Tomato bushy stunt virus genomic RNA accumulation is regulated by interdependent cis-acting elements within the movement protein open reading frames.

abstract：:We previously reported that mitogenic activation of porcine peripheral blood mononuclear cells resulted in production of porcine endogenous retrovirus(es) (PERV[s]) capable of productively infecting human cells (C. Wilson et al., J. Virol. 72:3082-3087, 1998). We now extend that analysis to show that additional passag...

journal_title：Journal of virology

authors： Wilson CA,Wong S,VanBrocklin M,Federspiel MJ

更新日期：2000-01-01 00:00:00

abstract：:To identify retroviral antigenic determinants recognized by CD4+ T helper cells during tumor rejection, we established four noncytolytic, helper-type, CD4+ T-cell clones by limiting dilution cultures of mixed lymphocyte-tumor cultures from mice immune to a Friend virus-induced tumor, FBL-3. Among these, three T helper...

journal_title：Journal of virology

authors： Iwashiro M,Kondo T,Shimizu T,Yamagishi H,Takahashi K,Matsubayashi Y,Masuda T,Otaka A,Fujii N,Ishimoto A

更新日期：1993-08-01 00:00:00

abstract：:Sapelovirus is a member of the family Picornaviridae and is emerging as an enteric porcine, simian, and avian pathogen. Here, we report the genome sequence of a novel porcine sapelovirus strain YC2011 isolated from piglets with severe diarrhea. The availability of the genome sequence is helpful to further investigatio...

journal_title：Journal of virology

authors： Chen J,Chen F,Zhou Q,Li W,Song Y,Pan Y,Zhang X,Xue C,Bi Y,Cao Y

更新日期：2012-10-01 00:00:00

abstract：:In order to clarify antigenic variations among various isolates of human herpesvirus 6 (HHV-6) and cross-reactivity among HHV-6, HHV-7, and human cytomegalovirus (HCMV) in the T-cell immune response, the antigenic specificity of the proliferative response mediated by 232 CD4+ human T-cell clones directed against HHV-6...

journal_title：Journal of virology

authors： Yasukawa M,Yakushijin Y,Furukawa M,Fujita S

更新日期：1993-10-01 00:00:00

abstract：:The effect of human cytomegalovirus infection on cellular DNA synthesis in human fibroblasts was measured by fluorometry and by incorporation of radiolabeled thymidine. The results show that although HCMV infection stimulates cellular DNA synthesis in both quiescent and serum-stimulated cells, radiolabeled thymidine i...

journal_title：Journal of virology

authors： Morin J,Johann S,O'Hara B,Gluzman Y

更新日期：1996-09-01 00:00:00

abstract：:Swine influenza viruses (SIV) naturally infect pigs and can be transmitted to humans. In the pig, genetic reassortment to create novel influenza subtypes by mixing avian, human, and swine influenza viruses is possible. An SIV vaccine inducing cross-protective immunity between different subtypes and strains circulating...

journal_title：Journal of virology

authors： Richt JA,Lekcharoensuk P,Lager KM,Vincent AL,Loiacono CM,Janke BH,Wu WH,Yoon KJ,Webby RJ,Solórzano A,García-Sastre A

更新日期：2006-11-01 00:00:00

abstract：:At mucosal sites, papillomavirus genomes can persist in the epithelial basal layer following immune-mediated regression. Subsequent T-cell depletion stimulates a 3- to 5-log increase in the viral copy number, to levels associated with productive infection. Reappearance of microlesions was rare within the short time fr...

journal_title：Journal of virology

authors： Maglennon GA,McIntosh PB,Doorbar J

更新日期：2014-01-01 00:00:00

abstract：:Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable dif...

journal_title：Journal of virology

authors： Neumann G,Geisbert TW,Ebihara H,Geisbert JB,Daddario-DiCaprio KM,Feldmann H,Kawaoka Y

更新日期：2007-03-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) is a DNA virus that acquires an envelope by budding into the inner nuclear membrane of an infected cell. Recombinant HSV-1 lacking the U(L)34 gene cannot undergo this event. U(L)34 and U(L)31, another viral protein, colocalize in an infected cell and are necessary and sufficient to ...

journal_title：Journal of virology

authors： Bjerke SL,Cowan JM,Kerr JK,Reynolds AE,Baines JD,Roller RJ

更新日期：2003-07-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in globular nuclear domains...

