Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells.

abstract：:ICP0, an alpha (immediate-early) protein of herpes simplex virus 1, performs at least two key functions. It blocks inhibition of viral-gene expression by interferon, a function dependent on the degradation of the ND10 components PML and SP100 by the ubiquitin ligase expressed by the RING finger (RF), and it blocks sil...

journal_title：Journal of virology

authors： Gu H,Roizman B

更新日期：2009-01-01 00:00:00

abstract：:NF-kappaB signaling is critical to the survival and transformation of cells infected by the human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here we have examined how elimination of the NF-kappaB transcription factor p50 from mice affects the life cycle of murine gammaherpesviru...

journal_title：Journal of virology

authors： Krug LT,Collins CM,Gargano LM,Speck SH

更新日期：2009-05-01 00:00:00

abstract：:Alphavirus infection of fibroblastic cell types in vitro inhibits host cell translation and transcription, leading to suppression of interferon alpha/beta (IFN-α/β) production. However, the effect of infection upon myeloid cells, which are often the first cells encountered by alphaviruses in vivo, is unclear. Previous...

journal_title：Journal of virology

authors： Bhalla N,Gardner CL,Downs SN,Dunn M,Sun C,Klimstra WB

更新日期：2019-11-26 00:00:00

abstract：:Hepatitis C virus (HCV) chronic infection is characterized by low-level or undetectable cellular immune responses against HCV antigens. HCV proteins have been shown to affect various intracellular events and modulate immune responses, although the precise mechanisms used to mediate these effects are not fully understo...

journal_title：Journal of virology

authors： Saito K,Ait-Goughoulte M,Truscott SM,Meyer K,Blazevic A,Abate G,Ray RB,Hoft DF,Ray R

更新日期：2008-04-01 00:00:00

abstract：:The recently discovered hepatitis G virus (HGV) or GB virus C (GBV-C) is widely distributed in human populations, and homologues such as HGV/GBV-CCPZ and GBV-A are found in a variety of different primate species. Both epidemiological and phylogenetic analyses support the hypothesis that GB viruses coevolved with their...

journal_title：Journal of virology

authors： Simmonds P,Smith DB

更新日期：1999-07-01 00:00:00

abstract：:Polyamides have been shown to bind double-stranded DNA by complementing the curvature of the minor groove and forming various hydrogen bonds with DNA. Several polyamide molecules have been found to have potent antiviral activities against papillomavirus, a double-stranded DNA virus. By analogy, we reason that polyamid...

journal_title：Journal of virology

authors： Gumpper RH,Li W,Castañeda CH,Scuderi MJ,Bashkin JK,Luo M

更新日期：2018-03-28 00:00:00

abstract：:Two regions of the hepatitis B virus (HBV) genome have been shown to display properties of a transcriptional enhancer. Enhancer 1 is active in most hepatoma lines examined as well as in some non-hepatocyte-derived cell lines. In contrast, enhancer 2 activity is strictly liver specific. In this study, we show that aden...

journal_title：Journal of virology

authors： Chen ST,Su H,Yee JK

更新日期：1992-12-01 00:00:00

abstract：:Electron micrographic studies of neuronal axons have produced contradictory conclusions on how alphaherpesviruses are transported from neuron cell bodies to axon termini. Some reports have described unenveloped capsids transported on axonal microtubules with separate transport of viral glycoproteins within membrane ve...

journal_title：Journal of virology

authors： Snyder A,Wisner TW,Johnson DC

更新日期：2006-11-01 00:00:00

abstract：:Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu and Nef proteins of primate lentiviruses. Like other host genes subject to viral antagonism, primate Tetherin genes have evolved u...

journal_title：Journal of virology

authors： Lim ES,Malik HS,Emerman M

更新日期：2010-07-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) mutants with codon insertions and deletions in IE-0, the gene encoding ICP0, were constructed. The HSV-1 deletion mutant dl1403 (N. D. Stow and E. C. Stow, J. Gen. Virol. 67:2571-2585, 1986) and an IE-0:lacZ transplacement vector isolated in this study were used to facilitate the co...

journal_title：Journal of virology

authors： Chen J,Silverstein S

更新日期：1992-05-01 00:00:00

abstract：:Reverse transcription in avian sarcoma virus (ASV) initiates from the 3' end of a tRNA(Trp) primer, which anneals near the 5' end of the RNA genome. The region around the primer-binding site (PBS) forms an elaborate stem structure composed of the U5-inverted repeat (U5-IR) stem, the U5-leader stem, and the association...

