Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.

abstract：:While cytomegalovirus (CMV) infections are often limited in host range by lengthy coevolution with a single host species, a few CMVs are known to deviate from this rule. For example, rhesus macaque CMV (RhCMV), a model for human CMV (HCMV) pathogenesis and vaccine development, can replicate in human cells, as well as ...

journal_title：Journal of virology

authors： Child SJ,Hickson SE,Bayer A,Malouli D,Früh K,Geballe AP

更新日期：2018-02-26 00:00:00

abstract：:Adenovirus infections cause significant morbidity and mortality in immunocompromised patients, yet little is known about the immune response to adenovirus infections. We established a system for the generation of a cytotoxic immune response to adenovirus in vitro. Cytotoxic T cells (CTLs) were derived from normal dono...

journal_title：Journal of virology

authors： Smith CA,Woodruff LS,Kitchingman GR,Rooney CM

更新日期：1996-10-01 00:00:00

abstract：:Human herpesvirus 7 (HHV-7) is a recently isolated betaherpesvirus that is prevalent in the human population, with primary infection usually occurring in early childhood. HHV-7 is related to human herpesvirus 6 (HHV-6) in terms of both biological and, from limited prior DNA sequence analysis, genetic criteria. However...

journal_title：Journal of virology

authors： Nicholas J

更新日期：1996-09-01 00:00:00

abstract：:Higher-order RNA structures in the 3' untranslated region (3'UTR) of enteroviruses are thought to play a pivotal role in viral negative-strand RNA synthesis. The structure of the 3'UTR was predicted by thermodynamic calculations using the STAR (structural analysis of RNA) computer program and experimentally verified u...

journal_title：Journal of virology

authors： Melchers WJ,Hoenderop JG,Bruins Slot HJ,Pleij CW,Pilipenko EV,Agol VI,Galama JM

更新日期：1997-01-01 00:00:00

abstract：:Human CD4(+) T-helper 1 cell responses to Epstein-Barr virus (EBV) infection are likely to be important in the maintenance of virus-specific CD8(+) memory and/or as antiviral effectors in their own right. The present work has used overlapping peptides as stimulators of gamma interferon release (i) to identify CD4(+) e...

journal_title：Journal of virology

authors： Leen A,Meij P,Redchenko I,Middeldorp J,Bloemena E,Rickinson A,Blake N

更新日期：2001-09-01 00:00:00

abstract：:We previously reported that human cytomegalovirus (HCMV) infection induces endoplasmic reticulum (ER) stress, resulting in activation of the unfolded protein response (UPR). Although some normal consequences of UPR activation (e.g., translation attenuation) are detrimental to viral infection, we have previously shown ...

journal_title：Journal of virology

authors： Isler JA,Maguire TG,Alwine JC

更新日期：2005-12-01 00:00:00

abstract：:Gammaretroviruses, such as murine leukemia virus (MLV), are functionally distinguished from lentiviruses, such as human immunodeficiency virus, by their inability to infect nondividing cells. Attempts to engineer this property into MLV have been hindered by an incomplete understanding of early events in the viral life...

journal_title：Journal of virology

authors： Yu JH,Schaffer DV

更新日期：2006-09-01 00:00:00

abstract：:A adenovirus type 5 host range mutant (hr440) has been isolated which is defective in a splicing event required to generate the middle-sized mRNA from early region 1A. This defect has been ascribed to two adjacent nucleotide changes which lie five and six nucleotides from the 5' splice site for this mRNA (Solnick, Nat...

journal_title：Journal of virology

authors： Solnick D,Anderson MA

更新日期：1982-04-01 00:00:00

abstract：:We recently found that a human T-cell leukemia virus type 1-infected cell line, MT-2, could support the replication of hepatitis C virus (HCV) (N. Kato, T. Nakazawa, T. Mizutani, and K. Shimotohno, Biochem. Biophys. Res. Commun. 206:863-869, 1995). In order to develop a culture system in which HCV replicates more effi...

journal_title：Journal of virology

authors： Mizutani T,Kato N,Saito S,Ikeda M,Sugiyama K,Shimotohno K

更新日期：1996-10-01 00:00:00

abstract：:An adult horse infected with a virulent, cell culture-adapted strain of equine infectious anemia virus (EIAV) developed cyclical thrombocytopenia in which the nadir of platelet counts coincided with peak febrile responses. In order to investigate the mechanism of thrombocytopenia during acute febrile episodes, four ad...

journal_title：Journal of virology

authors： Clabough DL,Gebhard D,Flaherty MT,Whetter LE,Perry ST,Coggins L,Fuller FJ