journal_title：Journal of virology

authors： Burkham J,Coen DM,Weller SK

更新日期：1998-12-01 00:00:00

abstract：UNLABELLED:Barrier dysfunction of airway epithelium may increase the risk for acquiring secondary infections or allergen sensitization. Both rhinovirus (RV) and polyinosinic-polycytidilic acid [poly(I·C)], a double-stranded RNA (dsRNA) mimetic, cause airway epithelial barrier dysfunction, which is reactive oxygen speci...

journal_title：Journal of virology

authors： Unger BL,Ganesan S,Comstock AT,Faris AN,Hershenson MB,Sajjan US

更新日期：2014-04-01 00:00:00

abstract：:Varicella-zoster virus (VZV) open reading frame 4 (ORF4) encodes a putative immediate-early protein which is homologous to herpes simplex virus type 1 (HSV-1) ICP27 on the basis of gene location and similarity in amino acid sequence. In transient expression assays, however, ORF4 and ICP27 exhibit different properties....

journal_title：Journal of virology

authors： Moriuchi H,Moriuchi M,Smith HA,Cohen JI

更新日期：1994-03-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 genome encodes the Tax protein that plays essential regulatory roles in HTLV-1 replication and oncogenic transformation of T lymphocytes....

journal_title：Journal of virology

authors： Gao L,Harhaj EW

更新日期：2013-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a global challenge to public health. Several factors have been proven to be critical for HCV entry, including the newly identified claudin-1 (CLDN1). However, the mechanism of HCV entry is still obscure. Presently, among the 20 members of the claudin family identified in humans so far, CLDN1...

journal_title：Journal of virology

authors： Zheng A,Yuan F,Li Y,Zhu F,Hou P,Li J,Song X,Ding M,Deng H

更新日期：2007-11-01 00:00:00

abstract：:We have used an antisense RNA approach in the analysis of gene function in human cytomegalovirus (HCMV). An astrocytoma cell line (U373-MG) that is permissive for virus replication was permanently transfected with a construct bearing sequence from HCMV UL44 (coding for the major late DNA-binding protein, ppUL44, also ...

journal_title：Journal of virology

authors： Ripalti A,Boccuni MC,Campanini F,Landini MP

更新日期：1995-04-01 00:00:00

abstract：:Effective, vaccine-induced CD8+ T-cell responses should recognize infected cells early enough to prevent production of progeny virions. We have recently shown that Gag-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells at 2 h postinfection, whereas Env-specific CD8+ T cells do not recognize i...

journal_title：Journal of virology

authors： Sacha JB,Chung C,Reed J,Jonas AK,Bean AT,Spencer SP,Lee W,Vojnov L,Rudersdorf R,Friedrich TC,Wilson NA,Lifson JD,Watkins DI

更新日期：2007-11-01 00:00:00

abstract：:Trigeminal ganglia (TG) from rabbits latently infected with either wild-type herpes simplex virus type 1 (HSV-1) or the latency-associated transcript (LAT) promoter deletion mutant 17DeltaPst were assessed for their viral chromatin profile and transcript abundance. The wild-type 17syn+ genomes were more enriched in th...

journal_title：Journal of virology

authors： Giordani NV,Neumann DM,Kwiatkowski DL,Bhattacharjee PS,McAnany PK,Hill JM,Bloom DC

更新日期：2008-06-01 00:00:00

abstract：:This study describes a method for increasing the immunogenicity of influenza virus vaccines by exploiting the natural anti-Gal antibody to effectively target vaccines to antigen-presenting cells (APC). This method is based on enzymatic engineering of carbohydrate chains on virus envelope hemagglutinin to carry the alp...

journal_title：Journal of virology

authors： Abdel-Motal UM,Guay HM,Wigglesworth K,Welsh RM,Galili U

更新日期：2007-09-01 00:00:00

abstract：:Genetic bottlenecks are important events in the genetic diversification of organisms and colonization of new ecological niches. Repeated bottlenecking of RNA viruses often leads to fitness losses due to the operation of Muller's ratchet. Herein we use vesicular stomatitis virus to determine the transmission population...

journal_title：Journal of virology

authors： Novella IS,Elena SF,Moya A,Domingo E,Holland JJ

更新日期：1995-05-01 00:00:00

abstract：:The sequence relations between Kirsten murine sarcoma virus (Ki-SV), Harvey murine sarcoma virus (Ha-SV), and a rat endogenous 30S RNA were studied by electron microscope heteroduplex analysis. The sequence relationships between the sarcoma viruses and their respective parental murine leukemia viruses (Kirsten and Mol...

