Abstract:
:Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing KSHV replication. This shows that KSHV vIRF4 suppresses host G1-S transition, possibly providing an intracellular milieu favorable for its replication.
journal_name
J Viroljournal_title
Journal of virologyauthors
Lee HR,Mitra J,Lee S,Gao SJ,Oh TK,Kim MH,Ha T,Jung JUdoi
10.1128/JVI.01897-15subject
Has Abstractpub_date
2015-10-21 00:00:00pages
1139-43issue
2eissn
0022-538Xissn
1098-5514pii
JVI.01897-15journal_volume
90pub_type
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pub_type: 杂志文章
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