Brome mosaic virus helicase- and polymerase-like proteins colocalize on the endoplasmic reticulum at sites of viral RNA synthesis.

abstract：:Corynebacteriophages beta and gamma are closely related but heteroimmune; hence, gamma reproduces in C7(beta). A series of gamma mutants, designated gamma-bin (beta-inhibited), has been isolated. They reproduce in only 2 to 14% of infected C7(beta) cells, and, as a result, plaque with an efficiency of 10(-4) to 10(-5)...

journal_title：Journal of virology

authors： Groman N,Rabin M

更新日期：1978-10-01 00:00:00

abstract：:Poliovirus (PV) is easily transferred to humans orally; however, no rodent model for oral infections has been developed because of the alimentary tract's low sensitivity to the virus. Here we showed that PV is inactivated by the low pH of the gastric contents in mice. The addition of 3% NaHCO3 to the viral inoculum in...

journal_title：Journal of virology

authors： Ohka S,Igarashi H,Nagata N,Sakai M,Koike S,Nochi T,Kiyono H,Nomoto A

更新日期：2007-08-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is a major cause of liver disease. The HCV polyprotein contains a hypervariable region (HVR1) located at the N terminus of the second envelope glycoprotein E2. The strong variability of this 27-amino-acid region is due to its apparent tolerance of amino acid substitutions toge...

journal_title：Journal of virology

authors： Penin F,Combet C,Germanidis G,Frainais PO,Deléage G,Pawlotsky JM

更新日期：2001-06-01 00:00:00

abstract：:The TAATGARAT motif in the herpes simplex virus (HSV) immediate-early (IE) gene promoters plays a key role in their activation by the Oct-1-Vmw65 complex, but its role in mediating inhibitory effects of cellular octamer-binding proteins is less clear. We have used indicator viruses containing reporter constructs with ...

journal_title：Journal of virology

authors： Thomas S,Coffin RS,Watts P,Gough G,Latchman DS

更新日期：1998-04-01 00:00:00

abstract：:Reovirus attachment protein σ1 engages glycan receptors and junctional adhesion molecule-A (JAM-A) and is thought to undergo a conformational change during the proteolytic disassembly of virions to infectious subvirion particles (ISVPs) that accompanies cell entry. The σ1 protein is also the primary target of neutrali...

journal_title：Journal of virology

authors： Dietrich MH,Ogden KM,Katen SP,Reiss K,Sutherland DM,Carnahan RH,Goff M,Cooper T,Dermody TS,Stehle T

更新日期：2017-01-31 00:00:00

abstract：:We have identified a spliced transcript that contains sequences from the HCMV UL29 and UL28 open reading frames. It contains amino-terminal UL29 sequences followed by UL28 sequences, and it includes a poly(A) signal derived from the 3'-untranslated region following the UL26 open reading frame. UL29/28 RNA is expressed...

journal_title：Journal of virology

authors： Mitchell DP,Savaryn JP,Moorman NJ,Shenk T,Terhune SS

更新日期：2009-10-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to int...

journal_title：Journal of virology

authors： Lund TC,Garcia R,Medveczky MM,Jove R,Medveczky PG

更新日期：1997-09-01 00:00:00

abstract：:Differentiating infected from vaccinated animals (DIVA) strategies have been central enabling techniques in several successful viral disease elimination programs. However, owing to their long and uncertain development process, no DIVA-compatible vaccines are available for many important diseases. We report herein a ne...

journal_title：Journal of virology

authors： Xue Q,Xu H,Liu H,Pan J,Yang J,Sun M,Chen Y,Xu W,Cai X,Ma H

更新日期：2020-02-28 00:00:00

abstract：:The 86-kDa IE2 protein (IE86) of human cytomegalovirus (HCMV) can act as both an activator and a repressor of gene expression. The mechanisms for both of these functions are not well defined. It has recently been demonstrated that this protein has sequence-specific DNA binding properties: it interacts directly with a ...

journal_title：Journal of virology

authors： Arlt H,Lang D,Gebert S,Stamminger T

更新日期：1994-07-01 00:00:00

abstract：:A number of full-length cDNA clones of Kunjin virus (KUN) were previously prepared; it was shown that two of them, pAKUN and FLSDX, differed in specific infectivities of corresponding in vitro transcribed RNAs by approximately 100,000-fold (A. A. Khromykh et al., J. Virol. 72:7270-7279, 1998). In this study, we analyz...