journal_title：Journal of virology

authors： Morris S,Johnson M,Stavnezer E,Leis J

更新日期：2002-08-01 00:00:00

abstract：:Transfection of the E6 and E7 genes of the high-risk human papillomaviruses (HPVs) into primary genital keratinocytes generates colonies of proliferating cells which are resistant to calcium- and serum-induced terminal differentiation. To genetically map the HPV gene(s) responsible for this cellular phenotype, we clon...

journal_title：Journal of virology

authors： Sherman L,Schlegel R

更新日期：1996-05-01 00:00:00

abstract：:The release of the ribonucleic acid (RNA)-containing phage MS2 from Escherichia coli is accompanied by cellular lysis at 37 C, whereas at 30 C phage are released from intact cells. Chloramphenicol or rifampin prevents the release of progeny phage particles at both temperatures. Neither drug causes an immediate cessati...

journal_title：Journal of virology

authors： Engelberg H,Soudry E

更新日期：1971-09-01 00:00:00

abstract：:Scrapie and Creutzfeldt-Jakob disease are transmissible, degenerative neurological diseases caused by prions. Considerable evidence argues that prions contain protease-resistant sialoglycoproteins, designated PrPSc, encoded by a cellular gene. The prion protein (PrP) gene also encodes a normal cellular protein designa...

journal_title：Journal of virology

authors： Butler DA,Scott MR,Bockman JM,Borchelt DR,Taraboulos A,Hsiao KK,Kingsbury DT,Prusiner SB

更新日期：1988-05-01 00:00:00

abstract：UNLABELLED:T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance entry of Ebola virus (EBOV) and other viruses by binding PtdSer on the viral envelope, concentrating ...

journal_title：Journal of virology

authors： Moller-Tank S,Albritton LM,Rennert PD,Maury W

更新日期：2014-06-01 00:00:00

abstract：:In order to clarify the effect of an accumulation of amino acid substitutions on the hemadsorption character of the influenza AH3 virus hemagglutinin (HA) protein, we introduced single-point amino acid changes into the HA1 domain of the HA proteins of influenza viruses isolated in 1968 (A/Aichi/2/68) and 1997 (A/Sydne...

journal_title：Journal of virology

authors： Nakajima K,Nobusawa E,Nagy A,Nakajima S

更新日期：2005-05-01 00:00:00

abstract：:We have determined the complete nucleotide sequence of an infectious cloned genome of ground squirrel hepatitis virus (GSHV), a nonpathogenic member of the hepadnavirus group. The genome is 3,311 base pairs long and contains the major open reading frames described for the related human and woodchuck hepatitis B viruse...

journal_title：Journal of virology

authors： Seeger C,Ganem D,Varmus HE

更新日期：1984-08-01 00:00:00

abstract：:Interactions between viruses and the host antibody immune response are critical in the development and control of disease, and antibodies are also known to interfere with the efficacy of viral vector-based gene delivery. The adeno-associated viruses (AAVs) being developed as vectors for corrective human gene delivery ...

journal_title：Journal of virology

authors： Gurda BL,DiMattia MA,Miller EB,Bennett A,McKenna R,Weichert WS,Nelson CD,Chen WJ,Muzyczka N,Olson NH,Sinkovits RS,Chiorini JA,Zolotutkhin S,Kozyreva OG,Samulski RJ,Baker TS,Parrish CR,Agbandje-McKenna M

更新日期：2013-08-01 00:00:00

abstract：:The mechanism of cellular src (c-src) transduction by a transformation-defective deletion mutant, td109, of Rous sarcoma virus was studied by sequence analysis of the recombinational junctions in three td109-derived recovered sarcoma viruses (rASVs). Our results show that two rASVs have been generated by recombination...

journal_title：Journal of virology

authors： Soong MM,Iijima S,Wang LH

更新日期：1986-09-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S c...

journal_title：Journal of virology

authors： Lee HR,Mitra J,Lee S,Gao SJ,Oh TK,Kim MH,Ha T,Jung JU

更新日期：2015-10-21 00:00:00

abstract：:The mechanism of action of hepatitis B virus (HBV) X protein in transcriptional transactivation and in tumorigenesis remains obscure. We have used the yeast two-hybrid system to identify a cellular protein that can interact with HBV X protein. This protein, designated X-associated protein 1 (XAP-1), is a human homolog...

