:2004-04-01 00:00:00
abstract:UNLABELLED:Type I IFN signaling, which is initiated through activation of the alpha interferon receptor (IFNAR), regulates the expression of proteins that are crucial contributors to immune responses. Paramyxoviruses, including human metapneumovirus (HMPV), have evolved mechanisms to inhibit IFNAR signaling, but the sp...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03275-14
更新日期:2015-04-01 00:00:00
abstract::Although the envelope gene of human immunodeficiency virus type 1 shows considerable strain variability, cysteine residues of the envelope protein are strongly conserved, suggesting that they are important to the envelope structure. We constructed and analyzed mutants of a biologically active molecular clone of human ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.5.2250-2259.1990
更新日期:1990-05-01 00:00:00
abstract::Reoviruses are encapsidated double-stranded RNA viruses that cause systemic disease in mice after peroral (p.o.) inoculation and primary replication in the intestine. In this study, we define components of the immune system involved in the clearing of reovirus from the proximal small intestine. The intestines of immun...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.2.1109-1116.1996
更新日期:1996-02-01 00:00:00
abstract::The severe acute respiratory syndrome coronavirus (SARS-CoV) was recently identified as the etiology of SARS. The virus particle consists of four structural proteins: spike (S), small envelope (E), membrane (M), and nucleocapsid (N). Recognition of a specific sequence, termed the packaging signal (PS), by a virus N pr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.22.13848-13855.2005
更新日期:2005-11-01 00:00:00
abstract::Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses. There are two ZAP isoforms arising from alternative splicing, which differ only at the C termini. It was recently reported that the long isoform (ZAPL) promotes proteasomal degradation of influenza A vir...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01909-16
更新日期:2017-01-03 00:00:00
abstract::Previous in vitro analyses have shown that the human immunodeficiency virus type 1 (HIV-1) integrase uses either manganese or magnesium to assemble as a stable complex on the donor substrate and to catalyze strand transfer. We now demonstrate that subsequent to assembly, catalysis of both 3' end processing and strand ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.7005-7011.1997
更新日期:1997-09-01 00:00:00
abstract::Adenovirus type 2 (Ad2)-transformed hamster and rat cells are susceptible to lysis by natural killer (NK) cells from the host of origin and are nontumorigenic in immunocompetent hamsters and rats, respectively. These NK-cell-susceptible, virus-transformed cells are, however, highly tumorigenic in athymic (nude) mice--...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.7.2155-2161.1987
更新日期:1987-07-01 00:00:00
abstract::Coupling of G proteins to ligand-engaged chemokine receptors is the paramount event in G-protein-coupled receptor signal transduction. Previously, we have demonstrated that the human cytomegalovirus-encoded chemokine receptor US28 mediates human vascular smooth muscle cell (SMC) migration in response to either RANTES ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.15.8382-8391.2004
更新日期:2004-08-01 00:00:00
abstract::Northern (RNA) blot analysis was used to determine the spatial and temporal distribution of bovine herpesvirus 1 (BHV-1) transcripts. Total RNA was isolated from Madin-Darby bovine kidney cells which had been infected with BHV-1.2b strain K22 or BHV-1.1 strain Jura in the presence or absence of metabolic inhibitors. C...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.11.4882-4889.1989
更新日期:1989-11-01 00:00:00
abstract::The fundamental event in prion disease is thought to be the posttranslational conversion of the cellular prion protein (PrPC) into a pathogenic isoform (PrPSc). The occurrence of PrPC on the cell surface and PrPSc in amyloid plaques in situ or in aggregates following purification complicates the study of the molecular...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.11.9413-9418.1998
更新日期:1998-11-01 00:00:00
abstract:UNLABELLED:Rotaviruses (RVs) are 11-segmented, double-stranded RNA viruses that cause severe gastroenteritis in children. In addition to an error-prone genome replication mechanism, RVs can increase their genetic diversity by reassorting genes during host coinfection. Such exchanges allow RVs to acquire advantageous ge...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01562-14
更新日期:2014-09-01 00:00:00
abstract::This study on Tomato bushy stunt virus identified and defined three previously unknown regulatory sequences involved in RNA accumulation that are located within the 3'-proximal nested movement protein genes p22 and p19. The first is a 16-nucleotide (nt) element termed III-A that is positioned at the very 3' end of p22...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.24.12747-12757.2002
更新日期:2002-12-01 00:00:00
abstract::Posttranslational modification-oligomerization, phosphorylation, and proteolytic cleavage-of the human papillomavirus (HPV) E4 protein occurs as the infected keratinocytes migrate up through the suprabasal wart layers. It has been postulated that these events modify E4 function during the virus life cycle. In HPV type...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.24.13920-13933.2004
更新日期:2004-12-01 00:00:00
abstract::We have tested triple and quadruple combinations of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins, and a high-titer anti-HIV-1 human immunoglobulin (HIVIG) preparation for their abilities to neutralize a chimeric si...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.4.3235-3240.1998
更新日期:1998-04-01 00:00:00
abstract::MicroRNAs (miRNAs) represent a conserved class of small noncoding RNAs that are found in all higher eukaryotes as well as some DNA viruses. miRNAs are 20 to 25 nucleotides in length and have important regulatory functions in biological processes such as embryonic development, cell differentiation, hormone secretion, a...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01689-08
更新日期:2009-04-01 00:00:00
abstract::We have analyzed the structure of rubella virus proteins labeled metabolically with [35S]methionine, [3H]mannose, and [3H]glucosamine or externally with [3H]borohydride after galactose oxidase treatment. Four structural proteins, with MrS of about 58,000 (E1), 47,000 (E2a), 42,000 (E2b), and 33,000 (C), were resolved ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.46.3.964-973.1983
更新日期:1983-06-01 00:00:00
abstract::The 104-S monoclonal antibody immunoprecipitated from herpes simplex virus type 2 (HSV-2)-infected cell extracts the 75,000-molecular-weight glycoprotein gF and its 65,000-molecular-weight precursor (pgF). The precursor pgF was sensitive to endoglycosidase H digestion, indicating the presence of high mannose-type olig...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.47.1.185-192.1983
更新日期:1983-07-01 00:00:00
abstract::Retroviruses integrate into cellular DNA nonrandomly. Lentiviruses such as human immunodeficiency virus type 1 (HIV-1) favor the bodies of active genes and gene-enriched transcriptionally active regions of chromosomes. The interaction between lentiviral integrase and the cellular protein lens epithelium-derived growth...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01148-12
更新日期:2013-01-01 00:00:00