更新日期：1991-11-01 00:00:00

abstract：:Ten bacteriophages that attack and lyse saprophytic strains of Bdellovibrio bacteriovorus were isolated. Morphological, serological, and host-range studies revealed that there were four different bdellovibrio phages present among the isolates. One of the phages lysed a strain of B. bacteriovorus that requires the pres...

journal_title：Journal of virology

authors： Althauser M,Samsonoff WA,Anderson C,Conti SF

更新日期：1972-09-01 00:00:00

abstract：:Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense vacuolation of the central nervous system gray matter and vacuolation and hypomyelination of some white matter tracts. Bas...

journal_title：Journal of virology

authors： Carlson GA,Banks S,Lund D,Reichert C,Groth D,Torchia M,Dearmond SJ,Prusiner SB

更新日期：1997-03-01 00:00:00

abstract：:We have previously demonstrated that the human papillomavirus (HPV) genome replicates effectively in U2OS cells after transfection using electroporation. The transient extrachromosomal replication, stable maintenance, and late amplification of the viral genome could be studied for high- and low-risk mucosal and cutane...

journal_title：Journal of virology

authors： Reinson T,Toots M,Kadaja M,Pipitch R,Allik M,Ustav E,Ustav M

更新日期：2013-01-01 00:00:00

abstract：:Coupling of G proteins to ligand-engaged chemokine receptors is the paramount event in G-protein-coupled receptor signal transduction. Previously, we have demonstrated that the human cytomegalovirus-encoded chemokine receptor US28 mediates human vascular smooth muscle cell (SMC) migration in response to either RANTES ...

journal_title：Journal of virology

authors： Melnychuk RM,Streblow DN,Smith PP,Hirsch AJ,Pancheva D,Nelson JA

更新日期：2004-08-01 00:00:00

abstract：UNLABELLED:An understanding of the antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines, but it has not been possible to examine these cells directly because HA binds to sialic acid (SA) on most cell types. Here, we use structure-based...

journal_title：Journal of virology

authors： Whittle JR,Wheatley AK,Wu L,Lingwood D,Kanekiyo M,Ma SS,Narpala SR,Yassine HM,Frank GM,Yewdell JW,Ledgerwood JE,Wei CJ,McDermott AB,Graham BS,Koup RA,Nabel GJ

更新日期：2014-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a prototypic member of the betaherpesvirus family. The HCMV virion is composed of a large DNA genome encapsidated within a nucleocapsid, which is wrapped within an inner proteinaceous tegument and an outer lipid envelope containing viral glycoproteins. Although genome encapsidation clea...

journal_title：Journal of virology

authors： Jarvis MA,Fish KN,Söderberg-Naucler C,Streblow DN,Meyers HL,Thomas G,Nelson JA

更新日期：2002-05-01 00:00:00

abstract：:ICP0 is a potent activator of herpes simplex virus type 1 gene expression in transient assays and in productive infection. A role for ICP0 in reactivation from latency in vivo has also been suggested on the basis of the observation that viruses with mutations in both copies of the diploid gene for ICP0 reactivate less...

journal_title：Journal of virology

authors： Cai W,Astor TL,Liptak LM,Cho C,Coen DM,Schaffer PA

更新日期：1993-12-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a newly identified coronavirus (CoV), SARS-CoV. The spike (S) glycoprotein of CoV is the major structural protein responsible for induction of host immune response and virus neutralization by antibodies. Hence, knowledge of neutralization...

journal_title：Journal of virology

authors： Zhang H,Wang G,Li J,Nie Y,Shi X,Lian G,Wang W,Yin X,Zhao Y,Qu X,Ding M,Deng H

更新日期：2004-07-01 00:00:00

abstract：:Glycoprotein B (gB) of herpes simplex virus (HSV) is one of four glycoproteins essential for viral entry and cell fusion. Recently, paired immunoglobulin-like type 2 receptor (PILRalpha) was identified as a receptor for HSV type 1 (HSV-1) gB. Both PILRalpha and a gD receptor were shown to participate in HSV-1 entry in...

journal_title：Journal of virology

authors： Fan Q,Lin E,Satoh T,Arase H,Spear PG

更新日期：2009-08-01 00:00:00

abstract：:West Nile virus (WNV) is a neurotropic flavivirus and the leading cause of mosquito-borne encephalitis in the United States. Recent studies in humans have found that dysfunctional T cell responses strongly correlate with development of severe WNV neuroinvasive disease. However, the contributions of human dendritic cel...