journal_title：Journal of virology

authors： Chien UH,Lai M,Shih TY,Verma IM,Scolnick EM,Roy-Burman P,Davidson N

更新日期：1979-09-01 00:00:00

abstract：:The endogenous transcriptase present in purified vesicular stomatitis (VS) virions was solubilized with a Triton X-100 high-salt solution. The polymerase activity was purified on glycerol gradients and by phosphocellulose column chromatography; the viral proteins present in the active enzyme fractions were identified ...

journal_title：Journal of virology

authors： Emerson SU,Wagner RR

更新日期：1973-12-01 00:00:00

abstract：:The latency-related (LR) gene of bovine herpesvirus 1 (BHV-1) is abundantly expressed during latency. A mutant BHV-1 strain that contains three stop codons at the 5' terminus of the LR gene (LR mutant) does not reactivate from latency. This study demonstrates that the LR mutant does not express open reading frame 2 or...

journal_title：Journal of virology

authors： Jiang Y,Inman M,Zhang Y,Posadas NA,Jones C

更新日期：2004-03-01 00:00:00

abstract：:A adenovirus type 5 host range mutant (hr440) has been isolated which is defective in a splicing event required to generate the middle-sized mRNA from early region 1A. This defect has been ascribed to two adjacent nucleotide changes which lie five and six nucleotides from the 5' splice site for this mRNA (Solnick, Nat...

journal_title：Journal of virology

authors： Solnick D,Anderson MA

更新日期：1982-04-01 00:00:00

abstract：:Enzymatic markers and electron microscopy were utilized to determine the cellular origin of the membrane types isolated from type 2 dengue virus-infected BHK cells by discontinuous sucrose gradient centrifugation. The results showed an apparent separation of plasma membrane, smooth and rough endoplasmic reticulum with...

journal_title：Journal of virology

authors： Stohlman SA,Wisseman CL Jr,Eylar OR,Silverman DJ

更新日期：1975-10-01 00:00:00

abstract：:Three distinct strains of murine rotavirus were adapted to growth in cell culture. These strains are genetically related but not identical; they are serotypically heterogeneous. The cultivatable strains were substantially more infectious (approximately 10(6)-fold) for suckling mice than heterologous simian rotaviruses...

journal_title：Journal of virology

authors： Greenberg HB,Vo PT,Jones R

更新日期：1986-02-01 00:00:00

abstract：:The adenovirus type 2 L1 region, which is located at 30.7 to 39.2 map units on the viral genome, is transcribed from the major late promoter during both early and late stages of virus replication, and a 52,000-Mr (52K) protein-55K protein doublet has been translated in vitro on L1-specific RNA. To investigate the bios...

journal_title：Journal of virology

authors： Lucher LA,Symington JS,Green M

更新日期：1986-03-01 00:00:00

abstract：:The sequence of 2,191 nucleotides encoding the env gene of murine retrovirus Akv was determined by using a molecular clone of the Akv provirus. Deduction of the encoded amino acid sequence showed that a single open reading frame encodes a 638-amino acid precursor to gp70 and p15E. In addition, there is a typical leade...

journal_title：Journal of virology

authors： Lenz J,Crowther R,Straceski A,Haseltine W

更新日期：1982-05-01 00:00:00

abstract：:Herpesviruses establish latency in suitable host cells after primary infection and persist in their host organisms for life. Most of the viral genes are silenced during latency, also enabling the virus to escape from an immune response. This study addresses the control of viral gene silencing by epigenetic mechanisms,...

journal_title：Journal of virology

authors： Alberter B,Vogel B,Lengenfelder D,Full F,Ensser A

更新日期：2011-06-01 00:00:00

abstract：UNLABELLED:Susceptibility or resistance to prion infection in humans and animals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's modulating role has not been well investigated. Compared to disease incubation times in wild-type homozygous ARQ/ARQ (where each triplet represents...

journal_title：Journal of virology

authors： Langeveld JP,Jacobs JG,Hunter N,van Keulen LJ,Lantier F,van Zijderveld FG,Bossers A

更新日期：2015-10-28 00:00:00

abstract：:Epstein-Barr virus (EBV) uses tonsils as the portal of entry to establish persistent infection. EBV is found in various B-cell subsets in tonsils but exclusively in memory B cells in peripheral blood. The in vitro susceptibilities of B-cell subsets to EBV infection have been studied solely qualitatively. In this work,...

journal_title：Journal of virology

authors： Dorner M,Zucol F,Berger C,Byland R,Melroe GT,Bernasconi M,Speck RF,Nadal D

更新日期：2008-05-01 00:00:00