journal_title：Journal of virology

authors： Liu WJ,Chen HB,Khromykh AA

更新日期：2003-07-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68; also known as MHV-68) can establish a latent infection in both inbred and outbred strains of mice and, as such, provides a tractable small-animal model to address mechanisms and cell types involved in the establishment and maintenance of chronic gammaherpesvirus infection. Latenc...

journal_title：Journal of virology

authors： Willer DO,Speck SH

更新日期：2003-08-01 00:00:00

abstract：:The nonstructural protein (NSs) of severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) sequesters TANK-binding kinase 1 (TBK1) into NSs-induced cytoplasmic structures to inhibit the phosphorylation and nuclear translocation of interferon (IFN) regulatory factor 3 (IRF3) and subsequent interferon beta (IFN-...

journal_title：Journal of virology

authors： Moriyama M,Igarashi M,Koshiba T,Irie T,Takada A,Ichinohe T

更新日期：2018-09-12 00:00:00

abstract：:The ability of the 3A protein of coxsackievirus B (CVB) to inhibit protein secretion was investigated for this study. Here we show that the ectopic expression of CVB 3A blocked the transport of both the glycoprotein of vesicular stomatitis virus, a membrane-bound secretory marker, and the alpha-1 protease inhibitor, a...

journal_title：Journal of virology

authors： Wessels E,Duijsings D,Notebaart RA,Melchers WJ,van Kuppeveld FJ

更新日期：2005-04-01 00:00:00

abstract：:The role of glycosylation and of disulfide bonds in the formation of the native structure of the Sendai virus hemagglutinin-neuraminidase (HN) and fusion (F0) glycoproteins was studied. In contrast to the HN and F0 synthesized in vivo, the proteins made from pSP6 transcripts in reticulocyte lysates, whether glycosylat...

journal_title：Journal of virology

authors： Vidal S,Mottet G,Kolakofsky D,Roux L

更新日期：1989-02-01 00:00:00

abstract：:Minimal transformants of rat F111 fibroblasts were established after infection with the large T antigen (large T)-encoding retroviral expression vector pZIPTEX (M. Brown, M. McCormack, K. Zinn, M. Farrell, I. Bikel, and D. Livingston, J. Virol. 60:290-293, 1986). Coexpression of small t antigen (small t) in these cell...

journal_title：Journal of virology

authors： Zerrahn J,Deppert W

更新日期：1993-03-01 00:00:00

abstract：:The adenovirus type 2 L1 region, which is located at 30.7 to 39.2 map units on the viral genome, is transcribed from the major late promoter during both early and late stages of virus replication, and a 52,000-Mr (52K) protein-55K protein doublet has been translated in vitro on L1-specific RNA. To investigate the bios...

journal_title：Journal of virology

authors： Lucher LA,Symington JS,Green M

更新日期：1986-03-01 00:00:00

abstract：:Human coronavirus NL63 (HCoV-NL63), a common human respiratory pathogen, is associated with both upper and lower respiratory tract disease in children and adults. Currently, no antiviral drugs are available to treat CoV infections; thus, potential drug targets need to be identified and characterized. Here, we identify...

journal_title：Journal of virology

authors： Chen Z,Wang Y,Ratia K,Mesecar AD,Wilkinson KD,Baker SC

更新日期：2007-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes four putative G protein-coupled receptors, including pUL78, whose rodent orthologues are known to be important for replication and spread in their hosts. To investigate the mechanism by which pUL78 contributes to viral replication and pathogenesis, we generated a derivative of the ...

journal_title：Journal of virology

authors： O'Connor CM,Shenk T

更新日期：2012-11-01 00:00:00

abstract：:The nucleotide sequence of the src gene and flanking regions of the Schmidt-Ruppin strain of Rous sarcoma virus (SR-A) was determined. The src region of SR-A was very homologous to that of recovered avian sarcoma virus (rASV1441), with only 17 differences among 1,578 nucleotides. The size of the predicted protein was ...

journal_title：Journal of virology

authors： Takeya T,Hanafusa H

更新日期：1982-10-01 00:00:00

abstract：:The adenovirus E1A transforming region, which encodes immortalization, partial cell transformation, and gene activation functions, expresses two early mRNAs, 13S and 12S. Multiple-T antigen species with different electrophoretic mobilities are formed from each mRNA, presumably by unknown posttranslational modification...

journal_title：Journal of virology

authors： Lucher LA,Brackmann KH,Symington JS,Green M

更新日期：1986-05-01 00:00:00

abstract：:An immunodominant envelope glycoprotein is encoded by the human herpesvirus 8 (HHV-8) (also termed Kaposi's sarcoma-associated herpesvirus) K8.1 gene. The functional role of glycoprotein K8.1 is unknown, and recognizable sequence homology to K8.1 is not detectable in the genomes of most other closely related gammaherp...