journal_title：Journal of virology

authors： Zimmerman MG,Bowen JR,McDonald CE,Pulendran B,Suthar MS

更新日期：2019-11-13 00:00:00

abstract：:The S protein of bovine coronavirus (BCV) has been isolated from the viral membrane and purified by gradient centrifugation. Purified S protein was identified as a viral hemagglutinin. Inactivation of the cellular receptors by sialate 9-O-acetylesterase and generation of receptors by sialylation of erythrocytes with N...

journal_title：Journal of virology

authors： Schultze B,Gross HJ,Brossmer R,Herrler G

更新日期：1991-11-01 00:00:00

abstract：:The gD, gB, and gH/gL glycoprotein quartet constitutes the basic apparatus for herpes simplex virus (HSV) entry into the cell and fusion. gD serves as a receptor binding glycoprotein and trigger of fusion. The conserved gB and gH/gL execute fusion. Central to understanding HSV entry/fusion has become the dissection of...

journal_title：Journal of virology

authors： Avitabile E,Forghieri C,Campadelli-Fiume G

更新日期：2009-10-01 00:00:00

abstract：:We performed live cell visualization assays to directly assess the interaction between competing adeno-associated virus (AAV) and herpes simplex virus type 1 (HSV-1) DNA replication. Our studies reveal the formation of separate AAV and HSV-1 replication compartments and the inhibition of HSV-1 replication compartment ...

journal_title：Journal of virology

authors： Glauser DL,Strasser R,Laimbacher AS,Saydam O,Clément N,Linden RM,Ackermann M,Fraefel C

更新日期：2007-05-01 00:00:00

abstract：:There are two types of infectious vaccinia virus particles: intracellular naked virions and extracellular enveloped virions (EEV). To determine the biological role of the enveloped form of vaccinia virus, we produced and characterized a mutant that is defective in EEV formation. The strategy involved replacement by ho...

journal_title：Journal of virology

authors： Blasco R,Moss B

更新日期：1991-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based pseudoparticles (HCVpp) incorporating a panel of full-length E1E2 clon...

journal_title：Journal of virology

authors： Owsianka A,Tarr AW,Juttla VS,Lavillette D,Bartosch B,Cosset FL,Ball JK,Patel AH

更新日期：2005-09-01 00:00:00

abstract：:Among Moloney murine leukemia viruses (Mo-MuLVs) having stop codons other than UAG at the gag-pol junction, Mo-MuLV with UAA, but not with UGA, had a replication disadvantage. Mo-MuLV with a glutamine codon (CAG) at the junction did not replicate. A revertant of this virus consisted of the original virus and a virus w...

journal_title：Journal of virology

authors： Odawara T,Yoshikura H,Ohshima M,Tanaka T,Jones DS,Nemoto F,Kuchino Y,Iwamoto A

更新日期：1991-11-01 00:00:00

abstract：:Although many human immunodeficiency virus type 1 (HIV-1)-infected persons are treated with multiple protease inhibitors in combination or in succession, mutation patterns of protease isolates from these persons have not been characterized. We collected and analyzed 2,244 subtype B HIV-1 isolates from 1,919 persons wi...

journal_title：Journal of virology

authors： Wu TD,Schiffer CA,Gonzales MJ,Taylor J,Kantor R,Chou S,Israelski D,Zolopa AR,Fessel WJ,Shafer RW

更新日期：2003-04-01 00:00:00

abstract：:We studied the effect of booster injections and the long-term immune response after injections of an anti-human immunodeficiency virus type 1 (HIV-1) lipopeptide vaccine. This vaccine was injected alone or with QS21 adjuvant to 28 HIV-uninfected volunteers. One month later, after a fourth injection of the vaccine, B- ...

journal_title：Journal of virology

authors： Gahéry-Ségard H,Pialoux G,Figueiredo S,Igéa C,Surenaud M,Gaston J,Gras-Masse H,Lévy JP,Guillet JG

更新日期：2003-10-01 00:00:00

abstract：:The human herpesvirus entry mediator C (HveC), also known as the poliovirus receptor-related protein 1 (PRR1) and as nectin-1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with such a receptor is an essential step in the p...

journal_title：Journal of virology

authors： Krummenacher C,Baribaud I,Ponce de Leon M,Whitbeck JC,Lou H,Cohen GH,Eisenberg RJ

更新日期：2000-12-01 00:00:00

abstract：:The state of intracellular viral DNA in cells infected with channel catfish virus has been studied by the Hirt selective extraction procedure and by restriction endonuclease digestion. The sedimentation properties and restriction patterns of viral DNA in the Hirt supernatant fraction indicate that the majority, if not...

journal_title：Journal of virology

authors： Cebrian J,Bucchini D,Sheldrick P

更新日期：1983-05-01 00:00:00