journal_title：Journal of virology

authors： Lee TH,Elledge SJ,Butel JS

更新日期：1995-02-01 00:00:00

abstract：:The herpes simplex virus (HSV) virion host shutoff (vhs) protein (UL41 gene product) is a component of the HSV virion tegument that triggers shutoff of host protein synthesis and accelerated mRNA degradation during the early stages of HSV infection. vhs displays weak amino acid sequence similarity to the fen-1 family ...

journal_title：Journal of virology

authors： Elgadi MM,Smiley JR

更新日期：1999-11-01 00:00:00

abstract：:Spumaviruses, or foamy viruses, express Gag proteins that are incompletely processed by the viral protease in cell cultures. To delineate the proteolytic cleavage sites between potential Gag subdomains, recombinant human spumaretrovirus (HSRV) Gag proteins of different lengths were expressed, purified by affinity chro...

journal_title：Journal of virology

authors： Pfrepper KI,Löchelt M,Rackwitz HR,Schnölzer M,Heid H,Flügel RM

更新日期：1999-09-01 00:00:00

abstract：:The protein kinase inhibitor H7 blocks influenza virus replication, inhibits production of the matrix protein (M1), and leads to a retention of the viral ribonucleoproteins (vRNPs) in the nucleus at late times of infection (K. Martin and A. Helenius, Cell 67:117-130, 1991). We show here that production of assembled vR...

journal_title：Journal of virology

authors： Bui M,Wills EG,Helenius A,Whittaker GR

更新日期：2000-02-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) typically displays two different phases in its life cycle, the default latent phase and the lytic phase. There is a short period of lytic gene expression in the early stage of KSHV primary infection. The factors involved in the shutdown process of lytic gene exp...

journal_title：Journal of virology

authors： Sun R,Liang D,Gao Y,Lan K

更新日期：2014-07-01 00:00:00

abstract：:The secreted cytokine alpha/beta interferon (IFN-alpha/beta) binds its receptor to activate the Jak-STAT signal transduction pathway, leading to formation of the heterotrimeric IFN-stimulated gene factor 3 (ISGF3) transcription complex for induction of IFN-stimulated genes (ISGs) and establishment of an antiviral stat...

journal_title：Journal of virology

authors： Zurney J,Kobayashi T,Holm GH,Dermody TS,Sherry B

更新日期：2009-03-01 00:00:00

abstract：:A single phosphorylation event at T-antigen residue Thr124 regulates initiation of simian virus 40 DNA replication. To explore this regulatory process, a series of peptides were synthesized, centered on Thr124. These peptides contain a nuclear localization signal (NLS) and a recognition site for cyclin/Cdk kinases. Wh...

journal_title：Journal of virology

authors： Kim RJ,Moine S,Reese DK,Bullock PA

更新日期：2002-12-01 00:00:00

abstract：:The recognition of naturally occurring rhadinoviruses in macaque monkeys has spurred interest in their use as models for human infection with Kaposi sarcoma-associated herpesvirus (human herpesvirus 8). Rhesus macaques (Macaca mulatta) and pig-tailed macaques (Macaca nemestrina) were inoculated intravenously with rhad...

journal_title：Journal of virology

authors： Mansfield KG,Westmoreland SV,DeBakker CD,Czajak S,Lackner AA,Desrosiers RC

更新日期：1999-12-01 00:00:00

abstract：:By marker rescue of bacteriophage SP02 sus mutants with purified bacteriophage SP02 DNA fragments, 11 of the 17 known bacteriophage SP02 sus loci were assigned to discrete DNA fragments. The left-most genetic locus, susA, was found to reside near one bacteriophage SP02 terminus (EcoRI-C1 fragment), whereas the right-m...

journal_title：Journal of virology

authors： Graham S,Sutton S,Yoneda Y,Young FE

更新日期：1982-04-01 00:00:00

abstract：UNLABELLED:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are critical in eliminating infection. We developed an animal model in which HBV-infected human hepatocytes are targeted by HBV-specific CTLs. After HBV inoculation in human hepatocyte-transplanted herpes simplex virus type-1 thymidine kinase-NO...

journal_title：Journal of virology

authors： Uchida T,Hiraga N,Imamura M,Tsuge M,Abe H,Hayes CN,Aikata H,Ishida Y,Tateno C,Yoshizato K,Ohdan H,Murakami K,Chayama K

更新日期：2015-10-01 00:00:00