journal_title：Journal of virology

authors： Birkmann A,Mahr K,Ensser A,Yağuboğlu S,Titgemeyer F,Fleckenstein B,Neipel F

更新日期：2001-12-01 00:00:00

abstract：:The cytopathic effect (CPE) seen with some subgroups of avian sarcoma and leukosis virus (ASLV) is associated with viral Env activation of the death-promoting activity of TVB (a tumor necrosis factor receptor-related receptor that is most closely related to mammalian TNF-related apoptosis-inducing ligand [TRAIL] recep...

journal_title：Journal of virology

authors： Klucking S,Collins AS,Young JA

更新日期：2005-07-01 00:00:00

abstract：:Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-Å resolution, and the cryo-electron microscopy (cryo-EM) image reconstruction of a full-length PCV2 vir...

journal_title：Journal of virology

authors： Khayat R,Brunn N,Speir JA,Hardham JM,Ankenbauer RG,Schneemann A,Johnson JE

更新日期：2011-08-01 00:00:00

abstract：:Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2,9...

journal_title：Journal of virology

authors： Pevenstein SR,Williams RK,McChesney D,Mont EK,Smialek JE,Straus SE

更新日期：1999-12-01 00:00:00

abstract：:We analyzed xenotropic murine leukemia virus-related virus (XMRV) integration site sequences previously identified from human prostate tissues for single-nucleotide polymorphisms (SNPs) to discriminate between patient and potential cell line sources of the proviruses. The SNPs of two integration sites were identical t...

journal_title：Journal of virology

authors： Rusmevichientong A,Das Gupta J,Elias PS,Silverman RH,Chow SA

更新日期：2011-12-01 00:00:00

abstract：:The mechanism of cellular src (c-src) transduction by a transformation-defective deletion mutant, td109, of Rous sarcoma virus was studied by sequence analysis of the recombinational junctions in three td109-derived recovered sarcoma viruses (rASVs). Our results show that two rASVs have been generated by recombination...

journal_title：Journal of virology

authors： Soong MM,Iijima S,Wang LH

更新日期：1986-09-01 00:00:00

abstract：:Interactions between the oncogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) and dendritic cells (DCs) are poorly characterized. We show here that monocyte-derived DCs form syncytia and are infected upon coculture with HTLV-1-infected lymphocytes. We examined the role of DC-specific ICAM-3-grabbing nonint...

journal_title：Journal of virology

authors： Ceccaldi PE,Delebecque F,Prevost MC,Moris A,Abastado JP,Gessain A,Schwartz O,Ozden S

更新日期：2006-05-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is an emerging pathogen and is the causative infectious agent of Kaposi sarcoma and two malignancies of B cell origin. To date, there is no licensed KSHV vaccine. Development of an effective vaccine against KSHV continues to be limited by a poor understanding of how the vir...

journal_title：Journal of virology

authors： Muniraju M,Mutsvunguma LZ,Foley J,Escalante GM,Rodriguez E,Nabiee R,Totonchy J,Mulama DH,Nyagol J,Wussow F,Barasa AK,Brehm M,Ogembo JG

更新日期：2019-07-30 00:00:00

abstract：:White root rot, caused by the ascomycete Rosellinia necatrix, is a devastating disease worldwide, particularly in fruit trees in Japan. Here we report on the biological and molecular properties of a novel bipartite double-stranded RNA (dsRNA) virus encompassing dsRNA-1 (8,931 bp) and dsRNA-2 (7,180 bp), which was isol...

journal_title：Journal of virology

authors： Chiba S,Salaipeth L,Lin YH,Sasaki A,Kanematsu S,Suzuki N

更新日期：2009-12-01 00:00:00

abstract：:NS4B is one of the nonstructural proteins of classical swine fever virus (CSFV), the etiological agent of a severe, highly lethal disease of swine. Protein domain analysis of the predicted amino acid sequence of the NS4B protein of highly pathogenic CSFV strain Brescia (BICv) identified a putative Toll/interleukin-1 r...

journal_title：Journal of virology

authors： Fernandez-Sainz I,Gladue DP,Holinka LG,O'Donnell V,Gudmundsdottir I,Prarat MV,Patch JR,Golde WT,Lu Z,Zhu J,Carrillo C,Risatti GR,Borca MV

更新日期：2010-02-01 00:00:00